Fight Aging! Newsletter, August 13th 2018
We report that the disruption of excitation-contraction coupling contributes to impaired force generation in the mouse model of Sod1 deficiency. Briefly, we found a significant reduction in sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity as well as reduced expression of proteins involved in calcium release and force generation. Another potential factor involved in EC uncoupling in Sod1-/- mice is oxidative damage to proteins involved in the contractile response. In summary, this study provides strong support for the coupling between increased oxidative stress and disruption of cellular excitation contraction machinery in mouse skeletal muscle. The novel quantitative mechanistic data provided here can lead to potential therapeutic interventions of SERCA dysfunction for sarcopenia and muscle diseases. Repair Biotechnologies Closes Seed Round, Joins Grapeseed.bio Incubator https://www.fightaging.org/archives/2018/08/repair-biotechnologies-closes-seed-round-joins-grapeseed-bio-incubator/ I had promised a short update on progress at Repair Biotechnologies, the company that Bill Cherman and I founded earlier this year to help advance the state of therapies to treat aging, and here it is. We recently closed a seed round with a number of investors in our close-knit community, and are presently setting up our modest headquarters near Syracuse, NY, alongside our allies at Ichor Therapeutics. The staff at Ichor, fresh from a sizable investment made by Juve...
This study contributes to the knowledge of, and possible reflections upon, the impact of physicians ’ personal beliefs and values on their attitudes toward important decisions in their patients’ lives.
Publication date: September 2020Source: Biotechnology Reports, Volume 27Author(s): Parastoo Mojtahed Zadeh-Ardabilia, Sima Kianpour Rad
Publication date: 2020Source: Computational and Structural Biotechnology Journal, Volume 18Author(s): Zhilan Zhang, Lin Li, Mengyuan Li, Xiaosheng Wang
Cancer-fighting Kronos and Spruce, targeting a serious hormonal condition, have a common investor in Omega Funds.
AbstractPurposeExertional-heat stress adversely disrupts gastrointestinal (GI) barrier integrity, whereby subsequent microbial translocation (MT) can result in potentially serious health consequences. To date, the influence of aerobic fitness on GI barrier integrity and MT following exertional-heat stress is poorly characterised.MethodTen untrained (UT;VO2max = 45 ± 3 ml·kg−1·min−1) and ten highly trained (HT;VO2max = 64 ± 4 ml·kg−1·min−1) males completed an ecologically valid (military) 80-mi...
Publication date: 1 December 2020Source: Journal of Molecular Liquids, Volume 319Author(s): Marouen Chemingui, Upendra B. Singh, Neelam Yadav, Roman S. Dabrowski, Ravindra Dhar
Publication date: Available online 19 September 2020Source: Life SciencesAuthor(s): Lang Guan Cun, Muhammad Waseem Ghani, Zhao Yi, Wu Jiang, Li Ye, Liu Bin, Muhammad Waseem Birmani, An Lilong, Xiao Mei
Publication date: Available online 19 September 2020Source: Life SciencesAuthor(s): Tapan Behl, Swati Chadha, Monika Sachdeva, Arun Kumar, Abdul Hafeez, Vineet Mehta, Simona Bungau
Publication date: November 2020Source: Fish &Shellfish Immunology, Volume 106Author(s): Zhenlu Wang, Lei Wang, Jiang Zhou, Jixing Zou, Lanfen Fan
Publication date: November 2020Source: Fish &Shellfish Immunology, Volume 106Author(s): Anna Peronato, Nicola Franchi, Ballarin Loriano
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