Exposure to benzene, toluene, ethylbenzene, and xylene (BTEX) at Nigeria's petrol stations: a review of current status, challenges and future directions
DISCUSSION: Currently, regulatory bodies' effectiveness and accountability in safeguarding OHS at NPSs leave much to be desired. Understanding the OHS of NPSs would inform future initiatives, policies, and regulations that would promote the health and safety of workers at NPSs. However, further studies need to be conducted to describe the vulnerability of PSWs and other Nigerians who are occupationally exposed to BTEX pollution. More importantly, controlling air pollution from hazardous air pollutants like BTEX is an essential component of OHS and integral to attaining the Sustainable Development Goals (SDG) 3, 7, and 11.P...
Source: Cancer Control - April 9, 2024 Category: Cancer & Oncology Authors: Emmanuel Ademola Anigilaje Zaheer Ahmad Nasir Christopher Walton Source Type: research
Air pollution and diabetes mellitus: Association and validation in a desert area in China
CONCLUSIONS: Our study provides robust evidence of a correlation between prolonged exposure to air pollution and the prevalence of DM among individuals living in the desert-adjacent areas. This research contributes to the expanding knowledge on the relationship between air pollution exposure and DM prevalence in desert-adjacent areas.PMID:38593183 | DOI:10.1210/clinem/dgae219 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 9, 2024 Category: Endocrinology Authors: Lin Li Weidong Ji Zhe Wang Yinlin Cheng Kuiying Gu Yushan Wang Yi Zhou Source Type: research
Air pollution and diabetes mellitus: Association and validation in a desert area in China
CONCLUSIONS: Our study provides robust evidence of a correlation between prolonged exposure to air pollution and the prevalence of DM among individuals living in the desert-adjacent areas. This research contributes to the expanding knowledge on the relationship between air pollution exposure and DM prevalence in desert-adjacent areas.PMID:38593183 | DOI:10.1210/clinem/dgae219 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 9, 2024 Category: Endocrinology Authors: Lin Li Weidong Ji Zhe Wang Yinlin Cheng Kuiying Gu Yushan Wang Yi Zhou Source Type: research
The clinical relevance of heme detoxification by the macrophage heme oxygenase system
Front Immunol. 2024 Mar 22;15:1379967. doi: 10.3389/fimmu.2024.1379967. eCollection 2024.ABSTRACTHeme degradation by the heme oxygenase (HMOX) family of enzymes is critical for maintaining homeostasis and limiting heme-induced tissue damage. Macrophages express HMOX1 and 2 and are critical sites of heme degradation in healthy and diseased states. Here we review the functions of the macrophage heme oxygenase system and its clinical relevance in discrete groups of pathologies where heme has been demonstrated to play a driving role. HMOX1 function in macrophages is essential for limiting oxidative tissue damage in both acute ...
Source: Atherosclerosis - April 8, 2024 Category: Cardiology Authors: Scott Yeudall Clint M Upchurch Norbert Leitinger Source Type: research
GSE262987 CLCF1/NF- κB Signaling Pathway Regulates Macrophage Efferocytosis to Ameliorate Neural Damage and Cognitive Dysfunction After CO Poisoning.
Contributors : Xudong Zhou ; Huiping Song ; Wei han ; Qin LiSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusSevere carbon monoxide (CO) poisoning can cause structural damage to the nervous system, leading to long-term cognitive dysfunction in patients. Correctly terminating the inflammatory response caused by neuronal damage is a prerequisite for tissue repair. Macrophages can clear the cell corpses/fragments caused by brain injury through efferocytosis, and produce cytokines to coordinate the immune response, promoting neuronal repair and regeneration. However, in the microe...
Source: GEO: Gene Expression Omnibus - April 7, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
Heterozygous gain of function variant in GUCY1A2 may cause autonomous ovarian hyperfunction
CONCLUSION: Our data define a syndromic autonomous ovarian puberty likely due to the activating allele p.(E486D) in GUCY1A2 leading to an increase in cGMP. The overlap with the ovarian symptoms of McCune-Albright syndrome suggests an impact of this cGMP increase on the cAMP pathway in the ovary. Additional cases will be needed to ensure a causal link.PMID:38578777 | DOI:10.1093/ejendo/lvae030 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 5, 2024 Category: Endocrinology Authors: Theresa Wittrien Alban Ziegler Anne R ühle Svenja Stomberg Ruben Meyer Dominique Bonneau Patrice Rodien Delphine Prunier-Mirebeau R égis Coutant S önke Behrends Source Type: research
Heterozygous gain of function variant in GUCY1A2 may cause autonomous ovarian hyperfunction
CONCLUSION: Our data define a syndromic autonomous ovarian puberty likely due to the activating allele p.(E486D) in GUCY1A2 leading to an increase in cGMP. The overlap with the ovarian symptoms of McCune-Albright syndrome suggests an impact of this cGMP increase on the cAMP pathway in the ovary. Additional cases will be needed to ensure a causal link.PMID:38578777 | DOI:10.1093/ejendo/lvae030 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 5, 2024 Category: Endocrinology Authors: Theresa Wittrien Alban Ziegler Anne R ühle Svenja Stomberg Ruben Meyer Dominique Bonneau Patrice Rodien Delphine Prunier-Mirebeau R égis Coutant S önke Behrends Source Type: research
Effect of implementation strategies on the routine provision of antenatal care addressing smoking in pregnancy: study protocol for a non-randomised stepped-wedge cluster controlled trial
This study aims to determine the effectiveness and cost effectiveness of implementation strategies in increasing the routine provision of recommended antenatal care for smoking cessation in public maternity services.
Methods and analysis
A non-randomised stepped-wedge cluster-controlled trial will be conducted in maternity services across three health sectors in New South Wales, Australia. Implementation strategies including guidelines and procedures, reminders and prompts, leadership support, champions, training and monitoring and feedback will be delivered sequentially to each sector over 4 months. Primary outcome measu...
Source: BMJ Open - April 5, 2024 Category: General Medicine Authors: Daly, J. B., Doherty, E., Tully, B., Wiggers, J., Hollis, J., Licata, M., Foster, M., Tzelepis, F., Lecathelinais, C., Kingsland, M. Tags: Open access, Health services research Source Type: research
Mortality surrogates in combined pulmonary fibrosis and emphysema
Extract
Emphysema is a common pulmonary finding on computed tomography (CT) imaging of idiopathic pulmonary fibrosis (IPF) patients [1]. The term combined pulmonary fibrosis and emphysema (CPFE) describes a potential clinical endotype characterised by the coexistence of upper-lobe-predominant emphysema, lower-lobe-predominant fibrosis and relative preservation of forced vital capacity (FVC) in the context of a disproportionately reduced gas transfer (diffusing capacity of the lung for carbon monoxide (DLCO)) [1–3]. CPFE is highly heterogeneous in terms of the distribution and relative extents of fibrosis and emphysem...
Source: European Respiratory Journal - April 4, 2024 Category: Respiratory Medicine Authors: Zhao, A., Gudmundsson, E., Mogulkoc, N., van Moorsel, C., Corte, T. J., Vasudev, P., Romei, C., Chapman, R., Wallis, T. J. M., Denneny, E., Goos, T., Savas, R., Ahmed, A., Brereton, C. J., van Es, H. W., Jo, H., De Liperi, A., Duncan, M., Pontoppidan, K., Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung disease Source Type: research
Combined pulmonary fibrosis and emphysema syndrome: the age of majority
Extract
Described in 1990, the combination of pulmonary fibrosis and emphysema is associated with a distinctive physiological profile, with preserved lung volumes and airflow, and severely altered diffusion capacity for carbon monoxide (DLCO) [1]. Combined pulmonary fibrosis and emphysema (CPFE) was individualised as a syndrome in 2005 in a series of 61 patients [2], which drew attention to its main characteristics, namely male predominance, history of smoking, severe dyspnoea on exertion, relatively preserved airflow rates and lung volumes on spirometry, severely impaired DLCO, exertional hypoxaemia, and a high propensity...
Source: European Respiratory Journal - April 4, 2024 Category: Respiratory Medicine Authors: Cottin, V. Tags: Editorials Source Type: research
Contextual bias in forensic toxicology decisions: A follow-up empirical study from China
J Forensic Sci. 2024 Apr 3. doi: 10.1111/1556-4029.15520. Online ahead of print.ABSTRACTThe impact of contextual bias has been demonstrated repeatedly across forensic domains; however, research on this topic in forensic toxicology is very limited. In our previous study, experimental data from only one context version were compared with the actual forensic biasing casework. As a follow-up, this controlled experiment with 159 forensic toxicology practitioners was conducted, to test whether knowledge of different contextual information influenced their forensic decision-making. Participants in different context groups were ta...
Source: Journal of Forensic Sciences - April 3, 2024 Category: Forensic Medicine Authors: Ning He Hongxia Hao Source Type: research
Genetic association between smoking and DLCO in idiopathic pulmonary fibrosis patients
Observational studies have shown that smoking is related to the diffusing capacity of the lungs for carbon monoxide (DLCO) in individuals with idiopathic pulmonary fibrosis (IPF). Nevertheless, further investi... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 3, 2024 Category: Respiratory Medicine Authors: Ziheng Yuan, Wanyang Lei, Xiqian Xing, Xiaohua He, Xiaoxian Huang, Li Wei, Yuanyuan Lv, Shuyi Qiu, Ziyu Yuan, Jiyang Wang and Mei Yang Tags: Research Source Type: research
An ecological analysis of associations between ambient air pollution and cancer incidence rates in Taiwan
Environ Sci Pollut Res Int. 2024 Apr 3. doi: 10.1007/s11356-024-33145-9. Online ahead of print.ABSTRACTAir pollution is deemed a human carcinogen and can be linked to certain types of cancer other than lung cancer. The present study aimed to investigate the pollutant-cancer associations in a population-level cohort. We obtained the annual age-standardized incidence rates of 28 different cancer types between 2015 to 2019 from the Taiwan Cancer Registry. Outdoor concentrations of particulate matter with a diameter of 10 μm or less (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), ground-level ozone (O3), and carbon mono...
Source: Environmental Science and Pollution Research International - April 2, 2024 Category: Environmental Health Authors: Sheena Yi-Hsin Cheng Yi-Chiung Hsu Shih-Ping Cheng Source Type: research
An ecological analysis of associations between ambient air pollution and cancer incidence rates in Taiwan
Environ Sci Pollut Res Int. 2024 Apr 3. doi: 10.1007/s11356-024-33145-9. Online ahead of print.ABSTRACTAir pollution is deemed a human carcinogen and can be linked to certain types of cancer other than lung cancer. The present study aimed to investigate the pollutant-cancer associations in a population-level cohort. We obtained the annual age-standardized incidence rates of 28 different cancer types between 2015 to 2019 from the Taiwan Cancer Registry. Outdoor concentrations of particulate matter with a diameter of 10 μm or less (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), ground-level ozone (O3), and carbon mono...
Source: Environmental Science and Pollution Research International - April 2, 2024 Category: Environmental Health Authors: Sheena Yi-Hsin Cheng Yi-Chiung Hsu Shih-Ping Cheng Source Type: research
Association Between Maternal Prenatal Exposure to Household Air Pollution and Child Respiratory Health: A Systematic Review and Meta-analysis
The objective of this study is to assess the level of association between prenatal household air pollution and child respiratory health, and to identify which HAP pollutants are associated with specific respiratory illnesses or symptoms and to what degree. Relevant studies were retrieved from PubMed databases up to April 27, 2010, and their reference lists were reviewed. Random effects models were applied to estimate summarized relative risks (RRs) and 95% confidence intervals (CIs). The analysis involved 11 studies comprising 387 767 mother-child pairs in total, assessing various respiratory health outcomes in children ex...
Source: The Yale Journal of Biology and Medicine - April 1, 2024 Category: Universities & Medical Training Authors: Krrishika Saxena Source Type: research
