The carbon monoxide prodrug oCOm ‐21 increases Ca2+ sensitivity of the cardiac myofilament
AbstractPatients undergoing cardiopulmonary bypass procedures require inotropic support to improve hemodynamic function and cardiac output. Current inotropes such as dobutamine, can promote arrhythmias, prompting a demand for improved inotropes with little effect on intracellular Ca2+ flux. Low-dose carbon monoxide (CO) induces inotropic effects in perfused hearts. Using the CO-releasing pro-drug, oCOm-21, we investigated if this inotropic effect results from an increase in myofilament Ca2+ sensitivity. Male Sprague Dawley rat left ventricular cardiomyocytes were permeabilized, and myofilament force was measured as a funct...
Source: Physiological Reports - March 16, 2024 Category: Physiology Authors: Fergus M. Payne,
Samantha Nie,
Gary M. Diffee,
Gerard T. Wilkins,
David S. Larsen,
Joanne C. Harrison,
James C. Baldi,
Ivan A. Sammut Tags: ORIGINAL ARTICLE Source Type: research
Not all wheeze is asthma
A 41-year-old man previously diagnosed with asthma presented with an influenza-like illness and breathlessness. He was treated for moderate-to-severe COVID-19 and exacerbation of asthma. CT pulmonary angiography (CTPA) revealed asymmetrical peribronchovascular ground-glass infiltrates consistent with COVID-19 and right main bronchial wall thickening with high-density material thought to be consistent with mucous impaction (figure 1A). He was discharged 8 days after admission. At review 4 months later, he reported ongoing breathlessness and cough productive of green sputum. Lung function tests showed a forced expiratory vol...
Source: Thorax - March 15, 2024 Category: Respiratory Medicine Authors: Ng, K. L., Park, J., Belcher, E., Moore, A. J. Tags: Images in Thorax, Thorax Source Type: research
Sensors, Vol. 24, Pages 1873: Deep Learning for Gas Sensing via Infrared Spectroscopy
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Deep learning methods, a powerful form of artificial intelligence, have been applied in a number of spectroscopy and gas sensing applications. However, the speciation of multi-component gas mixtures from infrared (IR) absorption spectra using deep learning remains to be explored. Here, we propose a one-dimensional deep convolutional neural network gas classification model for the identification of small molecules of interest based on IR absorption spectra in flexible user-defined frequency ranges. The molecules considered include ten that are of interest in the atmosphere or in industrial and environmental processe...
Source: Sensors - March 14, 2024 Category: Biotechnology Authors: M. Arshad Zahangir Chowdhury Matthew A. Oehlschlaeger Tags: Article Source Type: research
Synthesis, structural characterization, docking studies and bioactivities of carbon monoxide release molecules based on triphenylphosphonium-glycyrrhetinic acid derivatives
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D3NJ03536K, PaperHuapeng Liu, Ming-Zhe Ren, Yu-Jie Chen, Sheng-Yan Zhao, Yuan Liao, Xi-Cun Wang As a gasotransmitter, carbon monoxide could induce the tumor cells apoptosis by reversing the Warburg effect. The carbon monoxide-releasing molecules (CORMs) is a pleading option for CO administration, but how... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - March 12, 2024 Category: Chemistry Authors: Huapeng Liu Source Type: research
Exploring Rhodospirillum rubrum response to high doses of carbon monoxide under light and dark conditions
Appl Microbiol Biotechnol. 2024 Mar 11;108(1):258. doi: 10.1007/s00253-024-13079-5.ABSTRACTEnvironmental concerns about residues and the traditional disposal methods are driving the search for more environmentally conscious processes, such as pyrolysis and gasification. Their main final product is synthesis gas (syngas) composed of CO, CO2, H2, and methane. Syngas can be converted into various products using CO-tolerant microorganisms. Among them, Rhodospirillum rubrum is highlighted for its biotechnological potential. However, the extent to which high doses of CO affect its physiology is still opaque. For this reason, we ...
Source: Applied Microbiology and Biotechnology - March 11, 2024 Category: Microbiology Authors: Manuel S Godoy Irene Verd ú Santiago R de Miguel Jos é D Jiménez M Auxiliadora Prieto Source Type: research
Optic nerve sheath diameter measurements to predict delayed neurological sequelae after carbon monoxide poisoning
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - March 11, 2024 Category: Toxicology Authors: Yusuf Kenan TekinDepartment of Emergency Medicine, Sivas Cumhuriyet University, Sivas, Turkey Source Type: research
Study on the Catalytic Performance of ZnCrAl Co-precipitated Oxides Washed with Ammonium Carbonate Solution in the Synthesis of Light Olefins from Syngas
New J. Chem., 2024, Accepted Manuscript DOI: 10.1039/D4NJ00947A, PaperWenli Jiang, Heping Zheng, Daqiang Xiao, Yu Ren, Jian-Hua Tang The activation of carbon monoxide by the presence of oxygen vacancies is widely recognized as a crucial step in the direct synthesis of light olefins from syngas. However, little research... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - March 8, 2024 Category: Chemistry Authors: Wenli Jiang Source Type: research
Disparities in death at work: reflections on occupational injury fatality data
Despite many advances in workplace health and safety globally, worker death at work or from work remains an unfortunately common occurrence, and an enormous public health challenge on a global scale. The most recent global estimates, produced jointly by the WHO and the International Labour Organisation (ILO), show that the number of worker fatalities from occupational traumatic injury has not shifted this century. The WHO and ILO estimate a total of 363 283 acute occupational injury fatalities in 2016.1 These are a subset of the total estimated 1.9 million annual worker deaths from occupational exposures.1 The main causes ...
Source: Occupational and Environmental Medicine - March 8, 2024 Category: Occupational Health Authors: Collie, A. Tags: Commentary Source Type: research
Stereotactic Radiation Therapy in Early Non-Small Cell Lung Cancer and Interstitial Lung Disease: A Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this trial, use of SABR in patients with fibrotic ILD met the prespecified acceptability thresholds for both toxicity and efficacy, supporting the use of SABR for curative-intent treatment after a careful discussion of risks and benefits.TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03485378.PMID:38451491 | DOI:10.1001/jamaoncol.2023.7269 (Source: Cancer Control)
Source: Cancer Control - March 7, 2024 Category: Cancer & Oncology Authors: David A Palma Houda Bahig Andrew Hope Stephen Harrow Brock J Debenham Alexander V Louie Thi Trinh Thuc Toni Vu Edith Filion Andrea Bezjak Marie-Pierre Campeau Adele Duimering Meredith E Giuliani Joanna M Laba Pencilla Lang Benjamin H Lok X Melody Qu Srini Source Type: research
Quantifying regional radiation-induced lung injury in patients using hyperpolarized xenon-129 gas exchange magnetic resonance imaging.: Assessing RT lung injury with HP-xenon GX MRI
CONCLUSION: Hyperpolarized-129Xe MRI measured and quantified regional, RT-associated, dose-dependent changes in pulmonary gas exchange. This tool could enable future work to improve our understanding and management of RILI.PMID:38452858 | DOI:10.1016/j.ijrobp.2024.02.049 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - March 7, 2024 Category: Physics Authors: Leith J Rankine Junlan Lu Ziyi Wang Chris R Kelsey Lawrence B Marks Shiva K Das Bastiaan Driehuys Source Type: research
Quantifying regional radiation-induced lung injury in patients using hyperpolarized xenon-129 gas exchange magnetic resonance imaging.: Assessing RT lung injury with HP-xenon GX MRI
CONCLUSION: Hyperpolarized-129Xe MRI measured and quantified regional, RT-associated, dose-dependent changes in pulmonary gas exchange. This tool could enable future work to improve our understanding and management of RILI.PMID:38452858 | DOI:10.1016/j.ijrobp.2024.02.049 (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - March 7, 2024 Category: Physics Authors: Leith J Rankine Junlan Lu Ziyi Wang Chris R Kelsey Lawrence B Marks Shiva K Das Bastiaan Driehuys Source Type: research
Carboxyhemoglobin in Cardiac Surgery Patients and Its Association with Risk Factors and Biomarkers of Hemolysis
CONCLUSIONS: CO-Hb may represent a readily obtainable and frequently measured biomarker that has a moderate association with known biomarkers of and risk factors for hemolysis in on-pump cardiac surgery patients. These findings have potential clinical implications and warrant further investigation.PMID:38446702 | DOI:10.1213/ANE.0000000000006915 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 6, 2024 Category: Anesthesiology Authors: Akinori Maeda Dinesh Pandey Ryota Inokuchi Sofia Spano Anis Chaba Atthaphong Phongphithakchai Glenn Eastwood Hossein Jahanabadi Hung Vo Siven Seevanayagam Andrew Motley Rinaldo Bellomo Source Type: research
Carboxyhemoglobin in Cardiac Surgery Patients and Its Association with Risk Factors and Biomarkers of Hemolysis
CONCLUSIONS: CO-Hb may represent a readily obtainable and frequently measured biomarker that has a moderate association with known biomarkers of and risk factors for hemolysis in on-pump cardiac surgery patients. These findings have potential clinical implications and warrant further investigation.PMID:38446702 | DOI:10.1213/ANE.0000000000006915 (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - March 6, 2024 Category: Anesthesiology Authors: Akinori Maeda Dinesh Pandey Ryota Inokuchi Sofia Spano Anis Chaba Atthaphong Phongphithakchai Glenn Eastwood Hossein Jahanabadi Hung Vo Siven Seevanayagam Andrew Motley Rinaldo Bellomo Source Type: research
Pulmonary function testing in preoperative high-risk patients
ConclusionsOur screening program detected a relevant number of patients with previously unknown obstructive ventilatory disorders and impaired pulmonary gas exchange. This newly discovered sickness is associated with low metabolic equivalents and may influence perioperative outcomes. Whether optimized management of patients with previously unknown impaired lung function leads to a better outcome should be evaluated in multicenter studies.Trial registrationGerman Registry of Clinical Studies (DRKS00029337), registered on: June 22nd, 2022. (Source: Perioperative Medicine)
Source: Perioperative Medicine - March 5, 2024 Category: Surgery Source Type: research
Clinical correlates of a non-plexiform vasculopathy in patients diagnosed with idiopathic pulmonary arterial hypertension
This study reveals different vascular phenotypes within the current spectrum of patients diagnosed with IPAH, separated by clinical characteristics (age, sex, , history of cigarette smoking, and DLCO at diagnosis). Potential differences in underlying pathobiological mechanisms between patients with plexiform and non-plexiform / microvascular disease should be taken into account in future research strategies unravelling the pathophysiology of pulmonary hypertension and developing biology-targeted treatment approaches.PMID:38432552 | DOI:10.1016/j.chest.2024.02.046 (Source: Chest)
Source: Chest - March 3, 2024 Category: Respiratory Medicine Authors: Esther J Nossent Josien Smits Celine Seegers Lilian J Meijboom Anco Boonstra J Aman F S De Man Harm Jan Bogaard Teodora Radonic Peter Dorfm üller Anton Vonk Noordegraaf Source Type: research
