Predictive Mapping of Antimicrobial Resistance for Escherichia coli, Salmonella, and Campylobacter in Food-Producing Animals, Europe, 2000 –2021
R. Mulchandanzi et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - December 13, 2023 Category: Infectious Diseases Source Type: research
The Inhibitory Activity of Lactobacillus plantarum Supernatant against Enterobacteria, Campylobacter, and Tumor Cells
Cell-free supernatant ofLactobacillus plantarum exhibit a strong antimicrobial effect against a number of pathogenic enterobacteria (E. coli,Shigella flexneri,Salmonella typhimurium,Proteus mirabilis, andCampylobacter jejuni). The degree of growth inhibition in broth culture reached a high level for all tested bacteria. The highest rates were noted forP. mirabilis (by 13 times) and the lowest forS. flexneri (by 5 times) andC. jejuni (by 4.5 times). Significant antiproliferative effect of the supernatant on cells of tumor-derived epithelial cell lines was shown. The highest degree of inhibition (by 22 times) was observed fo...
Source: Bulletin of Experimental Biology and Medicine - December 13, 2023 Category: Biology Source Type: research
Suppression of pathogens in properly refrigerated raw milk
by M. E. Coleman, T. P. Oscar, T. L. Negley, M. M. Stephenson
Conflicting claims exist regarding pathogen growth in raw milk. A small pilot study was designed to provide definitive data on trends for pathogen growth and decline in raw bovine milk hygienically produced for direct human consumption. An independent laboratory conducted the study, monitoring gro wth and decline of pathogens inoculated into raw milk. Raw milk samples were inoculated with foodborne pathogens (Campylobacter,E.coli O157:H7,Listeria monocytogenes, orSalmonella) at lower ( (Source: PLoS One)
Source: PLoS One - December 12, 2023 Category: Biomedical Science Authors: M. E. Coleman Source Type: research
Microbiome analysis of saliva from oral squamous cell carcinoma (OSCC) patients and tobacco abusers with potential biomarkers for oral cancer screening
Heliyon. 2023 Nov 8;9(11):e21773. doi: 10.1016/j.heliyon.2023.e21773. eCollection 2023 Nov.ABSTRACTOral squamous cell carcinoma (OSCC) is the most common type of oral cancer and accounts for about 95% of all head and neck cancers with high mortality, usually at a late stage. Dysbiosis in the oral microbiome can lead to chronic inflammatory responses and may predispose to the development and progression of OSCC. Tobacco abuse plays an essential role in oral microbiome dysregulation and OSCC pathogenesis. We used 16S rRNA gene amplicon next-generation sequencing to examine microbial signatures unique to saliva from OSCC pati...
Source: Cancer Control - November 30, 2023 Category: Cancer & Oncology Authors: Bolaji Fatai Oyeyemi Urvinder S Kaur Amit Paramraj None Chintamani Ravi Tandon Abhinav Kumar Neel Sarovar Bhavesh Source Type: research
The 2022 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference: Summary of breakout workshops
This article provides a brief summary of the presentations and discussions at each workshop in order to share these sessions with the broader enteric vaccine field.PMID:38036392 | DOI:10.1016/j.vaccine.2023.11.045 (Source: Vaccine)
Source: Vaccine - November 30, 2023 Category: Allergy & Immunology Authors: Shahida Baqar Aurelio Bonavia A Louis Bourgeois Joseph J Campo Allison Clifford Kurt Hanevik Mateusz Hasso-Agopsowicz William Hausdorff Robert Kaminski Calman A MacLennan Nicholas Mantis Laura B Martin Richard Omore Marcela Pasetti Patricia Pavlinac Armel Source Type: research
The 2022 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference: Summary of breakout workshops
This article provides a brief summary of the presentations and discussions at each workshop in order to share these sessions with the broader enteric vaccine field.PMID:38036392 | DOI:10.1016/j.vaccine.2023.11.045 (Source: Vaccine)
Source: Vaccine - November 30, 2023 Category: Allergy & Immunology Authors: Shahida Baqar Aurelio Bonavia A Louis Bourgeois Joseph J Campo Allison Clifford Kurt Hanevik Mateusz Hasso-Agopsowicz William Hausdorff Robert Kaminski Calman A MacLennan Nicholas Mantis Laura B Martin Richard Omore Marcela Pasetti Patricia Pavlinac Armel Source Type: research
Specificity determinants revealed by the structure of glycosyltransferase Campylobacter concisus PglA
This study identifies distinguishing characteristics that set PglA apart within the GT4 enzyme family. Computational docking of the structure in the membrane in comparison to homologs points to differences in interact ions with the membrane-embedded acceptor and the structural analysis of the complex together with bioinformatics and site directed mutagenesis identifies donor sugar binding motifs. Notably, E113, conserved solely among PglA enzymes, forms a hydrogen bond with the GalNAc C6”-OH. Mutagenesis of E11 3 reveals activity consistent with this role in substrate binding, rather than stabilization of the oxocarbeniu...
Source: Protein Science - November 30, 2023 Category: Biochemistry Authors: Nemanja Vuksanovic,
Jozlyn R. Clasman,
Barbara Imperiali,
Karen N. Allen Tags: RESEARCH ARTICLE Source Type: research
Dual RNA-Seq reveals transcriptionally active microbes (TAMs) dynamics in the serum of dengue patients associated with disease severity
This study highlights the potential of the unexplored roles of the TAMs in modulating the dengue disease severity using the metatranscriptomic sequencing. This study serves to enhance our understanding of the distinctive microbial and hematologic signatures in the early infection stage that differentiate patients with high viral reads patients from those with low dengue viral reads. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - November 30, 2023 Category: Microbiology Source Type: research
Vertebral osteomyelitis caused by Campylobacter jejuni in an immunocompetent patient
ConclusionsWhileC. jejuni osteomyelitis is rare, it should still be suspected as a possible causative bacterial aetiology in patients with vertebral osteomyelitis, in particular when symptoms of diarrhoea is involved in the clinical presentation. Susceptibility testing is crucial due to emerging resistance, and targeted treatment strategies should rely upon such tests. (Source: Gut Pathogens)
Source: Gut Pathogens - November 30, 2023 Category: Microbiology Source Type: research
The 2022 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference: Summary of abstract-based presentations
This article reviews key points and highlighted research presented in each of the plenary conference sessions and poster presentations at the 2022 VASE Conference.PMID:38030421 | DOI:10.1016/j.vaccine.2023.11.031 (Source: Vaccine)
Source: Vaccine - November 29, 2023 Category: Allergy & Immunology Authors: Soumalya Banerjee Eileen M Barry Shahida Baqar A Louis Bourgeois Joseph J Campo Robert K M Choy Subhra Chakraborty Allison Clifford Carolyn Deal Marcus Estrada James Fleckenstein Mateusz Hasso-Agopsowicz William Hausdorff Ibrahim Khalil Nicole Maier Cynth Source Type: research
The 2022 Vaccines Against Shigella and Enterotoxigenic Escherichia coli (VASE) Conference: Summary of abstract-based presentations
This article reviews key points and highlighted research presented in each of the plenary conference sessions and poster presentations at the 2022 VASE Conference.PMID:38030421 | DOI:10.1016/j.vaccine.2023.11.031 (Source: Vaccine)
Source: Vaccine - November 29, 2023 Category: Allergy & Immunology Authors: Soumalya Banerjee Eileen M Barry Shahida Baqar A Louis Bourgeois Joseph J Campo Robert K M Choy Subhra Chakraborty Allison Clifford Carolyn Deal Marcus Estrada James Fleckenstein Mateusz Hasso-Agopsowicz William Hausdorff Ibrahim Khalil Nicole Maier Cynth Source Type: research
Impact of wet-lab protocols on quality of whole-genome short-read sequences from foodborne microbial pathogens
For successful elucidation of a food-borne infection chain, the availability of high-quality sequencing data from suspected microbial contaminants is a prerequisite. Commonly, those investigations are a joint effort undertaken by different laboratories and institutes. To analyze the extent of variability introduced by differing wet-lab procedures on the quality of the sequence data we conducted an interlaboratory study, involving four bacterial pathogens, which account for the majority of food-related bacterial infections: Campylobacter spp., Shiga toxin-producing Escherichia coli, Listeria monocytogenes, and Salmonella en...
Source: Frontiers in Microbiology - November 29, 2023 Category: Microbiology Source Type: research
Diagnostic accuracy and microbial profiles of tuberculous pleurisy: a comparative study of metagenomic next generation sequencing and GeneXpert Mycobacterium tuberculosis
This study aimed to evaluate the diagnostic accuracy of metagenomic next-generation sequencing (mNGS) and GeneXpert Mycobacterium tuberculosis (MTB) for identifying tuberculous pleurisy and analyzing the microbial profiles of both tuberculous and non-tuberculous pleural effusions.MethodsThe study enrolled 31 patients with suspected tuberculous pleurisy, of which 15 were confirmed to have tuberculous pleurisy and subsequently allocated to the tuberculous pleurisy group (TP group), while the remaining 16 individuals were assigned to the non-tuberculous pleurisy group (NTP group). mNGS and GeneXpert MTB were performed on pleu...
Source: Frontiers in cellular and infection microbiology - November 27, 2023 Category: Microbiology Source Type: research
Infective aortitis and subacute myocarditis due to Campylobacter fetus
A 79 year-old woman on chemotherapy for lung cancer was admitted for abdominal pain and diarrhea. Blood cultures became positive for Campylobacter fetus after 4 days and imipenem was started. Despite clinical improvement, repeated blood cultures showed persistent bacteremia. Positron emission tomography (PET-CT) revealed focal hypermetabolism of the aortic arch and the left ventricule bases. Echocardiography and cardiac enzymes were unremarkable. Given the suspected myocardial involvement, intravenous gentamycin was added but interrupted after one week due to toxicity. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - November 26, 2023 Category: Infectious Diseases Authors: Anaelle Lenherr, Sarah Boughdad, John O. Prior, Marie Nicod Lalonde, Paraskevas Filippidis Tags: Medical Imagery Source Type: research
A decade of Campylobacter and Campylobacter bacteraemias in a district general hospital and the surrounding London and South East region, England
Campylobacter bacteraemia is a rare complication of the most common bacterial gastrointestinal infection but is associated with significant morbidity and mortality. There is limited data describing current trends in surveillance and antimicrobial resistance for the Campylobacter strains involved. At the Epsom and St Helier ’s University Hospital (ESTH), we noted a marked increase in Campylobacter bacteraemia infections in 2021. (Source: Journal of Infection)
Source: Journal of Infection - November 20, 2023 Category: Infectious Diseases Authors: Alice Graham, Lois Hawkins, Sooria Balasegaram, Subha Narasimhan, John Wain, John Clarke, Rohini Manuel Source Type: research
