Decaffeinated green tea polyphenols supplementation had no adverse health effects in girls with obesity: a randomized controlled trial
CONCLUSIONS: This study indicated that the supplementation of 400 mg/d DGTP for 12 weeks had no adverse health effects in girls with obesity, providing evidence for the DGTP adoption in children research.PMID:38494693 | DOI:10.6133/apjcn.202403_33(1).0012 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Die Yao Luyao Xie Kun Du Xinyuan Yao Xiuhua Shen Source Type: research
Decaffeinated green tea polyphenols supplementation had no adverse health effects in girls with obesity: a randomized controlled trial
CONCLUSIONS: This study indicated that the supplementation of 400 mg/d DGTP for 12 weeks had no adverse health effects in girls with obesity, providing evidence for the DGTP adoption in children research.PMID:38494693 | DOI:10.6133/apjcn.202403_33(1).0012 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Die Yao Luyao Xie Kun Du Xinyuan Yao Xiuhua Shen Source Type: research
Decaffeinated green tea polyphenols supplementation had no adverse health effects in girls with obesity: a randomized controlled trial
CONCLUSIONS: This study indicated that the supplementation of 400 mg/d DGTP for 12 weeks had no adverse health effects in girls with obesity, providing evidence for the DGTP adoption in children research.PMID:38494693 | DOI:10.6133/apjcn.202403_33(1).0012 (Source: Asia Pacific Journal of Clinical Nutrition)
Source: Asia Pacific Journal of Clinical Nutrition - March 18, 2024 Category: Nutrition Authors: Die Yao Luyao Xie Kun Du Xinyuan Yao Xiuhua Shen Source Type: research
The effect of oral analgesic premedication on the success rate of inferior alveolar nerve block for teeth with irreversible pulpitis: A randomized clinical trial
Conclusions: Premedication with Pharmapain (an anti-inflammatory agent) and dexamethasone (a corticosteroid) does not enhance the success rate of the IANB technique in mandibular molars with irreversible pulpitis compared to placebo. However, the use of dexamethasone was significantly more effective than Pharmapain in reducing pain severity at inserting the first endodontic file. (Source: Journal of Dental Materials and Techniques)
Source: Journal of Dental Materials and Techniques - March 17, 2024 Category: Dentistry Source Type: research
Adora2A downregulation promotes caffeine neuroprotective effect against LPS-induced neuroinflammation in the hippocampus
Brain Res. 2024 Mar 15:148866. doi: 10.1016/j.brainres.2024.148866. Online ahead of print.ABSTRACTCaffeine has been extensively studied in the context of CNS pathologies as many researchers have shown that consuming it reduces pro-inflammatory biomarkers, potentially delaying the progression of neurodegenerative pathologies. Several lines of evidence suggest that adenosine receptors, especially A1 and A2A receptors, are the main targets of its neuroprotective action. We found that caffeine pretreatment 15 min before LPS administration reduced the expression of Il1b in the hippocampus and striatum. The harmful modulation of...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Paula Lemes Dos Santos Sanna Liebert Bernardes Carvalho Camila Cristina Dos Santos Afonso Kassia de Carvalho Rog ério Aires Jennyffer Souza Marcel Rodrigues Ferreira Alexander Birbrair Maria Martha Bernardi Alexandra Latini Rodrigo A Foganholi da Silva Source Type: research
Predictive models for sensory score and physicochemical composition of Yuezhou Longjing tea using near-infrared spectroscopy and data fusion
In conclusion, evaluating the quality of the five Yuezhou Longjing tea varieties using near-infrared spectroscopy and data fusion have proved as feasible.PMID:38493609 | DOI:10.1016/j.talanta.2024.125892 (Source: Talanta)
Source: Talanta - March 17, 2024 Category: Chemistry Authors: Yong Chen Mengqi Guo Kai Chen Xinfeng Jiang Zezhong Ding Haowen Zhang Min Lu Dandan Qi Chunwang Dong Source Type: research
Simulated pharmacokinetics of inhaled caffeine and melatonin from existing products indicate the lack of dosimetric considerations
This study applied a physiologically based pharmacokinetic modeling approach to predict the inhalation pharmacokinetics of caffeine and melatonin for different target indications related to the sleep-wake cycle. The model predicted rapid systemic delivery of caffeine and melatonin based on airway regional deposition of inhaled aerosol. A low inhaled dose of 1 mg of caffeine resulted in a 72.3-times lower plasma maximal concentration and was predicted to not improve cognitive performance task outcomes compared to oral consumption of coffee containing 80 mg of caffeine. Conversely, 2-mg oral and inhaled doses of melatonin un...
Source: Food and Chemical Toxicology - March 17, 2024 Category: Food Science Authors: Aditya R Kolli Arkadiusz K Kuczaj Florian Calvino-Martin Julia Hoeng Source Type: research
Adora2A downregulation promotes caffeine neuroprotective effect against LPS-induced neuroinflammation in the hippocampus
Brain Res. 2024 Mar 15:148866. doi: 10.1016/j.brainres.2024.148866. Online ahead of print.ABSTRACTCaffeine has been extensively studied in the context of CNS pathologies as many researchers have shown that consuming it reduces pro-inflammatory biomarkers, potentially delaying the progression of neurodegenerative pathologies. Several lines of evidence suggest that adenosine receptors, especially A1 and A2A receptors, are the main targets of its neuroprotective action. We found that caffeine pretreatment 15 min before LPS administration reduced the expression of Il1b in the hippocampus and striatum. The harmful modulation of...
Source: Brain Research - March 17, 2024 Category: Neurology Authors: Paula Lemes Dos Santos Sanna Liebert Bernardes Carvalho Camila Cristina Dos Santos Afonso Kassia de Carvalho Rog ério Aires Jennyffer Souza Marcel Rodrigues Ferreira Alexander Birbrair Maria Martha Bernardi Alexandra Latini Rodrigo A Foganholi da Silva Source Type: research
Predictive models for sensory score and physicochemical composition of Yuezhou Longjing tea using near-infrared spectroscopy and data fusion
In conclusion, evaluating the quality of the five Yuezhou Longjing tea varieties using near-infrared spectroscopy and data fusion have proved as feasible.PMID:38493609 | DOI:10.1016/j.talanta.2024.125892 (Source: Talanta)
Source: Talanta - March 17, 2024 Category: Chemistry Authors: Yong Chen Mengqi Guo Kai Chen Xinfeng Jiang Zezhong Ding Haowen Zhang Min Lu Dandan Qi Chunwang Dong Source Type: research
Simulated pharmacokinetics of inhaled caffeine and melatonin from existing products indicate the lack of dosimetric considerations
This study applied a physiologically based pharmacokinetic modeling approach to predict the inhalation pharmacokinetics of caffeine and melatonin for different target indications related to the sleep-wake cycle. The model predicted rapid systemic delivery of caffeine and melatonin based on airway regional deposition of inhaled aerosol. A low inhaled dose of 1 mg of caffeine resulted in a 72.3-times lower plasma maximal concentration and was predicted to not improve cognitive performance task outcomes compared to oral consumption of coffee containing 80 mg of caffeine. Conversely, 2-mg oral and inhaled doses of melatonin un...
Source: Food and Chemical Toxicology - March 17, 2024 Category: Food Science Authors: Aditya R Kolli Arkadiusz K Kuczaj Florian Calvino-Martin Julia Hoeng Source Type: research
Caffeine and neonatal acute kidney injury
AbstractAcute kidney injury is one of the most threatening diseases in neonates, with complex pathogenesis and limited treatment options. Caffeine is a commonly used central nervous system stimulant for treating apnea in preterm infants. There is compelling evidence that caffeine may have potential benefits for preventing neonatal acute kidney injury, but comprehensive reports are lacking in this area. Hence, this review aims to provide a summary of clinical data on the potential benefits of caffeine in improving neonatal acute kidney injury. Additionally, it delves into the molecular mechanisms underlying caffeine ’s ef...
Source: Pediatric Nephrology - March 15, 2024 Category: Urology & Nephrology Source Type: research
Molecules, Vol. 29, Pages 1318: Valorization of Coffee Silverskin Using Extraction Cycles and Water as a Solvent: Design of Process
-Tixier
Coffee silverskin is a byproduct of the coffee industry, appearing in large quantities during the roasting step. In this work, a sober and simple water process is proposed, using extractions cycles, to produce valuable products including (a) an extract rich in caffeine, (b) possibly pure caffeine, and (c) insoluble fibers. The hypothetical number of necessary cycles was calculated and compared to the number of cycles used experimentally. Two types of cycles, with and without water compensation, were compared for their water consumption and the amount of caffeine extracted. The use of cycles, with the resulting ...
Source: Molecules - March 15, 2024 Category: Chemistry Authors: Aziad é Chemat Didier Touraud Rainer M üller Werner Kunz Anne-Sylvie Fabiano-Tixier Tags: Article Source Type: research
Integrating Full Bayesian Inference and Student's t-Distribution Method for Enhanced Outlier Handling in Caffeine Population Pharmacokinetics: Assessing Drug-Drug Interactions with Enasidenib in Relapsed or Refractory AML and MDS Patients
In this study, a population pharmacokinetic analysis approach was employed to address challenges posed by high, nonzero baseline caffeine concentrations. Moreover, we integrated full Bayesian inference into this approach innovatively for a more detailed understanding of parameter uncertainty and greater modeling flexibility, alongside Student's t-distribution for robust error modeling in handling the abnormal outlier caffeine concentration data observed in this trial. Our analyses demonstrated that multiple doses of enasidenib altered caffeine clearance to a clinically meaningful extent, as evidenced by an approximate 8-fo...
Source: The Journal of Clinical Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Authors: Yiming Cheng Shengnan Du Hongxiang Hu Xiaomin Wang Leon Carayannopoulos Yan Li Source Type: research
Integrating Full Bayesian Inference and Student's t-Distribution Method for Enhanced Outlier Handling in Caffeine Population Pharmacokinetics: Assessing Drug-Drug Interactions with Enasidenib in Relapsed or Refractory AML and MDS Patients
In this study, a population pharmacokinetic analysis approach was employed to address challenges posed by high, nonzero baseline caffeine concentrations. Moreover, we integrated full Bayesian inference into this approach innovatively for a more detailed understanding of parameter uncertainty and greater modeling flexibility, alongside Student's t-distribution for robust error modeling in handling the abnormal outlier caffeine concentration data observed in this trial. Our analyses demonstrated that multiple doses of enasidenib altered caffeine clearance to a clinically meaningful extent, as evidenced by an approximate 8-fo...
Source: The Journal of Clinical Pharmacology - March 13, 2024 Category: Drugs & Pharmacology Authors: Yiming Cheng Shengnan Du Hongxiang Hu Xiaomin Wang Leon Carayannopoulos Yan Li Source Type: research
Hyperpolarized < sup > 15 < /sup > N caffeine, a potential probe of liver function and perfusion
CONCLUSION: These results establish the feasibility of hyperpolarization of hyperpolarized 15 N-caffeine, but further work is necessary to establish the role of this new agent to probe liver metabolism and perfusion.PMID:38469685 | DOI:10.1002/mrm.30070 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - March 12, 2024 Category: Radiology Authors: Cornelius von Morze Ashley Shaw Tyler Blazey Source Type: research
