Modeling Developmental Changes in Caffeine Clearance Considering Differences between Pre- and Postnatal Period
Biol Pharm Bull. 2024;47(4):861-867. doi: 10.1248/bpb.b23-00650.ABSTRACTTaguchi et al. reported that postmenstrual age (PMA) is a promising factor in describing and understanding the developmental change of caffeine (CAF) clearance. The aim of the present study was to quantify how developmental changes occur and to determine the effect of the length of the gestational period on CAF clearance. We performed a nonlinear mixed effect model (NONMEM) analysis and evaluated the fit of six models. A total of 115 samples were obtained from 52 patients with a mean age of 34.3 ± 18.2 d. The median values of gestational age (GA) and ...
Source: Biological and Pharmaceutical Bulletin - April 21, 2024 Category: Drugs & Pharmacology Authors: Haruka Ide Yukako Kawasaki Kentaro Tamura Taketoshi Yoshida Ryosuke Fujihara Akane Hara Masato Taguchi Source Type: research
Caffeine: how early is too early?
Pediatr Res. 2024 Apr 20. doi: 10.1038/s41390-024-03199-z. Online ahead of print.NO ABSTRACTPMID:38643263 | DOI:10.1038/s41390-024-03199-z (Source: Pediatric Research)
Source: Pediatric Research - April 20, 2024 Category: Pediatrics Authors: Ryan Kilpatrick Jonathan M Davis Jacob V Aranda Source Type: research
Phenotype-Genotype Correlation Applying a Cocktail Approach and an Exome Chip Analysis Reveals Further Variants Contributing to Variation of Drug Metabolism
Clin Pharmacol Ther. 2024 Apr 18. doi: 10.1002/cpt.3270. Online ahead of print.ABSTRACTAlthough great progress has been made in the fine-tuning of diplotypes, there is still a need to further improve the predictability of individual phenotypes of pharmacogenetically relevant enzymes. The aim of this study was to analyze the additional contribution of sex and variants identified by exome chip analysis to the metabolic ratio of five probe drugs. A cocktail study applying dextromethorphan, losartan, omeprazole, midazolam, and caffeine was conducted on 200 healthy volunteers. CYP2D6, 2C9, 2C19, 3A4/5, and 1A2 genotypes were an...
Source: Clinical Pharmacology and Therapeutics - April 19, 2024 Category: Drugs & Pharmacology Authors: Ruwen B öhm Henrike Bruckmueller Stefan Oswald Matthias H übenthal Meike Kaehler Lena Ehmke Jan H öcker Werner Siegmund Andre Franke Ingolf Cascorbi Source Type: research
Enzymatic and non-enzymatic removal of organic micropollutants with spent mushroom substrate of Agaricus bisporus
In this study, we assessed the removal of OMPs by spent mushroom substrate (SMS) of the white button mushroom (Agaricus bisporus) and by its aqueous tea extract. Removal of acesulfame K, antipyrine, bentazon, caffeine, carbamazepine, chloridazon, clofibric acid, and N, N-diethyl-meta-toluamide (DEET) by SMS and its tea was between 10 and 90% and 0-26%, respectively, in a 7-day period. Sorption to SMS particles was between 0 and 29%, which can thus not explain the removal difference between SMS and its tea, the latter lacking these particles. Carbamazepine was removed most efficiently by both SMS and its tea. Removal of OMP...
Source: Applied Microbiology and Biotechnology - April 19, 2024 Category: Microbiology Authors: Brigit van Brenk Fleur E L Kleijburg Antoine J B Kemperman Walter G J van der Meer Han A B W östen Source Type: research
Dose-Response Study of Caffeine on Postnatal Weight Gain in Premature Neonates-A Retrospective Cohort Study
CONCLUSION: Exposure to higher caffeine doses in this study cohort is associated with lower postnatal WG in preterm neonates than standard daily doses may be due to its catabolic effects and CC-APSEs.PMID:38617389 | PMC:PMC11016235 | DOI:10.1177/15593258241247185 (Source: Dose Response)
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Ijaz Hussain Manoj Kumar Amin Ali Fizzah Naz Wasif Ahmed Khan Muhammad Sohail Salat Shahzad Rauf Gul Ambreen Kashif Hussain Source Type: research
Sudden Reduction in Caffeine Intake Increases Serum Lithium Concentration to Supratherapeutic Level: A Case Report
Prim Care Companion CNS Disord. 2024 Apr 11;26(2):23cr03642. doi: 10.4088/PCC.23cr03642.NO ABSTRACTPMID:38621222 | DOI:10.4088/PCC.23cr03642 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - April 15, 2024 Category: Primary Care Authors: Jeffrey J Song Jorgen C Eyabi Poonam D Awatramani Brian G Mitchell Sudhanshu Y Nene Source Type: research
Sudden Reduction in Caffeine Intake Increases Serum Lithium Concentration to Supratherapeutic Level: A Case Report
Prim Care Companion CNS Disord. 2024 Apr 11;26(2):23cr03642. doi: 10.4088/PCC.23cr03642.NO ABSTRACTPMID:38621222 | DOI:10.4088/PCC.23cr03642 (Source: Primary Care)
Source: Primary Care - April 15, 2024 Category: Primary Care Authors: Jeffrey J Song Jorgen C Eyabi Poonam D Awatramani Brian G Mitchell Sudhanshu Y Nene Source Type: research
Dose-Response Study of Caffeine on Postnatal Weight Gain in Premature Neonates-A Retrospective Cohort Study
CONCLUSION: Exposure to higher caffeine doses in this study cohort is associated with lower postnatal WG in preterm neonates than standard daily doses may be due to its catabolic effects and CC-APSEs.PMID:38617389 | PMC:PMC11016235 | DOI:10.1177/15593258241247185 (Source: Dose Response)
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Ijaz Hussain Manoj Kumar Amin Ali Fizzah Naz Wasif Ahmed Khan Muhammad Sohail Salat Shahzad Rauf Gul Ambreen Kashif Hussain Source Type: research
Dose-Response Study of Caffeine on Postnatal Weight Gain in Premature Neonates-A Retrospective Cohort Study
CONCLUSION: Exposure to higher caffeine doses in this study cohort is associated with lower postnatal WG in preterm neonates than standard daily doses may be due to its catabolic effects and CC-APSEs.PMID:38617389 | PMC:PMC11016235 | DOI:10.1177/15593258241247185 (Source: Dose Response)
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Ijaz Hussain Manoj Kumar Amin Ali Fizzah Naz Wasif Ahmed Khan Muhammad Sohail Salat Shahzad Rauf Gul Ambreen Kashif Hussain Source Type: research
Dose-Response Study of Caffeine on Postnatal Weight Gain in Premature Neonates-A Retrospective Cohort Study
CONCLUSION: Exposure to higher caffeine doses in this study cohort is associated with lower postnatal WG in preterm neonates than standard daily doses may be due to its catabolic effects and CC-APSEs.PMID:38617389 | PMC:PMC11016235 | DOI:10.1177/15593258241247185 (Source: Dose Response)
Source: Dose Response - April 15, 2024 Category: Drugs & Pharmacology Authors: Ijaz Hussain Manoj Kumar Amin Ali Fizzah Naz Wasif Ahmed Khan Muhammad Sohail Salat Shahzad Rauf Gul Ambreen Kashif Hussain Source Type: research
Sudden Reduction in Caffeine Intake Increases Serum Lithium Concentration to Supratherapeutic Level: A Case Report
Prim Care Companion CNS Disord. 2024 Apr 11;26(2):23cr03642. doi: 10.4088/PCC.23cr03642.NO ABSTRACTPMID:38621222 | DOI:10.4088/PCC.23cr03642 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - April 15, 2024 Category: Primary Care Authors: Jeffrey J Song Jorgen C Eyabi Poonam D Awatramani Brian G Mitchell Sudhanshu Y Nene Source Type: research
