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Caffeine pharmacokinetics following umbilical vein injection during delayed cord clamping in preterm lambs
CONCLUSIONS: Caffeine injected directly into the UV during DCC is feasible but achieves lower concentrations due to high volume of distribution including maternal circulation. Further trials evaluating DUV caffeine injection should use higher caffeine doses.IMPACT: Respiratory stimulation with early caffeine may reduce the need for intubation in preterm infants. In the preterm lambs, caffeine injection directly into the umbilical vein during delayed cord clamping is feasible. Plasma caffeine concentrations are less than half when administered directly into the umbilical vein during delayed cord clamping compared to adminis...
Source: Pediatric Research - March 1, 2024 Category: Pediatrics Authors: Lida Zeinali Evan Giusto Heather Knych Amy Lesneski Houssam Joudi Morgan Hardie Deepika Sankaran Satyan Lakshminrusimha Payam Vali Source Type: research

GSE252809 RNA Sequencing Reveals Transcriptomic Changes in HEK293 Cells Following Introduction of rs16851030 DNA Variant
This study aimed to elucidate the funct ional impact of rs16851030 by using CRISPR/Cas9 approach to induce physiological changes associated with the DNA variant. rs16851030 was introduced into HEK293 cells through homology-directed repair. Edited cells were then fluorescence-enriched, sorted, isolated, and grown into single cell-derived c lones. The single-base edit was confirmed by Sanger sequencing. Finally, RNA sequencing was performed to elucidate the pathways affected by rs16851030. Our study provides valuable information about key pathways associated with rs16851030 DNA variant. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

The role of sheet-like TiO 2 in polyamide reverse osmosis membrane for enhanced removal of endocrine disrupting chemicals
Chemosphere. 2024 Feb 27:141108. doi: 10.1016/j.chemosphere.2024.141108. Online ahead of print.ABSTRACTThin film composite (TFC) reverse osmosis (RO) membrane shows good promise for treating wastewater containing endocrine disrupting chemical (EDC) pollutants. The incorporation of functional materials with exceptional structural and physico-chemical properties offers opportunities for the membranes preparation with enhanced permselectivity and better antifouling properties. The present study aims to improve the EDC removal efficiency of TFC RO membrane using two-dimensional titania nanosheets (TNS). RO membrane was prepare...
Source: Chemosphere - February 29, 2024 Category: Chemistry Authors: Nor Akalili Ahmad Pei Sean Goh Nur Alyaa Syfina Rosmawati Naim Mohd Sohaimi Abdullah Ahmad Fauzi Ismail Norbaya Hashim Nirmala Devi A P Kerisnan Kerishnan Nasehir Khan E M Yahaya Alias Mohamed Source Type: research

Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes - Kuopio Birth Cohort
CONCLUSIONS: Caffeine intake during the first trimester of pregnancy was not associated with the risk of GDM but a minor non-significant decrease was seen with moderate coffee intake. Although the average consumption of cola drinks was low in the KuBiCo cohort, higher consumption was associated with an increased risk of GDM. Further studies are needed to evaluate the safe amount of coffee during pregnancy, since the recommended caffeine intake was exceeded in almost half of the coffee drinkers.PMID:38423827 | DOI:10.1016/j.pcd.2024.02.005 (Source: Primary Care)
Source: Primary Care - February 29, 2024 Category: Primary Care Authors: Anni Kukkonen Sari Hantunen Ari Voutilainen Anu Ruusunen Lauri Uusitalo Katri Backman Raimo Voutilainen Markku Pasanen Pirkka V Kirjavainen Leea Keski-Nisula Source Type: research

Caffeine intake and its association with nutrition, sleep, and physical activity among schoolchildren in the United Arab Emirates: a national cross-sectional study
ConclusionExcessive intake of caffeine from different dietary sources coexists with unhealthy dietary and lifestyle behaviors and sleep problems. Tailoring educational programs and intervention strategies is warranted to correct the unhealthy intake of caffeine and the associated unhealthy dietary and lifestyle behaviors among schoolchildren in the UAE. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - February 28, 2024 Category: Nutrition Source Type: research

Maternal caffeine, coffee and cola drink intake and the risk of gestational diabetes – Kuopio Birth Cohort
Coffee intake is associated with a decreased risk of type 2 diabetes among non-pregnant people. We aimed to investigate the association between caffeine, coffee and cola drink intake in early pregnancy and the risk of gestational diabetes (GDM). (Source: Primary Care Diabetes)
Source: Primary Care Diabetes - February 28, 2024 Category: Primary Care Authors: Anni Kukkonen, Sari Hantunen, Ari Voutilainen, Anu Ruusunen, Lauri Uusitalo, Katri Backman, Raimo Voutilainen, Markku Pasanen, Pirkka V. Kirjavainen, Leea Keski-Nisula Source Type: research

Qualitative and quantitative analysis of cresols found in maskwio'mi (birch bark extract)
This study discusses the qualitative and quantitative GC-MS analysis of cresols found in maskwio'mi and the challenges of the complex organic matrix. Using caffeine as an internal standard, ortho-, meta-, and para-cresol in birch bark extract were determined t o be in the approximate order of 50–1500 ppm range with 3.24 ± 0.09 × 102 ng mg−1 (324 ppm), 8.7 ± 1.0 × 102 ng mg−1 (87 ppm), and 12.4 ± 1.6 × 102 ng mg−1 (1240 ppm), respectively, and thus suitable by Health Canada and FDA cosmetics regulation standards when the extract is co-formulated in creams to concentrations of 0.1–5 wt.% for topi...
Source: Canadian Journal of Chemistry - February 28, 2024 Category: Chemistry Authors: Viktor Lyczywek Rajendran Kaliaperumal Volodymyra Zuieva Sarah Titcombe Matthias Bierenstiel Source Type: research

SERCA-1 conformational change exerted by the Ca 2+ -channel blocker diltiazem affects mammalian skeletal muscle function
Cell Calcium. 2024 Feb 8;119:102852. doi: 10.1016/j.ceca.2024.102852. Online ahead of print.ABSTRACTIn skeletal muscle (SM), inward Ca2+-currents have no apparent role in excitation-contraction coupling (e-c coupling), however the Ca2+-channel blocker can affect twitch and tetanic muscle in mammalian SM. Experiments were conducted to study how diltiazem (DLZ) facilitates e-c coupling and inhibits contraction. 1) In complete Extensor Digitorum Longus (EDL) muscle and single intact fibres, 0.03 mM DLZ causes twitch potentiation and decreases force during tetanic activity, with increased fatigue. 2) In split open fibres isola...
Source: Cell Calcium - February 27, 2024 Category: Cytology Authors: Aura Jim énez-Garduño Ibrahim Ramirez-Soto Ileana Miranda-Rodr íguez Sof ía Gitler Alicia Ortega Source Type: research

VICTR: Venous transit time imaging by changes in T 1 relaxation
CONCLUSION: A noncontrast MRI technique, VICTR MRI, was developed to measure the VTT of the brain.PMID:38411277 | DOI:10.1002/mrm.30051 (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - February 27, 2024 Category: Radiology Authors: Wen Shi Dengrong Jiang Zhiyi Hu Vivek Yedavalli Yulin Ge Abhay Moghekar Hanzhang Lu Source Type: research