Caffeine pharmacokinetics following umbilical vein injection during delayed cord clamping in preterm lambs
CONCLUSIONS: Caffeine injected directly into the UV during DCC is feasible but achieves lower concentrations due to high volume of distribution including maternal circulation. Further trials evaluating DUV caffeine injection should use higher caffeine doses.IMPACT: Respiratory stimulation with early caffeine may reduce the need for intubation in preterm infants. In the preterm lambs, caffeine injection directly into the umbilical vein during delayed cord clamping is feasible. Plasma caffeine concentrations are less than half when administered directly into the umbilical vein during delayed cord clamping compared to adminis...
Source: Pediatric Research - March 1, 2024 Category: Pediatrics Authors: Lida Zeinali Evan Giusto Heather Knych Amy Lesneski Houssam Joudi Morgan Hardie Deepika Sankaran Satyan Lakshminrusimha Payam Vali Source Type: research
Caffeine pharmacokinetics following umbilical vein injection during delayed cord clamping in preterm lambs
CONCLUSIONS: Caffeine injected directly into the UV during DCC is feasible but achieves lower concentrations due to high volume of distribution including maternal circulation. Further trials evaluating DUV caffeine injection should use higher caffeine doses.IMPACT: Respiratory stimulation with early caffeine may reduce the need for intubation in preterm infants. In the preterm lambs, caffeine injection directly into the umbilical vein during delayed cord clamping is feasible. Plasma caffeine concentrations are less than half when administered directly into the umbilical vein during delayed cord clamping compared to adminis...
Source: Cell Research - March 1, 2024 Category: Cytology Authors: Lida Zeinali Evan Giusto Heather Knych Amy Lesneski Houssam Joudi Morgan Hardie Deepika Sankaran Satyan Lakshminrusimha Payam Vali Source Type: research
