Synthesis and Medicinal Applications of N-Heterocyclic Carbene Complexes based on Caffeine and other Xanthines
ChemMedChem. 2024 Apr 26:e202400118. doi: 10.1002/cmdc.202400118. Online ahead of print.ABSTRACTXanthines are purine derivatives predominantly found in plants. These include compounds such as caffeine, theophylline, and theobromine and exhibit a variety of pharmacological properties, demonstrating efficacy in treating neurodegenerative disorders, respiratory dysfunctions, and also in cancer. The versatile attributes of these materials render them privileged scaffolds for the development of compounds for various biological applications. Xanthines are N-heterocyclic carbene precursors that combine a pyrimidine and an imidazo...
Source: ChemMedChem - April 26, 2024 Category: Chemistry Authors: Giulia Francescato Maria In ês Paiva Silva Leitão Giulia Orsini Ana Petronilho Source Type: research
Can caffeine improve your performance? Psychophysiological effects - A systematic review
In conclusion, moderate doses of caffeine 3-6 mg/kg seem to be an effective strategy to improve the psychophysiological response in various contexts without generating detrimental effects on performance, as long as the intervention designs consider the variables that could condition its effect.PMID:38666339 | DOI:10.20960/nh.04820 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Nicolas Saavedra Vel ásquez V íctor Cuadrado Peñafiel Ricardo de la Vega Marcos Source Type: research
Can caffeine improve your performance? Psychophysiological effects - A systematic review
In conclusion, moderate doses of caffeine 3-6 mg/kg seem to be an effective strategy to improve the psychophysiological response in various contexts without generating detrimental effects on performance, as long as the intervention designs consider the variables that could condition its effect.PMID:38666339 | DOI:10.20960/nh.04820 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Nicolas Saavedra Vel ásquez V íctor Cuadrado Peñafiel Ricardo de la Vega Marcos Source Type: research
Can caffeine improve your performance? Psychophysiological effects - A systematic review
In conclusion, moderate doses of caffeine 3-6 mg/kg seem to be an effective strategy to improve the psychophysiological response in various contexts without generating detrimental effects on performance, as long as the intervention designs consider the variables that could condition its effect.PMID:38666339 | DOI:10.20960/nh.04820 (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - April 26, 2024 Category: Nutrition Authors: Nicolas Saavedra Vel ásquez V íctor Cuadrado Peñafiel Ricardo de la Vega Marcos Source Type: research
Platinum Nanoparticles Supported by Carbon Nanotubes: Improvement in electrochemical sensor performance for caffeine determination
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230067. doi: 10.1590/0001-3765202420230067. eCollection 2024.ABSTRACTPlatinum nanoparticles supported by carbon nanotubes were obtained by a simple chemical route and used for preparation of electrochemical sensor towards caffeine determination. Carbon nanotubes were used before and after an acid treatment, yielding two different materials. Morphological and structural characterization of these materials showed platinum nanoparticles (size around 12 nm) distributed randomly along carbon nanotubes. Modified electrodes were directly prepared through a dispersion of these materials. Vo...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Adir H Kalinke Luiz H Marcolino-Junior Marcio F Bergamini Aldo J G Zarbin Source Type: research
Platinum Nanoparticles Supported by Carbon Nanotubes: Improvement in electrochemical sensor performance for caffeine determination
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230067. doi: 10.1590/0001-3765202420230067. eCollection 2024.ABSTRACTPlatinum nanoparticles supported by carbon nanotubes were obtained by a simple chemical route and used for preparation of electrochemical sensor towards caffeine determination. Carbon nanotubes were used before and after an acid treatment, yielding two different materials. Morphological and structural characterization of these materials showed platinum nanoparticles (size around 12 nm) distributed randomly along carbon nanotubes. Modified electrodes were directly prepared through a dispersion of these materials. Vo...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Adir H Kalinke Luiz H Marcolino-Junior Marcio F Bergamini Aldo J G Zarbin Source Type: research
Platinum Nanoparticles Supported by Carbon Nanotubes: Improvement in electrochemical sensor performance for caffeine determination
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230067. doi: 10.1590/0001-3765202420230067. eCollection 2024.ABSTRACTPlatinum nanoparticles supported by carbon nanotubes were obtained by a simple chemical route and used for preparation of electrochemical sensor towards caffeine determination. Carbon nanotubes were used before and after an acid treatment, yielding two different materials. Morphological and structural characterization of these materials showed platinum nanoparticles (size around 12 nm) distributed randomly along carbon nanotubes. Modified electrodes were directly prepared through a dispersion of these materials. Vo...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Adir H Kalinke Luiz H Marcolino-Junior Marcio F Bergamini Aldo J G Zarbin Source Type: research
Platinum Nanoparticles Supported by Carbon Nanotubes: Improvement in electrochemical sensor performance for caffeine determination
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230067. doi: 10.1590/0001-3765202420230067. eCollection 2024.ABSTRACTPlatinum nanoparticles supported by carbon nanotubes were obtained by a simple chemical route and used for preparation of electrochemical sensor towards caffeine determination. Carbon nanotubes were used before and after an acid treatment, yielding two different materials. Morphological and structural characterization of these materials showed platinum nanoparticles (size around 12 nm) distributed randomly along carbon nanotubes. Modified electrodes were directly prepared through a dispersion of these materials. Vo...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Adir H Kalinke Luiz H Marcolino-Junior Marcio F Bergamini Aldo J G Zarbin Source Type: research
Platinum Nanoparticles Supported by Carbon Nanotubes: Improvement in electrochemical sensor performance for caffeine determination
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230067. doi: 10.1590/0001-3765202420230067. eCollection 2024.ABSTRACTPlatinum nanoparticles supported by carbon nanotubes were obtained by a simple chemical route and used for preparation of electrochemical sensor towards caffeine determination. Carbon nanotubes were used before and after an acid treatment, yielding two different materials. Morphological and structural characterization of these materials showed platinum nanoparticles (size around 12 nm) distributed randomly along carbon nanotubes. Modified electrodes were directly prepared through a dispersion of these materials. Vo...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Adir H Kalinke Luiz H Marcolino-Junior Marcio F Bergamini Aldo J G Zarbin Source Type: research
Platinum Nanoparticles Supported by Carbon Nanotubes: Improvement in electrochemical sensor performance for caffeine determination
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230067. doi: 10.1590/0001-3765202420230067. eCollection 2024.ABSTRACTPlatinum nanoparticles supported by carbon nanotubes were obtained by a simple chemical route and used for preparation of electrochemical sensor towards caffeine determination. Carbon nanotubes were used before and after an acid treatment, yielding two different materials. Morphological and structural characterization of these materials showed platinum nanoparticles (size around 12 nm) distributed randomly along carbon nanotubes. Modified electrodes were directly prepared through a dispersion of these materials. Vo...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Adir H Kalinke Luiz H Marcolino-Junior Marcio F Bergamini Aldo J G Zarbin Source Type: research
Platinum Nanoparticles Supported by Carbon Nanotubes: Improvement in electrochemical sensor performance for caffeine determination
An Acad Bras Cienc. 2024 Apr 22;96(1):e20230067. doi: 10.1590/0001-3765202420230067. eCollection 2024.ABSTRACTPlatinum nanoparticles supported by carbon nanotubes were obtained by a simple chemical route and used for preparation of electrochemical sensor towards caffeine determination. Carbon nanotubes were used before and after an acid treatment, yielding two different materials. Morphological and structural characterization of these materials showed platinum nanoparticles (size around 12 nm) distributed randomly along carbon nanotubes. Modified electrodes were directly prepared through a dispersion of these materials. Vo...
Source: An Acad Bras Cienc - April 24, 2024 Category: Science Authors: Adir H Kalinke Luiz H Marcolino-Junior Marcio F Bergamini Aldo J G Zarbin Source Type: research
Endocrine disrupting chemicals in children's and their parents' urine: Is the exposure related to the Chinese and Western lifestyle?
Int J Hyg Environ Health. 2024 Apr 22;259:114383. doi: 10.1016/j.ijheh.2024.114383. Online ahead of print.ABSTRACTChildren are known to be more vulnerable to exposure to endocrine-disrupting chemicals (EDCs) compared to adults, but evaluating the exposure pathways can be challenging. This research employed target and non-target analysis (NTA) to examine the exposure characteristics of EDCs in spot urine samples collected from 46 children's (aged 3-12 years) and their parents in Hong Kong (Chinese/Western lifestyle) and Guangzhou (mainly Chinese lifestyle). The results revealed that the geometric mean concentrations of phth...
Source: International Journal of Hygiene and Environmental health - April 23, 2024 Category: Environmental Health Authors: Na Li Jing Liu Guangguo Ying John Chi-Kin Lee Ting Fan Leung Adrian Covaci Wen-Jing Deng Source Type: research
Endocrine disrupting chemicals in children's and their parents' urine: Is the exposure related to the Chinese and Western lifestyle?
Int J Hyg Environ Health. 2024 Apr 22;259:114383. doi: 10.1016/j.ijheh.2024.114383. Online ahead of print.ABSTRACTChildren are known to be more vulnerable to exposure to endocrine-disrupting chemicals (EDCs) compared to adults, but evaluating the exposure pathways can be challenging. This research employed target and non-target analysis (NTA) to examine the exposure characteristics of EDCs in spot urine samples collected from 46 children's (aged 3-12 years) and their parents in Hong Kong (Chinese/Western lifestyle) and Guangzhou (mainly Chinese lifestyle). The results revealed that the geometric mean concentrations of phth...
Source: International Journal of Hygiene and Environmental health - April 23, 2024 Category: Environmental Health Authors: Na Li Jing Liu Guangguo Ying John Chi-Kin Lee Ting Fan Leung Adrian Covaci Wen-Jing Deng Source Type: research
Trends and prescribing patterns of antimigraine medicines in nine major cities in China from 2018 to 2022: a retrospective prescription analysis
ConclusionsMigraine treatment gradually converges toward evidence-based and guideline-recommended treatment. Attention should be given to opioid prescribing, weak evidence-based antidepressant use, and medication overuse in migraine treatment. (Source: The Journal of Headache and Pain)
Source: The Journal of Headache and Pain - April 23, 2024 Category: Neurology Source Type: research
Modeling Developmental Changes in Caffeine Clearance Considering Differences between Pre- and Postnatal Period
Biol Pharm Bull. 2024;47(4):861-867. doi: 10.1248/bpb.b23-00650.ABSTRACTTaguchi et al. reported that postmenstrual age (PMA) is a promising factor in describing and understanding the developmental change of caffeine (CAF) clearance. The aim of the present study was to quantify how developmental changes occur and to determine the effect of the length of the gestational period on CAF clearance. We performed a nonlinear mixed effect model (NONMEM) analysis and evaluated the fit of six models. A total of 115 samples were obtained from 52 patients with a mean age of 34.3 ± 18.2 d. The median values of gestational age (GA) and ...
Source: Biological and Pharmaceutical Bulletin - April 21, 2024 Category: Drugs & Pharmacology Authors: Haruka Ide Yukako Kawasaki Kentaro Tamura Taketoshi Yoshida Ryosuke Fujihara Akane Hara Masato Taguchi Source Type: research
