Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs
CONCLUSIONS: MSC-sEVs improved respiratory system physiology and alveolar formation in mechanically ventilated preterm lambs. MSC-sEVs may be an effective and safe therapy for appropriate functional and structural development of the lung in preterm infants who require mechanical ventilation and are at-risk of developing BPD.PMID:38563994 | DOI:10.1152/ajplung.00349.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Kurt H Albertine Andrew Rebentisch Elaine Dawson Jakob Van Boerum Emily Major Juraj Štipka Hannah Foreman David Headden Zo ë Vordos Emily Beck Zhengming Wang Haixia Yang Baifeng Yu Mar Janna Dahl Donald M Null Davide Bizzotto Chiara Veneroni Anna Lavizz Source Type: research
Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs
CONCLUSIONS: MSC-sEVs improved respiratory system physiology and alveolar formation in mechanically ventilated preterm lambs. MSC-sEVs may be an effective and safe therapy for appropriate functional and structural development of the lung in preterm infants who require mechanical ventilation and are at-risk of developing BPD.PMID:38563994 | DOI:10.1152/ajplung.00349.2023 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 2, 2024 Category: Cytology Authors: Kurt H Albertine Andrew Rebentisch Elaine Dawson Jakob Van Boerum Emily Major Juraj Štipka Hannah Foreman David Headden Zo ë Vordos Emily Beck Zhengming Wang Haixia Yang Baifeng Yu Mar Janna Dahl Donald M Null Davide Bizzotto Chiara Veneroni Anna Lavizz Source Type: research
Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs
CONCLUSIONS: MSC-sEVs improved respiratory system physiology and alveolar formation in mechanically ventilated preterm lambs. MSC-sEVs may be an effective and safe therapy for appropriate functional and structural development of the lung in preterm infants who require mechanical ventilation and are at-risk of developing BPD.PMID:38563994 | DOI:10.1152/ajplung.00349.2023 (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - April 2, 2024 Category: Respiratory Medicine Authors: Kurt H Albertine Andrew Rebentisch Elaine Dawson Jakob Van Boerum Emily Major Juraj Štipka Hannah Foreman David Headden Zo ë Vordos Emily Beck Zhengming Wang Haixia Yang Baifeng Yu Mar Janna Dahl Donald M Null Davide Bizzotto Chiara Veneroni Anna Lavizz Source Type: research
Mesenchymal stromal cell extracellular vesicles improve lung development in mechanically ventilated preterm lambs
CONCLUSIONS: MSC-sEVs improved respiratory system physiology and alveolar formation in mechanically ventilated preterm lambs. MSC-sEVs may be an effective and safe therapy for appropriate functional and structural development of the lung in preterm infants who require mechanical ventilation and are at-risk of developing BPD.PMID:38563994 | DOI:10.1152/ajplung.00349.2023 (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 2, 2024 Category: Cytology Authors: Kurt H Albertine Andrew Rebentisch Elaine Dawson Jakob Van Boerum Emily Major Juraj Štipka Hannah Foreman David Headden Zo ë Vordos Emily Beck Zhengming Wang Haixia Yang Baifeng Yu Mar Janna Dahl Donald M Null Davide Bizzotto Chiara Veneroni Anna Lavizz Source Type: research
Eye Diseases: When the Solution Comes from Plant Alkaloids
Planta Med DOI: 10.1055/a-2283-2350Plants are an incredible source of metabolites showing a wide range of biological activities. Among these, there are the alkaloids, which have been exploited for medical purposes since ancient times. Nowadays, many plant-derived alkaloids are the main components of drugs used as therapy for different human diseases. This review deals with providing an overview of the alkaloids used to treat eye diseases, describing the historical outline, the plants from which they are extracted, and the clinical and molecular data supporting their therapeutic activity. Among the different alkaloids that ...
Source: Planta Medica - April 2, 2024 Category: Drugs & Pharmacology Authors: Lorrai, Riccardo Cavaterra, Dario Giammaria, Sara Sbardella, Diego Tundo, Grazia Raffaella Boccaccini, Alessandra Tags: Reviews Source Type: research
Sex-Dependent Effect of Caffeine in Chronic Pain Symptoms
Caffeine has long been used as an analgesic adjuvant; however, its role in pain management is still not fully understood. In this cross-sectional analysis we assessed for associations between caffeine intake and severity of symptoms in a sample of chronic pain patients who reported dietary caffeine intake. A general linear model analysis was used to adjust for significant covariates and assess main effects. The sample (n=470) had a mean age of 58.1 ±12.8 years and was predominantly female (65.6%) and Caucasian (91.3%); a small proportion reported opioid use (4.7%). (Source: The Journal of Pain)
Source: The Journal of Pain - April 1, 2024 Category: Materials Science Authors: J. Ryan Scott, Andrew P. Schrepf, David A. Williams, Daniel J. Clauw, Steven E. Harte Source Type: research
In vivo Tebuconazole administration impairs heart electrical function and facilitates the occurrence of dobutamine-induced arrhythmias: Involvement of reactive oxygen species
In conclusion, TEB at the no observed adverse effect level (NOAEL) dose adversely affects heart electrical function, increases arrhythmic susceptibility, partially through ROS overproduction, and this phenotype is reversible by scavenging ROS with NAC.PMID:38556154 | DOI:10.1016/j.fct.2024.114596 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - March 31, 2024 Category: Food Science Authors: Jorge Lucas Teixeira-Fonseca Diego Santos Souza Michael Ramon de Lima Concei ção Leisiane Pereira Marques Aim ée Obolari Durço Polyana Leal da Silva Julliane V Joviano-Santos Artur Santos-Miranda Danilo Roman-Campos Source Type: research
Assessment of the Effects of Abrocitinib on the Pharmacokinetics of Probe Substrates of Cytochrome P450 1A2, 2B6 and 2C19 Enzymes and Hormonal Oral Contraceptives in Healthy Individuals
ConclusionsBased on the study results, abrocitinib is a moderate inhibitor of CYP2C19. Caution should be exercised when using abrocitinib concomitantly with narrow therapeutic index medicines that are primarily metabolized by CYP2C19 enzyme. Abrocitinib is a mild inhibitor of CYP1A2; however, the impact is not clinically relevant, and no general dose adjustment is recommended for CYP1A2 substrates. Abrocitinib does not inhibit CYP3A or induce CYP1A2/2B6/2C19/3A and does not affect the pharmacokinetics of contraceptives.Clinical Trials RegistrationClinicalTrials.gov registration IDs: NCT03647670, NCT05067439, NCT03662516. (...
Source: European Journal of Drug Metabolism and Pharmacokinetics - March 30, 2024 Category: Drugs & Pharmacology Source Type: research
Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer
Oncol Lett. 2024 Mar 14;27(5):209. doi: 10.3892/ol.2024.14342. eCollection 2024 May.ABSTRACTBreast cancer (BC) is the most common type of malignancy and the leading cause of cancer-associated mortality in women worldwide. As such, assessing the metabolic changes during human breast carcinogenesis is key for developing disease prevention methods and treatment. In the present study, non-targeted metabolomics with chemometrics based on ultra-high performance liquid chromatography-high-resolution mass spectrometry were performed to assess differences in serum metabolite patterns between patients with BC and healthy individuals...
Source: Oncology Letters - March 29, 2024 Category: Cancer & Oncology Authors: Qinqin Zhang Rongzhao Lu Ying Wu Yong Hong Ningxia Wang Cunchuan Wang Source Type: research
