Roles of TRPM channels in glioma
Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.ABSTRACTGliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. ...
Source: Cancer Biology and Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Zhigang Chen Han Xie Jun Liu JiaJia Zhao Ruixiang Huang Yufei Xiang Haoyuan Wu Dasheng Tian Erbao Bian Zhang Xiong Source Type: research
[11C]-methionine positron emission tomography in the evaluation of pediatric low-grade gliomas
CONCLUSIONS: Our study shows that [11C]-MET-PET reliably characterizes new and previously treated pLGGs. Our study also shows that quantitative parameters tend to decrease with treatment, and differences may exist between various pLGG types.PMID:38680989 | PMC:PMC11055465 | DOI:10.1093/noajnl/vdae056 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Emily Y Kim Amy L Vavere Scott E Snyder Jason Chiang Yimei Li Tushar Patni Ibrahim Qaddoumi Thomas E Merchant Giles W Robinson Joseph L Holtrop Barry L Shulkin Asim K Bag Source Type: research
Enhanced therapeutic efficacy for glioblastoma immunotherapy with an oncolytic herpes simplex virus armed with anti-PD-1 antibody and IL-12
In this study, we developed a new generation of oncolytic herpes simplex virus C5252 by deletion of a 15-kb internal repeat region and both copies of γ34.5 genes. Additionally, C5252 was armed with anti-programmed cell death protein 1 antibody and interleukin-12 to enhance its therapeutic efficacy for glioblastoma immune-virotherapy. In vitro and in vivo experiments demonstrate that C5252 has a remarkable safety profile and potent anti-tumor activity against glioblastoma. Mechanistic studies demonstrated that C5252 specifically induces cell apoptosis by caspase-3/7 activation via downregulating ciliary neurotrophic factor...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Lei Wang Xusha Zhou Xiaoqing Chen Yuanyuan Liu Yue Huang Yuan Cheng Peigen Ren Jing Zhao Grace Guoying Zhou Source Type: research
Roles of TRPM channels in glioma
Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.ABSTRACTGliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. ...
Source: Cancer Biology and Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Zhigang Chen Han Xie Jun Liu JiaJia Zhao Ruixiang Huang Yufei Xiang Haoyuan Wu Dasheng Tian Erbao Bian Zhang Xiong Source Type: research
Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research
The multifaceted functions of long non-coding RNA < em > HOTAIR < /em > in neuropathologies and its potential as a prognostic marker and therapeutic biotarget
The objective of this review is to recapitulate all the relevant data pertaining to the regulatory roles of HOTAIR in neuronal (patho)physiology. To this end, we discuss the pathogenic mechanisms of HOTAIR in multiple neuronal diseases, such as neurodegeneration, traumatic brain injury and neuropsychiatric disorders. Finally, we also summarize the results from the studies incriminating HOTAIR in the pathogeneses of gliomas and other brain cancers. Implications of HOTAIR serving as a suitable therapeutic target in neuropathologies are also discussed.PMID:38682637 | DOI:10.1017/erm.2024.11 (Source: Molecular Medicine)
Source: Molecular Medicine - April 29, 2024 Category: Molecular Biology Authors: Faraz Ahmad Ravi Sudesh Atheeq Toufeeq Ahmed Mohanapriya Arumugam Darin Mansor Mathkor Shafiul Haque Source Type: research
[11C]-methionine positron emission tomography in the evaluation of pediatric low-grade gliomas
CONCLUSIONS: Our study shows that [11C]-MET-PET reliably characterizes new and previously treated pLGGs. Our study also shows that quantitative parameters tend to decrease with treatment, and differences may exist between various pLGG types.PMID:38680989 | PMC:PMC11055465 | DOI:10.1093/noajnl/vdae056 (Source: Adv Data)
Source: Adv Data - April 29, 2024 Category: Epidemiology Authors: Emily Y Kim Amy L Vavere Scott E Snyder Jason Chiang Yimei Li Tushar Patni Ibrahim Qaddoumi Thomas E Merchant Giles W Robinson Joseph L Holtrop Barry L Shulkin Asim K Bag Source Type: research
Enhanced therapeutic efficacy for glioblastoma immunotherapy with an oncolytic herpes simplex virus armed with anti-PD-1 antibody and IL-12
In this study, we developed a new generation of oncolytic herpes simplex virus C5252 by deletion of a 15-kb internal repeat region and both copies of γ34.5 genes. Additionally, C5252 was armed with anti-programmed cell death protein 1 antibody and interleukin-12 to enhance its therapeutic efficacy for glioblastoma immune-virotherapy. In vitro and in vivo experiments demonstrate that C5252 has a remarkable safety profile and potent anti-tumor activity against glioblastoma. Mechanistic studies demonstrated that C5252 specifically induces cell apoptosis by caspase-3/7 activation via downregulating ciliary neurotrophic factor...
Source: Herpes - April 29, 2024 Category: Infectious Diseases Authors: Lei Wang Xusha Zhou Xiaoqing Chen Yuanyuan Liu Yue Huang Yuan Cheng Peigen Ren Jing Zhao Grace Guoying Zhou Source Type: research
Roles of TRPM channels in glioma
Cancer Biol Ther. 2024 Dec 31;25(1):2338955. doi: 10.1080/15384047.2024.2338955. Epub 2024 Apr 29.ABSTRACTGliomas are the most common type of primary brain tumor. Despite advances in treatment, it remains one of the most aggressive and deadly tumor of the central nervous system (CNS). Gliomas are characterized by high malignancy, heterogeneity, invasiveness, and high resistance to radiotherapy and chemotherapy. It is urgent to find potential new molecular targets for glioma. The TRPM channels consist of TRPM1-TPRM8 and play a role in many cellular functions, including proliferation, migration, invasion, angiogenesis, etc. ...
Source: Cancer Biology and Therapy - April 29, 2024 Category: Cancer & Oncology Authors: Zhigang Chen Han Xie Jun Liu JiaJia Zhao Ruixiang Huang Yufei Xiang Haoyuan Wu Dasheng Tian Erbao Bian Zhang Xiong Source Type: research
A review of natural products and small-molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges
Drug Dev Res. 2024 May;85(3):e22180. doi: 10.1002/ddr.22180.ABSTRACTIn 2021, the World Health Organization released the fifth edition of the central nervous system (CNS) tumor classification. This classification uses histopathology and molecular pathogenesis to group tumors into more biologically and molecularly defined entities. The prognosis of brain cancer, particularly malignant tumors, has remained poor worldwide, approximately 308,102 new cases of brain and other CNS tumors were diagnosed in the year 2020, with an estimated 251,329 deaths. The cost and time-consuming nature of studies to find new anticancer agents ma...
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Ardalan Pasdaran Irwin Darren Grice Azadeh Hamedi Source Type: research
Pharmacotherapeutic Potential of Bitter Gourd ( < em > Momordica charantia < /em > ) in Age-related Neurological Diseases
J Integr Neurosci. 2024 Apr 23;23(4):86. doi: 10.31083/j.jin2304086.ABSTRACTDue to the growth of the elderly population, age-related neurological disorders are an increasing problem. Aging begins very gradually and later leads to several neurological issues such as lower neurotransmitter levels, oxidative stress, neuronal inflammation, and continual neuronal loss. These changes might contribute to brain disorders such as Alzheimer's disease (AD), dementia or mild cognitive impairment, and epilepsy and glioma, and can also aggravate these disorders if they were previously present. Momordica charantia (bitter gourd), a membe...
Source: Journal of Integrative Neuroscience - April 29, 2024 Category: Neuroscience Authors: Seyed Mohammad Hosein Hosseini Adarmanabadi Orod Jalali Khalil Abadi Amirhossein Amiri Rozhina Tamannaeifar Sahar Balanian Mehdi Rasekhjam Mohammad Sadra Samiazar Sara Hasanpour Samira Peiravi Dorsa Alijanzadeh Mohadeseh Poudineh Hamidreza Amiri Seyed Ami Source Type: research
Two-headed UNetEfficientNets for parallel execution of segmentation and classification of brain tumors: incorporating postprocessing techniques with connected component labelling
ConclusionOur study demonstrates the high efficiency and accuracy of the proposed UNetEfficientNet-B4 model in the automatic and parallel detection and segmentation of brain tumors from MRI images. This approach holds promise for improving diagnosis and treatment planning for patients with brain tumors, potentially leading to better outcomes and prognosis. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 29, 2024 Category: Cancer & Oncology Source Type: research
Therapeutic efficacy of a novel self-assembled immunostimulatory siRNA combining apoptosis promotion with RIG-I activation in gliomas
Current cancer therapies often fall short in addressing the complexities of malignancies, underscoring the urgent need for innovative treatment strategies. RNA interference technology, which specifically suppr... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 29, 2024 Category: Research Authors: Junxiao Chen, Ziyuan Liu, Haiting Fang, Qing Su, Yiqi Fan, Luyao Song and Shuai He Tags: Research Source Type: research
Advanced diffusion MRI provides evidence for altered axonal microstructure and gradual peritumoral infiltration in GBM in comparison to brain metastases
ConclusionOur findings provide evidence of gradual alterations within the peritumoral zone of brain tumors. These are compatible with predominant (vasogenic) edema formation in metastases, whereas our findings in GBM are in line with an axonal destructive component in the immediate peritumoral area and evidence of tumor cell infiltration with accentuation in the tumor ’s vicinity. (Source: Clinical Neuroradiology)
Source: Clinical Neuroradiology - April 29, 2024 Category: Neurology Source Type: research
SUPRAMAX-study: supramaximal resection versus maximal resection for glioblastoma patients: study protocol for an international multicentre prospective cohort study (ENCRAM 2201)
This study is an international, multicentre, prospective, two-arm cohort study of observational nature. Consecutive glioblastoma patients will be operated with SMR or maximal resection at a 1:1 ratio. Primary endpoints are (1) overall survival and (2) proportion of patients with National Institute of Health Stroke Scale deterioration at 6 weeks, 3 months and 6 months postoperatively. Secondary endpoints are (1) residual CE and NCE tumour volume on postoperative T1-contrast and FLAIR (Fluid-attenuated inversion recovery) MRI scans; (2) progression-free survival; (3) receipt of adjuvant therapy with chemotherapy and radiothe...
Source: BMJ Open - April 29, 2024 Category: General Medicine Authors: Gerritsen, J. K. W., Young, J. S., Chang, S. M., Krieg, S. M., Jungk, C., van den Bent, M. J., Satoer, D. D., Ille, S., Schucht, P., Nahed, B. V., Broekman, M. L. D., Berger, M., De Vleeschouwer, S., Vincent, A. J. P. E. Tags: Open access, Oncology Source Type: research
