Correction to: A bis-boron boramino acid PET tracer for brain tumor diagnosis
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Amino acid PET vs. RANO MRI for prediction of overall survival in patients with recurrent high grade glioma under bevacizumab therapy
ConclusionFor monitoring of patients with rHGG under bevacizumab therapy, AA-PET should be preferred over RANO MRI. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Bioorthogonal Cu Single-atom Nanozyme for Synergistic Nanocatalytic Therapy, Photothermal Therapy, Cuproptosis, and Immunotherapy
Angew Chem Int Ed Engl. 2024 Apr 23:e202405937. doi: 10.1002/anie.202405937. Online ahead of print.ABSTRACTSingle-atom nanozymes (SAzymes) with atomically dispersed active sites are potential substitutes for natural enzymes. A systematic study of its multiple functions can in-depth understand SAzymes's nature, which remains elusive. Here, we develop a novel ultrafast synthesis of sputtered SAzymes by in situ bombarding-embedding technique. Using this method, sputtered copper (Cu) SAzymes (CuSA) is developed with unreported unique planar Cu-C3 coordinated configuration. To enhance the tumor-specific targeting, we employ a b...
Source: Angewandte Chemie - April 24, 2024 Category: Chemistry Authors: Luyan Wu Huihui Lin Xiang Cao Qiang Tong Fangqi Yang Yinxing Miao Deju Ye Quli Fan Source Type: research
Cancers, Vol. 16, Pages 1637: Pentraxin 3: A Main Driver of Inflammation and Immune System Dysfunction in the Tumor Microenvironment of Glioblastoma
Paola Capra
Brain tumors are a heterogeneous group of brain neoplasms that are highly prevalent in individuals of all ages worldwide. Within this pathological framework, the most prevalent and aggressive type of primary brain tumor is glioblastoma (GB), a subtype of glioma that falls within the IV-grade astrocytoma group. The death rate for patients with GB remains high, occurring within a few months after diagnosis, even with the gold-standard therapies now available, such as surgery, radiation, or a pharmaceutical approach with Temozolomide. For this reason, it is crucial to continue looking for cutting-edge therape...
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Sarah Adriana Scuderi Alessio Ardizzone Ayomide Eniola Salako Giuseppe Pant ò Fabiola De Luca Emanuela Esposito Anna Paola Capra Tags: Review Source Type: research
Genes, Vol. 15, Pages 535: Preservation of 5-Hydroxymethylcytosine Levels in LRIG1 across Genomic DNA and Cell-Free DNA in Glioma Patients
In this study, our aim was to identify cfDNA biomarkers by investigating genes that displayed significant differences between glioma patients and their corresponding controls. To accomplish this, we utilized publicly available data from the Gene Expression Omnibus, focusing on 5-hydroxymethylcytosine (5hmC) profiles in both cfDNA and genomic DNA (gDNA) from glioma patients and healthy individuals. The intersection of gene lists derived from these comparative analyses unveiled LRIG1 and ZNF703 as the two genes with elevated 5hmC levels in both the cfDNA of glioma patients and gDNA of glioma tissue compared to their respecti...
Source: Genes - April 24, 2024 Category: Genetics & Stem Cells Authors: Da ša Jevšinek Skok Luka Bolha Nina Hauptman Tags: Brief Report Source Type: research
Neurologic Dysphagia
This article aims to review the major categories of neurologic dysphagia, to outline specific findings and special considerations for each population, and to acknowledge the importance of integrating each patient ’s medical prognosis, goals of care, and developmental stage into a multidisciplinary treatment plan. (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 24, 2024 Category: ENT & OMF Authors: Jillian Nyswonger Sugg, Janet Waimin Lee Source Type: research
Paroxysmal Sympathetic Hyperactivity in the Acute Phase Post-Brain Tumour Surgery of Glioblastoma Multiforme
J Korean Neurosurg Soc. 2024 Apr 23. doi: 10.3340/jkns.2024.0026. Online ahead of print.NO ABSTRACTPMID:38650429 | DOI:10.3340/jkns.2024.0026 (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - April 23, 2024 Category: Neurosurgery Authors: Yasothai Sahadeevan Mazlina Mazlan Source Type: research
Classifying glioma via liquid biopsy--progress towards an unmet clinical need
Clin Cancer Res. 2024 Apr 23. doi: 10.1158/1078-0432.CCR-24-0423. Online ahead of print.ABSTRACTThe diagnosis and classification of glioma by liquid biopsy represents a critical unmet need in neuro oncology. A recent study demonstrates targeted next generation sequencing (NGS) of cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) as an evolving option for liquid biopsy in patients with glioma.PMID:38652677 | DOI:10.1158/1078-0432.CCR-24-0423 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Kalil G Abdullah Source Type: research
Diffusion- and Perfusion-Weighted MRI Radiomics for Survival Prediction in Patients with Lower-Grade Gliomas
CONCLUSION: Adding diffusion- and perfusion-weighted MRI radiomics to clinical features improved survival prediction in lower-grade glioma.PMID:38653567 | DOI:10.3349/ymj.2023.0323 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Chae Jung Park Sooyon Kim Kyunghwa Han Sung Soo Ahn Dain Kim Yae Won Park Jong Hee Chang Se Hoon Kim Seung-Koo Lee Source Type: research
Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors
Biochim Biophys Acta Rev Cancer. 2024 Apr 21:189102. doi: 10.1016/j.bbcan.2024.189102. Online ahead of print.ABSTRACTGliomas with Isocitrate dehydrogenase (IDH) mutation represent a discrete category of primary brain tumors with distinct and unique characteristics, behaviors, and clinical disease outcomes. IDH mutations lead to aberrant high-level production of the oncometabolite D-2-hydroxyglutarate (D-2HG), which act as a competitive inhibitor of enzymes regulating epigenetics, signaling pathways, metabolism, and various other processes. This review summarizes the significance of IDH mutations, resulting upregulation of ...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yosuke Kitagawa Ami Kobayashi Daniel P Cahill Hiroaki Wakimoto Shota Tanaka Source Type: research
Evaluating the predictive value of a coagulation-related gene model in glioma
CONCLUSION: This study established the correlation between the coagulation-related gene model and glioma prognosis, providing deeper insight into the mechanism and treatment of glioma.PMID:38650572 | DOI:10.5137/1019-5149.JTN.45238-23.2 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Ming Cao Jie Chen Rong-Zeng Guo Source Type: research
Relationship between brain tumors and intracranial aneurysms: a systematic review
CONCLUSION: There is a lack of evidence to affirm that the existence of brain neoplasm plays a role in the formation and rupture of intracranial aneurysms. Additionally, there is insufficient evidence to confirm a greater prevalence of intracranial aneurysms in individuals with brain tumors. The association of these two disorders does not appear to worsen patient outcome. Prognosis depends on tumor pathology for malignant cases and on subarachnoid hemorrhage in patients with ruptured aneurysms.PMID:38650567 | DOI:10.5137/1019-5149.JTN.43614-23.4 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Pedro Henrique Mouty Rabello N ícollas Nunes Rabelo Jo ão Paulo Telles Eberval Gadelha Figueiredo Source Type: research
Non-Detection of HCMV Total Genomic DNA in Human Glioma Cells Genome
CONCLUSION: We found that the genomic DNA of all the samples was negative for HCMV genomic DNA. Thus, HCMV could not be detected in human glioma tumors and we put forward that HCMV genomic DNA was not incorporated into the genomic DNA of glioma cells. Thus, total viral DNA is not involved in the pathogenesis of glioma; however, small viral particles or specific genes might be incorporated into the genomic DNA of glioma cells, leading to cancer development. This prompts further studies for verification.PMID:38650560 | DOI:10.5137/1019-5149.JTN.42717-22.1 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Dilek Gokturk Meryem Damla Ozdemir Dervis Mansuri Yilmaz Source Type: research
Expression of STAT3 and hypoxia markers in long-term surviving malignant glioma patients
Glioblastoma is a malignant and aggressive type of central nevous system malignancy characterized by many distinct biological features including extensive hypoxia. Hypoxia in glioblatoma associates with comple... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Katerina Dvorakova, Veronika Skarkova, Barbora Vitovcova, Jiri Soukup, Hana Vosmikova, Zuzana Pleskacova, Adam Skarka, Michael Christian Bartos, Petr Krupa, Petra Kasparova, Jiri Petera and Emil Rudolf Tags: Research Source Type: research
Intraoperative radiotherapy combined with spinal stabilization surgery —a novel treatment strategy for spinal metastases based on a first single-center experiences
Conclusion50 kV photon IORT for SM and consecutive unstable spine needing surgical intervention is safe and feasible and can be a promising technique in selected cases. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
