Pediatric-Like Brain Tumors in Adults
Adv Tech Stand Neurosurg. 2024;50:147-183. doi: 10.1007/978-3-031-53578-9_5.ABSTRACTPediatric brain tumors are different to those found in adults in pathological type, anatomical site, molecular signature, and probable tumor drivers. Although these tumors usually occur in childhood, they also rarely present in adult patients, either as a de novo diagnosis or as a delayed recurrence of a pediatric tumor in the setting of a patient that has transitioned into adult services.Due to the rarity of pediatric-like tumors in adults, the literature on these tumor types in adults is often limited to small case series, and treatment d...
Source: Advances and Technical Standards in Neurosurgery - April 9, 2024 Category: Neurosurgery Authors: Sandra Fernandes Dias Oliver Richards Martin Elliot Paul Chumas Source Type: research
Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma
ConclusionsOur results indicate that DMG-H3K27M cells rely on highly active purine synthesis, both from thede novo and salvage synthesis pathways. However, highly active salvage of free purine bases into mature guanylates can bypass inhibition of thede novo synthetic pathway. We conclude that inhibiting purine salvage may be a promising strategy to overcome treatment resistance in DMG-H3K27M tumors. (Source: Cancer and Metabolism)
Source: Cancer and Metabolism - April 9, 2024 Category: Cancer & Oncology Source Type: research
SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights
SIRPB1 expression is upregulated in various tumor types, including gliomas, and is known to contribute to tumor progression; nevertheless, its function in the immune milieu of gliomas is still mainly unknown. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - April 9, 2024 Category: Research Authors: Ren Geng, Yao Zhao, Wanzhen Xu, Xiaoshan Ma, Yining Jiang, Xuefei Han, Liyan Zhao and Yunqian Li Tags: Research Source Type: research
Ketogenic metabolic therapy in conjunction with standard treatment for glioblastoma: A case report
Oncol Lett. 2024 Mar 26;27(5):230. doi: 10.3892/ol.2024.14363. eCollection 2024 May.ABSTRACTGlioblastoma (GBM) is the most common primary malignant brain tumour in adults. The standard of care consists of surgical resection and concurrent chemoradiation, followed by adjuvant temozolomide chemotherapy. This protocol is associated with a median survival of 12-15 months, and <5% of patients survive >3 years. Ketogenic metabolic therapy (KMT) targets cancer cell metabolism by restricting glucose availability and evoking differential stress resistance and sensitization, which may augment the standard treatments and lead t...
Source: Oncology Letters - April 8, 2024 Category: Cancer & Oncology Authors: Matthew C L Phillips Ziad Thotathil Prashanth Hari Dass Fouzia Ziad Ben G Moon Source Type: research
Distribution of Bevacizumab into the Cerebrospinal Fluid of Children and Adolescents with Recurrent Brain Tumors
CONCLUSIONS: This pharmacokinetic pilot study indicated penetration of bevacizumab into the CSF in a population of children, adolescents, and young adults with recurrent brain tumors.PMID:38587585 | DOI:10.1007/s40272-024-00624-y (Source: Paediatric Drugs)
Source: Paediatric Drugs - April 8, 2024 Category: Pediatrics Authors: Iris K Minichmayr Ursula Knaack Johannes Gojo Daniel Senfter Christine Haberler Amedeo A Azizi Lisa Mayr Markus Zeitlinger Andreas Peyrl Source Type: research
