Real-World Use of Hypofractionated Radiotherapy for Primary CNS Tumors in the Elderly, and Implications on Medicare Spending
CONCLUSIONS: Although most Medicare beneficiaries received LCRT for primary brain tumors, HFRT utilization increased in hospital-affiliated centers. Despite high-level evidence for elderly patients, discrepancy in HFRT implementation by site of care persists. Further investigation is needed to understand why patients with short survival may still receive LCRT, because this has major quality-of-life and Medicare spending implications.PMID:38688308 | DOI:10.6004/jnccn.2023.7109 (Source: Journal of the National Comprehensive Cancer Network : JNCCN)
Source: Journal of the National Comprehensive Cancer Network : JNCCN - April 30, 2024 Category: Cancer & Oncology Authors: Kathryn R Tringale Andrew Lin Alexandra M Miller Atif Khan Linda Chen Melissa Zinovoy Yoshiya Yamada Yao Yu Luke R G Pike Brandon S Imber Source Type: research
BPTF promotes glioma development through USP34-mediated de-ubiquitination of FOXC1
In conclusion, the BPTF/FOXC1 axis was identified as a key promotor in glioma development and may be a potential target in the inhibition of glioma development.PMID:38686761 | DOI:10.14670/HH-18-748 (Source: Histology and Histopathology)
Source: Histology and Histopathology - April 30, 2024 Category: Cytology Authors: Yanling Pan Feng Yuan Zhiren Lin Yijie Li Source Type: research
The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization
In this study, we analyzed RNA-seq data from sGBM patients' glioma tissues with or without ZM fusion,and found that stemness and macrophage markers were more highly expressed in sGBM patients harboring ZM than in those without ZM fusion. ZM enhanced the self-renewal and proliferation of GSCs, thereby accelerating glioma progression. In addition, ZM-positive GSCs facilitated the infiltration of TAMs and drove their polarization toward an immunosuppressive phenotype, which was primarily accomplished through the extracellular secretion of ISG20. Our research identified the MET-STAT3-ISG20 axis within GSCs, thus demonstrating ...
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Yuxin Wang Jinghao Suo Zhixing Wang Kunnian Ran Yuan Tian Wei Han Yanwei Liu Xiaozhong Peng Source Type: research
Hypofractionated Radiation Therapy Suppresses Radioresistance in U87 Human Glioma Cells by Inhibiting Yap1 and Hsp90 Proteins
CONCLUSION: For this purpose, expression levels of radioresistance markers Yap-1 and Hsp90 were evaluated after treatment with HF-GKRT, and this was compared with single fraction Gamma Knife radiation therapy (SF-GKRT) in U87MG primary human glioblastoma cell line model. This would help design a novel radiation therapy regimen for glioblastoma patients by reducing the risk of radioresistance.PMID:38685786 | DOI:10.2174/0118744710300495240409074900 (Source: Current Radiopharmaceuticals)
Source: Current Radiopharmaceuticals - April 30, 2024 Category: Radiology Authors: Imran Khan Sadaf Mahfooz Busra Karacam Elif Burce Elbasan Kerime Akdur Ganime Coban Mustafa Aziz Hatiboglu Source Type: research
PL-hMSC and CH-hMSC derived soluble factors inhibit proliferation but improve hGBM cell migration by activating TGF- β and inhibiting Wnt signaling
Biosci Rep. 2024 Apr 30:BSR20231964. doi: 10.1042/BSR20231964. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is one of the most common and aggressive brain tumors. GBM resists most chemotherapeutic agents, resulting in a high mortality rate in patients. Human mesenchymal stem cells (hMSCs), which are parts of the cancer stroma, have been shown to be involved in the development and progression of GBM. However, different sources of hMSCs might affect GBM cells differently. In the present study, we established hMSCs from placenta(PL-hMSC) and chorion (CH-hMSC) to study the effects of their released soluble facto...
Source: Bioscience Reports - April 30, 2024 Category: Biomedical Science Authors: Tanawat Uthanaphun Sirikul Manochantr Chairat Tantrawatpan Duangrat Tantikanlayaporn Pakpoom Kheolamai Source Type: research
Multi-omics analysis reveals the association between specific solute carrier proteins gene expression patterns and the immune suppressive microenvironment in glioma
J Cell Mol Med. 2024 May;28(9):e18339. doi: 10.1111/jcmm.18339.ABSTRACTGlioma is the most prevalent malignant brain tumour. Currently, reshaping its tumour microenvironment has emerged as an appealing strategy to enhance therapeutic efficacy. As the largest group of transmembrane transport proteins, solute carrier proteins (SLCs) are responsible for the transmembrane transport of various metabolites and ions. They play a crucial role in regulating the metabolism and functions of malignant cells and immune cells within the tumour microenvironment, making them a promising target in cancer therapy. Through multidimensional da...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Wenjie Wu Cheng Jiang Wende Zhu Xiaobing Jiang Source Type: research
A potassium-chloride co-transporter with altered genome architecture functions as a suppressor in glioma
J Cell Mol Med. 2024 May;28(9):e18352. doi: 10.1111/jcmm.18352.ABSTRACTGliomas, the most lethal tumours in brain, have a poor prognosis despite accepting standard treatment. Limited benefits from current therapies can be attributed to genetic, epigenetic and microenvironmental cues that affect cell programming and drive tumour heterogeneity. Through the analysis of Hi-C data, we identified a potassium-chloride co-transporter SLC12A5 associated with disrupted topologically associating domain which was downregulated in tumour tissues. Multiple independent glioma cohorts were included to analyse the characterization of SLC12A...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Hongwei Liu Zhouyang Pan Xuelei Lin Long Chen Qi Yang Wei Zhang Luohuan Dai Yihao Zhang Wang Li Yinhua Chen Kang Peng Siyi Wanggou Feiyue Zeng Xuejun Li Source Type: research
Orexin-A mediates glioblastoma proliferation inhibition by increasing ferroptosis triggered by unstable iron pools and GPX4 depletion
In this report, we provide the first evidence that orexin-A exerts inhibitory effects on GBM proliferation via the induction of ferroptosis. This induction is achieved by instigating an unsustainable increase in iron levels and depletion of GPX4. Moreover, the regulation of TFRC, FTH1 and GPX4 expression through the targeting of NFE2L2 appears to be one of the potential mechanisms underlying orexin-A-induced ferroptosis.PMID:38685674 | PMC:PMC11058333 | DOI:10.1111/jcmm.18318 (Source: J Cell Mol Med)
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Rengzheng Huan Jiqin Zhang Jianhe Yue Sha Yang Guoqiang Han Yuan Cheng Ying Tan Source Type: research
An Optimization Numerical Spiking Neural Membrane System with Adaptive Multi-Mutation Operators for Brain Tumor Segmentation
Int J Neural Syst. 2024 Apr 30:2450036. doi: 10.1142/S0129065724500369. Online ahead of print.ABSTRACTMagnetic Resonance Imaging (MRI) is an important diagnostic technique for brain tumors due to its ability to generate images without tissue damage or skull artifacts. Therefore, MRI images are widely used to achieve the segmentation of brain tumors. This paper is the first attempt to discuss the use of optimization spiking neural P systems to improve the threshold segmentation of brain tumor images. To be specific, a threshold segmentation approach based on optimization numerical spiking neural P systems with adaptive mult...
Source: International Journal of Neural Systems - April 30, 2024 Category: Neurology Authors: Jianping Dong Gexiang Zhang Yangheng Hu Yijin Wu Haina Rong Source Type: research
A novel immune cell signature for predicting glioblastoma after radiotherapy prognosis and guiding therapy
Conclusion: The immune cell signature, comprising SDC-1, PLAUR, FN1, and CXCL13, holds promise as a predictive tool for assessing glioblastoma prognosis following radiotherapy. This signature also offers valuable guidance for tailoring treatment strategies, emphasizing its potential clinical relevance in improving patient outcomes.PMID:38687369 | DOI:10.1177/03946320241249395 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Rong Huang Xiaoxu Lu Xueming Sun Hui Wu Source Type: research
Clinical role of NDRG2-based methylation status on survival pattern of glioblastoma
CONCLUSION: Current findings highlight the importance of studying DNA methylation of NDRG2 as a key factor to understand the role of epigenetic alterations in GBM.PMID:38686946 | DOI:10.1177/03946320241250294 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - April 30, 2024 Category: Allergy & Immunology Authors: Menha Swellam Mohamed K Khalifa Amira M Nageeb Lobna Ezz El-Arab Manal El-Mahdy Khaled El-Bahy Magda Sayed Mahmoud Source Type: research
Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier
CONCLUSION: This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM management. Elucidation of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.PMID:38686045 | PMC:PMC11056000 | DOI:10.32604/or.2024.047278 (Source: Oncology Research)
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Karan Wadhwa Payal Chauhan Shobhit Kumar Rakesh Pahwa Ravinder Verma Rajat Goyal Govind Singh Archana Sharma Neha Rao Deepak Kaushik Source Type: research
Multi-cohort comprehensive analysis unveiling the clinical value and therapeutic effect of < em > GNAL < /em > in glioma
In this study, we aimed to investigate the role and relationship between OSPRGs and glioma. Univariate and multivariate Cox regression analyses were performed to assess the relationship between OSPRGs and the overall survival of glioma based on public cohorts, and the target gene (G Protein Subunit Alpha L, GNAL) was screened. The association of GNAL expression with clinicopathological characteristics, gene mutation landscape, tumor immune microenvironment (TIME), deoxyribonucleic acid (DNA) methylation, and naris-occlusion controlled genes (NOCGs) was performed. Immunohistochemistry was used to evaluate GNAL level in glio...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Zhen Liu Liangwang Yang Zhengxing Xie Hui Yu Tianyi Gu Daoming Shi Ning Cai Shenghua Zhuo Source Type: research
A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases
Oncol Res. 2024 Apr 23;32(5):849-875. doi: 10.32604/or.2024.047042. eCollection 2024.ABSTRACTGlioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12-15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Nilam Bhusare Maushmi Kumar Source Type: research
The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization
In this study, we analyzed RNA-seq data from sGBM patients' glioma tissues with or without ZM fusion,and found that stemness and macrophage markers were more highly expressed in sGBM patients harboring ZM than in those without ZM fusion. ZM enhanced the self-renewal and proliferation of GSCs, thereby accelerating glioma progression. In addition, ZM-positive GSCs facilitated the infiltration of TAMs and drove their polarization toward an immunosuppressive phenotype, which was primarily accomplished through the extracellular secretion of ISG20. Our research identified the MET-STAT3-ISG20 axis within GSCs, thus demonstrating ...
Source: Cellular Signalling - April 30, 2024 Category: Cytology Authors: Yuxin Wang Jinghao Suo Zhixing Wang Kunnian Ran Yuan Tian Wei Han Yanwei Liu Xiaozhong Peng Source Type: research
