Cancers, Vol. 16, Pages 1681: Extracellular Vesicles for Childhood Cancer Liquid Biopsy
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Liquid biopsy involves the utilization of minimally invasive or noninvasive techniques to detect biomarkers in biofluids for disease diagnosis, monitoring, or guiding treatments. This approach is promising for the early diagnosis of childhood cancer, especially for brain tumors, where tissue biopsies are more challenging and cause late detection. Extracellular vesicles offer several characteristics that make them ideal resources for childhood cancer liquid biopsy. Extracellular vesicles are nanosized particles, primarily secreted by all cell types into body fluids such as blood and urine, and contain molecula...
Source: Cancers - April 26, 2024 Category: Cancer & Oncology Authors: Nilubon Singhto Pongpak Pongphitcha Natini Jinawath Suradej Hongeng Somchai Chutipongtanate Tags: Review Source Type: research
KIAA0040 enhances glioma growth by controlling the JAK2/STAT3 signalling pathway
In this study, KIAA0040 expression levels were evaluated using qRT-PCR, WB and IHC, and functional assays were conducted to assess its impact on glioma progression, along with animal experiments. Moreover, WB was used to examine the impact of KIAA0040 on the JAK2/STAT3 signalling pathway. Our study found that KIAA0040 was increased in glioma and linked to tumour grade and poor clinical outcomes, serving as an independent prognostic factor. Functional assays showed that KIAA0040 enhances glioma growth, migration and invasion by activating the JAK2/STAT3 pathway. Of course, KIAA0040 enhances glioma growth by preventing tumou...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Jie He Kaming Xue Fei Fan Lin Li Xinyu Rao Wei Liu Chuansheng Nie Source Type: research
KIAA0040 enhances glioma growth by controlling the JAK2/STAT3 signalling pathway
In this study, KIAA0040 expression levels were evaluated using qRT-PCR, WB and IHC, and functional assays were conducted to assess its impact on glioma progression, along with animal experiments. Moreover, WB was used to examine the impact of KIAA0040 on the JAK2/STAT3 signalling pathway. Our study found that KIAA0040 was increased in glioma and linked to tumour grade and poor clinical outcomes, serving as an independent prognostic factor. Functional assays showed that KIAA0040 enhances glioma growth, migration and invasion by activating the JAK2/STAT3 pathway. Of course, KIAA0040 enhances glioma growth by preventing tumou...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Authors: Jie He Kaming Xue Fei Fan Lin Li Xinyu Rao Wei Liu Chuansheng Nie Source Type: research
Response to the Letter to the Editor regarding "Mobile phone use and brain tumour risk - COSMOS, a prospective cohort study"
Environ Int. 2024 Apr 21;187:108664. doi: 10.1016/j.envint.2024.108664. Online ahead of print.NO ABSTRACTPMID:38663236 | DOI:10.1016/j.envint.2024.108664 (Source: Environment International)
Source: Environment International - April 25, 2024 Category: Environmental Health Authors: Maria Feychting Joachim Sch üz Mireille B Toledano Roel Vermeulen Anssi Auvinen Aslak Harbo Poulsen Isabelle Deltour Rachel B Smith Joel Heller Hans Kromhout Anke Huss Christoffer Johansen Giorgio Tettamanti Paul Elliott Source Type: research
KIAA0040 enhances glioma growth by controlling the JAK2/STAT3 signalling pathway
In this study, KIAA0040 expression levels were evaluated using qRT-PCR, WB and IHC, and functional assays were conducted to assess its impact on glioma progression, along with animal experiments. Moreover, WB was used to examine the impact of KIAA0040 on the JAK2/STAT3 signalling pathway. Our study found that KIAA0040 was increased in glioma and linked to tumour grade and poor clinical outcomes, serving as an independent prognostic factor. Functional assays showed that KIAA0040 enhances glioma growth, migration and invasion by activating the JAK2/STAT3 pathway. Of course, KIAA0040 enhances glioma growth by preventing tumou...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Authors: Jie He Kaming Xue Fei Fan Lin Li Xinyu Rao Wei Liu Chuansheng Nie Source Type: research
KIAA0040 enhances glioma growth by controlling the JAK2/STAT3 signalling pathway
In this study, KIAA0040 expression levels were evaluated using qRT-PCR, WB and IHC, and functional assays were conducted to assess its impact on glioma progression, along with animal experiments. Moreover, WB was used to examine the impact of KIAA0040 on the JAK2/STAT3 signalling pathway. Our study found that KIAA0040 was increased in glioma and linked to tumour grade and poor clinical outcomes, serving as an independent prognostic factor. Functional assays showed that KIAA0040 enhances glioma growth, migration and invasion by activating the JAK2/STAT3 pathway. Of course, KIAA0040 enhances glioma growth by preventing tumou...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Authors: Jie He Kaming Xue Fei Fan Lin Li Xinyu Rao Wei Liu Chuansheng Nie Source Type: research
A Prognostic Methylation-Driven Two-Gene Signature in Medulloblastoma
In this study, we used six datasets totaling 1679 samples including RNA gene expression and DNA methylation data from primary MB as well as control samples from healthy cerebellum. We identified methylation-driven genes (MDGs) in MB, genes whose expression is correlated with their methylation. We employed LASSO regression, incorporating the MDGs as a parameter to develop the prognostic model. Through this approach, we deri ved a two-gene signature (GS-2) of candidate prognostic biomarkers for MB (CEMIP andNCBP3). Using a risk score model, we confirmed the GS-2 impact on overall survival (OS) with Kaplan-Meier analysis. We ...
Source: Journal of Molecular Neuroscience - April 25, 2024 Category: Neuroscience Source Type: research
Gut microbiota composition and metabolic characteristics in patients with Craniopharyngioma
Emerging evidence suggests that the gut microbiota is associated with various intracranial neoplastic diseases. It has been observed that alterations in the gut microbiota are present in gliomas, meningiomas, ... (Source: BMC Cancer)
Source: BMC Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Chunhui Liu, Fangzheng Liu, Ding Nie, Youchao Xiao, Wentao Wu, Yanfei Jia, Lu Jin, Ning Qiao, Kefan Cai, Siming Ru, Xin Liu, Yifan Song, Jintian Xu, Lei Cao and Songbai Gui Tags: Research Source Type: research
A Prognostic Methylation-Driven Two-Gene Signature in Medulloblastoma
In this study, we used six datasets totaling 1679 samples including RNA gene expression and DNA methylation data from primary MB as well as control samples from healthy cerebellum. We identified methylation-driven genes (MDGs) in MB, genes whose expression is correlated with their methylation. We employed LASSO regression, incorporating the MDGs as a parameter to develop the prognostic model. Through this approach, we deri ved a two-gene signature (GS-2) of candidate prognostic biomarkers for MB (CEMIP andNCBP3). Using a risk score model, we confirmed the GS-2 impact on overall survival (OS) with Kaplan-Meier analysis. We ...
Source: Journal of Molecular Neuroscience - April 25, 2024 Category: Neuroscience Source Type: research
Survival outcomes after using charged particle radiotherapy as a treatment modality for gliomas: A systematic review and meta-analysis
Charged particle therapy is an emerging radiation treatment for a number of tumors; however, more research is needed to determine its safety and efficacy when treating intra-axial brain tumors (commonly known as gliomas). The overall survival of patients treated with charged particle radiation versus those receiving photon therapy were compared in this systematic review and meta-analysis. (Source: Journal of Medical Imaging and Radiation Sciences)
Source: Journal of Medical Imaging and Radiation Sciences - April 25, 2024 Category: Radiology Authors: Bareq S. Al-Lami, Baqer S. Al-Lami, Yasir S. Al-Lami Tags: Review Article Source Type: research
Randomized self-controlled study comparing open-face vs. closed immobilization masks in fractionated cranial radiotherapy
Radiotherapy is an essential part in the management of primary and metastatic brain tumors. To ensure safe and reproducible delivery of radiotherapy, accurate patient positioning and immobilization is required. The standard-of-care immobilization for fractionated brain irradiation, as for head-and-neck cancer, is an individually made thermoplastic mask which is closed around the patient ’s face. Closed masks provide stability, accuracy and reproducibility of each treatment fraction [1,2,3]. The inter- and intrafraction accuracy described by setup and head motion uncertainties for intracranial radiotherapy are reportedly ...
Source: Radiotherapy and Oncology - April 25, 2024 Category: Radiology Authors: Mich èle Keane, Nienke Weitkamp, Indira Madani, Jonathan Day, Riccardo Dal Bello, Mariangela Zamburlini, Antonia Schiess, Amanda Moreira, Sophie Perryck, Katja Tomuschat, Marilyn Spencer, Stephanie Tanadini-Lang, Matthias Guckenberger, Michelle Brown Tags: Original Article Source Type: research
Cancers, Vol. 16, Pages 1644: Diffuse Gliomas with FGFR3::TACC3 Fusion: Morphological and Molecular Features and Classification Challenges
In conclusion, diffuse gliomas with FGFR3::TACC3 fusion do not constitute a distinct nosological entity, owing to their genetic and epigenetic diversity. Further studies are warranted to clarify the biological aggressiveness of tumors with low-grade histology to refine the grading and determine the optimal treatment strategy. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Elena Marastoni Davide Mulone Valeria Barresi Tags: Review Source Type: research
Amino acid PET vs. RANO MRI for prediction of overall survival in patients with recurrent high grade glioma under bevacizumab therapy
ConclusionFor monitoring of patients with rHGG under bevacizumab therapy, AA-PET should be preferred over RANO MRI. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
Correction to: A bis-boron boramino acid PET tracer for brain tumor diagnosis
(Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 24, 2024 Category: Nuclear Medicine Source Type: research
GMAlignNet: multi-scale lightweight brain tumor image segmentation with enhanced semantic information consistency
Phys Med Biol. 2024 Apr 24. doi: 10.1088/1361-6560/ad4301. Online ahead of print.ABSTRACTAlthough the U-shaped architecture, represented by UNet, has become a major network model for brain tumor segmentation, the repeated convolution and sampling operations can easily lead to the loss of crucial information. Additionally, directly fusing features from different levels without distinction can easily result in feature misalignment, affecting segmentation accuracy. On the other hand, traditional convolutional blocks used for feature extraction cannot capture the abundant multi-scale information present in brain tumor images. ...
Source: Physics in Medicine and Biology - April 24, 2024 Category: Physics Authors: Jianli Song Xiaoqi Lu Yu Gu Source Type: research
