Relationship between brain tumors and intracranial aneurysms: a systematic review
CONCLUSION: There is a lack of evidence to affirm that the existence of brain neoplasm plays a role in the formation and rupture of intracranial aneurysms. Additionally, there is insufficient evidence to confirm a greater prevalence of intracranial aneurysms in individuals with brain tumors. The association of these two disorders does not appear to worsen patient outcome. Prognosis depends on tumor pathology for malignant cases and on subarachnoid hemorrhage in patients with ruptured aneurysms.PMID:38650567 | DOI:10.5137/1019-5149.JTN.43614-23.4 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Pedro Henrique Mouty Rabello N ícollas Nunes Rabelo Jo ão Paulo Telles Eberval Gadelha Figueiredo Source Type: research
Non-Detection of HCMV Total Genomic DNA in Human Glioma Cells Genome
CONCLUSION: We found that the genomic DNA of all the samples was negative for HCMV genomic DNA. Thus, HCMV could not be detected in human glioma tumors and we put forward that HCMV genomic DNA was not incorporated into the genomic DNA of glioma cells. Thus, total viral DNA is not involved in the pathogenesis of glioma; however, small viral particles or specific genes might be incorporated into the genomic DNA of glioma cells, leading to cancer development. This prompts further studies for verification.PMID:38650560 | DOI:10.5137/1019-5149.JTN.42717-22.1 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Dilek Gokturk Meryem Damla Ozdemir Dervis Mansuri Yilmaz Source Type: research
Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors
Biochim Biophys Acta Rev Cancer. 2024 Apr 21:189102. doi: 10.1016/j.bbcan.2024.189102. Online ahead of print.ABSTRACTGliomas with Isocitrate dehydrogenase (IDH) mutation represent a discrete category of primary brain tumors with distinct and unique characteristics, behaviors, and clinical disease outcomes. IDH mutations lead to aberrant high-level production of the oncometabolite D-2-hydroxyglutarate (D-2HG), which act as a competitive inhibitor of enzymes regulating epigenetics, signaling pathways, metabolism, and various other processes. This review summarizes the significance of IDH mutations, resulting upregulation of ...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yosuke Kitagawa Ami Kobayashi Daniel P Cahill Hiroaki Wakimoto Shota Tanaka Source Type: research
Diffusion- and Perfusion-Weighted MRI Radiomics for Survival Prediction in Patients with Lower-Grade Gliomas
CONCLUSION: Adding diffusion- and perfusion-weighted MRI radiomics to clinical features improved survival prediction in lower-grade glioma.PMID:38653567 | DOI:10.3349/ymj.2023.0323 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Chae Jung Park Sooyon Kim Kyunghwa Han Sung Soo Ahn Dain Kim Yae Won Park Jong Hee Chang Se Hoon Kim Seung-Koo Lee Source Type: research
Paroxysmal Sympathetic Hyperactivity in the Acute Phase Post-Brain Tumour Surgery of Glioblastoma Multiforme
J Korean Neurosurg Soc. 2024 Apr 23. doi: 10.3340/jkns.2024.0026. Online ahead of print.NO ABSTRACTPMID:38650429 | DOI:10.3340/jkns.2024.0026 (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - April 23, 2024 Category: Neurosurgery Authors: Yasothai Sahadeevan Mazlina Mazlan Source Type: research
Classifying glioma via liquid biopsy--progress towards an unmet clinical need
Clin Cancer Res. 2024 Apr 23. doi: 10.1158/1078-0432.CCR-24-0423. Online ahead of print.ABSTRACTThe diagnosis and classification of glioma by liquid biopsy represents a critical unmet need in neuro oncology. A recent study demonstrates targeted next generation sequencing (NGS) of cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) as an evolving option for liquid biopsy in patients with glioma.PMID:38652677 | DOI:10.1158/1078-0432.CCR-24-0423 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Kalil G Abdullah Source Type: research
Evaluating the predictive value of a coagulation-related gene model in glioma
CONCLUSION: This study established the correlation between the coagulation-related gene model and glioma prognosis, providing deeper insight into the mechanism and treatment of glioma.PMID:38650572 | DOI:10.5137/1019-5149.JTN.45238-23.2 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Ming Cao Jie Chen Rong-Zeng Guo Source Type: research
Relationship between brain tumors and intracranial aneurysms: a systematic review
CONCLUSION: There is a lack of evidence to affirm that the existence of brain neoplasm plays a role in the formation and rupture of intracranial aneurysms. Additionally, there is insufficient evidence to confirm a greater prevalence of intracranial aneurysms in individuals with brain tumors. The association of these two disorders does not appear to worsen patient outcome. Prognosis depends on tumor pathology for malignant cases and on subarachnoid hemorrhage in patients with ruptured aneurysms.PMID:38650567 | DOI:10.5137/1019-5149.JTN.43614-23.4 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Pedro Henrique Mouty Rabello N ícollas Nunes Rabelo Jo ão Paulo Telles Eberval Gadelha Figueiredo Source Type: research
Non-Detection of HCMV Total Genomic DNA in Human Glioma Cells Genome
CONCLUSION: We found that the genomic DNA of all the samples was negative for HCMV genomic DNA. Thus, HCMV could not be detected in human glioma tumors and we put forward that HCMV genomic DNA was not incorporated into the genomic DNA of glioma cells. Thus, total viral DNA is not involved in the pathogenesis of glioma; however, small viral particles or specific genes might be incorporated into the genomic DNA of glioma cells, leading to cancer development. This prompts further studies for verification.PMID:38650560 | DOI:10.5137/1019-5149.JTN.42717-22.1 (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - April 23, 2024 Category: Neurosurgery Authors: Dilek Gokturk Meryem Damla Ozdemir Dervis Mansuri Yilmaz Source Type: research
Molecular biology and novel therapeutics for IDH mutant gliomas: The new era of IDH inhibitors
Biochim Biophys Acta Rev Cancer. 2024 Apr 21:189102. doi: 10.1016/j.bbcan.2024.189102. Online ahead of print.ABSTRACTGliomas with Isocitrate dehydrogenase (IDH) mutation represent a discrete category of primary brain tumors with distinct and unique characteristics, behaviors, and clinical disease outcomes. IDH mutations lead to aberrant high-level production of the oncometabolite D-2-hydroxyglutarate (D-2HG), which act as a competitive inhibitor of enzymes regulating epigenetics, signaling pathways, metabolism, and various other processes. This review summarizes the significance of IDH mutations, resulting upregulation of ...
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Yosuke Kitagawa Ami Kobayashi Daniel P Cahill Hiroaki Wakimoto Shota Tanaka Source Type: research
Diffusion- and Perfusion-Weighted MRI Radiomics for Survival Prediction in Patients with Lower-Grade Gliomas
CONCLUSION: Adding diffusion- and perfusion-weighted MRI radiomics to clinical features improved survival prediction in lower-grade glioma.PMID:38653567 | DOI:10.3349/ymj.2023.0323 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 23, 2024 Category: Universities & Medical Training Authors: Chae Jung Park Sooyon Kim Kyunghwa Han Sung Soo Ahn Dain Kim Yae Won Park Jong Hee Chang Se Hoon Kim Seung-Koo Lee Source Type: research
Paroxysmal Sympathetic Hyperactivity in the Acute Phase Post-Brain Tumour Surgery of Glioblastoma Multiforme
J Korean Neurosurg Soc. 2024 Apr 23. doi: 10.3340/jkns.2024.0026. Online ahead of print.NO ABSTRACTPMID:38650429 | DOI:10.3340/jkns.2024.0026 (Source: Journal of Korean Neurosurgical Society)
Source: Journal of Korean Neurosurgical Society - April 23, 2024 Category: Neurosurgery Authors: Yasothai Sahadeevan Mazlina Mazlan Source Type: research
Classifying glioma via liquid biopsy--progress towards an unmet clinical need
Clin Cancer Res. 2024 Apr 23. doi: 10.1158/1078-0432.CCR-24-0423. Online ahead of print.ABSTRACTThe diagnosis and classification of glioma by liquid biopsy represents a critical unmet need in neuro oncology. A recent study demonstrates targeted next generation sequencing (NGS) of cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) as an evolving option for liquid biopsy in patients with glioma.PMID:38652677 | DOI:10.1158/1078-0432.CCR-24-0423 (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - April 23, 2024 Category: Cancer & Oncology Authors: Kalil G Abdullah Source Type: research
Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data
ConclusionRNA sequencing is a promising approach for genotyping glioblastomas because it provides comprehensive information on gene expression and is relatively cost-effective. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - April 23, 2024 Category: Cancer & Oncology Source Type: research
Mesenchymal stem cells as therapeutic vehicles for glioma
Cancer Gene Therapy, Published online: 23 April 2024; doi:10.1038/s41417-024-00775-7Mesenchymal stem cells as therapeutic vehicles for glioma (Source: Cancer Gene Therapy)
Source: Cancer Gene Therapy - April 23, 2024 Category: Cancer & Oncology Authors: Tomoya Oishi Shinichiro Koizumi Kazuhiko Kurozumi Source Type: research
