Benign Prostatic Hyperplasia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse
In conclusion, our study revealed that over-activated Notch1 signaling induces prostatic enlargement by increasing androgen receptor sensitivity, disrupting cellular mitochondrial metabolism, increasing ROS, and a higher number of progenitor cells, all of which can be effectively rescued by NAC treatment.PMID:38538986 | DOI:10.1007/s00018-024-05143-0 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - March 28, 2024 Category: Cytology Authors: Jin-Wen Kang Jia-Peng He Ying-Nan Liu Yu Zhang Shan-Shan Song Qi-Xin Xu Shu-Wen Wei Lei Lu Xiang-Qi Meng Lin Xu Bin Guo Ren-Wei Su Source Type: research

Overexpression of Transmembrane Phosphatase with Tensin homology (TPTE) in prostate cancer is clinically significant, suggesting its potential as a valuable biomarker
CONCLUSION: Our findings indicate that increased TPTE expression is associated with progression of disease. The ability of anti-TPTE-p2 antibody to recognize and target the TPTE protein makes it a potential biomarker to assess and/or target the PCa.PMID:38546751 | DOI:10.1007/s00432-024-05694-6 (Source: Cell Research)
Source: Cell Research - March 28, 2024 Category: Cytology Authors: Nahid Zainodini Maryam Abolhasani Monireh Mohsenzadegan Mohammad M Farajollahi Elham Rismani Source Type: research

Overexpression of Transmembrane Phosphatase with Tensin homology (TPTE) in prostate cancer is clinically significant, suggesting its potential as a valuable biomarker
CONCLUSION: Our findings indicate that increased TPTE expression is associated with progression of disease. The ability of anti-TPTE-p2 antibody to recognize and target the TPTE protein makes it a potential biomarker to assess and/or target the PCa.PMID:38546751 | PMC:PMC10978697 | DOI:10.1007/s00432-024-05694-6 (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - March 28, 2024 Category: Cancer & Oncology Authors: Nahid Zainodini Maryam Abolhasani Monireh Mohsenzadegan Mohammad M Farajollahi Elham Rismani Source Type: research

Cancers, Vol. 16, Pages 1324: Blood-Based DNA Methylation Analysis by Multiplexed OBBPA-ddPCR to Verify Indications for Prostate Biopsies in Suspected Prostate Cancer Patients
In conclusion, the newly developed risk scores may help to confirm the clinical decision and prevent unnecessary prostate biopsy. (Source: Cancers)
Source: Cancers - March 28, 2024 Category: Cancer & Oncology Authors: Friedemann Jandeck Tautz Gutewort von Rein Sukocheva Fuessel Menschikowski Tags: Article Source Type: research

Overexpression of Transmembrane Phosphatase with Tensin homology (TPTE) in prostate cancer is clinically significant, suggesting its potential as a valuable biomarker
ConclusionOur findings indicate that increased TPTE expression is associated with progression of disease. The ability of anti-TPTE-p2 antibody to recognize and target the TPTE protein makes it a potential biomarker to assess and/or target the PCa. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - March 28, 2024 Category: Cancer & Oncology Source Type: research

Multivariate Statistical Evaluation of 20 Metals/Metalloid Levels in the Serum of Patients with Prostate Gland Diseases
This study elucidates the imbalances of the elements with BPH/PC patients and healthy subjects. For multiple comparisons, Bonferroni test was applied and principal component analysis was performed for measuring the multiple metals/metalloid exposure. Mean concentrations of Al, Cr, Pb, Cd, Na, Ni and K were found higher significantly (p < 0.05) in the serum of BPH patients compared with healthy controls, while average levels of Sb, Al, Cd, As, Mn, Sr, K and Pb were significantly (p < 0.05) elevated in PC patients than controls. The correlation patterns revealed significantly different mutual associations amo...
Source: Indian Journal of Clinical Biochemistry - March 25, 2024 Category: Biochemistry Source Type: research

Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation
CONCLUSION: The study demonstrates that ITLN-1 plays a significant role in inhibiting the development of BPH by reducing local inflammation in the prostate gland. These findings highlight the potential of ITLN-1 as a therapeutic target in the management of BPH.PMID:38519941 | DOI:10.1186/s10020-024-00805-y (Source: Molecular Medicine)
Source: Molecular Medicine - March 23, 2024 Category: Molecular Biology Authors: Yi-Yi Wang Guo-Qiang Zhu Kun Xia Hong-Bo Zeng Yun-Hui He Hui Xie Zhen-Xing Wang Ran Xu Source Type: research

Omentin-1 inhibits the development of benign prostatic hyperplasia by attenuating local inflammation
CONCLUSION: The study demonstrates that ITLN-1 plays a significant role in inhibiting the development of BPH by reducing local inflammation in the prostate gland. These findings highlight the potential of ITLN-1 as a therapeutic target in the management of BPH.PMID:38519941 | PMC:PMC10960431 | DOI:10.1186/s10020-024-00805-y (Source: Molecular Medicine)
Source: Molecular Medicine - March 23, 2024 Category: Molecular Biology Authors: Yi-Yi Wang Guo-Qiang Zhu Kun Xia Hong-Bo Zeng Yun-Hui He Hui Xie Zhen-Xing Wang Ran Xu Source Type: research

Transurethral surgical treatment for benign prostatic hyperplasia with detrusor underactivity: a systematic review and meta-analysis
ConclusionsOur meta-analysis results showed that transurethral surgery can improve the symptoms of BPH patients with DU. Surgery also showed advantages over pharmacological treatment for BPH patients with DU.Systematic review registrationPROSPERO CRD42023415188. (Source: Systematic Reviews)
Source: Systematic Reviews - March 22, 2024 Category: International Medicine & Public Health Source Type: research

Transurethral bipolar enucleation using a TUEB loop for large benign prostatic hyperplasia: a retrospective cohort study
ConclusionTUEB using a TUEB loop resulted in high levels of satisfaction regarding the enucleation efficiency, efficacy, and safety for BPH surgery regardless of the prostate size. TUEB should be considered one of the best treatment options for large BPH that is uncontrollable with medication. (Source: World Journal of Urology)
Source: World Journal of Urology - March 21, 2024 Category: Urology & Nephrology Source Type: research

Incidence of complications and urinary incontinence following endoscopic enucleation of the prostate in men with a prostate volume of 80 ml and above: results from a multicenter, real-world experience of 2512 patients
ConclusionsPV has no influence on complication and UI rates following EEP. Age is risk factor of postoperative UI. (Source: World Journal of Urology)
Source: World Journal of Urology - March 20, 2024 Category: Urology & Nephrology Source Type: research

PI-RADS v2.1 evaluation of prostate “nodule in nodule” variants: clinical, imaging, and pathological features
ConclusionWhen the inner nodules of “nodule in nodule” lesions in PI-RADS v2.1 category 1 in the TZ show incomplete capsulation or obscured margins, they are considered atypical nodules and might be upgraded to PI-RADS v2.1 category 3 if they exhibit marked diffusion restriction. However, further validation is needed.Critical relevance statementThis study first analyzed the relationship between clinical and pathological findings and the size, margin, and multimodal MRI manifestations of the prostate “nodule in nodule.” These findings could improve the diagnostic accuracy of PI-RADS v2.1 for prostate lesions.Key poi...
Source: Insights into Imaging - March 18, 2024 Category: Radiology Source Type: research

Nomogram predicting the efficacy of transurethral surgery in benign prostatic hyperplasia patients
CONCLUSION: The nomogram we developed included age, the compliance of the bladder, the function of the detrusor, and the severity of bladder outlet obstruction. The discrimination and calibration of the nomogram were confirmed by internal and external validation.PMID:38485798 | DOI:10.1007/s40520-024-02708-8 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 15, 2024 Category: Geriatrics Authors: Jing Zhou Zhu-Feng Peng Lu-Chen Yang Sheng-Zhuo Liu Pan Song Zheng-Huan Liu Lin-Chun Wang Jun-Hao Chen Kai Ma Yun-Fei Yu Liang-Ren Liu Qiang Dong Source Type: research

Nomogram predicting the efficacy of transurethral surgery in benign prostatic hyperplasia patients
CONCLUSION: The nomogram we developed included age, the compliance of the bladder, the function of the detrusor, and the severity of bladder outlet obstruction. The discrimination and calibration of the nomogram were confirmed by internal and external validation.PMID:38485798 | PMC:PMC10940401 | DOI:10.1007/s40520-024-02708-8 (Source: Aging Clinical and Experimental Research)
Source: Aging Clinical and Experimental Research - March 15, 2024 Category: Geriatrics Authors: Jing Zhou Zhu-Feng Peng Lu-Chen Yang Sheng-Zhuo Liu Pan Song Zheng-Huan Liu Lin-Chun Wang Jun-Hao Chen Kai Ma Yun-Fei Yu Liang-Ren Liu Qiang Dong Source Type: research

Effects of a proprietary mixture of extracts from Sabal serrulata fruits and Urtica dioica roots (WS ® 1541) on prostate hyperplasia and inflammation in rats and human cells
Conclusion: This data supports a beneficial effect of the clinically used WS® 1541 for the treatment of lower urinary tract symptoms associated with mild to moderate benign prostate syndrome and provides a scientific rationale for the combination of its components WS® 1473 and WS® 1031. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - March 15, 2024 Category: Drugs & Pharmacology Source Type: research