Benign Prostatic Hyperplasia Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Enhancing surgical outcomes: accurate identification and removal of prostate cancer with B7-H3-targeted NIR-II molecular imaging
ConclusionThe findings revealed that B7-H3 was a compelling imaging target for PCa. The AbB7 −H3-800CW molecular imaging probe is capable of accurately identifying PCa lesions and guiding their removal. This approach can potentially reduce the rate of surgical margins under NIR-II fluorescence guidance. (Source: European Journal of Nuclear Medicine and Molecular Imaging)
Source: European Journal of Nuclear Medicine and Molecular Imaging - April 22, 2024 Category: Nuclear Medicine Source Type: research

Mendelian randomization study supports positive bidirectional causal relationships between genetically predicted insomnia symptom and liability to benign prostatic hyperplasia
This study aimed to evaluate causal relationships between six sleep traits ([i] day ti... (Source: BMC Urology)
Source: BMC Urology - April 20, 2024 Category: Urology & Nephrology Authors: Nannan Li, Ke Yang, Liang Deng, Youjie Zeng, Si Cao and Dong Chen Tags: Research Source Type: research

Surgical Advances in Treating Benign Prostatic Hyperplasia in Africa: What About the Endoscopic Approach?
To assess the practices, trends, and challenges associated with the use of endoscopic techniques in Africa related to the surgical treatment of benign prostatic hyperplasia (Source: Urology)
Source: Urology - April 20, 2024 Category: Urology & Nephrology Authors: Ziba Ouima Justin Dieudonne, Saleh Abdelkerim Nedjim, Anteneh Tadesse Kifle, Kaleab Habtemichael Gebreselassie, Botcho Gnimdou, Mahamat Ali Mahamat, Muhawenimana Emmanuel, Coulibaly Noel, Ndoye Alain Khassim, Abdullahi Khalid, Lazarus John, Kirakoya Brahi Source Type: research

Evaluation of the learning curve for Thulium laser enucleation of the prostate in a contemporary cohort
ConclusionsIn our single-surgeon experience, we observed a learning curve of nearly 60 cases for the ThuLEP procedure in presence of a well-trained surgeon. Complication rate was low from the beginning of surgical experience. (Source: World Journal of Urology)
Source: World Journal of Urology - April 20, 2024 Category: Urology & Nephrology Source Type: research

Untargeted metabolomics reveals that declined PE and PC in obesity may be associated with prostate hyperplasia
ConclusionsIn conclusion, obese patients with BPH had a unique metabolic profile, and alterations in PE and PC in these patients be associated with the development and progression of BPH. (Source: PLoS One)
Source: PLoS One - April 19, 2024 Category: Biomedical Science Authors: Guorui Fan Source Type: research

Future aspects of plant derived bioactive metabolites as therapeutics to combat benign prostatic hyperplasia
CONCLUSION: The review proposes and endorses careful utilization of conventional medications that may be investigated further to discover possible PDE-5, 5 alpha-reductase, an alpha-blocker inhibitor for managing BPH. Even though most conventional formulations, such as 5 alpha-reductase, are readily available, systemic assessment of the effectiveness and mechanism of action of the herbal constituents is still necessary to identify novel chemical moieties that can be further developed for maximum efficacy. However, there exist abundant botanicals and medicinal plants across several regions of Africa, Asia, and the Americas,...
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Raman Krishnamoorthi Anand Ganapathy A Hari Priya V M Alaganandam Kumaran Source Type: research

Mechanism study on the effect of androgen antagonism in prostate cancer
CONCLUSION: Under the action of 4-HNE, the expression of AR-MAPK pathway related proteins increase. 4-HNE may promote the progression of prostate cancer through the AR-MAPK pathway, and 4-HNE is expected to become a new therapeutic target for CRPC.PMID:38602755 (Source: Cancer Control)
Source: Cancer Control - April 11, 2024 Category: Cancer & Oncology Authors: Xu Song Qiang Song Rong Wang Qing-Jun Zuo Zhi-Yuan Zhang Source Type: research

In vitro inhibition of 5- α reductase and in vivo suppression of benign prostatic hyperplasia by Physalis angulata ethyl acetate extract
Fitoterapia. 2024 Apr 8:105950. doi: 10.1016/j.fitote.2024.105950. Online ahead of print.ABSTRACTThe inhibitory effect against 5-α reductase of the ethyl acetate (EA) extract from Physalis angulata was evaluated in vitro using mouse prostate homogenates, and the suppression of benign prostatic hyperplasia (BPH) was assessed in a mouse model of testosterone-induced BPH. The EA extract exhibited a potentially inhibitory effect on 5-α reductase with an IC50 of 197 μg/ml. In BPH mice, the EA extract at a dose of 12 mg/kg was comparable to finasteride 5 mg/kg in suppressing BPH in terms of reducing absolute enlarged prostate...
Source: Fitoterapia - April 10, 2024 Category: Biochemistry Authors: Ngoc Phuc Nguyen Quoc Giang Le Vinh Nghi Truong Thi Ngoc Dung Nguyen Nguyen Truong Thang Phan Manh Hung Tran Source Type: research

Evaluation of < em > miR-130b-3p < /em > and < em > miR-375 < /em > levels and telomere length with telomerase activity in prostate cancer
Nucleosides Nucleotides Nucleic Acids. 2024 Apr 9:1-12. doi: 10.1080/15257770.2024.2334896. Online ahead of print.ABSTRACTProstate cancer (PC) is the most frequent cancer in males, as well as the second highest cause of cancer-related deaths in men. Differences in expression levels of miRNAs were linked with prostat cancer pathogenesis. qPCR was used to evaluate the expression of miR-130b-3p and miR-375 in Benign Prostate Hyperplasia (BPH (n = 20) and PC (n = 22, pre- and post-operative) patients plasma. Relative telomere lengths (RLTs) in genomic DNA isolated from plasma were measured with qPCR, and telomerase activity an...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 9, 2024 Category: Biochemistry Authors: Abdullah Karada ğ Ebubekir Dirican Çağdaş Gökhun Özmerdiven Ata Özen Semih Ayan Selda Kabadere Source Type: research

Knockout of phosphatidylethanolamine binding protein4 (PEBP4) promotes chronic non ‐bacterial prostatitis by mediating the activation of NF‐κB signaling
ConclusionThe knockout ofPEBP4 in experimental mice led to chronic prostatitis and the reduced expression of PEBP4 in patients with higher risk of chronic and non-bacterial prostatitis suggested that PEBP4 might act as a protective factor against chronic prostatitis. The knockout ofPEBP4 in RWPE-1 cells led to the increased activation of NF- κB and IκB, thus indicating that inhibition of PEBP4 faciliated the NF-κB signaling cascade. Our findings provide a new etiology and therapeutic target for chronic prostatitis. (Source: Andrology)
Source: Andrology - April 9, 2024 Category: Urology & Nephrology Authors: Hailan He, Guancheng Xiao, Xing Hu, Hui Luo, Yunfeng Liao, Biao Qian, Guoxi Zhang, Xiaofeng Zou, Junrong Zou Tags: ORIGINAL ARTICLE Source Type: research

An analysis of benign prostatic hyperplasia surgical treatment reimbursement trends across Canada: Examining provincial changes over the recent decade with comparison to cost of living changes
CONCLUSIONS: The compensation model for endoscopic BPH surgery does not have a unified structure in Canada that is consistent across provinces, nor does it keep up with inflation, possibly impacting future recruitment, increasing geographic disparities, and most importantly, limiting the adoption of new BPH therapies.PMID:38587981 | DOI:10.5489/cuaj.8638 (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - April 8, 2024 Category: Urology & Nephrology Authors: Anindyo Chakraborty Dean S Elterman Nicholas Corsi David Bouhadana Gregory Bailly Premal Patel Rowen McLellan Liam Hickey Daniel Costa Matthew Andrews Howard Evans Connor M Forbes Hazem Elmansy Malek Meskawi Naeem Bhojani Bilal Chugtai Kevin C Zorn Source Type: research