Interoceptive signals from the heart and coronary circulation in health and disease
Auton Neurosci. 2024 Apr 24;253:103180. doi: 10.1016/j.autneu.2024.103180. Online ahead of print.ABSTRACTThis review considers interoceptive signalling from the heart and coronary circulation. Vagal and cardiac sympathetic afferent sensory nerve endings are distributed throughout the atria, ventricles (mainly left), and coronary artery. A small proportion of cardiac receptors attached to thick myelinated vagal afferents are tonically active during the cardiac cycle. Dependent upon location, these mechanoreceptors detect fluctuations in atrial volume and coronary arterial perfusion. Atrial volume and coronary arterial signa...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Jonathan P Moore Source Type: research
Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis
Neurocase. 2024 Apr 27:1-4. doi: 10.1080/13554794.2024.2348221. Online ahead of print.ABSTRACTAnti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare and severe autoimmune encephalitis that displays neuropsychiatric symptoms and autonomic instability, e.g., hypoventilation and cardiac arrhythmia. Severe arrhythmia including asystole associated with this encephalitis is rare. Several causes have been suggested. Nevertheless, no report of the literature has described examination by functional brain imaging of a patient with asystole during anti-NMDA receptor encephalitis. This case is that of a 34-year-old woman dia...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Gaku Aboshi Takaki Akahane Keisuke Noto Ryota Kobayashi Masakazu Akiho Akihito Suzuki Source Type: research
Interoceptive signals from the heart and coronary circulation in health and disease
Auton Neurosci. 2024 Apr 24;253:103180. doi: 10.1016/j.autneu.2024.103180. Online ahead of print.ABSTRACTThis review considers interoceptive signalling from the heart and coronary circulation. Vagal and cardiac sympathetic afferent sensory nerve endings are distributed throughout the atria, ventricles (mainly left), and coronary artery. A small proportion of cardiac receptors attached to thick myelinated vagal afferents are tonically active during the cardiac cycle. Dependent upon location, these mechanoreceptors detect fluctuations in atrial volume and coronary arterial perfusion. Atrial volume and coronary arterial signa...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Jonathan P Moore Source Type: research
Regional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis
Neurocase. 2024 Apr 27:1-4. doi: 10.1080/13554794.2024.2348221. Online ahead of print.ABSTRACTAnti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a rare and severe autoimmune encephalitis that displays neuropsychiatric symptoms and autonomic instability, e.g., hypoventilation and cardiac arrhythmia. Severe arrhythmia including asystole associated with this encephalitis is rare. Several causes have been suggested. Nevertheless, no report of the literature has described examination by functional brain imaging of a patient with asystole during anti-NMDA receptor encephalitis. This case is that of a 34-year-old woman dia...
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Gaku Aboshi Takaki Akahane Keisuke Noto Ryota Kobayashi Masakazu Akiho Akihito Suzuki Source Type: research
Interoceptive signals from the heart and coronary circulation in health and disease
Auton Neurosci. 2024 Apr 24;253:103180. doi: 10.1016/j.autneu.2024.103180. Online ahead of print.ABSTRACTThis review considers interoceptive signalling from the heart and coronary circulation. Vagal and cardiac sympathetic afferent sensory nerve endings are distributed throughout the atria, ventricles (mainly left), and coronary artery. A small proportion of cardiac receptors attached to thick myelinated vagal afferents are tonically active during the cardiac cycle. Dependent upon location, these mechanoreceptors detect fluctuations in atrial volume and coronary arterial perfusion. Atrial volume and coronary arterial signa...
Source: Autonomic Neuroscience - April 27, 2024 Category: Neuroscience Authors: Jonathan P Moore Source Type: research
The additive prognostic value of end-systolic pressure-volume relation by stress CMR in patients with known or suspected coronary artery disease
ConclusionΔESPVR index by stress-CMR was independently associated with cardiac outcomes in patients with known/suspected CAD, in addition to replacement myocardial fibrosis and diabetes. Thus, the assessment of ΔESPVR index may be included into the standard stress-CMR exam to further stratify the patients. (Source: The International Journal of Cardiovascular Imaging)
Source: The International Journal of Cardiovascular Imaging - April 27, 2024 Category: Radiology Source Type: research
Arrhythmia detection by the graph convolution network and a proposed structure for communication between cardiac leads
One of the most common causes of death worldwide is heart disease, including arrhythmia. Today, sciences such as artificial intelligence and medical statistics are looking for methods and models for correct an... (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - April 27, 2024 Category: Research Authors: Bahare Andayeshgar, Fardin Abdali-Mohammadi, Majid Sepahvand, Afshin Almasi and Nader Salari Tags: Research Source Type: research
Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids
CONCLUSIONS: We demonstrated that direct injection of hiPSC-CSs restores the contractile functions of injured primate hearts with an acceptable risk of posttransplant arrhythmia. Although the mechanism for the functional benefits is not fully elucidated, these findings provide a strong rationale for conducting clinical trials using the equivalent CM products.PMID:38666382 | DOI:10.1161/CIRCULATIONAHA.123.064876 (Source: Circulation)
Source: Circulation - April 26, 2024 Category: Cardiology Authors: Hideki Kobayashi Shugo Tohyama Hajime Ichimura Noburo Ohashi Shuji Chino Yusuke Soma Hidenori Tani Yuki Tanaka Xiao Yang Naoko Shiba Shin Kadota Kotaro Haga Taijun Moriwaki Yuika Morita-Umei Tomohiko C Umei Otoya Sekine Yoshikazu Kishino Hideaki Kanazawa Source Type: research
Usmani-Riazuddin syndrome can have a recognizable phenotype: Report of a novel AP1G1 variant
In this report, we describe this syndrome for the second time, in association to a novel AP1G1 variant identified in a toddler with multisystemic involvement including intellectual disability, speech and developmental delay, behavioral anomalies, arrhythmias, hearing loss, skin changes, and limb defects. Next generation sequencing (NGS) analysis through clinical exome disclosed AP1G1: c.1969C>G (p.Leu657Val), de novo, likely pathogenic variant, according to ACMG classification criteria. Proband's facial features resembled the spectrum of chromatinopathies. Clinical pictures were analyzed and a clinical overlap was suppo...
Source: Clinical Genetics - April 26, 2024 Category: Genetics & Stem Cells Authors: Maria Gnazzo Giulia Pascolini Giovanni Parlapiano Francesco Petrizzelli Daniele Perrino Luigina Porco Andrea Bartuli Antonio Novelli Anwar Baban Source Type: research
Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids
CONCLUSIONS: We demonstrated that direct injection of hiPSC-CSs restores the contractile functions of injured primate hearts with an acceptable risk of posttransplant arrhythmia. Although the mechanism for the functional benefits is not fully elucidated, these findings provide a strong rationale for conducting clinical trials using the equivalent CM products.PMID:38666382 | DOI:10.1161/CIRCULATIONAHA.123.064876 (Source: Circulation)
Source: Circulation - April 26, 2024 Category: Cardiology Authors: Hideki Kobayashi Shugo Tohyama Hajime Ichimura Noburo Ohashi Shuji Chino Yusuke Soma Hidenori Tani Yuki Tanaka Xiao Yang Naoko Shiba Shin Kadota Kotaro Haga Taijun Moriwaki Yuika Morita-Umei Tomohiko C Umei Otoya Sekine Yoshikazu Kishino Hideaki Kanazawa Source Type: research
Usmani-Riazuddin syndrome can have a recognizable phenotype: Report of a novel AP1G1 variant
In this report, we describe this syndrome for the second time, in association to a novel AP1G1 variant identified in a toddler with multisystemic involvement including intellectual disability, speech and developmental delay, behavioral anomalies, arrhythmias, hearing loss, skin changes, and limb defects. Next generation sequencing (NGS) analysis through clinical exome disclosed AP1G1: c.1969C>G (p.Leu657Val), de novo, likely pathogenic variant, according to ACMG classification criteria. Proband's facial features resembled the spectrum of chromatinopathies. Clinical pictures were analyzed and a clinical overlap was suppo...
Source: Clinical Genetics - April 26, 2024 Category: Genetics & Stem Cells Authors: Maria Gnazzo Giulia Pascolini Giovanni Parlapiano Francesco Petrizzelli Daniele Perrino Luigina Porco Andrea Bartuli Antonio Novelli Anwar Baban Source Type: research
Regeneration of Nonhuman Primate Hearts With Human Induced Pluripotent Stem Cell-Derived Cardiac Spheroids
CONCLUSIONS: We demonstrated that direct injection of hiPSC-CSs restores the contractile functions of injured primate hearts with an acceptable risk of posttransplant arrhythmia. Although the mechanism for the functional benefits is not fully elucidated, these findings provide a strong rationale for conducting clinical trials using the equivalent CM products.PMID:38666382 | DOI:10.1161/CIRCULATIONAHA.123.064876 (Source: Circulation)
Source: Circulation - April 26, 2024 Category: Cardiology Authors: Hideki Kobayashi Shugo Tohyama Hajime Ichimura Noburo Ohashi Shuji Chino Yusuke Soma Hidenori Tani Yuki Tanaka Xiao Yang Naoko Shiba Shin Kadota Kotaro Haga Taijun Moriwaki Yuika Morita-Umei Tomohiko C Umei Otoya Sekine Yoshikazu Kishino Hideaki Kanazawa Source Type: research
Usmani-Riazuddin syndrome can have a recognizable phenotype: Report of a novel AP1G1 variant
In this report, we describe this syndrome for the second time, in association to a novel AP1G1 variant identified in a toddler with multisystemic involvement including intellectual disability, speech and developmental delay, behavioral anomalies, arrhythmias, hearing loss, skin changes, and limb defects. Next generation sequencing (NGS) analysis through clinical exome disclosed AP1G1: c.1969C>G (p.Leu657Val), de novo, likely pathogenic variant, according to ACMG classification criteria. Proband's facial features resembled the spectrum of chromatinopathies. Clinical pictures were analyzed and a clinical overlap was suppo...
Source: Clinical Genetics - April 26, 2024 Category: Genetics & Stem Cells Authors: Maria Gnazzo Giulia Pascolini Giovanni Parlapiano Francesco Petrizzelli Daniele Perrino Luigina Porco Andrea Bartuli Antonio Novelli Anwar Baban Source Type: research
Climbers at High Altitudes at Risk of Heart Rhythm Abnormalities
More than one-third of climbers who were exposed to the low-pressure and low-oxygen environment of Mount Everest experienced a cardiac arrhythmia during their climb, a small study found. The data came from 41 healthy men who were, on average, in their mid-30s. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 26, 2024 Category: General Medicine Source Type: research
Impact of abdominal compression on heart and stomach motion for stereotactic arrhythmia radioablation
CONCLUSIONS: AC was not a consistent motion management method for STAR, nor does not uniformly affect the separation distance between LVCs and the stomach. If AC is employed in future STAR protocols, the motion of the target volume and its relative distance to the stomach should be compared on two 4DCTs: one while the patient is FB and one under AC.PMID:38661250 | DOI:10.1002/acm2.14346 (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - April 25, 2024 Category: Information Technology Authors: Daniel David Cecchi Nicolas Paul Ploquin Salman Faruqi Hali Morrison Source Type: research
