LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF
Cell Mol Life Sci. 2024 Apr 10;81(1):175. doi: 10.1007/s00018-024-05193-4.ABSTRACTPhenotypic transformation of vascular smooth muscle cells (VSMCs) plays a crucial role in abdominal aortic aneurysm (AAA) formation. CARMN, a highly conserved, VSMC-enriched long noncoding RNA (lncRNA), is integral in orchestrating various vascular pathologies by modulating the phenotypic dynamics of VSMCs. The influence of CARMN on AAA formation, particularly its mechanisms, remains enigmatic. Our research, employing single-cell and bulk RNA sequencing, has uncovered a significant suppression of CARMN in AAA specimens, which correlates stron...
Source: Cellular and Molecular Life Sciences : CMLS - April 10, 2024 Category: Cytology Authors: Shenrong Liu Haobin Zhou Dunzheng Han Haoyu Song Yuanqing Li Shangfei He Yipeng Du Kai Wang Xingfu Huang Xin Li Zheng Huang Source Type: research
Matrix metalloproteinase and aortic aneurysm: a two-sample Mendelian randomization study
This study used a two-sample Mendelian randomization (MR) analysis to look into the causal relationship between MMPs and the risk of AA.MMP and aortic aneurysm (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - April 10, 2024 Category: Surgery Authors: Tao Qin, Jiankai Zhong, Pinglan Li, Jianlin Liang, Meijun Li, Guangjun Zhang Tags: Basic Science Research Source Type: research
Assessment of fitness for open repair in patients with infrarenal abdominal aortic aneurysms
This study suggests that a subset of patient deemed unfit for open repair may be incorrectly classified. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 10, 2024 Category: Surgery Authors: Mitri K. Khoury, Micah A. Thornton, Matthew J. Eagleton, Sunita D. Srivastava, Nikolaos Zacharias, Anahita Dua, Abhisekh Mohapatra Source Type: research
Surgeon-modified fenestrated endovascular grafts and thoracoscope-assisted fixation for treatment of thoraco-abdominal aortic aneurysms
We describe a successful urgent hybrid... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - April 10, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Hong Wang, Wei Wang, Weifan Wang and Debin Liu Tags: Case Report Source Type: research
Center-level Outcomes Following Elective Fenestrated Endovascular Aortic Aneurysm Repair in the Vascular Quality Initiative Database
This retrospective review of a prospectively collected vascular surgery registry found that hospital volume does not impact risk-adjusted perioperative mortality for complex branched and fenestrated endovascular aneurysm repair. The authors conclude that these procedures may not require the same center volume benchmarks as open surgical repair. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 9, 2024 Category: Surgery Authors: Andrew Hawkins, Ruyun Jin, W. Darrin Clouse, Margaret Tracci, M. Libby Weaver, Behzad Farivar Source Type: research
Long-term outcomes of chimney endovascular aneurysm repair procedure for complex abdominal aortic pathologies
To update our earlier experience and to evaluate long-term outcomes of chimney endovascular aortic repair performed for selected cases with complex abdominal aortic aneurysm. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 9, 2024 Category: Surgery Authors: Paolo Verlato, Leonardo Foresti, Trijntje Bloemert –Tuin, Santi Trimarchi, Constantijn E.V.B. Hazenberg, Joost A. van Herwaarden Source Type: research
Assessment and Follow Up of the Aortic Root by 2-D Echocardiography
Two dimensional echocardiography is a widely available, noninvasive means of evaluating the heart and aorta, which provides extensive and detailed diagnostic information with potential prognostic value for events linked to cardiac anatomic and functional findings. (1) The aortic root is readily imaged in most people and provides reproducible measurements at several locations. (2-4) Acquired aortic root enlargement occurs in several significant disease states, including aortic valve abnormalities, chronically elevated blood pressure, and aortic aneurysm and dissection.(5-8) Long standing questions have existed regarding nor...
Source: The American Journal of Cardiology - April 9, 2024 Category: Cardiology Authors: James L. Vacek Tags: Editorial Source Type: research
Long-term results of etiology-based thoracic endovascular aortic repair: a single-center experience
AbstractThe use of thoracic endovascular aortic repair (TEVAR) for thoracic aortic aneurysm (TAA) and Stanford type B aortic dissection (TBAD) has been increasing; however, in terms of etiology, the differences of long term after TEVAR outcomes remain unexplored. Thus, we investigated etiology-specific long-term results of TEVAR for TAA and TBAD. A total of 421 TEVAR procedures were performed at our institution from July 2007 to December 2021; 249 TAA cases and 172 TBAD cases were included. Traumatic aortic dissection and aortic injury cases were excluded. The mean observation duration was 5.7 years. The overall 30-day m...
Source: Heart and Vessels - April 9, 2024 Category: Cardiology Source Type: research
5-year Outcomes of Fenestrated and Branched Endovascular Repair of Complex Aortic Aneurysms Based on Aneurysm Extent
To evaluate the 5-year outcomes of fenestrated/branched endovascular aortic repair (F/BEVAR) for the treatment of complex aortic aneurysms stratified by the aneurysm extent. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 9, 2024 Category: Surgery Authors: Stephen J. Raulli, Vivian Carla Gomes, F. Ezequiel Parodi, Priya Vasan, Dichen Sun, William A. Marston, Luigi Pascarella, Katharine L. McGinigle, Jacob C. Wood, Mark A. Farber Source Type: research
Living in High-Poverty Areas is Associated with Reduced Survival in Patients with Thoracoabdominal Aortic Aneurysm
In this retrospective observational study of 575 patients with TAAAs, mortality was significantly increased in patients living in high-poverty areas and reduced if living over 100 miles from the treatment center. Patients living in high-poverty areas may require more comprehensive medical care. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 9, 2024 Category: Surgery Authors: Karissa Yamaguchi, Karina Newhall, Natasha I. Edman, Sara L. Zettervall, Matthew P. Sweet Source Type: research
Assessment and Follow-Up of the Aortic Root by 2-Dimensional Echocardiography
The 2-dimensional echocardiography is a widely available, noninvasive means of evaluating the heart and aorta, which provides extensive and detailed diagnostic information with potential prognostic value for events linked to cardiac anatomic and functional findings.1 The aortic root is readily imaged in most patients and provides reproducible measurements at several locations.2 –4 Acquired aortic root enlargement occurs in several significant disease states, including aortic valve abnormalities, chronically increased blood pressure, and aortic aneurysm and dissection. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 9, 2024 Category: Cardiology Authors: James L. Vacek Tags: Editorial Source Type: research
Exploiting light-based 3D-printing for the fabrication of mechanically enhanced, patient-specific aortic grafts
This study reports on the development and characterisation of an alternative vascular graft material. An alginate:PEGDA (AL:PE) interpenetrating polymer network (IPN) hydrogel has been produced with uniaxial tensile tests revealing similar strength and stiffness (0.39 ± 0.05 MPa and 1.61 ± 0.19 MPa, respectively) to the human aorta. Moreover, AL:PE tubular conduits of similar geometrical dimensions to segments of the aorta were produced, either via conventional moulding methods or stereolithography (SLA) 3D-printing. While both fabrication methods successfully demonstrated AL:PE hydrogel production, SLA 3D-printing was m...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 8, 2024 Category: Materials Science Authors: Lisa Asciak Roger Domingo-Roca Jamie R Dow Robbie Brodie Niall Paterson Philip E Riches Wenmiao Shu Christopher McCormick Source Type: research
Exploiting light-based 3D-printing for the fabrication of mechanically enhanced, patient-specific aortic grafts
This study reports on the development and characterisation of an alternative vascular graft material. An alginate:PEGDA (AL:PE) interpenetrating polymer network (IPN) hydrogel has been produced with uniaxial tensile tests revealing similar strength and stiffness (0.39 ± 0.05 MPa and 1.61 ± 0.19 MPa, respectively) to the human aorta. Moreover, AL:PE tubular conduits of similar geometrical dimensions to segments of the aorta were produced, either via conventional moulding methods or stereolithography (SLA) 3D-printing. While both fabrication methods successfully demonstrated AL:PE hydrogel production, SLA 3D-printing was m...
Source: Journal of the Mechanical Behavior of Biomedical Materials - April 8, 2024 Category: Materials Science Authors: Lisa Asciak Roger Domingo-Roca Jamie R Dow Robbie Brodie Niall Paterson Philip E Riches Wenmiao Shu Christopher McCormick Source Type: research
Cutdown is Associated with Higher 30-day Unplanned Readmissions and Wound Complications Than Percutaneous Access for EVAR
A 2023 Cochrane review showed no difference in bleeding/wound infection complications, short-term mortality and aneurysm exclusion between the percutaneous and cut-down approach for femoral access in endovascular aortic aneurysm repair (EVAR). In contrast, single-center studies have shown bilateral cutdown resulting in higher readmission rates due to higher rates of groin wound infections. Whether 30-day readmission rates vary by type of access during EVAR procedures is unknown. The goal of this study was to ascertain which femoral access approach for EVAR is associated with the lowest risk of 30-day readmission. (Source: ...
Source: Annals of Vascular Surgery - April 8, 2024 Category: Surgery Authors: Meagan Read, Trung Nguyen, Kevin Swan, Dean J. Arnaoutakis, Anahita Dua, Eric Toloza, Murray Shames, Charles Bailey, Christopher A. Latz Tags: Clinical Research Source Type: research
Patient perceptions of surveillance of small abdominal aortic aneurysms in the over 85s
Recently instigated local practice for patients with small abdominal aortic aneurysms (AAAs) involves contacting all patients, aged ≥85 years, to discuss with them the advantages and disadvantages of removal from surveillance. However, reasons why patients opt to remain on, or come off, surveillance, are currently unknown. The current study’s objective is to explore patient perception of surveillance decision-making. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - April 6, 2024 Category: Surgery Authors: Summer Jones-Webster, Miles Davenport, Sayuri Weerakkody, Elisabeth Smith, Phil Reed, Jeremy J. Tree, Lisa A. Osborne, David C. Bosanquet Tags: Clinical Research Source Type: research
