Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors
Biomed Pharmacother. 2024 Apr 11;174:116564. doi: 10.1016/j.biopha.2024.116564. Online ahead of print.ABSTRACTDuring resolution of inflammation, specialized proresolving mediators (SPMs), including resolvins, are produced to restore tissue homeostasis. We hypothesized that there might be a dysregulation of SPMs pathways in pathological vascular remodeling and that resolvin D2 (RvD2) might prevent vascular remodeling and contractile and endothelial dysfunction in a model of obesity and hypertension. In aortic samples of patients with or without abdominal aortic aneurysms (AAA), we evaluated gene expression of enzymes involv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Raquel Rodrigues-Diez Constanza Ballesteros-Martinez Rosa Mar ía Moreno-Carriles Francisco Nistal Luc ía S Díaz Del Campo Victoria Cachofeiro Jesmond Dalli Ana B Garc ía-Redondo Juan M Redondo Mercedes Salaices Ana M Briones Source Type: research
Mid-term results of "off-label" use of the Endurant stentgraft in patients with infrarenal abdominal aortic aneurysms
CONCLUSION: In this study, real-life experience with the Endurant II and IIS stentgraft is described. Non-adherence with instructions for use was associated with a higher risk of endoleak type IA (p = .06). In the early postoperative period, there were more patients with limb occlusion; this finding was not observed anymore at the end of the follow-up period.PMID:38606774 | DOI:10.1177/17085381241247265 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Denise Michelle Danielle Özdemir-van Brunschot David Holzhey Spiridon Botsios Source Type: research
Can HALP score predict post-contrast acute kidney injury and 6-year mortality in patients undergoing endovascular abdominal aneurysm repair?
CONCLUSIONS: The HALP score, which can be calculated with a simple formula, can be used to predict PC-AKI and medium-long-term mortality in EVAR patients.PMID:38607832 | DOI:10.1177/17085381241246905 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Ahmet Özderya Sinan Şahin Tolga Ko şmaz Mehmet Ali Maz Murat G ökhan Yerlikaya Ali R ıza Akyüz Muhammet Ra şit Sayın Hakan Erkan Source Type: research
Mid-term results of "off-label" use of the Endurant stentgraft in patients with infrarenal abdominal aortic aneurysms
CONCLUSION: In this study, real-life experience with the Endurant II and IIS stentgraft is described. Non-adherence with instructions for use was associated with a higher risk of endoleak type IA (p = .06). In the early postoperative period, there were more patients with limb occlusion; this finding was not observed anymore at the end of the follow-up period.PMID:38606774 | DOI:10.1177/17085381241247265 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Denise Michelle Danielle Özdemir-van Brunschot David Holzhey Spiridon Botsios Source Type: research
Can HALP score predict post-contrast acute kidney injury and 6-year mortality in patients undergoing endovascular abdominal aneurysm repair?
CONCLUSIONS: The HALP score, which can be calculated with a simple formula, can be used to predict PC-AKI and medium-long-term mortality in EVAR patients.PMID:38607832 | DOI:10.1177/17085381241246905 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Ahmet Özderya Sinan Şahin Tolga Ko şmaz Mehmet Ali Maz Murat G ökhan Yerlikaya Ali R ıza Akyüz Muhammet Ra şit Sayın Hakan Erkan Source Type: research
Resolvin D2 prevents vascular remodeling, hypercontractility and endothelial dysfunction in obese hypertensive mice through modulation of vascular and proinflammatory factors
Biomed Pharmacother. 2024 Apr 11;174:116564. doi: 10.1016/j.biopha.2024.116564. Online ahead of print.ABSTRACTDuring resolution of inflammation, specialized proresolving mediators (SPMs), including resolvins, are produced to restore tissue homeostasis. We hypothesized that there might be a dysregulation of SPMs pathways in pathological vascular remodeling and that resolvin D2 (RvD2) might prevent vascular remodeling and contractile and endothelial dysfunction in a model of obesity and hypertension. In aortic samples of patients with or without abdominal aortic aneurysms (AAA), we evaluated gene expression of enzymes involv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 12, 2024 Category: Drugs & Pharmacology Authors: Raquel Rodrigues-Diez Constanza Ballesteros-Martinez Rosa Mar ía Moreno-Carriles Francisco Nistal Luc ía S Díaz Del Campo Victoria Cachofeiro Jesmond Dalli Ana B Garc ía-Redondo Juan M Redondo Mercedes Salaices Ana M Briones Source Type: research
Mid-term results of "off-label" use of the Endurant stentgraft in patients with infrarenal abdominal aortic aneurysms
CONCLUSION: In this study, real-life experience with the Endurant II and IIS stentgraft is described. Non-adherence with instructions for use was associated with a higher risk of endoleak type IA (p = .06). In the early postoperative period, there were more patients with limb occlusion; this finding was not observed anymore at the end of the follow-up period.PMID:38606774 | DOI:10.1177/17085381241247265 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Denise Michelle Danielle Özdemir-van Brunschot David Holzhey Spiridon Botsios Source Type: research
Can HALP score predict post-contrast acute kidney injury and 6-year mortality in patients undergoing endovascular abdominal aneurysm repair?
CONCLUSIONS: The HALP score, which can be calculated with a simple formula, can be used to predict PC-AKI and medium-long-term mortality in EVAR patients.PMID:38607832 | DOI:10.1177/17085381241246905 (Source: Vascular)
Source: Vascular - April 12, 2024 Category: Surgery Authors: Ahmet Özderya Sinan Şahin Tolga Ko şmaz Mehmet Ali Maz Murat G ökhan Yerlikaya Ali R ıza Akyüz Muhammet Ra şit Sayın Hakan Erkan Source Type: research
Artificial Intelligence With Deep Learning Enables Assessment of Aortic Aneurysm Diameter and Volume Through Different Computed Tomography Phases
(Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - April 11, 2024 Category: Surgery Authors: Quentin Coastaliou, Claire Webster, Colin Bicknell, Anna Pouncey, Eric Ducasse, Caroline Caradu Tags: Research Letter Source Type: research
The Association Between Frailty and Outcomes Following Ruptured Abdominal Aortic Aneurysm Repair
Endovascular aortic repair (EVAR) is a less invasive method than the more physiologically stressful open surgical repair (OSR) for patients with anatomically appropriate abdominal aortic aneurysm (AAA). Early postoperative outcomes are associated with both patients ’ physiologic reserve and the physiologic stresses of the surgical intervention. Among frail patients with reduced physiologic reserve, the stress of an aortic rupture in combination with the stress of an operative repair are less well tolerated, raising the risk of complications and mortality. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 11, 2024 Category: Surgery Authors: Jia Yu, Yekaterina Khamzina, Jason Kennedy, Nathan L. Liang, Daniel E. Hall, Shipra Arya, Edith Tzeng, Katherine M. Reitz Source Type: research
Utility of Motor Evoked Potentials in Contemporary Open Thoracoabdominal Aortic Repair
Paraplegia remains one of the major complications of contemporary open thoracoabdominal aortic aneurysm (TAAA) repair. Intraoperative motor-evoked potentials (MEPs) act as a surrogate measure for spinal cord homeostasis. The purpose of this study was to evaluate the results of intraoperative neuromonitoring in contemporary TAAA repair and its association with postoperative spinal cord ischemia. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 11, 2024 Category: Surgery Authors: Roberto G. Aru, David P. Stonko, Li T. Tan, Rebecca A. Sorber, Caitlin W. Hicks, James H. Black Source Type: research
Creation of a shared medical decision support tool for the management of abdominal aortic aneurysms
Patients with an unruptured abdominal aortic aneurysm (AAA) at the surgical threshold may benefit from aneurysmal exclusion either by open surgery or endovascular repair. A patient decision aid (PtDA) could be useful to help patients and their surgeons choose between the two techniques. The aim of this study was to develop a shared medical decision support tool, in french language, for the surgical treatment of AAA. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - April 11, 2024 Category: Surgery Authors: Marie Dumaus é, Marie Mouillard, Quentin Balézeaux, Eric Ducasse, Caroline Caradu, Yves-Marie Vincent Tags: Clinical Research Source Type: research
Analysis of Vascular Smooth Muscle Cells from Thoracic Aortic Aneurysms Reveals DNA Damage and Cell Cycle Arrest as Hallmarks in Bicuspid Aortic Valve Patients
J Proteome Res. 2024 Apr 9. doi: 10.1021/acs.jproteome.3c00649. Online ahead of print.ABSTRACTThoracic aortic aneurysm (TAA) is mainly sporadic and with higher incidence in the presence of a bicuspid aortic valve (BAV) for unknown reasons. The lack of drug therapy to delay TAA progression lies in the limited knowledge of pathophysiology. We aimed to identify the molecular hallmarks that differentiate the aortic dilatation associated with BAV and tricuspid aortic valve (TAV). Aortic vascular smooth muscle cells (VSMCs) isolated from sporadic TAA patients with BAV or TAV were analyzed by mass spectrometry. DNA oxidative dama...
Source: Cell Research - April 10, 2024 Category: Cytology Authors: Ariadna Martin-Blazquez Marta Martin-Lorenzo Aranzazu Santiago-Hernandez Angeles Heredero Alicia Donado Juan A Lopez Miriam Anfaiha-Sanchez Rocio Ruiz-Jimenez Vanesa Esteban Jesus Vazquez Gonzalo Aldamiz-Echevarria Gloria Alvarez-Llamas Source Type: research
LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF
Cell Mol Life Sci. 2024 Apr 10;81(1):175. doi: 10.1007/s00018-024-05193-4.ABSTRACTPhenotypic transformation of vascular smooth muscle cells (VSMCs) plays a crucial role in abdominal aortic aneurysm (AAA) formation. CARMN, a highly conserved, VSMC-enriched long noncoding RNA (lncRNA), is integral in orchestrating various vascular pathologies by modulating the phenotypic dynamics of VSMCs. The influence of CARMN on AAA formation, particularly its mechanisms, remains enigmatic. Our research, employing single-cell and bulk RNA sequencing, has uncovered a significant suppression of CARMN in AAA specimens, which correlates stron...
Source: Cellular and Molecular Life Sciences : CMLS - April 10, 2024 Category: Cytology Authors: Shenrong Liu Haobin Zhou Dunzheng Han Haoyu Song Yuanqing Li Shangfei He Yipeng Du Kai Wang Xingfu Huang Xin Li Zheng Huang Source Type: research
LncRNA CARMN inhibits abdominal aortic aneurysm formation and vascular smooth muscle cell phenotypic transformation by interacting with SRF
Cell Mol Life Sci. 2024 Apr 10;81(1):175. doi: 10.1007/s00018-024-05193-4.ABSTRACTPhenotypic transformation of vascular smooth muscle cells (VSMCs) plays a crucial role in abdominal aortic aneurysm (AAA) formation. CARMN, a highly conserved, VSMC-enriched long noncoding RNA (lncRNA), is integral in orchestrating various vascular pathologies by modulating the phenotypic dynamics of VSMCs. The influence of CARMN on AAA formation, particularly its mechanisms, remains enigmatic. Our research, employing single-cell and bulk RNA sequencing, has uncovered a significant suppression of CARMN in AAA specimens, which correlates stron...
Source: Cellular and Molecular Life Sciences : CMLS - April 10, 2024 Category: Cytology Authors: Shenrong Liu Haobin Zhou Dunzheng Han Haoyu Song Yuanqing Li Shangfei He Yipeng Du Kai Wang Xingfu Huang Xin Li Zheng Huang Source Type: research
