Prospective Randomized Pilot Trial Comparing Prophylactic versus Therapeutic Cerebrospinal Fluid Drainage During Complex Endovascular Thoracoabdominal Aortic Aneurysm Repair
Endovascular techniques have transformed the management of thoracoabdominal aortic aneurysms (TAAA). However, spinal cord ischemia (SCI) remains a prevalent and devastating complication. Prophylactic drainage of cerebrospinal fluid (CSF) is among the proposed strategies for prevention of SCI. Although prophylactic CSF drainage is widely-used and conceptually attractive, prophylactic CSF drains have not been demonstrated to definitively prevent the occurrence, nor mitigate, the severity of SCI in endovascular TAAA repair. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 5, 2024 Category: Surgery Authors: Juliet Blakeslee-Carter, Zdenek Novak, Jan O. Jansen, Andres Schanzer, Matthew J. Eagleton, Mark A. Farber, Warren Gasper, W. Anthony Lee, Gustavo S. Oderich, Carlos H. Timaran, Darren B. Schneider, Matthew P. Sweet, Adam W. Beck Source Type: research
Prospective randomized pilot trial comparing prophylactic vs therapeutic cerebrospinal fluid drainage during complex endovascular thoracoabdominal aortic aneurysm repair
Endovascular techniques have transformed the management of thoracoabdominal aortic aneurysms (TAAAs). However, spinal cord ischemia (SCI) remains a prevalent and devastating complication. Prophylactic drainage of cerebrospinal fluid (CSF) is among the proposed strategies for prevention of SCI. Although prophylactic CSF drainage is widely used and conceptually attractive, prophylactic CSF drains have not been demonstrated to definitively prevent the occurrence nor mitigate the severity of SCI in endovascular TAAA repair. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 5, 2024 Category: Surgery Authors: Juliet Blakeslee-Carter, Zdenek Novak, Jan O. Jansen, Andres Schanzer, Matthew J. Eagleton, Mark A. Farber, Warren Gasper, W. Anthony Lee, Gustavo S. Oderich, Carlos H. Timaran, Darren B. Schneider, Matthew P. Sweet, Adam W. Beck Source Type: research
Technical challenges during emergent endovascular aneurysm repair with the ALTO system
Expert Rev Med Devices. 2024 Apr 3. doi: 10.1080/17434440.2024.2339416. Online ahead of print.ABSTRACTINTRODUCTION: Ruptured abdominal aortic aneurysms (AAAs) pose an immediate threat for patient's life and endovascular repair (EVAR) is currently the preferred treatment modality in the presence of suitable anatomy. This is determined based on the requirements of each endograft as described in the instructions for use (IFU). The new ALTO system (Endologix, Irvin, CA, U.S.A.), can accommodate a great range of anatomies such as short necks and/or narrow access, but its unique design requires specific technical modifications d...
Source: Expert Review of Medical Devices - April 4, 2024 Category: Medical Devices Authors: Nikolaos Kontopodis Elias Kehagias Christos Chronis Nikolaos Nasis Dimitrios Tsetis Christos V Ioannou Source Type: research
Technical challenges during emergent endovascular aneurysm repair with the ALTO system
Expert Rev Med Devices. 2024 Apr 5:1-7. doi: 10.1080/17434440.2024.2339416. Online ahead of print.ABSTRACTINTRODUCTION: Ruptured abdominal aortic aneurysms (AAAs) pose an immediate threat for patient's life and endovascular repair (EVAR) is currently the preferred treatment modality in the presence of suitable anatomy. This is determined based on the requirements of each endograft as described in the instructions for use (IFU). The new ALTO system (Endologix, Irvin, CA, U.S.A.), can accommodate a great range of anatomies such as short necks and/or narrow access, but its unique design requires specific technical modificatio...
Source: Expert Review of Medical Devices - April 4, 2024 Category: Medical Devices Authors: Nikolaos Kontopodis Elias Kehagias Christos Chronis Nikolaos Nasis Dimitrios Tsetis Christos V Ioannou Source Type: research
An In-Vitro Comparison of Steady State Leakage Rates Through Introducer Sheaths Used for fenestrated Endovascular Aortic Aneurysm Repair
– fEVAR involves deploying a covered stent into the aorta followed by multiple visceral stents through fenestrations in the main body of graft. The most commonly used large sheaths for cannulation of visceral vessels are the Gore DrySeal Flex, Cook Performer Check-Flo and Medtronic Sentrant. None of these sheaths were designed for the insertion of multiple sheaths, and so a slow but steady leakage of blood occurs during the procedure. The aim of this paper is to assess in an in vitro setting which large bore sheath has the best valve for use when multiple smaller sheaths are inserted through it. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - April 4, 2024 Category: Surgery Authors: James Corden, Kamran Khan, Jan Hon Wong, Ruari Hodgin, Ferdinand Serracino-Inglott Tags: Clinical Research Source Type: research
Clinical significance of elevated D-dimer in emergency department patients: a retrospective single-center analysis
ConclusionThis is the first paper to identify multiple causes of elevated D-dimer levels in Saudi Arabia population within the ED and it clearly highlights their accurate and diagnostic values. These findings draw attention to the importance of considering the specific clinical context and utilizing additional diagnostic tools when evaluating patients with elevated D-dimer levels. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - April 3, 2024 Category: Emergency Medicine Source Type: research
Endosutured aneurysm repair (ESAR) of abdominal aortic aneurysms with short necks achieves acceptable mid-term outcomes – results from the PERU registry.
The study aims to describe midterm outcomes following treatment of infrarenal abdominal aortic aneurysms (AAAs) with short necks by endosutured aneurysm repair (ESAR) using the Heli-FX EndoAnchor system. (Source: Annals of Vascular Surgery)
Source: Annals of Vascular Surgery - April 3, 2024 Category: Surgery Authors: Andr és Reyes Valdivia, Kyriakos Oikonomou, Ross Milner, Apostolos Pitoulias, Michel M.P. J. Reijnen, Karin Pfister, Giovanni Tinelli, Csaba Csobay-Novák, Giovanni Pratesi, Luis Mariano Ferreira, Jean-Paul P.M. de Vries, Arindam Chaudhuri, Contributors Tags: Clinical Research Source Type: research
An inconspicuous identification: isolation and identification of a novel Pichia species presenting as fungemia following cardiac surgery.
An 84-year-old woman with an implantable cardiac pacemaker and a history of temporal arteritis on chronic prednisone (7 mg/day) noted increasing bilateral lower extremity edema approximately 2 months prior to hospital admission. The patient, an avid traveler, was born in South Africa and moved to the United States Pacific Northwest in the early 1960s. An outpatient transthoracic echocardiogram demonstrated an ascending aortic aneurysm and moderate aortic stenosis. CT angiogram confirmed severe aneurysmal dilation of the ascending thoracic aorta (7.4 cm), aortic arch (4.7 cm), and descending thoracic aorta (3.7 cm). (Source...
Source: International Journal of Infectious Diseases - April 3, 2024 Category: Infectious Diseases Authors: Allorie T. Caldwell, Toni Gabald ón, Verónica Mixão, Nancy L. Wengenack, Benjamin P. Westley, Ryan W. Stevens Tags: Case Report Source Type: research
Risk factors of 30-day and long-term mortality and outcomes in open repair of thoracoabdominal aortic aneurysm
Open repair of thoracoabdominal aortic aneurysm (TAAA) was characterized by significant risk of postoperative mortality and morbidity. The aim of this study was to determine the perioperative predictors of ear... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - April 2, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Sudena Wang, Chunrong Wang, Yuchen Gao, Yu Tian, Jia Liu and Yuefu Wang Tags: Research Source Type: research
LXR α Promotes Abdominal Aortic Aneurysm Formation Through UHRF1 Epigenetic Modification of miR-26b-3p
CONCLUSIONS: Our study reveals a pivotal role of the LXRα/UHRF1/miR-26b-3p axis in AAA and provides potential biomarkers and therapeutic targets for AAA.PMID:38557060 | DOI:10.1161/CIRCULATIONAHA.123.065202 (Source: Circulation)
Source: Circulation - April 1, 2024 Category: Cardiology Authors: Xiao Guo Jianmei Zhong Yichao Zhao Yanan Fu Ling-Yue Sun Ancai Yuan Junling Liu Alex F Chen Jun Pu Source Type: research
Recent advances regarding the potential roles of invariant natural killer T cells in cardiovascular diseases with immunological and inflammatory backgrounds
Int Immunol. 2024 Apr 1:dxae019. doi: 10.1093/intimm/dxae019. Online ahead of print.ABSTRACTInvariant natural killer T (iNKT) cells, which bear αβ-type T cell antigen-receptors, recognize glycolipid antigens in a cluster of differentiation 1d (CD1d)-restricted manner. Regarding these cells, the unique modes of thymic selection and maturation elucidate innateness, irrespective of them also being members of the adaptive immune system as a T cell. iNKT cells develop and differentiate into NKT1 [interferon γ (IFN-γγ-producing], NKT2 [interleukin 4 (IL-4)/IL-13-producing], or NKT17 (IL-17-producing) subsets in the thymus. ...
Source: Atherosclerosis - April 1, 2024 Category: Cardiology Authors: Kazuya Iwabuchi Masashi Satoh Kazuhisa Yoshino Naoki Ishimori Source Type: research
Saccular abdominal aortic aneurysm in adolescence with tuberous sclerosis
Key clinical messageAbdominal aortic aneurysm complicated by tuberous sclerosis is rare, particularly in patients over the age of 10. It is important to screen for abdominal aortic aneurysm in adolescents diagnosed with tuberous sclerosis regularly.AbstractA 15-year-old girl who was diagnosed with tuberculous sclerosis complicated with a saccular aortic abdominal aneurysm (AAA), measuring 19 × 18 mm in diameter. The patient underwent open repair of AAA using a 11 mm straight prosthetic graft. It is important to screen for AAA in adolescents diagnosed with tuberous sclerosis regularly. (Source: Clinical Case Reports)
Source: Clinical Case Reports - April 1, 2024 Category: General Medicine Authors: Takumi Umibe,
Hironobu Nishiori,
Shintaro Koizumi,
Hiroki Ikeuchi,
Goro Matsumiya Tags: CASE IMAGE Source Type: research
