The plasma peptides of Alzheimer ’s disease

ConclusionProteins apparently expressed in the brain that were directly related to Alzheimer ’s including Nerve Growth Factor (NFG), Sphingomyelin Phosphodiesterase, Disrupted in Schizophrenia 1 (DISC1), the cell death regulator retinitis pigmentosa (NXNl1) that governs the loss of nerve cells in the retina and the cell death regulator ZC3H12A showed much higher observation frequency in A D plasma vs the matched control. There was a striking agreement between the proteins known to be mutated or dis-regulated in the brains of AD patients with the proteins observed in the plasma of AD patients from endogenous peptides including NBN, BAG1, NOX1, PDCD5, SGK3, UBE2G1, SMPD3 neuronal prote ins associated with synapse function such as KSYTL4, VTI1B and brain specific proteins such as TBATA.
Source: Clinical Proteomics - Category: Biochemistry Source Type: research