Preliminary evaluation of shaken baby syndrome using [18F]GE180

Conclusions: The preliminary biodistribution study showed [18F]GE180 had a much higher uptake in the shaken group of the AHT animal model than the control group early in the study. [18F]GE180, a TSPO specific radioligand for neuroinflammation and glial cell activation, may be a favorable tracer for noninvasive detection of mild traumatic brain injury in AHT, which still presents a challenge using traditional MRI or CT imaging modality. More studies are ongoing to correlate the biodistribution results to PET imaging and histological analyses.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Basic Science - Inflammation and Dementia Source Type: research