Mesothelioma Clinical Trial Targets Latest Gene Therapy

Pioneering pulmonologists Dr. Steven Albelda and Dr. Daniel Sterman have worked for more than 20 years on developing gene therapy to effectively combat pleural mesothelioma cancer. The payoff may have finally arrived. Albelda and Sterman’s long-awaited, phase III clinical trial will open this month to evaluate the efficacy of TR002, a novel gene therapy drug, when used in combination with celecoxib and gemcitabine. TR002, a form of immunotherapy, is a genetically engineered adenovirus that triggers the anti-tumor effects of interferon, a naturally occurring protein that destroys cancer cells. “The hope is, if it works like earlier studies have shown so far, that we may have a new treatment option, a new standard-of-care treatment to offer patients with mesothelioma,” said Sterman, director of pulmonary oncology at New York University Langone Medical Center. “We’re excited about the potential.” Earlier Study Was Impressive In an earlier, phase II study of TR002, the disease control rate was 87.5% for patients who either were newly diagnosed or were failed by standard chemotherapy. In second-line treatment, they had a median survival time of 17 months, almost double the historical control. The three-year survival rate was 20 percent. “A phase III trial gives us the possibility — we have no idea what the results will be — of having another important drug in our armamentarium with potentially proven benefits for mesothelioma p...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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In this study, we found two species, Milnesium pacificum sp. nov. and Milnesium tardigradum Doyère, 1840, from three southern islands and two cold regions in Japan, respectively. Milnesium pacificum sp. nov., having dorsal sculpturing, exhibits an early positive change in claw configuration. On the other hand, M. tardigradum s.s. from Japan has an early negative claw configuration change, as has been reported in a recent study on the neotype population of this species. We performed DNA barcoding for both species, which indicated that M. pacificum sp. nov. has a close affinity with an undescribed Milnesium species co...
Source: Zoological Science - Category: Zoology Authors: Tags: Zoolog Sci Source Type: research
The objective of this study was to prepare the liver targeting drug delivery system (TDDS) of artesunate (ART)-loaded polyethylene glycol (PEG)-Poly (D, L-lactic-co-glycolic) acid (PLGA) nanoparticles (NPs) modified by glycyrrhetinic acid (GA), and evaluate its in vitro cytotoxicity.Significance: The GA-PEG-PLGA-ART NPs enhanced the in vitro cytotoxicity on HCC cell lines. The development of GA-PEG-PLGA NPs will greatly push the clinical applications of ART as a novel anticancer drug.Methods: The NPs were prepared using solvent evaporation method, and the formulation was optimized through an orthogonal design. In addition,...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
PMID: 32976788 [PubMed - as supplied by publisher]
Source: Health Physics - Category: Physics Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
Authors: Miserocchi E, Giuffrè C, Modorati GM, Cimaz R Abstract Italy was the first European country to be affected by the SARS-CoV-2 pandemic. In this scenario, we had to face a new clinical approach in our Pediatric Rheumatology Unit for the management of patients affected by juvenile idiopathic arthritis (JIA)-associated uveitis. During the lockdown (phase 1), the weekly outpatient clinic was discontinued and telephone consultations were set up. A toll-free telephone number was instituted for emergencies. None of our children with JIA-associated uveitis was advised to stop the ongoing immunosuppressant sy...
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Abstract Polycarboxylate polymers have been common components of consumer and institutional cleaning products for decades. With interest heightened in the potential environmental impact of polymers, the American Cleaning Institute, the industry trade association of the cleaning products industry in the United States, is reassessing the state of the science regarding the environmental safety of polymers in cleaning products. In this case study, acrylic acid homopolymers and acrylic acid-maleic acid copolymers are evaluated using historical ecotoxicity data that have been reported over the past three decades. The ev...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
Neath Port Talbot, Torfaen and the Vale of Glamorgan face further measures; Le Monde reports32% of outbreaks in France found in schools or universitiesRegular ‘circuit breaker’ lockdowns ‘could help control Covid’Minister refuses to guarantee students will be home for ChristmasBoris Johnson faces revolt over forcing through Covid measuresAustralia: ‘We should not pretend everybody is suffering equally’See all our coronavirus coverage2.50pmBSTInMarseille,a coronavirus hotspot, the city ’s top flight football team has been given a government order to play behind closed doors. InGerma...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak France UK news Europe Infectious diseases Science World news Saudi Arabia Japan South Korea Australia news Source Type: news
Abstract Long non-coding RNAs (lncRNAs) cancer susceptibility candidate 2 (CASC2) has been characterized as a tumor suppressor in glioma. Although CASC2 may predict the prognosis of glioma patients, the role and mechanism of CASC2 in human glioblastoma remain to be fully illuminated. Expression of CASC2 and miR- 18a was detected using RT-qPCR. Cell growth was evaluated by MTT assay, colony formation assay, and flow cytometry; metastasis and epithelial-mesenchymal transition (EMT) were determined with transwell assay and Western blot, respectively. The target binding between CASC2 and miR-18a was predicted on Starb...
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
This study represents the first report of miR-214 on global gene expression in the context of HPV. PMID: 32975231 [PubMed - in process]
Source: Journal of Biosciences - Category: Biomedical Science Authors: Tags: J Biosci Source Type: research
Despite now having evidence that test and trace is the only way to fight the virus, the UK has lost control at the crucial moment• Dr William Hanage is professor of the evolution and epidemiology of infectious disease at HarvardBritain is in the grip of an extraordinarily dangerous outbreak of forgetfulness. During the spring, more than50,000 people died – far more than the yearly total for any flu outbreak in living memory. Deaths are, sadly, an expected outcome of any pandemic. But this experience is also an opportunity to learn – assuming governments are willing to do so.Since the first outbreaks of Cov...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Health policy Science US news UK news Boris Johnson Politics Source Type: news
We report outcomes and evaluate patient factors and the impact of surgical evolution on outcomes in consecutive ulcerative colitis patients who had restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) at an Australian institution over 26 years. Methods: Data including clinical characteristics, medical therapy pre-surgery and surgical outcomes were collected. We divided eligible patients into three period arms (period 1: 1990-1999; period 2: 2000-2009; period 3: 2010-2016). Outcomes of interest were IPAA leak and pouch failure. Results: Two hundred and twelve patients were included. Median follow up ...
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
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