Opting In: The Value of Vaccines

A young boy in Pakistan receives an oral polio vaccine (OPV). Over the last 30 years huge progress has been made against polio and it is now only endemic in 2 countries, Afghanistan and Pakistan, with only 33 cases confirmed cases last year. Credit: Ashfaq Yusufzai/IPSBy Tharanga YakupitiyageUNITED NATIONS, May 1 2019 (IPS) Since the introduction of vaccines, diseases such as measles and polio were quickly becoming a thing of the past. However, the world’s progress on immunisation is now being threatened. According to the World Health Organisation (WHO), 85 percent of the world’s children received basic vaccines, including the measles and diptheria-tetanus-pertussis (DTP) vaccines, which can protect them from infectious diseases that cause serious illness and even death. In fact, measles immunisation resulted in an 80 percent drop in measles-related deaths between 2000 and 2017 worldwide. Still, access to vaccines remain elusive for many out-of-reach communities. In 2017, an estimated 20 million infants did not receive the DTP vaccine, 60 percent of whom live in just 10 countries, including Afghanistan, the Democratic Republic of the Congo, Iraq, and Nigeria. A rising anti-vaccination movement is also threatening to dismantle progress. In the United States, there are now more than 700 cases of measles across 22 states making it the highest figures the country has seen since 2000. The phenomenon has prompted some states to not only make immunisation mandatory,...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Featured Global Headlines Health IPS UN: Inside the Glasshouse North America Population Regional Categories TerraViva United Nations diptheria-tetanus-pertussis (DTP) human papillomavirus (HPV) Measles Vaccines World Health Organ Source Type: news

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This report describes a new lethal case of Rickettsia rickettsii infection in a child from Northwestern Colombia, after ten years of the last outbreaks in the same region. Colombian public-health authorities should consider to include this severe rickettsiosis in the compulsory-reporting diseases, with the aim of knowing its burden in the country.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, we found that the PPL length of Korean SG isolates varied from 11 to 21 prolines and was longer than that of a live vaccine strain, SG 9R (9 prolines). According to growth competition in chickens, the growth of an SG isolate with a PPL length of 17 prolines exceeded that of an SG isolate with a PPL length of 15 prolines. We investigated the pseudogenes of the field isolates, SG 9R and reference strains in GenBank by resequencing and comparative genomics. The pseudogene profiles of the field isolates were notably different from those of the foreign SG strains, and they were subdivided into 7 pseudogene subgro...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 24 May 2019Source: Veterinary MicrobiologyAuthor(s): Sante Roperto, Valeria Russo, Francesca De Falco, Alessandra Rosati, Cornel Catoi, Franco RopertoAbstractE5 protein, the major oncoprotein of the bovine Deltapapillomavirus genus, has been detected in 17 of the 19 urothelial cancers by molecular and morphological procedures. In 10 urothelial cancers, the oxygen sensitive subunit HIF-1α, which is upregulated by hypoxia, was overexpressed. Mitophagy, the selective autophagic removal of dysfunctional mitochondria, was upregulated in hypoxic neoplastic cells infected by BPVs which was...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 25 May 2019Source: Preventive Veterinary MedicineAuthor(s): Ricardo Lopes, Amanda Brinch Kruse, Liza Rosenbaum Nielsen, Telmo Pina Nunes, Lis AlbanAbstractIn modern livestock farming, there is an increasing understanding that antimicrobial (AM) consumption must be kept low – preferably without compromising animal welfare or productivity. This requires an understanding of the relationship between AM use, productivity, biosecurity, vaccination and herd demographics. To obtain this, we undertook an Additive Bayesian Network analysis using data from 2014-15, covering 157 Danish sow herd...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
Conclusion: Formal consensus was achieved for the first time on a core list of knowledge items on how exercises and physical activities might stimulate anticancer immunity. This core list might be considered at the time of developing training/educational interventions and/or continuing education for primary healthcare providers and CAM practitioners. Future studies are still needed to investigate if such consensual lists might improve congruence in cancer care continuum and improve survival rates and wellbeing of cancer patients and survivors. PMID: 31118968 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Conclusion:   CoBaT-Y017 presented a significant safety and tolerability in healthy volunteers to allow its further development by starting a phase II clinical study. PMID: 31118966 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Authors: Oei SL, Thronicke A, Schad F Abstract In early tumor development, cancer cells develop a plethora of strategies to escape surveillance from the adaptive and innate immune system. Cancer immunotherapies, in particular immune checkpoint inhibitors, are becoming a highly promising cancer therapeutic approach that has remarkable increased progress in combating various cancer types. Unfortunately, their mechanisms of action induce some complications, such as inflammatory reactions and immune-related adverse events. In the management of side effects during anticancer therapy, complementary and integrative therap...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 25 May 2019Source: Biosensors and BioelectronicsAuthor(s): Shao Su, Qian Sun, Ling Wan, Xiaodan Gu, Dan Zhu, Yi Zhou, Jie Chao, Lianhui WangAbstractUltrasensitive detection of cancer biomarkers has shown great promise for precision medicine. Here, a triple signal amplification strategy was developed for analysis of carcinoembryonic antigen (CEA) by using MoS2-based nanocomposites. Gold nanoparticles-decorated molybdenum disulfide nanocomposite (MoS2-AuNPs) was used to construct the modified electrode and nanoprobe, which could efficiently amplify electrochemical signal due to its large su...
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
Publication date: Available online 24 May 2019Source: Molecular Aspects of MedicineAuthor(s): Ester Saus, Susana Iraola-Guzmán, Jesse R. Willis, Anna Brunet-Vega, Toni GabaldónAbstractThe gastrointestinal tract harbors most of the microbiota associated with humans. In recent years, there has been a surge of interest in assessing the relationships between the gut microbiota and several gut alterations, including colorectal cancer. Changes in the gut microbiota in patients suffering colorectal cancer suggest a possible role of host-microbe interactions in the origin and development of this malignancy and, at th...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Soft Matter, 2019, Accepted Manuscript DOI: 10.1039/C9SM00526A, PaperMatteo Campo, Simon Kaspar Schnyder, John Jairo Molina, Thomas Speck, Ryoichi Yamamoto The migration of cells is relevant for processes such as morphogenesis, wound healing, and invasion of cancer cells. In order to move, single cells deform cyclically. However, it is not... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
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