Join my unique protocol to eliminate Syndrome Zero

Today I want to talk to you about how to beat the most urgent public health threat of our time — a condition I call Syndrome Zero. This condition is at the root of almost every chronic disease we face today — including obesity, heart disease, cancer, Alzheimer’s, arthritis, high blood pressure, metabolic syndrome, diabetes and even hip fractures. It already afflicts billions of people on the planet — and within a matter of decades, it will see nearly every man, woman and child in America suffer from at least one chronic disease. The good news is that this plague is stoppable. But here’s the problem… Mainstream medicine has no clue how to treat it… Even the World Health Organization doesn’t know what to do about it. In a minute, you’ll learn how we have been reversing Syndrome Zero here at the Sears Institute for Anti-Aging Medicine — and some of the things you can start doing today to get off the path to chronic disease and back to robust health. You see, whenever you eat carbohydrates, insulin is released. But too much insulin production overwhelms the insulin receptors in your cells and makes them insulin-resistant. This results in dangerously high glucose levels — but it also overwhelms your body’s natural ability to produce cellular energy and fight disease. And these insulin spikes force your body to pack on the pounds through a process called lipogenesis — the conversion of carbohydrates int...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Alzheimer's arthritis Cancer diabetes heart disease high blood pressure hip fractures metabolic syndrome obesity Syndrome Zero Source Type: news

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SMAD4 is the only common SMAD in TGF-β signaling that usually impedes immune cell activation in the tumor microenvironment. However, we demonstrated here that selective deletion of Smad4 in NK cells actually led to dramatically reduced tumor cell rejection and augmented tumor cell metastases, reduced murine CMV clearance, as well as impeded NK cell homeostasis and maturation. This was associated with a downregulation of granzyme B (Gzmb), Kit, and Prdm1 in Smad4-deficient NK cells. We further unveiled the mechanism by which SMAD4 promotes Gzmb expression. Gzmb was identified as a direct target of a transcriptional com...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The stroma of solid tumors can exclude or limit immune infiltration, or lead to the recruitment of tumor-promoting rather than tumor-attacking immune cells. This finding was reported by Jayaprakash et al. in this issue of the JCI, and it was particularly prominent in the hypoxic zones of tumors in the transgenic adenocarcinoma of the mouse prostate (TRAMP) cancer models. A current clinical goal of immune checkpoint blockade (ICB) is to extend its utility to more patients by converting immunologically “cold” tumors that do not provoke a strong immunological response to “hot” tumors that are invaded b...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Despite the success of immune checkpoint blockade against melanoma, many “cold” tumors like prostate cancer remain unresponsive. We found that hypoxic zones were prevalent across preclinical prostate cancer and resisted T cell infiltration even in the context of CTLA-4 and PD-1 blockade. We demonstrated that the hypoxia-activated prodrug TH-302 reduces or eliminates hypoxia in these tumors. Combination therapy with this hypoxia-prodrug and checkpoint blockade cooperated to cure more than 80% of tumors in the transgenic adenocarcinoma of the mouse prostate–derived (TRAMP-derived) TRAMP-C2 model. Immunofluo...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The paper, titled 'Debt or Death?', used data on 9.5 million nationally-representative patients between 1998 and 2014, who spend an average of $92,098 a year trying to stay alive.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Source: Peerview CME/CE Video Podcast - Internal Medicine International - Category: Internal Medicine Authors: Tags: Science, Medicine Source Type: video
Conclusion: GSTP1 and CYPs expressions are increased in intracranial tumors. These results should be confirmed with larger series and different enzyme subtypes.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
The start-up ’s optofluidic system could help get personalized cancer cell therapies to more people
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Publication date: Available online 15 October 2018Source: European Journal of Surgical OncologyAuthor(s): Han-Yu Deng, Liang Hou, Panpan Zha, Kai-Li Huang, Lei PengAbstractBackgroundWhether sarcopenia has any impact on long-term survival of patients with surgically treated non-small cell lung cancer (NSCLC) remains unclear. We conducted a meta-analysis focusing on current topic comprehensively for the first time.MethodsWe systematically searched relevant studies in PubMed, Embase, and Cochrane Library up to July 3, 2018. Data of 5-year overall survival (OS) and disease-free survival (DFS) rates as well as hazard ratio (HR)...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Three-dimensional mammography screening detected 34 percent more breast cancer tumors than the traditional process of a single image, according to a study.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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