'Fat but fit' people may still be at risk of heart disease

Conclusion This large, valuable study confirms that – as has long been thought – an increased BMI is linked with an increased risk of heart disease. It shows that people with an obese BMI had a higher risk of heart disease, even if they didn't have other risk factors like high cholesterol and high blood pressure, proving that body fat is an independent risk factor. That said, this study does have some limitations. For example, definitions of being metabolically unhealthy aren't entirely consistent with other definitions of metabolic syndrome. This was also only assessed at the start of the study, and risk factors may have varied among individuals during follow-up. And not all participants in the centres across Europe were general population samples. They may have included a higher proportion of those with risk factors. Nevertheless, the study on the whole supports our understanding of the modifiable risk factors for heart disease, and shows that being obese in itself increases your risk, regardless of your metabolic health.        More importantly, it also shows it's possible to be "not fat but unfit" if your BMI is within the recommended range but you have one or more metabolic risk factors. The best way to prevent heart disease, reduce your BMI, and prevent or reverse the symptoms of metabolic syndrome are quitting smoking if you smoke, getting regular exercise, eating healthily, trying to achieve a...
Source: NHS News Feed - Category: Consumer Health News Tags: Obesity Source Type: news

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Publication date: Available online 14 July 2020Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): L. Khojastepour, M. Moannaei, H.R. Eftekharian, M.S. Khaghaninejad, M. Mahjoori-Ghasrodashti, S. Tavanafar
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 15 July 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): M.G. Rajanandh
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 13 July 2020Source: Canadian Journal of DiabetesAuthor(s): Yiting Wang, Fang Liu
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Conclusion: This is the first study that reported the altered expression of exosomal miR-34a among children and adolescents with T1DM. Moreover, association of miR-34a with markers of dyslipidemia and endothelial dysfunction was identified, suggesting that it could play a role in regulation of lipid metabolism and endothelial function in T1DM. PMID: 32654473 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research
Authors: Dourado M, Cavalcanti F, Vilar L, Cantilino A Abstract CKD has a high prevalence worldwide, mainly due to its main etiologies-diabetes and hypertension. It has high cardiovascular morbidity and mortality, with traditional risk factors such as atherosclerosis, hypertension, diabetes, smoking, and left ventricular hypertrophy being common. Nontraditional cardiovascular risk factors, such as anemia, hyperparathyroidism, chronic inflammation, and microalbuminuria, are also well studied. Prolactin is a hormone not only related to lactation but also being considered a uremic toxin by some authors. It accumulates...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Erratum to "Gastroenteropancreatic Neuroendocrine Neoplasia Characterization in Portugal: Results from the NETs Study Group of the Portuguese Society of Endocrinology, Diabetes and Metabolism". Int J Endocrinol. 2020;2020:9184324 Authors: Santos AP, Vinagre J, Soares P, Claro I, Sanches AC, Gomes L, Fernandes I, Catarino AL, Preto J, Pereira BD, Marques AP, Rodrigues F, Amaral C, Rocha G, Mellidez JC, Simões H, Lopes JM, Bugalho MJ, On Behalf Of The NETs Study Group Of The Portuguese Society Of Endocrinology Diabetes And Metabolism Abstract [This corrects the article DOI: 10.1155/2019/...
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Conclusions: Maternal serum TG/HDL levels at late gestation are positively associated with neonatal body weight and the risk of macrosomia in women without DM. Maintaining maternal lipid levels in an appropriate range is important in the context of fetal overgrowth and primary prevention of macrosomia. PMID: 32655633 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Publication date: Available online 14 July 2020Source: Seminars in Cancer BiologyAuthor(s): Rui Caetano Oliveira, Henrique Alexandrino, Maria Augusta Cipriano, Filipe Caseiro Alves, José Guilherme Tralhão
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Source Type: research
Conclusion: Currently, available evidence indicates that SMI, as an adjuvant for basic Western medicine treatment, can improve the cardiac function of patients with CHF with good safety outcomes. Because of the high risk of bias among the included RCTs and the large heterogeneity of partial outcomes, the findings of this study must be verified by high-quality studies with large sample sizes. PMID: 32655670 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
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