Antiepileptic drugs for chronic non-cancer pain in children and adolescents.
CONCLUSIONS: This review identified only two small studies, with insufficient data for analysis.As we could undertake no meta-analysis, we were unable to comment about efficacy or harm from the use of antiepileptic drugs to treat chronic non-cancer pain in children and adolescents. Similarly, we could not comment on our remaining secondary outcomes: Carer Global Impression of Change; requirement for rescue analgesia; sleep duration and quality; acceptability of treatment; physical functioning; and quality of life.We know from adult randomised controlled trials that some antiepileptics, such as gabapentin and pregabalin, can be effective in certain chronic pain conditions.We found no evidence to support or refute the use of antiepileptic drugs to treat chronic non-cancer pain in children and adolescents.
PMID: 28779491 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Cooper TE, Wiffen PJ, Heathcote LC, Clinch J, Howard R, Krane E, Lord SM, Sethna N, Schechter N, Wood C Tags: Cochrane Database Syst Rev Source Type: research
More News: Amitriptyline | Brain | Cancer | Cancer & Oncology | Cancer in Adolescents | Childhood Cancer | Children | Chronic Pain | Clinical Trials | Complex Regional Pain Syndrome | Databases & Libraries | Depression | Epilepsy | Fibromyalgia | Gabapentin | Gallstones | General Medicine | Genetics | Headache | International Medicine & Public Health | Lyrica | Men | Migraine | Neurology | Neurontin | Pain | Pediatrics | Sleep Disorders | Sleep Medicine | Study | WHO