New Study Shows Aspirin May Prevent Mesothelioma

Simple aspirin could be the key to preventing or delaying the growth of malignant mesothelioma for those who spent years working in high-risk occupations, a new report shows. Researchers at the University of Hawaii Cancer Center concluded the popular over-the-counter medication can inhibit the growth of mesothelioma tumor cells by blocking the inflammatory effects of a particular molecule that plays a critical role in the progression of the disease. Although the study used lab mice, its relevance already has reached the clinical stage. "The findings were very convincing. The aspirin worked really well. It increased survival [in mice] dramatically," associate professor of the school's thoracic oncology program, Dr. Haining Yang, told Asbestos.com. "For anyone at high risk for mesothelioma later in life, taking aspirin might be a good option in terms of prevention." The medical journal Cell Death &Disease published the study in June. Those at High Risk of Developing Mesothelioma People at high risk of exposure includes those with a genetic susceptibility to the disease, as well as those who worked in occupations where asbestos was prevalent such as construction, shipbuilding, military, insulation and automobile repair. Mesothelioma is caused primarily by exposure to toxic asbestos, the naturally occurring mineral used extensively throughout much of the 20th century. Asbestos was coveted for its ability to strengthen...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Treatment & Doctors Source Type: news

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Gantumur Battogtokh, Yong-Yeon Cho, Joo Young Lee, Hye Suk Lee, Han Chang Kang
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Authors: Schaefer A, Lubos E, Pietzsch JB, Pietzsch M, Weber S, Blankenberg S, Reichenspurner H, Schäfer U, Conradi L Abstract AIMS: The German healthcare system was among the first to introduce transcatheter mitral valve repair (TMVR) in routine care. Objective of this study was to analyze adoption and utilization patterns and to estimate impact of TMVR availability on mitral valve (MV) procedure volumes in the first 8 years after commercialization. METHODS AND RESULTS: Procedure volumes were collected from German Federal Statistics Office databases for TMVR and mitral valve surgery (MVS) from 2008-2015. ...
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
CONCLUSIONS: The Portico TAVI system allows safe and effective treatment of aortic stenosis in patients at increased surgical risk. At 30 days, mortality was low, and good haemodynamic performance was indicated by low transvalvular gradient and a low rate of moderate or higher PVL. PMID: 30111522 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
CONCLUSIONS: In the EXCEL trial, PCI of LM disease with TRA was associated with comparable early and late clinical outcomes as TFA. PMID: 30111521 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
PANCREATIC cancer symptoms can include weight loss, fatigue and poor digestion. But you could also be at risk of the deadly disease if your stools look like this, revealed ITV This Morning's Dr Zoe Williams. What does a healthy poo look like?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Oncol Res Treat
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research
Authors: Saud B, Paudel G Abstract Air pollution has been a major problem of 21st century for both developed and developing world. It has a negative impact on various environmental aspects which directly or indirectly affect the quality of human health. Nepal, especially Kathmandu, in the current situation, is observing rapid urbanization and various infrastructure development projects. As a result, these sorts of human activities have been responsible for increasing air pollution in an enormous rate inside Kathmandu Valley. Chronic exposure of deteriorated air increases the chance of Noncommunicable Disease (NCD) ...
Source: Journal of Environmental and Public Health - Category: Environmental Health Tags: J Environ Public Health Source Type: research
Advanced stage neuroblastoma is a very aggressive pediatric cancer with limited treatment options and a high mortality rate. Glycogen synthase kinase-3β (GSK-3β) is a potential therapeutic target in neuroblastoma. Using immunohistochemical staining, we observed positive GSK-3β expression in 67% of human neuroblastomas (34 of 51 cases). Chemically distinct GSK-3 inhibitors (AR-A014418, TDZD-8, and 9-ING-41) suppressed the growth of neuroblastoma cells, whereas 9-ING-41, a clinically relevant small-molecule GSK-3β inhibitor with broad-spectrum preclinical antitumor activity, being the most potent. Inhibit...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) functions as a crucial regulator of metastasis in lung cancer. The aim of this study is to unravel the underlying mechanisms of lncRNA MALAT1 in non-small-cell lung cancer (NSCLC). A cohort of 36 NSCLC tumor tissues and adjacent normal tissues was collected postoperatively from patients with NSCLC. qRT-PCR was performed to detect the expression of MALAT1 in both NSCLC tissues and cell lines. Cell migration and invasion were monitored by wound healing assay and transwell invasion assay. Western blot was used to detect the expression ...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
In this study, MAP30, a ribosome-inactivating protein reported to have apoptotic effects on cancer cells, was fused with S3, an epidermal growth factor receptor (EGFR)-targeting peptide. In addition, CsA was used to investigate whether it can further promote the apoptotic effects of S3 fused MAP30 (MAP30–S3). Our result showed that the internalization of FITC-labeled MAP30–S3 was increased significantly by S3 in HeLa cells. Unexpectedly, MAP30–S3 only showed a minor decrease in the viability of EGFR-overexpressing cancer cells, including HeLa, SMMC-7721, and MGC803 (IC50>5 μmol/l). However, 2...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research
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