CCR Grand Rounds: Lentiviral Gene Therapy for Blood Disorders: Wiskott-Aldrich Syndrome

CCR Grand Rounds “ Lentiviral Gene Therapy for Blood Disorders: Wiskott-Aldrich Syndrome ” Sung-Yun Pai, M.D.Chief and Senior Investigator Immune Deficiency Cellular Therapy ProgramCenter for Cancer Research, NCIFriday, May 10, 202412:00 – 1:00 p.m.Lipsett AmphitheaterAlso available to view via NIH Videocast.Dr. Sung-Yun Pai received her M.D. degree from Harvard Medical School where she worked in the laboratory of Dr. Barbara Bierer on the cellular biology of calcineurin and mechanism of action of cyclosporine, tacrolimus, and sirolimus. She trained in pediatrics at Boston Children ’ s Hospital and pediatric hematology-oncology at Boston Children ’ s Hospital and Dana-Farber Cancer Institute. There she performed post-doctoral work in the laboratories of Drs. Jeffrey Leiden, I-Cheng Ho, and Laurie Glimcher demonstrating the critical roles of the transcription factor GATA3 in thymocyte development, T helper 2 cell specification and function, as well as in CD8 T cells, invariant NK-T cells, and collaboratively in breast cancer and keratinocyte development. As faculty she specialized in clinical hematopoietic stem cell transplantation for children with inborn errors of immunity and led a research program focused on development, implementation, and analysis of clinical trials of transplantation and gene therapy for these disorders. She was appointed to Associate Professor at Harvard Medical School in 2016 and served as Associate Director then Co-Director of the Gene Ther...
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