Researchers unlock new answers in quest for safer, more effective opioid therapy

Researchers unlock new answers in quest for safer, more effective opioid therapy A University of Arizona Health Sciences study uncovered new ways in which Hsp90-inhibitor drugs in the spinal cord are showing promise as potential pain therapeutics. Today University of Arizona Health Sciencesnhg-042920_opioid_research_4516-hero-web.jpg New research led by John Streicher provides additional insight into one of the foundational mechanisms that supports the role of Hsp90 in pain relief, and the findings may open the door for increased effectiveness and lower dosage of opioids. Noelle Haro-Gomez/University of Arizona Health SciencesHealthAdaptationCollege of Medicine - TucsonDeterminationExpertsExploration Media contact(s)Blair Willis University of Arizona Health Sciencesbmw23@arizona.edu520-626-2101University of Arizona Health Sciences researchers are taking the foot off the brake in their quest to improve opioid therapy while decreasing its side effects.Led by  John Streicher, an associate professor in the Department of Pharmacology in the  UArizona College of Medicine – Tucson and a member of the UArizona Health Sciences Comprehensive Pain and Addiction Center, the researchers have expanded upon their previous research focused on one specific protein – heat shock protein 90, known as Hsp90 – and its role in opioid receptor activation and pain relief. Their prior investigations have found that inhibiting Hsp90 in signaling pathways in the spinal cord has an i...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research