Mitrix Bio Works on the Production of Mitochondria for Transplantation

One of the more practical near term approaches to address the age-related decline of mitochondrial function is transplantation of functional mitochondria. As an approach, it bypasses all of the remaining unknowns relating to the biochemistry of mitochondrial aging. Cells will take up whole mitochondria and make use of them, and early studies suggest that providing new mitochondria can improve tissue function when native mitochondria are impaired. It is likely that this improvement will last for only a limited time, as the same processes that degrade the function of mitochondria, such as a lack of effective mitophagy, will still operate on the new arrivals. If that limited time is a few months to a few years, that will nonetheless gives tissues a chance to restore themselves to some degree - and the therapy can always be repeated. The major focus of the few companies presently working towards this goal of mitochondrial transplantation is the development of practical methods of production of mitochondria. Ultimately, therapies for aging humans that replace mitochondria throughout the body will require enormous numbers of these organelles, and thus the development of a cost-effective means of manufacture at scale. Even producing enough mitochondria for demonstrations in mice proved to be an initial hurdle. It is interesting to see reports along the way in this process of development, such as the materials provided by Mitrix Bio, noted here. Academic papers will be forthco...
Source: Fight Aging! - Category: Research Authors: Tags: Longevity Industry Source Type: blogs