Mechanistic Understanding of the Antiviral Properties of Pistachios and Zeaxanthin against HSV-1
Viruses. 2023 Jul 29;15(8):1651. doi: 10.3390/v15081651.ABSTRACTThe search for alternative clinical treatments to fight resistance and find alternative antiviral treatments for the herpes simplex virus (HSV) is of great interest. Plants are rich sources of novel antiviral, pharmacologically active agents that provide several advantages, including reduced side effects, less resistance, low toxicity, and different mechanisms of action. In the present work, the antiviral activity of Californian natural raw (NRRE) and roasted unsalted (RURE) pistachio polyphenols-rich extracts was evaluated against HSV-1 using VERO cells. Two ...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Rosamaria Pennisi Paola Trischitta Maria Pia Tamburello Davide Barreca Giuseppina Mandalari Maria Teresa Sciortino Source Type: research

Mechanistic Understanding of the Antiviral Properties of Pistachios and Zeaxanthin against HSV-1
Viruses. 2023 Jul 29;15(8):1651. doi: 10.3390/v15081651.ABSTRACTThe search for alternative clinical treatments to fight resistance and find alternative antiviral treatments for the herpes simplex virus (HSV) is of great interest. Plants are rich sources of novel antiviral, pharmacologically active agents that provide several advantages, including reduced side effects, less resistance, low toxicity, and different mechanisms of action. In the present work, the antiviral activity of Californian natural raw (NRRE) and roasted unsalted (RURE) pistachio polyphenols-rich extracts was evaluated against HSV-1 using VERO cells. Two ...
Source: Herpes - August 26, 2023 Category: Infectious Diseases Authors: Rosamaria Pennisi Paola Trischitta Maria Pia Tamburello Davide Barreca Giuseppina Mandalari Maria Teresa Sciortino Source Type: research

Basking in the sun: how mosses photosynthesise and survive in Antarctica
Photosynth Res. 2023 Jul 29. doi: 10.1007/s11120-023-01040-y. Online ahead of print.ABSTRACTThe Antarctic environment is extremely cold, windy and dry. Ozone depletion has resulted in increasing ultraviolet-B radiation, and increasing greenhouse gases and decreasing stratospheric ozone have altered Antarctica's climate. How do mosses thrive photosynthetically in this harsh environment? Antarctic mosses take advantage of microclimates where the combination of protection from wind, sufficient melt water, nutrients from seabirds and optimal sunlight provides both photosynthetic energy and sufficient warmth for efficient metab...
Source: Cell Research - July 29, 2023 Category: Cytology Authors: Hao Yin Alicia V Perera-Castro Krystal L Randall Johanna D Turnbull Melinda J Waterman Jodie Dunn Sharon A Robinson Source Type: research

Viruses, Vol. 15, Pages 1651: Mechanistic Understanding of the Antiviral Properties of Pistachios and Zeaxanthin against HSV-1
a Sciortino The search for alternative clinical treatments to fight resistance and find alternative antiviral treatments for the herpes simplex virus (HSV) is of great interest. Plants are rich sources of novel antiviral, pharmacologically active agents that provide several advantages, including reduced side effects, less resistance, low toxicity, and different mechanisms of action. In the present work, the antiviral activity of Californian natural raw (NRRE) and roasted unsalted (RURE) pistachio polyphenols-rich extracts was evaluated against HSV-1 using VERO cells. Two different extraction methods, with or without n-...
Source: Viruses - July 29, 2023 Category: Virology Authors: Rosamaria Pennisi Paola Trischitta Maria Pia Tamburello Davide Barreca Giuseppina Mandalari Maria Teresa Sciortino Tags: Article Source Type: research

Molecules, Vol. 28, Pages 5438: Carotenoids and Fatty Acids Obtained from Paprika Capsicum annuum by Supercritical Carbon Dioxide and Ethanol as Co-Extractant
³Åºwik Paprika Capsicum annuum L. contains useful molecules such as carotenoids and polyunsaturated fatty acids, which are considered high-value functional and health ingredients. To obtain these compounds, paprika was extracted using different methods (Soxhlet, SC-CO2, and SC-CO2 with co-extractant) and at different parameters. The results showed that the carotenoid content decreased with the addition of the co-extractant while the fatty acid content and yield increased. It was found that the highest carotenoid content (capsanthin > β-carotene > capsorubin > zeaxanthin &am...
Source: Molecules - July 16, 2023 Category: Chemistry Authors: Dorota Kostrzewa Barbara Mazurek Marcin Kostrzewa Emilia J óźwik Tags: Article Source Type: research

AcMADS32 positively regulates carotenoid biosynthesis in kiwifruit by activating AcBCH1/2 expression
Int J Biol Macromol. 2023 May 22:124928. doi: 10.1016/j.ijbiomac.2023.124928. Online ahead of print.ABSTRACTFruits provide abundant carotenoid nutrients for humans, whereas the understanding of the transcriptional regulatory mechanisms of carotenoids in fruits is still limited. Here, we identified a transcription factor AcMADS32 in kiwifruit, which was highly expressed in the fruit, correlated with carotenoid content and localized in the nucleus. The silencing expression of AcMADS32 significantly reduced the content of β-carotene and zeaxanthin and expression of β-carotene hydroxylase gene AcBCH1/2 in kiwifruit, while tr...
Source: International Journal of Biological Macromolecules - May 24, 2023 Category: Biochemistry Authors: Hui Xia Zhiyi Lin Zunzhen He Yuqi Guo Xinling Liu Honghong Deng Minzhang Li Yue Xie Mingfei Zhang Jin Wang Xiulan Lv Qunxian Deng Xian Luo Yi Tang Lijin Lin Dong Liang Source Type: research

AcMADS32 positively regulates carotenoid biosynthesis in kiwifruit by activating AcBCH1/2 expression
Int J Biol Macromol. 2023 May 22:124928. doi: 10.1016/j.ijbiomac.2023.124928. Online ahead of print.ABSTRACTFruits provide abundant carotenoid nutrients for humans, whereas the understanding of the transcriptional regulatory mechanisms of carotenoids in fruits is still limited. Here, we identified a transcription factor AcMADS32 in kiwifruit, which was highly expressed in the fruit, correlated with carotenoid content and localized in the nucleus. The silencing expression of AcMADS32 significantly reduced the content of β-carotene and zeaxanthin and expression of β-carotene hydroxylase gene AcBCH1/2 in kiwifruit, while tr...
Source: International Journal of Biological Macromolecules - May 24, 2023 Category: Biochemistry Authors: Hui Xia Zhiyi Lin Zunzhen He Yuqi Guo Xinling Liu Honghong Deng Minzhang Li Yue Xie Mingfei Zhang Jin Wang Xiulan Lv Qunxian Deng Xian Luo Yi Tang Lijin Lin Dong Liang Source Type: research

Fluorescence Lifetime Imaging Ophthalmoscopy and the Influence of Oral Lutein/zeaxanthin Supplementation on Macular Pigment (FLOS) – A pilot study
Oral lutein (L) and zeaxanthin (Z) supplementation enhances macular pigment optical density (MPOD) and plays a protective role in the development of age-related macular degeneration (AMD). Fluorescence lifetime imaging ophthalmoscopy (FLIO) is a novel in vivo retinal imaging method that has been shown to correlate to classical MPOD measurements and might contribute to a metabolic mapping of the retina in the future. Our aim was to show that oral supplementation of L and Z affects the FLIO signal in a positive way, in patients with AMD. (Source: Clinical Nutrition ESPEN)
Source: Clinical Nutrition ESPEN - May 15, 2023 Category: Nutrition Authors: Damian Jaggi, Yasmin Solberg., Chantal Dysli., Joel Lincke., Oussama Habra., Adrian Wyss., Sebastian Wolf., Martin Zinkernagel. Tags: Original article Source Type: research

Characterization of pigment produced by high carotenoid yielding bacteria < em > Paracoccus marcusii < /em > RSPO1 and evaluation of its anti-diabetic, anti-microbial and antioxidant properties
Nat Prod Res. 2023 May 5:1-10. doi: 10.1080/14786419.2023.2208358. Online ahead of print.ABSTRACTHigh pigment producing bacteria was isolated and identified as Paracoccus marcusii RSPO1 using biochemical and 16s rRNA identification. Bacterial pigment production was optimised using parameters like inoculum size, nitrogen source, pH, temperature, and agitation speed. Carotenoids production was 7,240 ± 41 µg L-1 after optimization. The silica column purified pigment was characterized using UV-visible spectroscopy, TLC, FTIR, LC-ESI-MS and NMR, which revealed its composition as astaxanthin, zeaxanthin, ζ-carotene and β-zea...
Source: Natural Product Research - May 5, 2023 Category: Biochemistry Authors: Raj Naik Shilpa Gupte Source Type: research

Characterization of pigment produced by high carotenoid yielding bacteria < em > Paracoccus marcusii < /em > RSPO1 and evaluation of its anti-diabetic, anti-microbial and antioxidant properties
Nat Prod Res. 2023 May 5:1-10. doi: 10.1080/14786419.2023.2208358. Online ahead of print.ABSTRACTHigh pigment producing bacteria was isolated and identified as Paracoccus marcusii RSPO1 using biochemical and 16s rRNA identification. Bacterial pigment production was optimised using parameters like inoculum size, nitrogen source, pH, temperature, and agitation speed. Carotenoids production was 7,240 ± 41 µg L-1 after optimization. The silica column purified pigment was characterized using UV-visible spectroscopy, TLC, FTIR, LC-ESI-MS and NMR, which revealed its composition as astaxanthin, zeaxanthin, ζ-carotene and β-zea...
Source: Natural Product Research - May 5, 2023 Category: Biochemistry Authors: Raj Naik Shilpa Gupte Source Type: research

Characterization of pigment produced by high carotenoid yielding bacteria < em > Paracoccus marcusii < /em > RSPO1 and evaluation of its anti-diabetic, anti-microbial and antioxidant properties
Nat Prod Res. 2023 May 5:1-10. doi: 10.1080/14786419.2023.2208358. Online ahead of print.ABSTRACTHigh pigment producing bacteria was isolated and identified as Paracoccus marcusii RSPO1 using biochemical and 16s rRNA identification. Bacterial pigment production was optimised using parameters like inoculum size, nitrogen source, pH, temperature, and agitation speed. Carotenoids production was 7,240 ± 41 µg L-1 after optimization. The silica column purified pigment was characterized using UV-visible spectroscopy, TLC, FTIR, LC-ESI-MS and NMR, which revealed its composition as astaxanthin, zeaxanthin, ζ-carotene and β-zea...
Source: Natural Product Research - May 5, 2023 Category: Biochemistry Authors: Raj Naik Shilpa Gupte Source Type: research

Characterization of pigment produced by high carotenoid yielding bacteria < em > Paracoccus marcusii < /em > RSPO1 and evaluation of its anti-diabetic, anti-microbial and antioxidant properties
Nat Prod Res. 2023 May 5:1-10. doi: 10.1080/14786419.2023.2208358. Online ahead of print.ABSTRACTHigh pigment producing bacteria was isolated and identified as Paracoccus marcusii RSPO1 using biochemical and 16s rRNA identification. Bacterial pigment production was optimised using parameters like inoculum size, nitrogen source, pH, temperature, and agitation speed. Carotenoids production was 7,240 ± 41 µg L-1 after optimization. The silica column purified pigment was characterized using UV-visible spectroscopy, TLC, FTIR, LC-ESI-MS and NMR, which revealed its composition as astaxanthin, zeaxanthin, ζ-carotene and β-zea...
Source: Natural Product Research - May 5, 2023 Category: Biochemistry Authors: Raj Naik Shilpa Gupte Source Type: research

The zeaxanthin present in a tomato line rich in this carotenoid is as bioavailable as that present in the food sources richest in this xanthophyll
The objective was to compare the bioaccessibility and intestinal cell uptake efficiency of ZEA from Xantomato to that present in the richest sources of this compound. Bioaccessibility was assessed using in vitro digestions and uptake efficiency using Caco-2 cells. Xantomato ZEA bioaccessibility was not statistically different from that of common fruits and vegetables rich in this compound. Xantomato ZEA uptake efficiency (7.8%) was lower (P < 0.05) than that of orange pepper (10.6%) but not different from that of corn (6.9%). Therefore, the results of the in vitro digestion/Caco-2 cell model suggest that Xantomato ZEA c...
Source: Cell Research - April 29, 2023 Category: Cytology Authors: Lisa Morand-Laffargue Joseph Hirschberg Charlotte Halimi Charles Desmarchelier Patrick Borel Source Type: research

Oxidative balance score reflects vascular endothelial function of Chinese community dwellers
Conclusion: The decreasing OBS level was associated with low endothelial function and high oxidative stress. The dietary OBS, rather than the lifestyle OBS, was more closely associated with endothelial function. (Source: Frontiers in Physiology)
Source: Frontiers in Physiology - April 17, 2023 Category: Physiology Source Type: research

Inverse correlations between serum carotenoids and respiratory morbidity and mortality: the Third National Health and Nutrition Examination Survey
The objective was to evaluate the association between Serum carotenoid levels and respiratory morbidity and mortality in a nationally representative sample of US adults. Design: We assessed the association of serum carotenoid levels with respiratory morbidity and mortality using logistic regression and proportional hazards regression models. Meanwhile, a series of confounders were controlled in regression models and RCS, which included age, sex, race, marriage, education, income, drinking, smoking, regular exercise, BMI, daily energy intake, vitamin E, vitamin C, fruit intake, vegetable intake, diabetes, hypertension, asth...
Source: The British Journal of Nutrition - April 11, 2023 Category: Nutrition Authors: Ruiming Yang Ziteng Cao Xin Liu Mengjie Xiao Mengyao Li Yunyan Chen Luyao Chen Changhao Sun Xia Chu Qiang Ren Wei Wei Source Type: research