In Silico Screening of Some Active Phytochemicals to Identify Promising Inhibitors Against SARS-CoV-2 Targets
CONCLUSION: The present in silico screening study suggested that active phytomolecules from medicinal plants could inhibit SARS-CoV-2 targets. The elite docked compounds with drug-like properties have a harmless ADMET profile, which may help to develop promising COVID-19 inhibitors.PMID:37861016 | DOI:10.2174/0115701638243222230920051050 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 20, 2023 Category: Drugs & Pharmacology Authors: V Alagarsamy V Raja Solomon S Murugesan P Shyam Sundar M D Muzaffar-Ur-Rehman Ala Chandu A Dharshini Aishwarya B Narendhar M T Sulthana V Ravikumar Source Type: research
In Silico Screening of Some Active Phytochemicals to Identify Promising Inhibitors Against SARS-CoV-2 Targets
CONCLUSION: The present in silico screening study suggested that active phytomolecules from medicinal plants could inhibit SARS-CoV-2 targets. The elite docked compounds with drug-like properties have a harmless ADMET profile, which may help to develop promising COVID-19 inhibitors.PMID:37861016 | DOI:10.2174/0115701638243222230920051050 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 20, 2023 Category: Drugs & Pharmacology Authors: V Alagarsamy V Raja Solomon S Murugesan P Shyam Sundar M D Muzaffar-Ur-Rehman Ala Chandu A Dharshini Aishwarya B Narendhar M T Sulthana V Ravikumar Source Type: research
In Silico Screening of Some Active Phytochemicals to Identify Promising Inhibitors Against SARS-CoV-2 Targets
CONCLUSION: The present in silico screening study suggested that active phytomolecules from medicinal plants could inhibit SARS-CoV-2 targets. The elite docked compounds with drug-like properties have a harmless ADMET profile, which may help to develop promising COVID-19 inhibitors.PMID:37861016 | DOI:10.2174/0115701638243222230920051050 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - October 20, 2023 Category: Drugs & Pharmacology Authors: V Alagarsamy V Raja Solomon S Murugesan P Shyam Sundar M D Muzaffar-Ur-Rehman Ala Chandu A Dharshini Aishwarya B Narendhar M T Sulthana V Ravikumar Source Type: research
Serum carotenoid levels are positively associated with DNA methylation of thioredoxin-interacting protein
Conclusions: The findings of this study suggest that carotenoid intake may protect against age-related diseases by altering TXNIP DNA methylation status in men.PMID:37735933 | DOI:10.1024/0300-9831/a000791 (Source: International Journal for Vitamin and Nutrition Research)
Source: International Journal for Vitamin and Nutrition Research - September 22, 2023 Category: Nutrition Authors: Keisuke Maeda Hiroya Yamada Eiji Munetsuna Ryosuke Fujii Mirai Yamazaki Yoshitaka Ando Genki Mizuno Yoshiki Tsuboi Hiroaki Ishikawa Koji Ohashi Shuji Hashimoto Nobuyuki Hamajima Koji Suzuki Source Type: research
Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration
CONCLUSIONS: Moderate-certainty evidence suggests that antioxidant vitamin and mineral supplementation (AREDS: vitamin C, E, beta-carotene, and zinc) probably slows down progression to late AMD. People with intermediate AMD have a higher chance of benefiting from antioxidant supplements because their risk of progression is higher than people with early AMD. Although low-certainty evidence suggested little effect with lutein/zeaxanthin alone compared with placebo, exploratory subgroup analyses from one large American study support the view that lutein/zeaxanthin may be a suitable replacement for the beta-carotene used in th...
Source: Cochrane Database of Systematic Reviews - September 13, 2023 Category: General Medicine Authors: Jennifer R Evans John G Lawrenson Source Type: research
Characterization of an efficient CRISPR-iCas9 system in Yarrowia lipolytica for the biosynthesis of carotenoids
Appl Microbiol Biotechnol. 2023 Aug 29. doi: 10.1007/s00253-023-12731-w. Online ahead of print.ABSTRACTThe application of clustered regularly interspaced short palindromic repeats-Cas (CRISPR-Cas9) technology in the genetic modification of Yarrowia lipolytica is challenged by low efficiency and low throughput. Here, a highly efficient CRISPR-iCas9 (with D147Y and P411T mutants) genetic manipulation tool was established for Y. lipolytica, which was further utilized to integrate carotene synthetic key genes and significantly improve the target product yield. First, CRISPR-iCas9 could shorten the time of genetic modification ...
Source: Applied Microbiology and Biotechnology - August 29, 2023 Category: Microbiology Authors: Qi Hang Chen Ya Dan Qian Yong Jie Niu Ching Yuan Hu Yong Hong Meng Source Type: research
Characterization of an efficient CRISPR-iCas9 system in Yarrowia lipolytica for the biosynthesis of carotenoids
Appl Microbiol Biotechnol. 2023 Aug 29. doi: 10.1007/s00253-023-12731-w. Online ahead of print.ABSTRACTThe application of clustered regularly interspaced short palindromic repeats-Cas (CRISPR-Cas9) technology in the genetic modification of Yarrowia lipolytica is challenged by low efficiency and low throughput. Here, a highly efficient CRISPR-iCas9 (with D147Y and P411T mutants) genetic manipulation tool was established for Y. lipolytica, which was further utilized to integrate carotene synthetic key genes and significantly improve the target product yield. First, CRISPR-iCas9 could shorten the time of genetic modification ...
Source: Applied Microbiology and Biotechnology - August 29, 2023 Category: Microbiology Authors: Qi Hang Chen Ya Dan Qian Yong Jie Niu Ching Yuan Hu Yong Hong Meng Source Type: research
Characterization of an efficient CRISPR-iCas9 system in Yarrowia lipolytica for the biosynthesis of carotenoids
Appl Microbiol Biotechnol. 2023 Aug 29. doi: 10.1007/s00253-023-12731-w. Online ahead of print.ABSTRACTThe application of clustered regularly interspaced short palindromic repeats-Cas (CRISPR-Cas9) technology in the genetic modification of Yarrowia lipolytica is challenged by low efficiency and low throughput. Here, a highly efficient CRISPR-iCas9 (with D147Y and P411T mutants) genetic manipulation tool was established for Y. lipolytica, which was further utilized to integrate carotene synthetic key genes and significantly improve the target product yield. First, CRISPR-iCas9 could shorten the time of genetic modification ...
Source: Applied Microbiology and Biotechnology - August 29, 2023 Category: Microbiology Authors: Qi Hang Chen Ya Dan Qian Yong Jie Niu Ching Yuan Hu Yong Hong Meng Source Type: research
