Zeaxanthin prevents ferroptosis by promoting mitochondrial function and inhibiting the p53 pathway in free fatty acid-induced HepG2 cells
In this study, free fatty acid (FFA) induced HepG2 cells were used as a cell model for NAFLD. Our results suggest that ZEA exerts antioxidative and anti-inflammatory effects in FFA-induced HepG2 cells. Moreover, ZEA acted as a ferroptosis inhibitor, significantly reducing reactive oxygen species (ROS) generation and iron overload and improving mitochondrial dysfunction in FFA-induced HepG2 cells. In addition, ZEA downregulated the expression of p53 and modulated downstream targets, such as GPX4, SLC7A11, SAT1, and ALOX15, which contributed to the reduction in cellular lipid peroxidation. Our findings suggest that ZEA has t...
Source: Mol Biol Cell - January 23, 2023 Category: Molecular Biology Authors: Huimin Liu Jie Yan Fengtao Guan Zhibo Jin Jiahan Xie Chongrui Wang Meihong Liu Jingsheng Liu Source Type: research
Zeaxanthin prevents ferroptosis by promoting mitochondrial function and inhibiting the p53 pathway in free fatty acid-induced HepG2 cells
In this study, free fatty acid (FFA) induced HepG2 cells were used as a cell model for NAFLD. Our results suggest that ZEA exerts antioxidative and anti-inflammatory effects in FFA-induced HepG2 cells. Moreover, ZEA acted as a ferroptosis inhibitor, significantly reducing reactive oxygen species (ROS) generation and iron overload and improving mitochondrial dysfunction in FFA-induced HepG2 cells. In addition, ZEA downregulated the expression of p53 and modulated downstream targets, such as GPX4, SLC7A11, SAT1, and ALOX15, which contributed to the reduction in cellular lipid peroxidation. Our findings suggest that ZEA has t...
Source: Biochimica et Biophysica Acta - January 23, 2023 Category: Biochemistry Authors: Huimin Liu Jie Yan Fengtao Guan Zhibo Jin Jiahan Xie Chongrui Wang Meihong Liu Jingsheng Liu Source Type: research
Zeaxanthin prevents ferroptosis by promoting mitochondrial function and inhibiting the p53 pathway in free fatty acid-induced HepG2 cells
In this study, free fatty acid (FFA) induced HepG2 cells were used as a cell model for NAFLD. Our results suggest that ZEA exerts antioxidative and anti-inflammatory effects in FFA-induced HepG2 cells. Moreover, ZEA acted as a ferroptosis inhibitor, significantly reducing reactive oxygen species (ROS) generation and iron overload and improving mitochondrial dysfunction in FFA-induced HepG2 cells. In addition, ZEA downregulated the expression of p53 and modulated downstream targets, such as GPX4, SLC7A11, SAT1, and ALOX15, which contributed to the reduction in cellular lipid peroxidation. Our findings suggest that ZEA has t...
Source: Mol Biol Cell - January 23, 2023 Category: Molecular Biology Authors: Huimin Liu Jie Yan Fengtao Guan Zhibo Jin Jiahan Xie Chongrui Wang Meihong Liu Jingsheng Liu Source Type: research
Molecules, Vol. 28, Pages 858: Carotenoid Content and Profiles of Pumpkin Products and By-Products
nčić
The goal of this review is to provide an overview of the current findings on the major carotenoids and their content in pumpkin products and by-products. The content of total carotenoids and the composition of carotenoids in pumpkins depend mainly on the species and cultivar, pedoclimatic conditions, the part of the plant (pulp, peel or seed), extraction procedures and the type of solvent used for extraction. The major carotenoids identified in pumpkins were β-carotene, α-carotene, lutein and zeaxanthin. β-Carotene is the major carotenoid in most pumpkin species. The numbe...
Source: Molecules - January 15, 2023 Category: Chemistry Authors: Antonela Nin čević Grassino Suzana Rimac Brn čić Marija Badanjak Sabolovi ć Jana Šic Žlabur Roko Marovi ć Mladen Brn čić Tags: Review Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
Carotenoid components and their biosynthesis in a bud mutant of Shiranui mandarin ( < em > Citrus reticulata < /em > Blanco) with citrine flavedo
J Zhejiang Univ Sci B. 2023 Jan 15;24(1):94-100. doi: 10.1631/jzus.B2200431.ABSTRACTCarotenoids are secondary metabolite responsible for colored pigments in plants and microbes (Li et al., 2022). They are a class of C40 tetraterpenoids consisting of eight isoprenoid units, and can be classified into carotenes and xanthophylls on the basis of their functional groups (Saini et al., 2015). Carotenes can be linear (phytoene, phytofluene, and ζ-carotene) or branched (β-carotene and α-carotene). Xanthophylls comprise β,β-xanthophylls (β-cryptoxanthin, zeaxanthin, violaxanthins, and neoxanthin) and β,ε-x...
Source: J Zhejiang Univ Sci ... - January 12, 2023 Category: Science Authors: Xun Wang Jinqiu Huang Zongyan Yin Ke Xu Dong Jiang Lijin Lin Xiaoai Zhang Zhihui Wang Source Type: research
