Progress in Developing Pharmacologic Agents to Treat Bulimia Nervosa
AbstractThis paper reviews past and current progress in developing pharmacologic agents for the treatment of individuals with bulimia nervosa (BN). We searched the literature and clinical trial registries for compounds studied in BN, the related condition, binge eating disorder (BED), and preclinical models of binge-eating behavior. Drug classes evaluated included antidepressants, antiepileptic drugs, stimulants and other medications for attention-deficit/hyperactivity disorder, opioid antagonists, and weight loss agents, among others. The only available drugs with established efficacy in BN at this time include antidepres...
Source: CNS Drugs - December 6, 2018 Category: Neurology Source Type: research
The influence of hormone therapy with drospirenone-estradiol on endometrioid type endometrial cancer patients.
CONCLUSION: Postoperative hormone therapy with DRSP/E2 in EC survivors did not increase recurrence or the death rate.
PMID: 30022635 [PubMed - as supplied by publisher] (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - July 21, 2018 Category: OBGYN Tags: J Gynecol Oncol Source Type: research
The effects of different therapeutic modalities on cardiovascular risk factors in women with polycyst ıc ovary syndrome: A randomızed controlled study
This study was designed to evaluate the effects of 3 mg drospirenone/30 μg ethinyl estradiol (OC) alone or combined with 1700 mg metformin on metabolic risk factors. (Source: Taiwanese Journal of Obstetrics and Gynecology)
Source: Taiwanese Journal of Obstetrics and Gynecology - June 1, 2018 Category: OBGYN Authors: Serkan Bodur, Ozgur Dundar, Mine Kanat-Pektas, Mehmet Ferdi Kinci, Levent Tutuncu Tags: Original Article Source Type: research
A comparison of two different oral contraceptives in patients with severe primary dysmenorrhoea.
In this study, although there was no superiority in pain relief between the treatment groups, lower VAS scores and lower RI values of uterine arteries were seen after treatment. Both OCPs relieve pain in severe PD. There was no serious adverse effect in the patients. What the implications are of these findings for clinical practice and/or further research: Estradiol valerate/dienogest, which is a routinely prescribed drug for heavy menstrual bleeding in women who desire oral contraception, is as effective as ethinylestradiol/drospirenone in pain relief.
PMID: 29537325 [PubMed - as supplied by publisher] (Source: Jo...
Source: Journal of Obstetrics and Gynaecology - March 17, 2018 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
[Customization of hormonal contraception].
Authors: DE Leo V, Cianci A, DI Carlo C, Cappelli V, Fruzzetti F
Abstract
In the last few years new oral contraceptives have been marketed showing a better safety profile for women. They are the result of important changes made to the old compounds. As far as the estrogenic component, with the aim of decreasing side effects, the dose of ethinyl estradiol has been reduced and synthetic estrogens have been replaced by natural estradiol, further improving the safety profile. Also the progestin component in the last years has been changed in terms of dose, endocrine and metabolic characteristics. Levonorgestre...
Source: Minerva Ginecologica - January 20, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research
Simultaneous total occlusion of two coronary arteries associated with use of drospirenone-ethinyl estradiol (oral contraceptive).
In this report, a 33-year-old woman who had used drospirenone-ethinyl estradiol for 6 months was admitted with MI and symptoms of cardiogenic shock. Coronary angiography revealed the total occlusion of 2 coronary arteries and so percutaneous coronary intervention was performed. To the best of our knowledge, this is the first case report of simultaneous total occlusion of 2 coronary arteries associated with the use of drospirenone-ethinyl estradiol in the English-language medical literature.
PMID: 29339693 [PubMed - in process] (Source: Turk Kardiyoloji Dernegi arsivi)
Source: Turk Kardiyoloji Dernegi arsivi - January 1, 2018 Category: Cardiology Authors: Atmaca H, Köprülü D, Kiriş T, Zeren G, Şahin İ Tags: Turk Kardiyol Dern Ars Source Type: research
Endocrine disruptors affect larval zebrafish behavior: Testing potential mechanisms and comparisons of behavioral sensitivity to alternative biomarkers
Publication date: Available online 6 October 2017 Source:Aquatic Toxicology Author(s): Thomas W.K. Fraser, Abdolrahman Khezri, Anna M. Lewandowska-Sabat, Theodore Henry, Erik Ropstad Larval zebrafish (Danio rerio) are a tool for assessing endocrine disruption during early development. Here, we investigated the extent to which a simple light/dark behavioral test at five days post fertilization could compliment current methods within the field. We exposed fertilized embryos to hormones (17β-estradiol, testosterone, dihydrotestosterone, 11-ketotestosterone, thyroxine, triiodothyronine, progesterone, and hydrocortisone...
Source: Aquatic Toxicology - October 7, 2017 Category: Toxicology Source Type: research
Treatment of Premenstrual Breakthrough of Depression With Adjunctive Oral Contraceptive Pills Compared With Placebo
Conclusions: Findings from this small randomized trial suggest that OCP augmentation of antidepressants may not be effective for treating premenstrual breakthrough of depression. Future studies should target women established to have hormonal sensitivity prior to antidepressant therapy and those with fewer lifetime depressive episodes. (Source: Journal of Clinical Psychopharmacology)
Source: Journal of Clinical Psychopharmacology - August 31, 2017 Category: Psychiatry Tags: Brief Reports Source Type: research
Different inhibitory potential of sex hormones on NNK detoxification in vitro: A possible explanation for gender-specific lung cancer risk
In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication step of this tobacco-specific carcinogen. It is mediated by different carbonyl reductases of the SDR (CBR1 and 11 βHSD1) and AKR (AKR1B10, AKR1C1, AKR1C2 and AKR1C4) superfamilies. Inhibition constants of NNK reduction were determined with male (testosterone) and female (estradiol, progesterone) sex hormones and the contraceptives ethinylestradiol and drospirenone in A549 cells and with purified enzymes. (Source: Cancer Letters)
Source: Cancer Letters - July 22, 2017 Category: Cancer & Oncology Authors: Claudia Stapelfeld, Karolina-Theresa Neumann, Edmund Maser Tags: Original Article Source Type: research
Different inhibitory potential of sex hormones on NNK detoxification in vitro: a possible explanation for gender-specific lung cancer risk
In this study, we examined the inhibition of NNK reduction to NNAL, the first and most important detoxication step of this tobacco-specific carcinogen. It is mediated by different carbonyl reductases of the SDR (CBR1 and 11 βHSD1) and AKR (AKR1B10, AKR1C1, AKR1C2 and AKR1C4) superfamilies. Inhibition constants of NNK reduction were determined with male (testosterone) and female (estradiol, progesterone) sex hormones and the contraceptives ethinylestradiol and drospirenone in A549 cells and with purified enzymes. (Source: Cancer Letters)
Source: Cancer Letters - July 22, 2017 Category: Cancer & Oncology Authors: Claudia Stapelfeld, Karolina-Theresa Neumann, Edmund Maser Source Type: research
Pharmacodynamics of combined estrogen-progestin oral contraceptives: 2. Effects on hemostasis.
Abstract
INTRODUCTION: The pharmacodynamic effects of various combined oral estrogen-progestin combinations (COC) are examined for their components alone or in the various combined formulations. Special emphasis is given to products containing natural estrogens. Areas covered: Recent information on the effect of androgens, estrogens, progestins, as well as various COC combinations on the coagulation cascade will be reviewed aiming at providing an updated picture. The present article reviews hemostatic changes occurring during use of classic and modern combinations of estrogens (ethinyl estradiol, estradiol...
Source: Pharmacological Reviews - July 17, 2017 Category: Drugs & Pharmacology Authors: Farris M, Bastianelli C, Rosato E, Brosens I, Benagiano G Tags: Expert Rev Clin Pharmacol Source Type: research
Comparing the androgenic and estrogenic properties of progestins used in contraception and hormone therapy.
Abstract
Progestins used in endocrine therapies bind to multiple steroid receptors and are associated with several side-effects. It is thus important to understand the relationship between steroid receptor cross-reactivity and the side-effect profile of progestins. In cell lines that express negligible levels of steroid receptors, we report for the first time the binding affinities, potencies and efficacies of selected progestins from different generations determined in parallel. We show that the progestins bind to the androgen receptor (AR) with similar affinities to each other and progesterone, while non...
Source: Biochemical and Biophysical Research communications - July 12, 2017 Category: Biochemistry Authors: Louw-du Toit R, Perkins MS, Hapgood JP, Africander D Tags: Biochem Biophys Res Commun Source Type: research
Treatment of premenstrual dysphoria with continuous versus intermittent dosing of oral contraceptives: Results of a three ‐arm randomized controlled trial
ConclusionsThe study fails to replicate a uniquely beneficial effect of continuous COC on PMD. Additional work is needed to understand the psychosocial context bolstering the placebo response in women with PMD. (Source: Depression and Anxiety)
Source: Depression and Anxiety - July 1, 2017 Category: Psychiatry Authors: Tory A. Eisenlohr ‐Moul, Susan S. Girdler, Jacqueline L. Johnson, Peter J. Schmidt, David R. Rubinow Tags: RESEARCH ARTICLE Source Type: research
Estetrol combined with drospirenone: an oral contraceptive with high acceptability, user satisfaction, well-being and favourable body weight control.
CONCLUSIONS: The present study shows that 15 mg estetrol combined with 3 mg DRSP is associated with a high-user acceptability and satisfaction, and with a favourable body weight control.
PMID: 28641030 [PubMed - as supplied by publisher] (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - June 22, 2017 Category: Reproduction Medicine Authors: Apter D, Zimmerman Y, Beekman L, Mawet M, Maillard C, Foidart JM, Coelingh Bennink HJT Tags: Eur J Contracept Reprod Health Care Source Type: research
Heme-Nitrosylated Hemoglobin and Oxidative Stress in Women Consuming Combined Contraceptives. Clinical Application of the EPR Spectroscopy.
CONCLUSION: This cross-sectional cohort study demonstrates that a decrease of HbNO measured by quantitative EPR in human venous erythrocytes is correlated with the development of endothelial dysfunction under CPs consumption, in parallel with increased vascular oxidative stress.
PMID: 28392282 [PubMed - as supplied by publisher] (Source: Free Radical Biology and Medicine)
Source: Free Radical Biology and Medicine - April 6, 2017 Category: Biology Authors: Lobysheva II, van Eeckhoudt S, Rifahi A, Pothen L, Dei Zotti F, Beauloye C, Balligand JL Tags: Free Radic Biol Med Source Type: research
