Pharmacodynamics of combined estrogen-progestin oral contraceptives: 2. Effects on hemostasis.

Pharmacodynamics of combined estrogen-progestin oral contraceptives: 2. Effects on hemostasis. Expert Rev Clin Pharmacol. 2017 Jul 17;: Authors: Farris M, Bastianelli C, Rosato E, Brosens I, Benagiano G Abstract INTRODUCTION: The pharmacodynamic effects of various combined oral estrogen-progestin combinations (COC) are examined for their components alone or in the various combined formulations. Special emphasis is given to products containing natural estrogens. Areas covered: Recent information on the effect of androgens, estrogens, progestins, as well as various COC combinations on the coagulation cascade will be reviewed aiming at providing an updated picture. The present article reviews hemostatic changes occurring during use of classic and modern combinations of estrogens (ethinyl estradiol, estradiol, estradiol valerate and estetrol) and new progestins (desogestrel, gestodene, dienogest, drospirenone, nomegestrol acetate), compared to classic compounds, such as levonorgestrel. Both pro- and anti-coagulatory effects of COC in healthy women are detailed and possible links with incidence of thromboembolic events are discussed. Expert commentary: Overall, the picture is reassuring: the use of natural estrogens and of new generation progestins has reduced pro-coagulatory changes in healthy subjects, although the observed differences in the risk of venous thromboembolism between second and third generation progestins is still incompletely understood. At t...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Tags: Expert Rev Clin Pharmacol Source Type: research

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Authors: Burnham K, Reinert JP Abstract INTRODUCTION: The exact risk of developing a thromboembolic event (TEE) while using complement 1 esterase inhibitors (C1-INH) is currently undetermined for patients with hereditary angioedema (HAE). This systematic review aimed to define the potential risk of TEEs from these agents. AREAS COVERED: This evaluation covers publications examining or mentioning the risk of TEEs in association with C1-INHs. A systematic literature search was conducted utilizing PubMed, Scopus, and ProQuest. This review utilized search results through January 2020 and followed the PRISMA recomme...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Publication date: Available online 1 June 2020Source: Urology Case ReportsAuthor(s): Ibrahim Boukhannous, Tarik Mhanna, Amine EL. Houmaidi, Mohammed Aynaou, Mehdi Chennoufi, Ali Barki
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
In a recent issue of Annals, Cho et al investigated the risk of deep venous thrombosis after carbon monoxide poisoning. They found that it was significantly increased by 90 days after carbon monoxide poisoning. The authors used a cohort crossover design in...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Conditions:   Deep Venous Thrombosis;   Post Thrombotic Syndrome Interventions:   Combination Product: Catheter directed thrombolysis plus anticoagulation;   Drug: Anticoagulation Sponsor:   University of Toledo Health Science Campus Recruiting
Source: - Category: Research Source Type: clinical trials
Source: BMJ Comments - Category: General Medicine Source Type: forums
Editor's Summary by Angel Desai, MD, JAMA Fishbein Fellow, for the Journal of the American Medical Association's June 2, 2020 issue
Source: JAMA: This Week's Audio Commentary - Category: General Medicine Authors: Source Type: podcasts
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Han Liu, Ziqi Lu, Bingqing Lin, Janis Yaxian Zhan, Shuhua Gui, Wenpei Chen, Ping Tang, Peng Li, Wei Yang, Baoqin Lin
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Infection may be an acute precipitant of cardiovascular events. However, the relationships between different types of infection and cardiovascular events are less known. Our objective was to determine if exposure to infections of different organ systems in different time periods increases risk of myocardial infarction or venous thromboembolism.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Clinical Research Study Source Type: research
AbstractThe predictive value of and the influencing factors associated with early neurological improvement (ENI) among patients with acute basilar artery occlusion (BAO) have not been well studied. The present study aimed to evaluate whether ENI predicted a better functional outcome and to identify the influencing factors of ENI. We performed a prospective observational analysis among 187 patients with acute BAO who underwent endovascular treatment (EVT) in Beijing Tiantan Hospital from January 2012 to July 2018. ENI was defined as having a drop on the National Institutes of Health Stroke Scale (NIHSS) by 8 or more scores ...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
ConclusionCurrently no consensus regarding the prevention of VTE in pediatric trauma exists. Prospective application of PTS/EAST guidelines has been limited, likely due to poor quality of evidence and a reliance on post-injury metrics. Results of this survey suggest that further investigation is needed to more clearly define the risk of VTE in children, evaluate, and prospectively validate alternative scoring systems for VTE prevention in injured children.Level of evidenceN/A —Survey.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
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