Progress in Developing Pharmacologic Agents to Treat Bulimia Nervosa

AbstractThis paper reviews past and current progress in developing pharmacologic agents for the treatment of individuals with bulimia nervosa (BN). We searched the literature and clinical trial registries for compounds studied in BN, the related condition, binge eating disorder (BED), and preclinical models of binge-eating behavior. Drug classes evaluated included antidepressants, antiepileptic drugs, stimulants and other medications for attention-deficit/hyperactivity disorder, opioid antagonists, and weight loss agents, among others. The only available drugs with established efficacy in BN at this time include antidepressants (especially selective serotonin reuptake inhibitors [SSRIs]) and the antiepileptic topiramate, though the efficacy of these compounds is modest at best. The only medications we found currently receiving empirical study in people with BN were fluoxetine, other serotonergic antidepressants, intranasal naloxone, lisdexamfetamine dimesylate, phentermine –topiramate combination, the antiandrogenic oral contraceptive ethinyl estradiol plus drospirenone, and prazosin. Preclinical models suggest that nociceptin receptor antagonists, the selective serotonin 5-HT2C receptor agonist lorcaserin, monoamine stabilizers, and selective orexin-1 receptor anta gonists might be helpful. We found no evidence of a drug developed specifically for the treatment of individuals with BN. Future areas for research in the pharmacotherapy of BN are suggested. Importantly, un...
Source: CNS Drugs - Category: Neurology Source Type: research

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Publication date: Available online 12 December 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Naomi Tistarelli, Corrado Fagnani, Miriam Troianiello, Maria Antonietta Stazi, Walter AdrianiAbstractAttention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children worldwide, and also the recognition of its persistence into adulthood is increasing. While ADHD in childhood is highly heritable and mostly driven by familial factors, during adulthood it appears to show a lower heritability, even if there is not total agreement on this yet. This disorder often co-occurs with many othe...
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Conclusions: Studies on the prevalence rates of EDs in ADHD and ASD and vice versa are heterogeneous, but they indicate frequent association. While there is growing evidence of clinical overlaps between the three disorders, it remains difficult to determine whether overlapping characteristics (e.g., social withdrawal) are due to common comorbidities (e.g., depression) or are instead primarily associated with EDs and neurodevelopmental disorders. Furthermore, prospective studies are required to better understand how these disorders are related and whether ADHD and ASD could be either specific or nonspecific predisposing fac...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Yes: there are opiates that derive from various food proteins that exert peculiar effects on the human brain. The worst? The opiates that come from the gliadin protein of wheat and related grains. Opiate receptor researchers at the National Institutes of Health originally coined the term “gluteomorphin” nearly 40 years ago when it was determined that the gliadin protein of wheat undergoes partial digestion (since humans lack the digestive enzymes to fully digest proline-rich amino acid sequences in proteins from seeds of grasses) to yield peptides that are 4- to 5-amino acids long. Some of these peptides w...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Opioids addictive binge eating bulimia eating disorders Gliadin opiates wheat belly Source Type: blogs
We can link grain consumption with causing or worsening some of the most mysterious brain disorders that have eluded the medical community for years, such as schizophrenia, epilepsy, depression, bipolar disorder, and, more recently, autism and ADHD. Are you and your kids unknowingly under the influence of opiates? Opiates come disguised in many forms.   Grains contain opiates. Not figuratively, but quite literally. These opiates are not too different from morphine or heroin. Yes, wheat and grains, cleverly disguised as a multigrain loaf of bread to make sandwiches or a hot, steamy plate of macaroni and cheese for the ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates adhd bipolar disorder brain fog concentration Depression diy health Dr. Davis epilepsy grain-free headaches Inflammation mind mood swings OCD opiates schizophrenia undoctored wheat belly Wheat Belly Tot Source Type: blogs
We describe the effects of LDX (50mg and 70mg) on the Sheehan Disability Scale (SDS; exploratory endpoint) from both studies. Design: The SDS was assessed at baseline, Week 6, and Week 12/early termination. Analyses included mixed-effects models for repeated measures for the examination of SDS total and domain score changes and a generalized estimating equation model to assess dichotomized remission status (remission [total score ?6] versus nonremission [total score>6]). Results: Least squares (95% confidence interval [CI]) mean treatment differences for SDS total score change from baseline at Week 12 were -2.80 (-3.98,...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Drug Development Original Research binge eating disorder disability functionality lisdexamfetamine dimesylate Sheehan Disability Scale Source Type: research
CONCLUSIONS: In our study the comorbidity between ADHD and ED appeared to be frequent, particularly among patients with AN-BP. ED inpatients with higher level of anxiety and more abnormal eating attitudes and bulimic symptoms should be assessed for potentially associated ADHD. PMID: 28534123 [PubMed - as supplied by publisher]
Source: Eating and weight disorders : EWD - Category: Eating Disorders & Weight Management Authors: Tags: Eat Weight Disord Source Type: research
Very little is known about the prevalence of ADHD symptoms in Bulimia Nervosa and Binge Eating Disorder and even less in other eating disorders. This knowledge gap is of clinical importance since stimulant tre...
Source: BMC Psychiatry - Category: Psychiatry Authors: Source Type: research
DiscussionPeople with ADHD have a higher risk of comorbidity with an ED and people with an ED also have higher levels of comorbidity with ADHD. Future studies should address if patients with this comorbidity have a different prognosis, course and treatment response when compared to patients with either disorder alone. ResumenObjetivo: Ha habido interés en saber si la gente con Trastorno por Déficit de Atención e Hiperactividad (TDAH) están en mayor riesgo de desarrollar un Trastorno de la Conducta Alimentaria (TCA). El objetivo de este estudio fue estimar el tamaño de esta asociació...
Source: International Journal of Eating Disorders - Category: Eating Disorders and Weight Management Authors: Tags: Review Source Type: research
Abstract Few studies have assessed the association between attention‐deficit hyperactivity disorder (ADHD) and eating disorders (ED) separately in men and women, especially in representative samples. Using data from the National Comorbidity Survey Replication, lifetime and past 12‐month prevalence of Diagnostic and Statistical Manual of Mental Disorders IV, ADHD was compared in men and women with and without diagnoses of Diagnostic and Statistical Manual of Mental Disorders IV ED and any binge eating (BE) using logistic regression models adjusted for gender and age. In both sexes, those with lifetime and past 12‐mont...
Source: European Eating Disorders Review - Category: Eating Disorders and Weight Management Authors: Tags: Brief Report Source Type: research
Conclusion The SCIP is reliable and valid diagnostic interview, is compatible with experimental psychopathology and personalized psychiatry research, and is in line with the NIMH RDoC framework. The SCIP Instruction Manual is also available for download by visiting http://innovationscns.com/wp-content/uploads/SCIP_Instruction_Manual_2015.pdf. Acknowledgment Dr. Aboraya had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. References 1.     Stone M. Healing the Mind: A History of Psychiatry from Antiquity to the Present. In: ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools Current Issue Evaluations Psychiatry Reliability of Diagnoses Review Scales Trial Methodology descriptive psychopathology diagnostic criteria dimensional scores Psychiatric interview SCIP Standard for Clinicians Source Type: research
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