What We Know About the Effect of Psychotropic Drugs on Migrant Kids
A federal judge on Monday ruled that the government must obtain parental or guardian consent before administering psychotropic drugs—those that can affect the brain or behavior—to migrant children in its care. But plenty of questions still remain about what these drugs do to young brains in the first place. “The benefits or risks of psychotropic medications to brain development are only beginning to be evaluated,” says Dr. Manpreet Singh, director of the Pediatric Mood Disorders Program at Stanford University. “We haven’t actually looked, directly and in systematic ways, at the effects o...
Source: TIME: Health - July 31, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Drugs healthytime onetime Source Type: news

Migraine Prevention: Botox Wins, but Another Drug Enters the Ring Migraine Prevention: Botox Wins, but Another Drug Enters the Ring
An open-label study prefers Botox over topiramate, but a new migraine prophylactic drug has joined the market, raising options as well as questions.Medscape Internal Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 30, 2018 Category: Consumer Health News Tags: Internal Medicine Commentary Source Type: news

Fremanezumab May Offer Prevention for Refractory Migraine Fremanezumab May Offer Prevention for Refractory Migraine
A CGRP agent in development to prevent chronic migraine demonstrates efficacy in patients previously treated with topiramate or onabotulinumtoxinA.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 16, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Botox Tops Topiramate for Chronic Migraine Prevention Botox Tops Topiramate for Chronic Migraine Prevention
Researchers compared tolerability, functional improvement, and more in a head-to-head comparison between onabotulinumtoxinA and topiramate for chronic migraine prevention.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 16, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Chronic Migraine, Not Treatment, Tied to Cognitive Impairment Chronic Migraine, Not Treatment, Tied to Cognitive Impairment
New research evaluates the possible role of comorbidities and topiramate treatment in cognitive impairment in patients with chronic migraine.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 5, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Topiramate for Seizures in Preterm Newborns Linked With Necrotizing Enterocolitis Topiramate for Seizures in Preterm Newborns Linked With Necrotizing Enterocolitis
Out of 10 preterm neonates who received topiramate for seizures, four developed radiographic signs of necrotizing enterocolitis (NEC), according to researchers at the University of Miami Miller School of Medicine.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - June 21, 2018 Category: Intensive Care Tags: Pediatrics News Source Type: news

What Treatment is Recommended for Common Headaches?
Discussion Headache is pain in the scalp, forehead, orbits and temple. Facial and neck pain are usually excluded from this definition. It is a common problem with more than 6 million pediatric patients having migraine. Headaches can also have co-morbidities and more than 1 primary headache type can co-exist. The costs are high both economically and in the quality of life for the patients and families. A review of common headache types and indications for neuroimaging can be found here. Treatment is necessarily multi-pronged. Patients should understand their diagnosis so they can understand what reasonably can be expected...
Source: PediatricEducation.org - January 15, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Topiramate Dose in Mom Affects Oral Cleft Risk in Child Topiramate Dose in Mom Affects Oral Cleft Risk in Child
Higher doses of the drug taken early in pregnancy by women with epilepsy were associated with higher risk for oral clefts in offspring; lower doses used for other indications showed a weaker link.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 5, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

More proof prescriptions and pregnancy don’t mix: Epilepsy drug found to affect fetal development, causing cleft palate
(Natural News) In the last 10 years, topiramate, an anti-epileptic drug, has been increasingly prescribed to prevent seizures. It is also used to treat bipolar disorder and migraine headaches. Topiramate is also an ingredient for a weight-loss drug that was recently approved by the Food and Drug Administration (FDA). Earlier studies have determined that women who took topiramate... (Source: NaturalNews.com)
Source: NaturalNews.com - January 4, 2018 Category: Consumer Health News Source Type: news

Topiramate in early pregnancy increases risk of oral clefts
Risk of cleft lip or cleft palate is greater if mother takes a higher dose of the drug Related items fromOnMedica Adverse pregnancy outcomes far more likely in epilepsy Study reveals mental cost of epilepsy in pregnancy Cannabis derivative cannabidiol reduces seizures in severe epilepsy disorder New guidelines on epilepsy in pregnancy Epilepsy drug linked to 4,000 birth defects in France (Source: OnMedica Latest News)
Source: OnMedica Latest News - January 2, 2018 Category: UK Health Source Type: news

Risk of Oral Clefts with Topiramate May Be Dose-Dependent (CME/CE)
(MedPage Today) -- Higher doses tied to higher risk of cleft lip, palate (Source: MedPage Today Neurology)
Source: MedPage Today Neurology - December 30, 2017 Category: Neurology Source Type: news

The dangers of epilepsy drugs for pregnant women
Harvard Medical School researchers discovered that 12.3 children in every 1,000 are born with an oral cleft for mothers on high doses of topiramate, which is branded as Topamax. (Source: the Mail online | Health)
Source: the Mail online | Health - December 29, 2017 Category: Consumer Health News Source Type: news

Can Devices Replace Drugs for Migraine Treatment?
Migraine headache sufferers, particularly those who suffer from multiple debilitating episodes per month, can now ask their physicians about versatile non-pharmaceutical, non-invasive treatment devices that can both prevent migraines and lessen the severity of acute attacks. FDA has granted within the past few months expanded use clearance for two devices that work on the principle of neuromodulation. Interestingly enough, one of the devices, manufactured by Belgium-based Cefaly, had been cleared in 2014 for migraine prevention and was granted expanded approval for acute migraine treatment in November; the other, the Sprin...
Source: MDDI - December 29, 2017 Category: Medical Devices Authors: Greg Goth Tags: Electronics Source Type: news

Topiramate in early pregnancy increases risk of oral clefts
(Brigham and Women's Hospital) A new study by investigators from Brigham and Women's Hospital and the Harvard T.H. Chan School of Public Health suggest that using topiramate in early pregnancy, particularly at the high doses used for epilepsy, increases the risk of oral clefts. Their results are published in Neurology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 28, 2017 Category: International Medicine & Public Health Source Type: news

Epilepsy Drug Could Raise Birth Defect Risks
Researchers found that pregnant women with epilepsy who take the drug topiramate during their first trimester  may boost the risk that their child will be born with a cleft lip or cleft palate. (Source: WebMD Health)
Source: WebMD Health - December 27, 2017 Category: Consumer Health News Source Type: news

Epilepsy Drug, #Topiramate, Could Raise Birth Defect Risks
WEDNESDAY, Dec. 27, 2017 -- A common anti-seizure drug may pose a birth defect problem for pregnant women, a new study warns. Researchers found that pregnant women with epilepsy who take the drug topiramate during their first trimester may boost... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 27, 2017 Category: General Medicine Source Type: news

Epilepsy Drug, Topiramate, Could Raise Birth Defect Risks
WEDNESDAY, Dec. 27, 2017 -- A common anti-seizure drug may pose a birth defect problem for pregnant women, a new study warns. Researchers found that pregnant women with epilepsy who take the drug topiramate during their first trimester may boost... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 27, 2017 Category: General Medicine Source Type: news

Epilepsy Drug Could Raise Birth Defect Risks
WEDNESDAY, Dec. 27, 2017 -- A common anti-seizure drug may pose a birth defect problem for pregnant women, a new study warns. Researchers found that pregnant women with epilepsy who take the drug topiramate during their first trimester may boost the... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - December 27, 2017 Category: General Medicine Source Type: news

Does dosing of drug for mom make a difference for baby's risk of cleft lip, palate?
(American Academy of Neurology) Taking a higher dose of topiramate during the first three months of pregnancy may increase a baby's risk of cleft lip or cleft palate more than when taking a lower dose, according to a study published in the Dec. 27, 2017, online issue of Neurology ® , the medical journal of the American Academy of Neurology. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 27, 2017 Category: International Medicine & Public Health Source Type: news

Topiramate in Early Pregnancy Increases Risk of Oral Clefts
Study finds that taking a higher dose of the drug in the first trimester increases risk of cleft lip or cleft palate more than taking a lower dose. (Source: BWH for Journalists)
Source: BWH for Journalists - December 27, 2017 Category: Research Source Type: news

No magic pill to cure alcohol dependence yet
(Society for the Study of Addiction) A new study published by the scientific journal Addiction has found no reliable evidence for using nalmefene, naltrexone, acamprosate, baclofen or topiramate to control drinking in patients with alcohol dependence or alcohol use disorder. At best, some treatments showed low to medium efficacy in reducing drinking, but those findings were from studies with a high risk of bias. None demonstrated any benefit on health outcomes. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - September 21, 2017 Category: International Medicine & Public Health Source Type: news

Perampanel with concomitant levetiracetam and topiramate: post hoc analysis of adverse events related to hostility and aggression - Chung S, Williams B, Dobrinsky C, Patten A, Yang H, Laurenza A.
In 4 Phase III registration trials (3 in patients with partial seizures, N=1480; 1 in patients with PGTCS, N=163), perampanel administered to patients already receiving 1-3 concomitant antiepileptic drugs (AEDs) demonstrated statistically superior efficacy... (Source: SafetyLit)
Source: SafetyLit - August 24, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

FDA Drug Safety Communication: Risk of oral clefts in children born to mothers taking Topamax (topiramate)
[03-04-2011] The U.S. Food and Drug Administration (FDA) is informing the public of new data that show that there is an increased risk for the development of cleft lip and/or cleft palate (oral clefts) in infants born to women treated with Topamax (topiramate) during pregnancy. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 4, 2017 Category: Drugs & Pharmacology Source Type: news

Short-term adjunct of topiramate to antipsychotics in schizophrenia improves the psychopathology and has weight maintenance
This study included RCTs of antipsychotic cotreatment with topiramate in patients with schizophrenia-spectrum disorders (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 21, 2017 Category: Consumer Health News Source Type: news

Topamax (Topiramate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 26, 2017 Category: Drugs & Pharmacology Source Type: news

9 Surprising Reasons You Have A Headache
For Allure, by Cassie Shortsleeve. Headaches have a special kind of way of ruining even the best of days. And it seems just about anything (those super elegant candles you just splurged on, your aunt’s voice, that third glass of wine...) can cause finicky little beasts to start banging tambourines in your brain. If you feel like you have specific headache triggers, you probably do. Most headaches have them, but it can be difficult to pinpoint exactly what caused the paint to come on in the first place. “There are probably 1,000 causes of headaches,” says Mark W. Green M.D., director of headache and pain ...
Source: Healthy Living - The Huffington Post - April 17, 2017 Category: Consumer Health News Source Type: news

Qudexy XR (Topiramate Extended-Release Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 17, 2017 Category: Drugs & Pharmacology Source Type: news

Once-Daily Topiramate Approved for Migraine Prophylaxis Once-Daily Topiramate Approved for Migraine Prophylaxis
Extended-release capsules get the final FDA go-ahead for migraine prevention in both adults and adolescents aged 12 years and older who have migraine headaches.FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 31, 2017 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

FDA Approves Expanded Indication for Qudexy XR (topiramate) Extended-Release Capsules to Include Prophylaxis of Migraine Headache in Adults and Adolescents
MAPLE GROVE, Minn., March 30, 2017 /PRNewswire/ -- Upsher-Smith Laboratories, Inc. (Upsher-Smith) today announced that it has received U.S. Food and Drug Administration (FDA) final approval of two supplemental new drug applications (sNDAs) for... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 30, 2017 Category: Drugs & Pharmacology Source Type: news

Qsymia (Phentermine and Topiramate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 6, 2017 Category: Drugs & Pharmacology Source Type: news

Trokendi XR (Topiramate Extended-release Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 30, 2016 Category: Drugs & Pharmacology Source Type: news

Topiramate for acute affective episodes in bipolar disorder in adults
Bipolar disorder is a common recurrent illness with high levels of chronicity. Previous trials have suggested that the anticonvulsant topiramate may be efficacious in bipolar disorder. This is an update of a previous Cochrane review (last published 2006) on the role of topiramate in bipolar disorder. To assess the effects of topiramate for acute mood episodes in bipolar disorder in adults compared to placebo, alternative pharmacological treatment, and combination pharmacological treatment as measured by treatment of symptoms on specific rating scales for individual episodes. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 3, 2016 Category: Consumer Health News Source Type: news

Weight Loss Pills And Products Don't Work And Aren't Safe
Our ancestors lived in a feast or famine world. When you don't know where your next meal is coming from, or when it will arrive, the smart play is to pig out every time food is available. Our genes are programmed to extract as much energy as possible from what we eat and to store any extra energy in fat reservoirs, available in reserve for future famines. These deeply ingrained genetic tendencies worked great in the austere world of our ancestors, but are a disaster in our current world of refrigerators, ubiquitous fast food joints and milk shakes. Only one third of Americans are now able to maintain a normal weight; one ...
Source: Science - The Huffington Post - September 5, 2016 Category: Science Source Type: news

Newer epilepsy drugs may be safer during pregnancy
Steven Reinberg, HealthDay News Pregnant women who take the new epilepsy drugs levetiracetam and topiramate don't run the risk of harming their infant's mental development, researchers report. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 1, 2016 Category: Consumer Health News Source Type: news

No Effect on Cognition of Prenatal Exposure to Newer AEDs No Effect on Cognition of Prenatal Exposure to Newer AEDs
Prenatal exposure to levetiracetam or topiramate was not associated with lower IQ, expressive language, or verbal abilities in school-aged kids. The same was true for valproate, but only at low doses.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - September 1, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Newer Epilepsy Drugs May Be Safer During Pregnancy
THURSDAY, Sept. 1, 2016 -- Women who take the new epilepsy drugs levetiracetam and topiramate during pregnancy don't run the risk of harming their infant's mental development, British researchers report. But the commonly prescribed anti-seizure... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 1, 2016 Category: Journals (General) Source Type: news

' Tentative' FDA Nod to Trokendi XR for Migraine Prevention'Tentative' FDA Nod to Trokendi XR for Migraine Prevention
The agency granted tentative approval to expand the label for an extended-release topiramate product, already approved for epilepsy, to include prophylaxis of migraine in adults, pending expiry of pediatric exclusivity in 2017.FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - August 22, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

Topiramate for Patients With Migraine and Epilepsy Topiramate for Patients With Migraine and Epilepsy
Migraine is quite common in patients with epilepsy. Is the anti-epileptic drug topiramate a safe and effective option to treat patients with comorbid epilepsy and migraine?Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 16, 2016 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Phentermine-topiramate tops competition for long-term weight loss
SAN DIEGO – Phentermine-topiramate was the most effective long-term weight loss drug, based on findings from a network meta-analysis from the University of California, San Diego. The investigators... (Source: Clinical Endocrinology News)
Source: Clinical Endocrinology News - June 20, 2016 Category: Endocrinology Source Type: news

Phentermine-topiramate tops competition for long-term weight loss
SAN DIEGO – Phentermine-topiramate was the most effective long-term weight loss drug, based on findings from a network meta-analysis from the University of California, San Diego. The investigators... (Source: Family Practice News)
Source: Family Practice News - June 20, 2016 Category: Primary Care Source Type: news

Two Weight-Loss Drugs Have Highest Odds for 5% ReductionTwo Weight-Loss Drugs Have Highest Odds for 5% Reduction
Phentermine-topiramate and liraglutide were most likely among five obesity drugs approved by the FDA for long-term use to help people achieve a 5% weight loss over a year, a meta-analysis shows. Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - June 15, 2016 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

5 weight loss drugs that actually work in the US
Scientists at the University of California found of the drugs - orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide - the last two, marketed as Qsymia, Saxenda and Victoza were most effective. (Source: the Mail online | Health)
Source: the Mail online | Health - June 15, 2016 Category: Consumer Health News Source Type: news

Revealed... the 5 weight loss drugs that ACTUALLY work - helping obese people shed up to 20lbs in a year
Scientists at the University of California found of the drugs - orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide - the last two, marketed as Qsymia, Saxenda and Victoza were most effective. (Source: the Mail online | Health)
Source: the Mail online | Health - June 14, 2016 Category: Consumer Health News Source Type: news

Study compares effectiveness of weight-loss drugs
In an analysis that included nearly 30,000 overweight or obese adults, compared with placebo, orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were each associated with achieving at least 5 percent weight loss at 52 weeks, and phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss, according to a study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 14, 2016 Category: Science Source Type: news

Phentermine-topiramate shows best chance of weight loss at 1 year
The combination weight-loss drug phentermine plus topiramate is associated with the highest odds of individuals being able to lose 5% of their body weight within 1 year, according to a meta-analysis... (Source: Clinical Endocrinology News)
Source: Clinical Endocrinology News - June 14, 2016 Category: Endocrinology Source Type: news

Phentermine-topiramate shows best chance of weight loss at 1 year
The combination weight-loss drug phentermine plus topiramate is associated with the highest odds of individuals being able to lose 5% of their body weight within 1 year, according to a meta-analysis... (Source: Family Practice News)
Source: Family Practice News - June 14, 2016 Category: Primary Care Source Type: news

Pharmacotherapy Utilisation in Alcohol Dependence
The objectives of this project are: Use expert knowledge and systematic investigation to develop a case definition for alcohol dependence in CPRD; Compare treatment utilisation for patients with alcohol dependence; Explore factors that may influence the treatment pathway; Explore the national-level variation in the overall usage of medication for alcohol dependence; and Compare the attrition of drugs used in alcohol dependence as indexed by persistence of prescribing. Outline of Methods The data was sourced from the Clinical Practice Research Datalink (CPRD), a large database which contains anonymised primary c...
Source: Alcohol Research UK - June 8, 2016 Category: Addiction Authors: admin Tags: Alcohol Insights Source Type: news

Topiramate: a novel therapeutic candidate for diabetes and aggression ? Positron emission tomography (PET) findings - Yulug B, Hanoglu L, Tavlı AM, Cakir T, Olmuscelik O, Pakoz B, Ünlü G.
BACKGROUND: There is still limited knowledge regarding the role of impaired brain glucose metabolism in the generation of aggression during diabetes. Additionally, there are rapidly replicating piece of evidence suggesting that topiramate may exert signifi... (Source: SafetyLit)
Source: SafetyLit - March 11, 2016 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

FDA Drug Safety Communication: Risk of oral clefts in children born to mothers taking Topamax (topiramate)
[03-04-2011] The U.S. Food and Drug Administration (FDA) is informing the public of new data that show that there is an increased risk for the development of cleft lip and/or cleft palate (oral clefts) in infants born to women treated with Topamax (topiramate) during pregnancy. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 11, 2016 Category: Drugs & Pharmacology Source Type: news

Topiramate for Substance Use: Upside/DownsideTopiramate for Substance Use: Upside/Downside
Topiramate, which has shown promise as a treatment for substance use disorders, reduces the amount of cannabis users consume, but at the cost of increased adverse effects. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 26, 2016 Category: Consumer Health News Tags: Psychiatry News Source Type: news