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Perampanel with concomitant levetiracetam and topiramate: post hoc analysis of adverse events related to hostility and aggression - Chung S, Williams B, Dobrinsky C, Patten A, Yang H, Laurenza A.
In 4 Phase III registration trials (3 in patients with partial seizures, N=1480; 1 in patients with PGTCS, N=163), perampanel administered to patients already receiving 1-3 concomitant antiepileptic drugs (AEDs) demonstrated statistically superior efficacy... (Source: SafetyLit)
Source: SafetyLit - August 24, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

FDA Drug Safety Communication: Risk of oral clefts in children born to mothers taking Topamax (topiramate)
[03-04-2011] The U.S. Food and Drug Administration (FDA) is informing the public of new data that show that there is an increased risk for the development of cleft lip and/or cleft palate (oral clefts) in infants born to women treated with Topamax (topiramate) during pregnancy. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - August 4, 2017 Category: Drugs & Pharmacology Source Type: news

Short-term adjunct of topiramate to antipsychotics in schizophrenia improves the psychopathology and has weight maintenance
This study included RCTs of antipsychotic cotreatment with topiramate in patients with schizophrenia-spectrum disorders (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 21, 2017 Category: Consumer Health News Source Type: news

Topamax (Topiramate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 26, 2017 Category: Drugs & Pharmacology Source Type: news

9 Surprising Reasons You Have A Headache
For Allure, by Cassie Shortsleeve. Headaches have a special kind of way of ruining even the best of days. And it seems just about anything (those super elegant candles you just splurged on, your aunt’s voice, that third glass of wine...) can cause finicky little beasts to start banging tambourines in your brain. If you feel like you have specific headache triggers, you probably do. Most headaches have them, but it can be difficult to pinpoint exactly what caused the paint to come on in the first place. “There are probably 1,000 causes of headaches,” says Mark W. Green M.D., director of headache and pain ...
Source: Healthy Living - The Huffington Post - April 17, 2017 Category: Consumer Health News Source Type: news

Qudexy XR (Topiramate Extended-Release Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 17, 2017 Category: Drugs & Pharmacology Source Type: news

Once-Daily Topiramate Approved for Migraine Prophylaxis Once-Daily Topiramate Approved for Migraine Prophylaxis
Extended-release capsules get the final FDA go-ahead for migraine prevention in both adults and adolescents aged 12 years and older who have migraine headaches.FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 31, 2017 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

FDA Approves Expanded Indication for Qudexy XR (topiramate) Extended-Release Capsules to Include Prophylaxis of Migraine Headache in Adults and Adolescents
MAPLE GROVE, Minn., March 30, 2017 /PRNewswire/ -- Upsher-Smith Laboratories, Inc. (Upsher-Smith) today announced that it has received U.S. Food and Drug Administration (FDA) final approval of two supplemental new drug applications (sNDAs) for... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 30, 2017 Category: Drugs & Pharmacology Source Type: news

Qsymia (Phentermine and Topiramate) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - February 6, 2017 Category: Drugs & Pharmacology Source Type: news

Trokendi XR (Topiramate Extended-release Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - December 30, 2016 Category: Drugs & Pharmacology Source Type: news

Topiramate for acute affective episodes in bipolar disorder in adults
Bipolar disorder is a common recurrent illness with high levels of chronicity. Previous trials have suggested that the anticonvulsant topiramate may be efficacious in bipolar disorder. This is an update of a previous Cochrane review (last published 2006) on the role of topiramate in bipolar disorder. To assess the effects of topiramate for acute mood episodes in bipolar disorder in adults compared to placebo, alternative pharmacological treatment, and combination pharmacological treatment as measured by treatment of symptoms on specific rating scales for individual episodes. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - October 3, 2016 Category: Consumer Health News Source Type: news

Weight Loss Pills And Products Don't Work And Aren't Safe
Our ancestors lived in a feast or famine world. When you don't know where your next meal is coming from, or when it will arrive, the smart play is to pig out every time food is available. Our genes are programmed to extract as much energy as possible from what we eat and to store any extra energy in fat reservoirs, available in reserve for future famines. These deeply ingrained genetic tendencies worked great in the austere world of our ancestors, but are a disaster in our current world of refrigerators, ubiquitous fast food joints and milk shakes. Only one third of Americans are now able to maintain a normal weight; one ...
Source: Science - The Huffington Post - September 5, 2016 Category: Science Source Type: news

Newer epilepsy drugs may be safer during pregnancy
Steven Reinberg, HealthDay News Pregnant women who take the new epilepsy drugs levetiracetam and topiramate don't run the risk of harming their infant's mental development, researchers report. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 1, 2016 Category: Consumer Health News Source Type: news

No Effect on Cognition of Prenatal Exposure to Newer AEDs No Effect on Cognition of Prenatal Exposure to Newer AEDs
Prenatal exposure to levetiracetam or topiramate was not associated with lower IQ, expressive language, or verbal abilities in school-aged kids. The same was true for valproate, but only at low doses.Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - September 1, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Newer Epilepsy Drugs May Be Safer During Pregnancy
THURSDAY, Sept. 1, 2016 -- Women who take the new epilepsy drugs levetiracetam and topiramate during pregnancy don't run the risk of harming their infant's mental development, British researchers report. But the commonly prescribed anti-seizure... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - September 1, 2016 Category: Journals (General) Source Type: news

' Tentative' FDA Nod to Trokendi XR for Migraine Prevention'Tentative' FDA Nod to Trokendi XR for Migraine Prevention
The agency granted tentative approval to expand the label for an extended-release topiramate product, already approved for epilepsy, to include prophylaxis of migraine in adults, pending expiry of pediatric exclusivity in 2017.FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - August 22, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

Topiramate for Patients With Migraine and Epilepsy Topiramate for Patients With Migraine and Epilepsy
Migraine is quite common in patients with epilepsy. Is the anti-epileptic drug topiramate a safe and effective option to treat patients with comorbid epilepsy and migraine?Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 16, 2016 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Phentermine-topiramate tops competition for long-term weight loss
SAN DIEGO – Phentermine-topiramate was the most effective long-term weight loss drug, based on findings from a network meta-analysis from the University of California, San Diego. The investigators... (Source: Clinical Endocrinology News)
Source: Clinical Endocrinology News - June 20, 2016 Category: Endocrinology Source Type: news

Phentermine-topiramate tops competition for long-term weight loss
SAN DIEGO – Phentermine-topiramate was the most effective long-term weight loss drug, based on findings from a network meta-analysis from the University of California, San Diego. The investigators... (Source: Family Practice News)
Source: Family Practice News - June 20, 2016 Category: Primary Care Source Type: news

Two Weight-Loss Drugs Have Highest Odds for 5% ReductionTwo Weight-Loss Drugs Have Highest Odds for 5% Reduction
Phentermine-topiramate and liraglutide were most likely among five obesity drugs approved by the FDA for long-term use to help people achieve a 5% weight loss over a year, a meta-analysis shows. Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - June 15, 2016 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

5 weight loss drugs that actually work in the US
Scientists at the University of California found of the drugs - orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide - the last two, marketed as Qsymia, Saxenda and Victoza were most effective. (Source: the Mail online | Health)
Source: the Mail online | Health - June 15, 2016 Category: Consumer Health News Source Type: news

Revealed... the 5 weight loss drugs that ACTUALLY work - helping obese people shed up to 20lbs in a year
Scientists at the University of California found of the drugs - orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide - the last two, marketed as Qsymia, Saxenda and Victoza were most effective. (Source: the Mail online | Health)
Source: the Mail online | Health - June 14, 2016 Category: Consumer Health News Source Type: news

Study compares effectiveness of weight-loss drugs
In an analysis that included nearly 30,000 overweight or obese adults, compared with placebo, orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide were each associated with achieving at least 5 percent weight loss at 52 weeks, and phentermine-topiramate and liraglutide were associated with the highest odds of achieving at least 5 percent weight loss, according to a study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - June 14, 2016 Category: Science Source Type: news

Phentermine-topiramate shows best chance of weight loss at 1 year
The combination weight-loss drug phentermine plus topiramate is associated with the highest odds of individuals being able to lose 5% of their body weight within 1 year, according to a meta-analysis... (Source: Clinical Endocrinology News)
Source: Clinical Endocrinology News - June 14, 2016 Category: Endocrinology Source Type: news

Phentermine-topiramate shows best chance of weight loss at 1 year
The combination weight-loss drug phentermine plus topiramate is associated with the highest odds of individuals being able to lose 5% of their body weight within 1 year, according to a meta-analysis... (Source: Family Practice News)
Source: Family Practice News - June 14, 2016 Category: Primary Care Source Type: news

Pharmacotherapy Utilisation in Alcohol Dependence
The objectives of this project are: Use expert knowledge and systematic investigation to develop a case definition for alcohol dependence in CPRD; Compare treatment utilisation for patients with alcohol dependence; Explore factors that may influence the treatment pathway; Explore the national-level variation in the overall usage of medication for alcohol dependence; and Compare the attrition of drugs used in alcohol dependence as indexed by persistence of prescribing. Outline of Methods The data was sourced from the Clinical Practice Research Datalink (CPRD), a large database which contains anonymised primary c...
Source: Alcohol Research UK - June 8, 2016 Category: Addiction Authors: admin Tags: Alcohol Insights Source Type: news

Topiramate: a novel therapeutic candidate for diabetes and aggression ? Positron emission tomography (PET) findings - Yulug B, Hanoglu L, Tavlı AM, Cakir T, Olmuscelik O, Pakoz B, Ünlü G.
BACKGROUND: There is still limited knowledge regarding the role of impaired brain glucose metabolism in the generation of aggression during diabetes. Additionally, there are rapidly replicating piece of evidence suggesting that topiramate may exert signifi... (Source: SafetyLit)
Source: SafetyLit - March 11, 2016 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

FDA Drug Safety Communication: Risk of oral clefts in children born to mothers taking Topamax (topiramate)
[03-04-2011] The U.S. Food and Drug Administration (FDA) is informing the public of new data that show that there is an increased risk for the development of cleft lip and/or cleft palate (oral clefts) in infants born to women treated with Topamax (topiramate) during pregnancy. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 11, 2016 Category: Drugs & Pharmacology Source Type: news

Topiramate for Substance Use: Upside/DownsideTopiramate for Substance Use: Upside/Downside
Topiramate, which has shown promise as a treatment for substance use disorders, reduces the amount of cannabis users consume, but at the cost of increased adverse effects. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - January 26, 2016 Category: Consumer Health News Tags: Psychiatry News Source Type: news

Teens and medicines that cause birth defects: Do doctors drop the ball?
My 14-year-old daughter recently started taking isotretinoin, a medication that can help severe acne — and that can cause severe birth defects. I knew that there was a process in place for preventing pregnancy in girls taking it, but I was caught off guard by just how many hoops we had to jump through to get her prescription. There were two pregnancy tests a month apart at the beginning, continued monthly pregnancy tests as well as monthly online questions about contraception and her understanding of the effects of the medicine, and a special ID card that has to be brought to the pharmacy within a very short window a...
Source: New Harvard Health Information - January 19, 2016 Category: Consumer Health News Authors: Claire McCarthy, MD Tags: Children's Health Drugs and Supplements Family Planning and Pregnancy Parenting Source Type: news

Drug curbs marijuana use, but with tough side effects
Doctors have no approved medicine to help treat marijuana dependence and abuse, but in small new clinical trial, topiramate reduced the amount of cannabis heavy smokers used when they lit up. The results also show, however, that many volunteers couldn't tolerate the drug's side effects. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - January 14, 2016 Category: Science Source Type: news

Drug curbs marijuana use, but with tough side effects
(Brown University) Doctors have no approved medicine to help treat marijuana dependence and abuse, but in small new clinical trial topiramate reduced the amount of cannabis heavy smokers used when they lit up. The results also show, however, that many volunteers couldn't tolerate the drug's side effects. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 14, 2016 Category: Global & Universal Source Type: news

Topiramate in the Treatment of Alcohol Use DisordersTopiramate in the Treatment of Alcohol Use Disorders
What is the evidence for using topiramate for alcoholism? Medscape Pharmacists (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - October 1, 2015 Category: Psychiatry Tags: Psychiatry Ask the Expert Source Type: news

FDA Okays Topiramate ER (Qudexy) Monotherapy in Children FDA Okays Topiramate ER (Qudexy) Monotherapy in Children
Once-a-day capsules are now approved as initial monotherapy for children aged 2 years and up with partial-onset seizures or primary generalized tonic-clonic seizures. FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - June 4, 2015 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

Anticonvulsant May Trigger, Exacerbate Eating DisordersAnticonvulsant May Trigger, Exacerbate Eating Disorders
The anticonvulsant topiramate, which is approved to treat pediatric epilepsy, migraine, and migraine prevention, may trigger or exacerbate eating disorders in young at-risk patients. Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - April 10, 2015 Category: Psychiatry Tags: Psychiatry News Source Type: news

How One Woman Copes With Bipolar Disorder
In 'Letter to Joey,' I talk about the worries of living with my elderly mother, and how months of struggling to complete routine tasks and projects led me to realize I was suffering from bad side effects from Topamax. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - April 4, 2015 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

phentermine and topiramate extended-release (Qsymia)
Title: phentermine and topiramate extended-release (Qsymia)Category: MedicationsCreated: 2/23/2015 12:00:00 AMLast Editorial Review: 2/23/2015 12:00:00 AM (Source: MedicineNet Weight Management General)
Source: MedicineNet Weight Management General - February 23, 2015 Category: Eating Disorders and Weight Management Source Type: news

Obesity Drug Safety Debate Escalates in Medical Journal Obesity Drug Safety Debate Escalates in Medical Journal
Arguments and accusations fly as physicians and others debate the FDA's wisdom in approving lorcaserin and phentermine-topiramate. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 4, 2014 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Everything You Need to Know About Topamax/Topir...
Topamax - generic topiramate - is an anticonvulsant approved for use in treating epilepsy and migraine headaches. It is also frequently prescribed off-label for bipolar disorder. Information on uses, major warnings, and the effectiveness of Topamax for weight loss. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - July 24, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Migraines: How being switched to cheaper drugs could put you at risk
Alicia Ferrango, 45, first experienced migraines in her 30s, but her problems were kept at bay with Topamax until her GP prescribed a generic version of the drug. (Source: the Mail online | Health)
Source: the Mail online | Health - July 1, 2014 Category: Consumer Health News Source Type: news

Everything You Need to Know About Topamx/Topira...
Topamax - generic topiramate - is an anticonvulsant approved for use in treating epilepsy and migraine headaches. It is also frequently prescribed off-label for bipolar disorder. Information on uses, major warnings, and the effectiveness of Topamax for weight loss. (Source: About.com Bipolar Disorder)
Source: About.com Bipolar Disorder - May 3, 2014 Category: Psychiatry Authors: bipolar.guide at about.com Tags: health Source Type: news

Carey Danis & Lowe Launches Topamax Investigation
A pharmaceutical product liability litigation firm, Carey Danis & Lowe announced that they have launched an investigation into alleged Topamax related injuries following news that a Philadelphia...(PRWeb April 14, 2014)Read the full story at http://www.prweb.com/releases/carey-danis-lowe/topamax-settlement/prweb11753824.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - April 16, 2014 Category: Pharmaceuticals Source Type: news

Flood Law Group Now Available to Investigate Birth Defect Claims...
Flood Law Group today announced that they are available to investigate claims of birth defects such as cleft palates or cleft lips that could be related to the use of the prescription drug Topamax...(PRWeb April 02, 2014)Read the full story at http://www.prweb.com/releases/topamax-birth-defect/flood-law-group/prweb11722815.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - April 2, 2014 Category: Pharmaceuticals Source Type: news

Topamax Approval for Migraines Expanded to Younger Users
Title: Topamax Approval for Migraines Expanded to Younger UsersCategory: Health NewsCreated: 3/31/2014 12:36:00 PMLast Editorial Review: 4/1/2014 12:00:00 AM (Source: MedicineNet Migraine General)
Source: MedicineNet Migraine General - April 1, 2014 Category: Neurology Source Type: news

Topiramate Approved for Migraine Prevention in Adolescents (FREE)
By Amy Orciari Herman The FDA has approved the antiepileptic topiramate (Topamax) to prevent migraine in adolescents aged 12 to 17, the agency announced on Friday. It's the first drug approved for … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - March 31, 2014 Category: Primary Care Source Type: news

FDA Okays First Drug for Migraine Prevention in AdolescentsFDA Okays First Drug for Migraine Prevention in Adolescents
The FDA has approved topiramate for prophylaxis of migraine in adolescents aged 12 to 17, the first such approval for this age group. FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - March 29, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

FDA approves Topamax for migraine prevention in adolescents
Today, the U.S. Food and Drug Administration approved Topamax (topiramate) for prevention (prophylaxis) of migraine headaches in adolescents ages 12 to 17. This is the first FDA approval of a drug for migraine prevention in this age group. The medication is taken on a daily basis to reduce the frequency of migraine headaches. (Source: Food and Drug Administration)
Source: Food and Drug Administration - March 28, 2014 Category: American Health Source Type: news

Qudexy XR (Topiramate Extended-Release Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 28, 2014 Category: Drugs & Pharmacology Source Type: news

FDA Okays Another Extended-Release Topiramate for Epilepsy FDA Okays Another Extended-Release Topiramate for Epilepsy
FDA has approved another once-daily extended-release formulation of topiramate (Qudexy XR), this one for children as young as 2 years and in the form of capsules that can be opened and the contents sprinkled on food. FDA Approvals (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 13, 2014 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Upsher-Smith's antiepileptic drug Qudexy XR gets FDA approval
Upsher-Smith Laboratories (Upsher-Smith) has secured approval from the US Food and Drug Administration (FDA) for Qudexy XR (topiramate) extended-release capsules, indicated as initial monotherapy in patients ten years or older with partial-onset seiz… (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - March 13, 2014 Category: Pharmaceuticals Source Type: news