Sex hormones reduce NNK detoxification through inhibition of short-chain dehydrogenases/reductases and aldo-keto reductases in vitro
Publication date: Available online 28 February 2017 Source:Chemico-Biological Interactions Author(s): Claudia Stapelfeld, Edmund Maser Carbonyl reduction is an important metabolic pathway for endogenous and xenobiotic substances. The tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, nicotine-derived nitrosamine ketone) is classified as carcinogenic to humans (IARC, Group 1) and considered to play the most important role in tobacco-related lung carcinogenesis. Detoxification of NNK through carbonyl reduction is catalyzed by members of the AKR- and the SDR-superfamilies which include AKR1B...
Source: Chemico Biological Interactions - February 28, 2017 Category: Biochemistry Source Type: research
Sex hormones reduce NNK detoxification through inhibition of short-chain dehydrogenases/reductases and aldo-keto reductases in vitro.
Abstract
Carbonyl reduction is an important metabolic pathway for endogenous and xenobiotic substances. The tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, nicotine-derived nitrosamine ketone) is classified as carcinogenic to humans (IARC, Group 1) and considered to play the most important role in tobacco-related lung carcinogenesis. Detoxification of NNK through carbonyl reduction is catalyzed by members of the AKR- and the SDR-superfamilies which include AKR1B10, AKR1C1, AKR1C2, AKR1C4, 11β-HSD1 and CBR1. Because some reductases are also involved in steroid metabolism, ...
Source: Chemico-Biological Interactions - February 27, 2017 Category: Molecular Biology Authors: Stapelfeld C, Maser E Tags: Chem Biol Interact Source Type: research
Cervicovaginal agenesis treated with modified Yang-Monti technique in two steps: Case report and literature review
Conclusion The two-steps modified Yang-Monti technique represents a safe alternative for the management of cervicovaginal agenesis. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - January 19, 2017 Category: Surgery Source Type: research
Pooled analysis of two randomized, open-label studies comparing the effects of nomegestrol acetate/17 β-estradiol and drospirenone/ethinyl estradiol on bleeding patterns in healthy women
To obtain more precise and detailed information regarding the bleeding patterns of nomegestrol acetate (NOMAC)/17 β-estradiol (E2) and drospirenone/ethinyl estradiol (DRSP/EE) and to identify whether baseline demographic characteristics were associated with unscheduled bleeding, absent scheduled bleeding, or amenorrhea. (Source: Contraception)
Source: Contraception - December 20, 2016 Category: OBGYN Authors: Diana Mansour, Carolyn Westhoff, Uma Kher, Tjeerd Korver Tags: Original Research Source Type: research
Pharmacodynamics of combined estrogen-progestin oral contraceptives: Effects on metabolism.
Authors: Bastianelli C, Farris M, Rosato E, Brosens I, Benagiano G
Abstract
INTRODUCTION: The risk-benefit profile of any pharmacologic agent must be evaluated against risks connected with the events to be avoided. This is especially true in the case of hormonal contraception, not intended to combat a disease. Over the six decades during which their use has progressively expanded, the risk-benefit profile of combined oral contraceptives (COC) has substantially changed, with new combinations, dosages and mode of administration appearing on the market. Area covered: In a series of articles, recent informatio...
Source: Expert Review of Clinical Pharmacology - December 17, 2016 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Effect of hormone replacement therapy with the anti-mineralocorticoid progestin Drospirenone compared to tibolone on endothelial function and central haemodynamics in post-menopausal women
Drospirenone (DRSP) is an antialdosterone agent with progestogenic and antiandrogenic effects. This compound, has been recently used in combination with 17 ß-estradiol (E2) as hormonal therapy in postmenopausal women and has been shown to exert a significant antihypertensive effect in hypertensive post-menopausal women. Aim of the present study was to compare the effect of DRSP/E2 with those of Tibolone (T) on endothelial function, arterial stiffness, and lipid profile of early postmenopausal women naïve on post-menopausal hormonal therapy.Twenty-four women met the inclusion criteria and entered the study. (Source: Inter...
Source: International Journal of Cardiology - November 7, 2016 Category: Cardiology Authors: Cristiana Vitale, Caterina Mammi, Marco Gambacciani, Novella Russo, Ilaria Spoletini, Massimo Fini, Maurizio Volterrani, Giuseppe M.C. Rosano Source Type: research
Myo-Inositol in the Treatment of Teenagers Affected by PCOS.
Conclusions. Administration of MI is a safe and effective method to prevent and correct metabolic disorders in teenagers affected by PCOS. With combination of MI and OCPs antiandrogenic effects are enhanced, negative impact of OCPs on weight gain is balanced, and metabolic profile is improved.
PMID: 27635134 [PubMed] (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - September 18, 2016 Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Low-dose oral contraceptive-induced acute myocardial infarction.
CONCLUSION: Low-dose OCs may also be responsible for acute MI even in a very young female without any cardiovascular risk factors. Therefore, the clinicians should be aware of this mortal events during follow-up of the patient using OCs.
PMID: 27608962 [PubMed - as supplied by publisher] (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - September 8, 2016 Category: Reproduction Medicine Authors: Aslan AN, Süygün H, Sivri S, Keleş T Tags: Eur J Contracept Reprod Health Care Source Type: research
Reduced haemostatic effects with drospirenone-based oral contraceptives containing estetrol versus ethinyl estradiol
The effects of estetrol (E4), a natural foetal estrogen, combined with drospirenone (DRSP) were evaluated on plasma levels of Sex Hormone Binding Globulin (SHBG), angiotensinogen and 12 haemostasis markers. (Source: Contraception)
Source: Contraception - August 31, 2016 Category: OBGYN Authors: Cornelis Kluft, Yvette Zimmerman, Marie Mawet, Christine Klipping, Ingrid J.M. Duijkers, Jacoline Neuteboom, Jean-Michel Foidart, Herjan Coelingh Bennink Tags: Original research article Source Type: research
Reduced hemostatic effects with drospirenone-based oral contraceptives containing estetrol vs. ethinyl estradiol
The effects of estetrol (E4), a natural fetal estrogen, combined with drospirenone (DRSP) were evaluated on plasma levels of sex hormone-binding globulin (SHBG), angiotensinogen and 12 hemostasis markers. (Source: Contraception)
Source: Contraception - August 31, 2016 Category: OBGYN Authors: Cornelis Kluft, Yvette Zimmerman, Marie Mawet, Christine Klipping, Ingrid J.M. Duijkers, Jacoline Neuteboom, Jean-Michel Foidart, Herjan Coelingh Bennink Tags: Original research article Source Type: research
Comparative study of the therapeutic effects of Drospirenone (DRSP, 3 mg) with Ethinyl Estradiol (EE, 20 mcg) pill with or without Metformin 500 mg in polycystic ovary syndrome (PCOS)
To compare the therapeutic effects of Drospirenone (DRSP,3 mg) with Ethinyl Estradiol (EE,20 mcg) pill with or without Metformin (500 mg) in polycystic ovary syndrome (PCOS) patients at 6 and 12 months of treatment. (Source: Fertility and Sterility)
Source: Fertility and Sterility - August 31, 2016 Category: Reproduction Medicine Authors: S.M. Bhattacharya, B. Biswas, A. Basu Tags: Poster session Source Type: research
A multicentre, open-label, randomised phase III study comparing a new levonorgestrel intrauterine contraceptive system (LNG-IUS 8) with combined oral contraception in young women of reproductive age.
CONCLUSIONS: LNG-IUS 8 and EE/DRSP were associated with similarly high user satisfaction rates. However, LNG-IUS 8 users were significantly more likely to prefer to continue their contraceptive method post-study, indicating that a levonorgestrel intrauterine system is an appealing contraceptive option for young women.
PMID: 27494570 [PubMed - as supplied by publisher] (Source: The European Journal of Contraception and Reproductive Health Care)
Source: The European Journal of Contraception and Reproductive Health Care - August 4, 2016 Category: Reproduction Medicine Authors: Borgatta L, Buhling KJ, Rybowski S, Roth K, Rosen K Tags: Eur J Contracept Reprod Health Care Source Type: research
Superior Mesenteric Vein Thrombosis Associated with Hormonal Contraceptive Use
A 44-year-old woman was admitted with a 7-day history of lower abdominal pain and nausea. Physical examination demonstrated tenderness in the lower abdomen without signs of peritonitis. There were no specific findings in the laboratory evaluation. She had a history of dysmenorrhea for 15 years and was taking a combined hormonal contraceptive containing 0.02 mg ethinyl estradiol and 3 mg drospirenone for 19 months. Contrast-enhanced computed tomography showed superior mesenteric vein thrombosis (SMVT). Systemic anticoagulant infusion was immediately administered and the symptoms disappeared within 2 days. The thrombus disap...
Source: Case Reports in Gastroenterology - June 6, 2016 Category: Gastroenterology Source Type: research
Effect of combined drospirenone with estradiol for hypertensive postmenopausal women: a systemic review and meta-analysis
10.1080/09513590.2016.1183629Xu Zhao (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - May 12, 2016 Category: Endocrinology Authors: Xu ZhaoXiao-Fang ZhangYang ZhaoXin LinNing-Yin LiGanesh PaudelQiong-Ying WangXiao-Wei ZhangXiu-Li LiJing Yu Source Type: research
Effects of drospirenone on adhesion molecule expression and monocyte adherence in human endothelial cells
Conclusions DRSP did not increase the expression of adhesion molecules or monocytoid cell adherence to endothelial cells, indicating that DRSP could reduce the risk of atherogenesis caused by MPA. These results suggest that DRSP may be an alternative to MPA in hormone replacement therapy. (Source: European Journal of Obstetrics and Gynecology and Reproductive Biology)
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - April 6, 2016 Category: OBGYN Source Type: research
