New evidences and clarifications by world leaders in maternal fetal medicine.
Authors: Sisti G Abstract PMID: 30547497 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - December 14, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Histological evaluation of the prevalence of adenomyosis, myomas and of their concomitance.
The objective of this study is to evaluate the prevalence of adenomyosis, leiomyomas and of their concomitance in women who underwent hysterectomy. METHODS: An observational study carried out on a cohort of 347 women who underwent hysterectomy from a sample of 2383 patients who had gynecological surgery for benign disease in a single University Hospital between 2013 and 2016. An histological evaluation of all surgical specimens was carried out for the presence of adenomyosis and leiomyomas. Prevalence of adenomyosis alone, of leiomyomas alone or of their concomitance was evaluated. RESULTS: In 140 women, indication...
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Knowledge and attitudes of midwives regarding reprotoxic agents during pregnancy: snapshot of the Marseille area, southern France.
Authors: Sunyach C, Didierjean H, Bretelle F, Perrin J, Courbiere B Abstract PMID: 30486634 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Updates on the management of placenta accreta spectrum.
Authors: Di Mascio D, Calì G, D'antonio F Abstract Placenta accreta spectrum (PAS) disorders is a multifactorial process that encompasses a heterogeneous group of conditions characterized by an abnormal invasion of trophoblastic tissue through the myometrium and uterine serosa. PAS is associated with a high burden of adverse maternal outcomes including severe life-threatening hemorrhage, need for blood transfusion, damage to adjacent organs, and death. Prenatal screening of PAS is mandatory so that women may be counselled about the severity of this condition to plan management with a multidisciplinary team a...
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Cumulative live birth rates in IVF.
CONCLUSIONS: Cumulative LBR are a more suitable are more comprehensive when reporting success in an IVF program. Cumulative LBR increase with the number of oocytes retrieved, suggesting that ovarian stimulation may have a minimal or no detrimental effect on oocyte/embryo quality. PMID: 30486636 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Fetoscopic spina bifida repair.
CONCLUSIONS: Continued refinement of a minimally invasive strategy for prenatal treatment of spina bifida is necessary to maximize benefits to the child and further minimize maternal risks and preterm birth. PMID: 30486637 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Uterine transposition technique: update and review.
Authors: Ribeiro R, Baiocchi G, Tsunoda AT, Linhares JC, Pareja R Abstract To review and discuss the uterine transposition technique for preserving fertility in patients who require pelvic radiotherapy. Uterine transposition was developed from adapting well-established surgical techniques with the goal of keeping the uterus and adnexa outside the radiotherapy field in order to preserve their function. The uterine transposition technique is presented step by step, with discussion of the literature that served as the basis for the technique's development. Its most recent modifications, resulting from the authors' exp...
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Evaluation of safety and skin tolerability of organic cotton pads in case of irritative vulvitis.
CONCLUSIONS: Results demonstrated that organic cotton pads, in each part, are safe and do not impair any physiological activities of the tissue substrates. PMID: 30465412 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 23, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Is fertility sparing surgery a treatment option for young patients with yolk sac tumor?
We present a narrative review of the multispecialty fertility sparing surgical and medical approach of women with YST. PMID: 30465413 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 23, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pearls in clinical obstetrics: challenges in anticoagulation in pregnancy.
Authors: Della Torre M, Digiovanni LM, Sutherland MB Abstract Women are at increased risk for VTE during both pregnancy and in the post-partum period. We have conducted a comprehensive literature review of the use of anticoagulation in pregnancy for pregnant women at increased risk for venous thromboembolism (VTE). Multiple factors, including physiologic and pharmacokinetic changes make the treatment and prevention of VTE complicated in pregnancy. Adequate treatment and prevention of VTE in pregnancy is critically important, yet good quality medical studies continue to be lacking. There is a growing amount of data ...
Source: Minerva Ginecologica - October 27, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Update in non invasive prenatal testing.
Authors: D'ambrosio V, Squarcella A, Vena F, Di Mascio D, Corno S, Pajno C, Piccioni MG, Brunelli R, Pizzuti A, Benedetti Panici P, Giancotti A Abstract Non-invasive prenatal test (NIPT) has revolutionized the approach to prenatal diagnosis and, to date, it is the most superior screening method for the common autosomal aneuploidies, mostly trisomy 21. This screening has having a significant population-wide impact on the uptake of conventional screening and diagnostic testing. In recent years, emerging genomic technologies, largely based around next generation sequencing, have expanded the analyses to the sub- chrom...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Effects of adenomyosis on obstetric outcomes: a literature review.
CONCLUSIONS: The potential consequences of adenomyosis during pregnancy are difficult to evaluate because, now, there are few data available concerning adenomyosis and major obstetrical complications and because the study populations of those studies were small. Our results suggest that women with adenomyosis have needed of a prenatal management in a tertiary center. PMID: 30318871 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Management of endometriosis from diagnosis to treatment. Roadmap for the future.
Authors: Muzii L, Di Tucci C, Di Feliciantonio M, Galati G, Marchetti C, Perniola G, Pecorini F, Benedetti Panici P Abstract Endometriosis, in spite of decades of research on the topic, remains a mysterious and elusive disease. Both in the fields of diagnosis and treatment, many issues remain unresolved, and the scientific community strives in trying to find universal criteria for diagnosis, and algorithms of treatment that may be universally applied. Recently, there has been a shift away from the view of the need of invasive diagnosis and therapy with the universal use of laparoscopy. Today the diagnosis of endome...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Epigenetics and the vaginal microbiome: influence of the microbiota on the histone deacetylase level in vaginal epithelial cells from pregnant women.
Authors: Witkin SS, Nasioudis D, Leizer J, Minis E, Boester A, Forney LJ Abstract Histone deacetylase (HDAC) influences the acetylation status of histones at gene promotor loci, providing an epigenetic mechanism that regulates gene expression. We determined if variations in the composition of the vaginal microbiome in pregnant women were associated with alterations in the level of HDAC1 in vaginal epithelial cells and whether this influenced the concentration of compounds present in vaginal fluid. Vaginal epithelial cells were obtained from 150 women in their first trimester of pregnancy, lysed and assayed for HDAC...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Managing fetal growth restriction: surveillance tests and their interpretation.
Authors: Seravalli V, Di Tommaso M, Petraglia F Abstract The main challenges in pregnancies affected by fetal growth restriction consist in identifying signs of disease progression and determining the appropriate timing of delivery. The risk of continuing the pregnancy must be balanced with the risk of prematurity, which depends on gestational age. To allow appropriate monitoring of the growth-restricted fetus, several surveillance tests are available. These include ultrasound Doppler velocimetry of feto-placental vessels, cardiotocography, and amniotic fluid evaluation. It is well known that the combination of tes...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Management of gynecological cancer in pregnant patients.
CONCLUSIONS: Management of pregnant women with cancer should be performed in specialized cancer centers and all cases should be discussed with a multidisciplinary approach. In the present review, we discuss the current recommendations for the management of pregnancies complicated by cancer and neonatal outcomes. PMID: 30318875 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

The Role of novel biomarker HE4 in Gynecologic malignancies.
CONCLUSIONS: This systematic review confirms the importance of HE4 in the diagnosis of epithelial ovarian cancer and its promising role in endometrial cancer (endometrioid hystology). PMID: 30318876 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Dyslipidemia in pregnancy and maternal-fetal outcome.
Authors: Nasioudis D, Doulaveris G, Kanninen TT Abstract Hyperlipidemia is a known cause of atherosclerosis and directly contributes to the current epidemic in cardio-vascular disease. Pregnancy is typified by an increase in serum levels of total cholesterol and triglycerides pushed by the rise in estrogen, progesterone and lactogen. Mobilization of stored fat depots in late pregnancy may provide a reservoir of fatty acids for fetal growth and placental tissue steroid synthesis. This physiologic increase in lipids performs an essential role during pregnancy; however, elevated levels of lipids in predisposed women o...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Role of robotic surgery on pelvic floor reconstruction.
Authors: Giannini A, Russo E, Malacarne E, Cecchi E, Mannella P, Simoncini T Abstract Over the past two decades, minimally invasive surgery (MIS) abdominal surgery has increasingly been used to treat pelvic organ prolapse. Besides the several advantages associated with minimal invasiveness, this approach bridged the gap between the benefits of vaginal surgery with the surgical success rates of open abdominal procedures. The most commonly performed procedure for suspension of the vaginal apex for postoperative vaginal prolapse by robotic-assisted laparoscopy is the sacrocolpopexy. Conventional laparoscopic applicati...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Fetal anemia.
Authors: Argoti PS, Mari G Abstract The diagnosis and management of fetal anemia has been at the forefront of advances in the fields of fetal physiology, immunology, fetal imaging, and fetal therapy among others. Alloimmunization and parvovirus infection are the leading cause of fetal anemia in the United States. The middle cerebral artery peak systolic velocity (MCA-PSV)diagnoses fetal anemia. Its discovery is considered one of the most important achievements in fetal medicine. Accumulation of experience in recent years as well as refinement of surgical techniques have led to safer invasive procedures. It is expec...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Effects of progestogens in women with preterm premature rupture of membranes.
Authors: Di Sarno R, Raffone A, Saccone G Abstract Different strategies have been adopted for prevention of spontaneous preterm birth, including use of progestogens. So far, five randomized trials have been published evaluating the efficacy of progestogens in women with PPROM, including a total of 425 partipants. All the five trials enrolled pregnant women with singleton pregnancies randomized between 20 and 34 weeks of gestation. In four trials women were randomized to either weekly intramuscular 250 mg 17α-hydroxyprogesterone-caproate or placebo, while Mirzaei et al. was a three arms trials in which women r...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Errors and pitfalls in reading the cardiotocographic tracing.
Authors: Di Tommaso M, Seravalli V, Petraglia F Abstract Reading of fetal heart rate (FHR) tracing during labor remains one of the most controversial and problematic issues in Obstetrics. The incorrect interpretation of CTG can be due to errors and pitfalls. Some common errors are related to the incorrect use of oxytocin, specifically to the failure to recognize tachysystole, to correct it and to use oxytocin to accelerate labor when the fetal heart rate tracing is not reassuring. A common error is also the incorrect interpretation of deceleration that leads to unnecessary and often dangerous interventions, despite...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Sentinel Node biopsy for treatment of endometrial cancer. State of the art.
Authors: Papadia A, Gasparri ML, Wang J, Radan AP, Mueller MD Abstract The risk of lymph nodal metastases in endometrial cancer varies greatly according to the characteristics of the primary tumor. Surgical staging with a systematic lymphadenectomy in endometrial cancer is debated since three decades. On one hand, it provides important pathological information on the spread of the tumor allowing for an appropriate decision making on adjuvant treatment but on the other side it is characterized by a non negligible short and long term morbidity. In the past decades, various efforts have been made in the attempt to app...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Optimal settings for childbirth.
CONCLUSIONS: The key elements identified in this paper have the potential to inform further investigations for the design or renovation of all birth places (including hospitals) in order to optimise the salutogenic component of any setting in any country. PMID: 30299042 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Postpartum stretchmarks: repairing activity of an oral Centella asiatica supplementation (Centellicum ®).
Postpartum stretchmarks: repairing activity of an oral Centella asiatica supplementation (Centellicum®). Minerva Ginecol. 2018 Oct;70(5):629-634 Authors: Hu S, Belcaro G, Hosoi M, Feragalli B, Luzzi R, Dugall M Abstract BACKGROUND: This registry study evaluates the effects of oral Centellicum®, a new preparation of Centella asiatica (CA) on cutaneous stretchmarks (SMs) on the lower abdominal wall in comparison with the topical treatment with a specific antistretch cream. This cream is used for pregnancy SMs. The aim of the management was to give back to the structurally damaged skin areas (appa...
Source: Minerva Ginecologica - October 10, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

An innovative approach to evaluate preeclampsia risk in the first trimester of pregnancy.
Authors: Turdo F, Boatti L, Mignone F, Moretti F, Campiglio M, Colosi E PMID: 30293401 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 10, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Novel sonographic method for the evaluation of the defects in the pubocervical fascia in patients with genital prolapse.
Authors: Manodoro S, Palmieri S, Cola A, Milani R, Frigerio M PMID: 30293402 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 10, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Humanities in the undergraduate medical and midwifery curriculum: a descriptive Italian comparative study.
CONCLUSIONS: A greater breadth of humanities studies was included in midwifery schools. However, their relative importance appears to be low, given the low level of academic credits and lack of presence as independent subjects. PMID: 30291699 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 7, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Optimal outcomes and women's positive pregnancy experience: a comparison between the World Health Organization guideline and recommendations in European national antenatal care guidelines.
CONCLUSIONS: Findings outline convergences and divergences with the WHO recommendations. They highlight the need for considering women's views more in the development of evidence-based recommendations and in practice for positive impacts on perinatal health at a global level, and on the experiences of each family. PMID: 30291700 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 7, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Ovarian tumors secreting androgens: an infrequent cause of hyperandrogenism.
CONCLUSIONS: Sex cord stromal tumors of the ovary are rare, and can be characterized by virilization for most patients. The majority of the tumors are benign, with few cases having low-grade malignancy. The suspicion and correct evaluation of these women will lead to an early diagnosis and improve their quality of life. PMID: 30291701 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 7, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Effectiveness, quality of life and sexual functions in women with anterior compartment prolapse treated by native tissue repair: a mini-review.
Authors: Monti M, Schiavi MC, Colagiovanni V, Sciuga V, D'oria O, Cerone G, Scudo M, Zullo MA, Muzii L, Benedetti Panici P Abstract Anterior compartment defect is the most common pelvic organ prolapse. It is defined as the descent of the bladder into the anterior vaginal wall. The etiology is multifactorial and the main risk factors are vaginal delivery and conditions associated with increased abdominal strain. Aging is significantly associated with the prevalence and severity of pelvic organ prolapse. Treatment may be conservative or surgical according to symptoms, prolapse degree and not forgetting both patient a...
Source: Minerva Ginecologica - October 7, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Efficacy of needle retractor device in single-incision slings for treatment of stress urinary incontinence.
CONCLUSIONS: The current study showed that the presence of a needle retractor device to avoid unintentional tip displacement for single-incision sling had no impact on objective and subjective postoperative continence. However, a reduced rate of de novo overactive bladder syndrome was observed after implantation of single-incision sling with needle retractor. PMID: 30264950 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Does supraphysiologic estradiol level during IVF have any effect on Oocyte/Embryo quality? A sibling embryo cohort analysis of fresh and subsequent frozen embryo transfer.
Authors: Sarkar P, Gandhi A, Plosker S, Ying Y, Mayer J, Imudia AN Abstract AIM: To determine the effect of supraphysiologic serum estradiol (E2) level on oocyte and embryo development during IVF cycles. METHODS: This is a retrospective data analysis of all autologous IVF cycles where fresh embryo transfer was performed followed by subsequent frozen embryo transfer (FET) using cryopreserved sibling embryos were included. Primary outcome was live birth rate (LBR). Secondary outcomes were oocyte and embryo characteristics. RESULTS: Patients with high E2 [defined as serum peak E2> 50th percentile (3727 pg/m...
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Variation in caesarean section rates in Cyprus, Italy and Iceland: an analysis of the role of the media.
CONCLUSIONS: Those working in the media have an ethical responsibility to critically examine the impact of high national CS rates, and to report on solutions that could optimize both the safety and the wellbeing of mothers and babies. PMID: 30264952 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Findings from the Italian Babies Born Better (B3) survey.
CONCLUSIONS: Mothers highly value respectful, skilled and loving care that gives them a strong sense of personal achievement and confidence, and birth environments that support this. There was distinct variation in the percentage of positive comments made across Italian regions. PMID: 30264953 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

The gonadotropin system, lessons from animal models and clinical cases.
Authors: Szymańska K, Kałafut J, Rivero-Müller A Abstract This review article centres upon family of gonadotropin hormones which consists of two pituitary hormones - follicle-stimulating hormone (FSH) and luteinizing hormone (LH) as well as one non- pituitary hormone - human chorionic gonadotropin (hCG) secreted by placenta, and their receptors. Gonadotropins play an essential role in proper sexual development, puberty, gametogenesis, maintenance of pregnancy and male sexual differentiation during the fetal development. They belong to the family of glycoprotein hormones thus they constitute heterodimeric pro...
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Gonadotropin-releasing hormone analog therapeutics.
Authors: Newton CL, Riekert C, Millar RP Abstract Dysregulation at any level of the Hypothalamic-Pituitary-Gonadal (HPG) axis results in, or aggravates, a number of hormone-dependent diseases such as delayed or precocious puberty, infertility, prostatic and ovarian cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, endometriosis, uterine fibroids, lean body mass, as well as metabolism and cognitive impairment. As gonadotropin-releasing-hormone (GnRH) is an essential regulator of the HPG axis, agonist and antagonist analogs are efficacious in the treatment of these conditions. GnRH analogs also play ...
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Molecular human reproduction: advancements in clinical and basic research.
Authors: Casarini L PMID: 30264956 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Molecular and functional insights into gonadotrophin hormone receptor dimerisation and oligomerisation.
Authors: Agwuegbo UC, Jonas KC Abstract The gonadotrophin hormones, follicle stimulating hormone and luteinising hormone, are essential for reproduction. They work in concert to control multiple aspects of gonadal function to ultimately produce meiotically competent and fertilisable gametes, provide the optimal endometrial environment and support for implantation and maintain pregnancy via progesterone production throughout the first trimester of pregnancy. These complex and multidimensional functions are mediated via the gonadotrophin hormone receptors, luteinising hormone receptor (LHR) and follicle stimulating h...
Source: Minerva Ginecologica - September 20, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

New insights into maternity care design and delivery. Editorial commentary.
Authors: Downe S PMID: 30226028 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 20, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

The cAMP/PKA pathway: steroidogenesis of the antral follicular stage.
Authors: Riccetti L, Sperduti S, Lazzaretti C, Casarini L, Simoni M Abstract Pituitary gonadotropins, follicle-stimulating (FSH) and luteinizing hormone (LH), promote follicular recruitment and support antral follicle growth, maturation and selection, resulting in ovulation of the dominant follicle. FSH and LH biological functions are mediated by G protein-coupled receptors, FSHR and LHCGR, resulting in the activation of a number of signaling cascades, such as the cAMP/PKA pathway. Some in vitro data are consistent with the dual, proliferative and pro-apoptotic role of cAMP, leaving unanswered questions on how cAMP...
Source: Minerva Ginecologica - September 1, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Crosstalk between gonadotropins and thyroid axis.
Authors: De Vincentis S, Monzani ML, Brigante G Abstract Gonadotropins and thyroid hormones are essential, respectively, for reproduction and metabolism. The classical endocrinological approach is based on the detection of axes that start from the hypothalamus and arrive at the final effector organ, in this case gonads and thyroid. However, several clues suggest that these axes do not work in parallel, but they dialogue with each other. In this article, we review evidences demonstrating crosstalk between gonadotropins and thyroid axis. Firstly, there is an undeniable structural similarity of both hormones and recep...
Source: Minerva Ginecologica - July 13, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

β-arrestins and biased signalling in gonadotropin receptors.
β-arrestins and biased signalling in gonadotropin receptors. Minerva Ginecol. 2018 Jul 10;: Authors: De Pascali F, Reiter E Abstract Gonadotropin receptors include the follicle stimulating hormone receptor (FSHR) and the luteinizing hormone/choriogonadotropin receptor (LHCGR), both belong to the G protein- coupled receptor (GPCR) superfamily and being essential to reproduction. FSHR is activated by follicle stimulating hormone (FSH) while LHCGR is activated by either luteinizing hormone (LH) or choriogonadotropin (CG). Upon ligand binding, gonadotropin receptors undergo conformational changes that...
Source: Minerva Ginecologica - July 13, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Update on oogenesis in vitro.
CONCLUSIONS: Over the years, many improvements have been made on ovarian tissue cultures with the future purpose that patients will be provided with a greater number of developmentally competent oocytes for fertility preservation. PMID: 29999288 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 13, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Programmed cell death in the human ovary.
Authors: Marcozzi S, Rossi V, Salustri A, De Felici M, Klinger FG Abstract During woman's reproductive life, only about 400 of primordial follicles will develop into a pre- ovulatory follicle and undergo ovulation, releasing an oocyte available for fertilization. The process of formation and selection of these follicles is complex and involves a multistep process characterized by a balance between survival and death of the oocytes and the surrounding follicular cells. Although the mechanisms underlying such process are not completely clarified yet, it's common idea that they can occur through various types of progr...
Source: Minerva Ginecologica - July 13, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Preoperative and postoperative ultrasound assessment of stress urinary incontinence.
CONCLUSIONSː Ultrasound could be an important step during preoperative and post-operative assessment of patients affected by stress urinary incontinence. PMID: 29952478 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 29, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Efficacy of an intimate oil solution containing visnadine in women self-reporting sexual symptoms.
Authors: Caputo A, Natoli A, Radice R, Zanardi G, Giacomelli L PMID: 29952501 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 29, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Robot-assisted laparoscopic single-site hysterectomy: our experience and multicentric comparison with single-port laparoscopy.
CONCLUSIONS: This study confirms the safety and reproducibility of the RSS. The comparison between RSS and LESS techniques has shown that RSS has important advantages over the LESS, like deeper learning curve, lower OT not correlated with age and uterus size. PMID: 29856186 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 2, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Comparison of patients' reported pain following office hysteroscopy with and without endometrial biopsy: a prospective study.
Authors: New EP, Sarkar P, Sappenfield E, Mikhail E, Plosker S, Imudia AN Abstract BACKGROUND: When performing office based gynecologic procedures, one must provide patients with appropriate counseling on anticipated pain prior to the procedure. The goal of this study was to investigate whether there is any difference in patients' pain perception when office hysteroscopy (OH) is performed alone compared with when it is performed with endometrial biopsy (EMB) for various gynecologic indications. METHODS: A prospective study was performed of patients undergoing office hysteroscopy alone or in combination with end...
Source: Minerva Ginecologica - June 2, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

[New methods for prediction of preterm birth: the PAMG-1 Test].
Authors: Di Fabrizio L, Giardina I, Cetin I, Di Tommaso M, Ciavattini A, Locci M, Facchinetti F, Zonca M, Di Renzo GC Abstract OBJECTIVE: To assess the efficacy of PAMG-1 test (placental alpha microglobulin-1) in cervicovaginal secretions collected immediately following transvaginal ultrasound (TVUS) of women with signs and symptoms of pretermlabor (PTL), clinically intact membranes and cervical length between 15 and 30 mm for the prediction of imminent spontaneous delivery (within 7 days of testing), as well as delivery
Source: Minerva Ginecologica - June 2, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research