Log in to search using one of your social media accounts:

 

[Role of vitamin D in female reproduction].
Authors: DE Leo V, Cappelli V, Morgante G, DI Sabatino A Abstract La vit. D, o calcitriolo, è stata identificata inizialmente nei primi anni '20 ed ha un ruolo chiave nella regolazione del metabolismo osseo, nell'omeostasi del calcio e del fosforo e nel promuovere la mineralizzazione ossea. Le azioni della vit. D sono mediante tramite un recettore nucleare (VDR), che è espresso in numerosi organi come l'intestino, l'osso e il rene, ma anche nelle gonadi, nel seno, nel pancreas, nel sistema cardiovascolare, nel cervello (microglia) e nelle cellule del sistema immunitario. In tutti questi tessuti bersag...
Source: Minerva Ginecologica - November 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Adenomyosis: fertility and obstetric outcome. A comprehensive literature review.
Authors: Buggio L, Monti E, Gattei U, Dridi D, Vercellini P Abstract Adenomyosis is a benign condition characterized by the presence of endometrial glands and stroma deep within the myometrium. In recent years, the potential negative impact of adenomyosis on in vitro fertilization clinical outcomes has gained momentum, as well as, the possible link of this condition with obstetrical complications. The aim of this narrative review is to elucidate the possible association between uterine adenomyosis, infertility, and poor obstetrical outcomes. Several theories have been proposed to clarify the potential harmful impac...
Source: Minerva Ginecologica - November 10, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Upcoming strategies in obstetrics: how the technology of clinical audit may reduce cesarean birth.
Authors: Paracchini S, Masturzo B, Tangolo D, Roletti E, Piazzese A, Attini R, Rolfo A, Todros T Abstract BACKGROUND: The rate of cesarean delivery is currently increasing all over Europe. In Italy it reaches 38% of all child births. Therefore, it is important to identify the clinical and organizational variables that determine the appropriateness of elective cesarean delivery. With this aim we chose the technology of clinical audit, a process that promotes improvement in clinical practice through systematic review of clinical care in relation with explicit standards derived from scientific literature. METHODS:...
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

[Differential diagnosis and management of abnormal uterine bleeding in adolescence].
Authors: Motta T, Laganà AS, Valenti G, LA Rosa VL, Noventa M, Vitagliano A, Chiofalo B, Rapisarda AM, Rossetti D, Vitale SG Abstract Abnormal uterine bleeding (AUB) is defined as any atypical genital bleeding originating from the uterine cavity, without the characteristics of normal menstrual period. AUB is an important symptom both for adolescents and their parents, and it usually leads to a state of anxiety. Although about 95% of AUB could be considered as a dysfunctional disorder, AUB requires well-defined diagnostic procedures in order to detect a physical cause, ruling out complex or systemic diseases,...
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Efficacy and acceptance of the sacral neuromodulation in the treatment of female lower urinary tract dysfunctions.
Authors: Adile B, Speciale P, Gugliotta G, Consiglio P, Manzone M, Adile G, Saitta S, Perino A, Calagna G PMID: 29083137 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

An early-customized low glycaemic-index diet prevents adverse pregnancy outcomes in overweight/obese women.
Authors: Petrella E, Tamborrino V, DI Cerbo L, Neri I, Facchinetti F Abstract OBJECTIVE: To determine whether the prescription and follow-up of a behavioral program (customized nutritional advices and a constant physical activity) influences the occurrence of unfavorable maternal/neonatal outcomes among overweight/obese women. METHODS: A case-control study (1:3) included single pregnant women with BMI≥25, enrolled at 1st trimester. Cases (95) were prescribed (by both the dietitian and gynecologist) a low-glycemic index diet with an average intake of 1700/1800 Kcal/day plus 30 minutes walking at least 3 times...
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Ultrasonography reappraisal of tubal patency in Assisted Reproduction Technology patients: comparison between 2D and 3D- sonohysterosalpingography. A pilot study.
Authors: Riganelli L, Casorelli A, Caccetta J, Merlino L, Mariani M, Savone D, Carrone A, Franceschetti S, Aragona C, Pietrangeli D, Aragona A, Capri O, Piccioni MG Abstract BACKGROUND: The aim of this study was to compare 2D and 3D-sonohysterosalpingography (2D - 3D- HyFoSy) with previous diagnostic laparoscopy in the diagnosis of tubal patency, and compare each procedure in terms of procedure's time, perceived pain and complication rate. METHODS: We prospectively recruited infertile women, previously submitted to laparoscopy and randomly allocated into 2D-HyFoSy (group I) and 3D-HyFoSy (group II). We analyzed...
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pregnancy outcomes in women with endometriosis.
CONCLUSIONS: In our population, endometriosis was not found as a risk factor for obstetrical complications or adverse perinatal outcomes. Larger population based cohort studies are needed to clarify the relationship between endometriosis and adverse pregnancy outcomes. PMID: 29063747 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 25, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Increasing survival of metastatic breast cancer through locoregional surgery.
CONCLUSIONS: Our cohort supports that locoregional treatment in selected patients with de novo metastatic breast cancer significantly improved survival, so it might be considered in combination with systemic therapy. PMID: 28994557 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Flexible CO2 laser fiber: first look at the learning curve required in gynecological laparoscopy training.
Authors: Vanni VS, Ottolina J, Candotti G, Castellano LM, Tandoi I, DE Stefano F, Poppi G, Ferrari S, Candiani M Abstract BACKGROUND: The advent of flexible CO2 laser fiber to gynecology arena might represent a turning point in the use of laser energy on a large-scale basis in gynecological surgery. However, there might be some concerns regarding the degree of surgical skills required to use the flexible system. The purpose of our study is to evaluate whether flexible CO2 laser fiber is technically accessible. METHODS: Fourteen residents in Obstetrics and Gynecology without surgical experience attending laparos...
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Spontaneous rupture of bilateral pelvic vessels following vacuum assisted vaginal delivery.
Authors: Yandel A, Jiang X, Yochim MN, Schnatz PF PMID: 28994559 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Epidemiology and pathogenesis of fulminant viral hepatitis in pregnant women: a review.
Authors: Tosone G, Simeone D, Spera AM, Viceconte G, Bianco V, Orlando R Abstract The pregnancy-associated immunological and hormonal changes may alter the immune response to infectious agents, including hepatitis viruses. Therefore, this phenomenon may affect the clinical course and the outcome of acute viral hepatitis in pregnant women. For this reason, we have focused on epidemiological and pathogenetic aspects of the fulminant liver failure caused by acute viral hepatitis reviewing PubMED in April of 2017. Although all the viruses might cause a fulminant AVH in a pregnant woman, the large majority of fulminant ...
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Urine protein to creatinine ratio: a point of care for the diagnosis of preeclampsia.
CONCLUSIONS: 1)the UPCR test is highly correlated with 24h-UPET;2)we propose a novel and sensitive cut-off for the diagnosis of preeclampsia by UPCR test;and 3)the UPCR test can be used for the identification of hypertensive patients with preeclampsia and severe disease. PMID: 28994561 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Can unexplained infertility be evaluated by a new immunological four biomarkers panel? A pilot study.
CONCLUSIONS: Further validation studies are needed to prove that there is a correlation between unexplained infertility and immunological disorders screened by the IMMUNOX Panel, nevertheless our data shows that this diagnostic approach may be helpful to predict and to identify women at higher risk of IVF cycles failure. PMID: 28994562 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

An update on the genetics of pre-eclampsia.
Authors: Agius A, Sultana R, Camenzuli C, Calleja-Agius J, Balzan R Abstract Pre-eclampsia is a progressive multisystem disorder that is exclusive to human pregnancy and defined as new hypertension presenting after 20 weeks with significant proteinuria. It is a multifactorial condition with a strong genetic component and several genes have been linked with this disorder. The main players implicated in the pathogenesis of preeclampsia include immune maladaptation, haemodynamics, endothelial function, thrombophilic disorders, oxidative stress and lipid metabolism. All of these mechanisms encompass genetic factors tha...
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Targeted therapy for ovarian cancer: the rapidly evolving landscape of PARP inhibitor use.
CONCLUSIONS: The landscape of PARP inhibitor use for ovarian cancer is rapidly evolving and PARP inhibitors have become more available as a targeted therapy option for ovarian cancer treatment. PMID: 28994564 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Morcellation of occulted sarcomas during laparoscopic myomectomy and hystrectomy for patients with large fibroid uterus.
Authors: Tinelli A, Farghaly SA Abstract In April 2014, the United States of America Food and Drug Administration (FDA) published a safety communication warning of the risk of an unsuspected uterine sarcoma being morcellated during a laparoscopic procedure, and advised against the use of power morcellation. In November of the same year, this agency stated: 1. Laparoscopic power morcellators are contraindicated for removal of uterine tissue containing suspected fibroids in patients who are peri- or post-menopausal, or are candidates for "en bloc" tissue removal. 2. Laparoscopic power morcellators are contr...
Source: Minerva Ginecologica - October 5, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Menopause and hormone replacement therapy. The 2017 recommendations of the Italian Menopause Society.
Authors: Gambacciani M, Biglia N, Cagnacci A, DI Carlo C, Caruso S, Cicinelli E, DE Leo V, Farris M, Gambera A, Guaschino S, Lanzone A, Paoletti AM, Russo N, Vicariotto F, Villa P, Volpe A Abstract In the last decade the risk benefits ratio of HRT has been reevaluated mainly in tens of cardiovascular risk. Present Consensus Statement is largely inspired by the Global Consensus on Menopausel Hormone Therapy in 2013 and 2016 by leading global menopause societies (The American Society for Reproductive Medicine, The Asia Pacific Menopause Federation, The Endocrine Society, The European Menopause and Andropause Society,...
Source: Minerva Ginecologica - October 5, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Prognosis and cost-effectiveness of IVF in poor responders according to the Bologna criteria.
Authors: Busnelli A, Somigliana E Abstract Poor ovarian response (POR) to controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) is one of the most challenging issue in the field of reproductive medicine. However, even if improving IVF outcome in poor responders (PORs) represents a main priority, the lack of a unique definition of POR has hampered research in this area. In order to overcome this impediment, an ESHRE Campus Workshop was organized in Bologna in 2010 and reached a consensus on the criteria for the diagnosis of POR ('Bologna criteria'). In this review we aimed to estimate the progno...
Source: Minerva Ginecologica - September 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

A modern approach to the management of patients candidate to assisted reproductive technologies.
Authors: Venturella R, Vaiarelli A, Lico D, Ubaldi FM, Zullo F, DI Carlo C Abstract The growing use of Assisted Reproductive Technologies (ART) and the incorrect information from mass media, determined in the public the wrong idea that the right moment of life for programming a pregnancy can be delayed well beyond the physiological fertile age. Spare and insufficient health authorities' interventions are driven to explain to the general population the reduction of the fertility potential of couples and particularly of women with advancing age. This situation, characterized by more and more women seeking for pregnan...
Source: Minerva Ginecologica - September 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Optimising preconception health in women of reproductive age.
Authors: Lang AY, Boyle JA, Fitzgerald G, Teede H, Mazza D, Moran LJ, Harrison C Abstract There is a growing realisation that efforts to optimise the health of women and reduce the risk of adverse maternal, perinatal and neonatal outcomes during pregnancy should commence in the preconception period. The preconception period (prior to or between pregnancies) provides an opportune time to address reproductive intentions and promote and support wellbeing and healthy behaviour change regardless of pregnancy intention. Research over the last 30 years has explored the influence of a range of preconception risk factors an...
Source: Minerva Ginecologica - September 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Gynecological and obstetrical management of rheumatic diseases in reproductive age.
Authors: Pepe F, Stracquadanio M, Privitera A, Ciotta L, DE Luca F Abstract The gynecologist's role in the management of rheumatic patients is complex: it includes the prevention of damage caused by drugs, the counseling about contraception to avoid pregnancy while taking teratogen drugs, the scheduling of pregnancy during the quiescent phase of the specific disease, the replacement of teratogen drugs and a competent management of the pregnancy. The task is carried out as part of a multidisciplinary team with particular attention on differential diagnosis between specific complications of pregnancy and the complica...
Source: Minerva Ginecologica - September 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Is pH a vaginal health marker? Phemale study.
Authors: Palacios S, González SP, Jesus Cancelo M Abstract OBJECTIVES: Epidemiological data regarding vaginal pH in Spain are scarce. An epidemiological study was therefore undertaken to confirm the physiological pattern of vaginal pH in Spanish women. The primary outcome measure was vaginal pH. Secondary outcomes included the relationship between vaginal pH and BMI, physical activity, working status, contraceptive use, sexual intercourse in the two days prior to the visit and clinical vaginal symptoms. METHODS: Cross-sectional study in which 2,136 healthy women over 18 years of age who requested a check...
Source: Minerva Ginecologica - September 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pelvic floor evaluation with transperineal ultrasound: a new approach.
Authors: Vellucci F, Regini C, Barbanti C, Luisi S Abstract The increased life expectancy, the importance of the prevention in younger age and the role of the pelvic floor disfunction not only in the disease of the third age, but also in the childbearing age, as the influence on the type of delivery, underline the importance of the evaluation of the pelvic floor. The evaluation of pelvic floor is generally clinical, but in the last 2 decades, the use of ultrasound has become a mainstream diagnostic tool in the investigation of female pelvic organ prolapse, urinary and fecal incontinence and defecation disorders, pr...
Source: Minerva Ginecologica - September 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Does endometriosis influence the age of menopause?
Authors: Ottolina J, Bartiromo L, Viganò P, Makieva S, Schimberni M, Candiani M Abstract Endometriosis is an inflammatory disease affecting 7-10% of women throughout their reproductive life. Few data are available regarding the age at menopause of women affected by this disease. Most of the available evidence, although scanty, would indicate that both ovarian surgery for endometriomas and endometriosis "per se" appear to influence age at menopause. Other factors might interfere with the age at menopause of women affected by endometriosis. The purpose of this review is to examine the age at menopaus...
Source: Minerva Ginecologica - September 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

In vitro maturation in women with polycystic ovaries and high Anti Mullerian Hormone levels: a retrospective study.
Authors: Gunasheela D, Murali R, Menon JG, Hiremath N, Son WY PMID: 28752726 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 29, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Maternal mortality in the developed world: a review of surveillance methods, levels and causes of maternal deaths during 2006-2010.
This article provides an overview of surveillance methods, levels, and causes of maternal mortality in developed countries (Europe and the United States) during 2006-2010. Accurate identification of maternal deaths is not always possible, and no two countries in the world use the same surveillance methods for maternal mortality. Despite limitations (underestimation, missclassification), routine vital registration systems are the backbone of maternal mortality surveillance systems in developed countries. Enhanced surveillance methods involve linkages between deaths of women of reproductive age and births within the precedin...
Source: Minerva Ginecologica - July 19, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Fertility preservation options in pre-pubertal females: feasibility, safety and outcomes.
Authors: Newton HL, Glaser AW, Picton HM PMID: 28707851 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 16, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Does fibroids surgery by endoscopy or laparotomy represent a malignancy threat?
CONCLUSIONS: The frequency of unsuspected ESS was 1/2,269 among the women who underwent myomectomies and hysterectomies for the treatment of benign uterine fibroids. The total incidence of uterine sarcoma was 7/2,275 among the patients who had presumed uterine fibroids or a suspicion of uterine sarcoma prior to undergoing the surgical procedures. PMID: 28696085 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pregnancy after breast cancer: hope after the storm.
CONCLUSIONS: This review will highlight and summarize the current evidence and the research perspectives of pregnancy after breast cancer, to provide healthcare professionals the information they need to properly counsel young women with breast cancer who desire to conceive. PMID: 28696086 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Efficacy of carboxymethyl beta-glucan in cervical intraepithelial neoplasia: a retrospective, case-control study.
CONCLUSIONS: In conclusion, Colpofix® gel represents a valid alternative to "wait and see" strategy in patients affected by CIN1. Further prospective studies are warranted to confirm these results. PMID: 28675291 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 6, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

The use of morphokinetic as a predictor of implantation.
This article focuses on the different time-lapse systems burgeoning on the market and the use of morphokinetics as a predictor of embryo implantation. PMID: 28643503 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 25, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

[Evaluation of the effects of a natural dietary supplement with cranberry, Noxamicina ® and D-mannose in recurrent urinary infections in perimenopausal women].
CONCLUSIONS: This multicenter clinical study revealed the excellent efficacy and tolerability of Kistinox® Forte sachets in the treatment and prevention of urinary disorders in peri- and postmenopausal women. The posology of a sachet a day during the first 10 days of the month for 3 months was well tolerated by the patients, who did not report any disorder arising from the product. PMID: 28608666 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 15, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Dynamic quadripolar radiofrequency treatment of vaginal laxity/menopausal vulvo-vaginal atrophy: 12-month efficacy and safety.
CONCLUSIONS: Safety was excellent during all DQRF procedures and over the 12 months following the end of the treatment sessions. VLQ, PISQ-12 and SSQ scores (women with vaginal laxity), VAS self-evaluation of VVA/GSM symptoms and overall satisfaction with sexual life (women with VVA/GSM symptoms) improved rapidly, reaching almost normal levels by the last DQRF session and suggesting rapid, but also persistent, vaginal rejuvenation in both indications. A late tendency to some slight deterioration in women treated for vaginal laxity suggests such women might benefit from new DQRF treatments 6 to 9 months after the previous c...
Source: Minerva Ginecologica - June 15, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Outcomes of vaginal lipofilling with the tumescent technique.
Authors: Pellegrino A, Damiani GR, Pirovano C, Villa M, Strippoli D, Fantini F PMID: 28608668 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 15, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Early detection of recurrence or progression disease in patients with ovarian cancer after primary debulking surgery: a diagnostic challenge still unresolved. Correlation between CT findings and CA 125 levels.
CONCLUSIONS: Increase in CA 125 levels>10.5% could be sufficiently predictive of PD requiring CT examination. Change of -0.5% is sufficiently predictive of absence of PD. Increase 0.5% needs clinical correlation to establish correct timing and extension of CT examination. Attention must be played in reducing number and extent of CT examinations to reduce exposure dose. PMID: 28598136 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 10, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

The effectiveness of psychosocial assessment in the detection and management of postpartum depression: a systematic review.
CONCLUSIONS: Presently there is a paucity of published data on the effectiveness of psychosocial assessment in the detection and management of postnatal depression and results show conflicting evidence. Further randomised controlled trials are recommended to further elucidate the effectiveness of psychosocial assessments. PMID: 28598137 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 10, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Unexplained infertility: live-birth's prognostic factors to determine the ART management.
CONCLUSIONS: To avoid couple's drop-out, we advise to start infertility treatment for unexplained infertility with two IUI before undergoing IVF if IUI failure. PMID: 28598138 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 10, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Mini-sling efficacy in obese versus non-obese patients for treatment of stress urinary incontinence.
CONCLUSIONS: The current study showed that single-incision sling Miniarc seems to be an effective treatment irrespective of BMI. Operative data, complications, objective and subjective outcomes were similar for normal weight, overweight and obese women. PMID: 28598139 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 10, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Time remaining in labor and probability of vaginal delivery as a function of the angle of progression in a low risk population with a normal first stage of labor. In-house observational study and comparison with the data in the literature.
Authors: Masturzo B, Piazzese A, Paracchini S, Quezada MS, Todros T, Farina A Abstract OBJECTIVE: The aim of the study was to investigate whether the angle of progression (AoP), as measured by transperineal ultrasound, was predictive of both the time remaining in labor and vaginal delivery. STUDY DESIGN: This was a prospective observational cohort study involving 270 low-risk women with singleton pregnancies at term. The AoP, measured at the end of the first stage of labor, was used as a predictive variable of time remaining in labor and mode of delivery. The Kaplan Meier and Cox algorithms were used to evaluat...
Source: Minerva Ginecologica - June 9, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

The current management of deep endometriosis. A systematic review.
CONCLUSIONS: Until further comparative studies regarding medical versus surgical treatment for DE are concluded, currently, surgery is the best option for patients with DE and severe pain (VAS>7). PMID: 28545293 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - May 27, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Endometriosis: still a problem?
Authors: Angioni S PMID: 28545294 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - May 27, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Maternal thyroid function in women undergoing controlled ovarian hyperstimulation during in vitro fertilization and its relation to reproductive outcome.
Authors: Abdul Karim AK, Azrai Abu M, Chelliah B, Mohd Razi ZR, Omar MH, Othman H, Man ZC Abstract BACKGROUND: We conducted a study to evaluate the changes in thyroid function during Controlled Ovarian Hyperstimulation (COH) and its association with the outcome of assisted reproductive technique (ART). METHODS: This is a prospective cohort study done in University Hospital Fertility clinic for one year duration. A total of eighty eight euthyroid women who underwent COH as part of planned in vitro fertilization were invited to participate in this study. Serum thyroid function of each women will be monitored befo...
Source: Minerva Ginecologica - April 28, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Myomectomy: technique and current indications.
Authors: Rakotomahenina H, Rajaonarison J, Wong L, Brun JL Abstract BACKGROUND: Uterine fibroids are the commonest benign tumor of the female genital tract. They affect a significant proportion of reproductive aged women and may cause excessive menstrual bleeding, pelvic pain or pressure, and adversely affect reproductive outcomes. However, many women remain asymptomatic. Fibroids are the first indication for hysterectomy, but myomectomy is the most suitable surgical option for women who desire preservation of their fertility potential. Only a selected group of women of childbearing age will benefit from a myomecto...
Source: Minerva Ginecologica - April 28, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Efficacy and tolerability of a plant-based, multi-component cream (Ginetrox ®) in vulvovaginal disorders of the genitourinary syndrome during menopause.
CONCLUSIONS: This preliminary study suggests that the plant-based, multi-component cream Ginetrox® could be effective and safe in counteracting menopause-related vaginal discomfort symptoms. PMID: 28420227 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - April 21, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Outcome of endometrial cancer after lymphadenectomy, a single center retrospective analysis of 829 cases with long-lasting follow-up.
Authors: Greco P, Martinello R, Indraccolo U, Borghi C, Bonaccorsi G, Scutiero G Abstract BACKGROUND: Role of lymphadenectomy in endometrial cancer is unclear. Our objective is to assess the role of lymphadenectomy in endometrial cancer. METHODS: 829 cases of endometrial cancer from a single non-oncological center were reviewed retrospectively from 1981 to 2014. Multivariable Cox regression analyses were performed. Independent variables were: 2009 FIGO stage, histological type of endometrial cancer (non-endometrioid, endometrioid, grading 1, 2 and 3), radicality on parametria, lymphatic dissection (any kind) (y...
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

The role of seminal fluid in infertility.
Authors: Bonnic J, Fenech A, Muscat C, Calleja-Agius J Abstract Approximately 15 % of couples worldwide are considered infertile, with up to 50 % due to a defect in the male reproductive physiology. Many of these latter defects are idiopathic or genetically related and mostly focused on the spermatozoon and as such, the majority of studies to date have focused mainly on disorders related with the sperm cell. In this review, the importance of seminal fluid integrity and its effect on the female reproductive physiology is described in the context of male infertility. Human seminal plasma contains a vast array of prot...
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Teratology of valproic acid: an updated review of the possible mediating mechanisms.
Authors: Ponzano A, Tiboni GM Abstract Valproic acid (VPA) is an anti-epileptic drug (AED) which is currently being investigated for its potential application in the treatment of several types of cancers, including solid and non-solid tumor. It is well known that prenatal exposure to VPA largely increases the risk for malformations and other developmental disorders. This review concentrates on clinical and experimental data on congenital anomalies attributed to maternal VPA exposure during. Particular emphasis is paid to the potential mechanisms underlying VPA-induced malformations. Although several mechanisms have...
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Clinical profile of women with VVA who are not candidates for local vaginal oestrogen therapy.
Authors: Nappi RE, Murina F, Perrone G, Villa P, Biglia N Abstract Vulvar and vaginal atrophy (VVA) is a chronic medical condition in postmenopausal women, which is predominantly due to a permanent cessation of ovarian oestrogen production. Current available treatment options for VVA are over-the-counter (OTC) symptomatic relief products or local oestrogen therapy (LET) aiming to treat this underlying atrophic condition. Recent surveys indicated that these products decrease sexual spontaneity, are messy and indiscrete. Ospemifene is an oral daily drug, which has proven to treat vaginal dryness and dyspareunia effec...
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in breast cancer patients.
Authors: Conte B, Del Mastro L Abstract Since the survival of patients with cancer has significantly improved, chemotherapy-related premature ovarian failure (POF) in young cancer survivors has become a major issue in oncology. POF is associated with several health-related negative consequences, including menopausal symptoms, increased risk of cardiovascular diseases, osteoporosis, sexual disfunction, and infertility1-5. According to the major international guidelines, embryo/oocyte cryopreservation are the standard procedures for fertility preservation in young cancer women6,7. However, these techniques do not pro...
Source: Minerva Ginecologica - April 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research