[HPV vaccination: not only female adolescents and not only prophylactic. Review and position paper of the Italian HPV Study Group (IHSG)].
Authors: Origoni M, Cristoforoni P, Mariani L, Costa S, Preti M, Sandri MT, Preti EP, Ghelardi A, Perino A Abstract HPV vaccination has been introduced in clinical practice in recent years and represents the most effective strategy of primary prevention of cervical carcinoma and of female genital preneoplastic conditions. One of the major issues of the subject is represented by vaccination coverage of the target population. Since its introduction, HPV vaccine efficacy has been progressively demonstrated also towards extragenital HPV-correlated conditions and in males too. Moreover, even subjects of older age groups...
Source: Minerva Ginecologica - November 21, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Femininity and gynecologic oncologic surgery: the key role of a tailored approach.
Authors: Domenici L, Salerno MG, Benedetti Panici P PMID: 31741365 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 21, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Duration of ovarian stimulation is predictive of in vitro fertilization outcomes.
CONCLUSIONS: In an IVF cycle, optimal ovarian response and pregnancy outcome is associated with stimulation duration of at least 9 days. Both accelerated and delayed follicular recruitment are indicators for suboptimal response. PMID: 31741366 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 21, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Ultrasound fetal anthropometry to identify large-for-gestational-age: a meta-analysis.
CONCLUSIONS: Current ultrasound fetal anthropometry is not strongly helpful, but the values of anthropometric formulas provided by future ultrasound are expected especially as the primary screening of LGA. PMID: 31741367 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 21, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

The absence of culturable bacteria from at term placentae from HIV-negative and positive women argues against a placental unique microbiota.
Authors: Fiore JR, Di Stefano M, Greco P, Elnour MO, Alwazzeh MJ, Santantonio T PMID: 31741368 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 21, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Joint recommendations for the diagnosis and treatment of vulvo-vaginal atrophy in women in the peri- and post-menopausal phases from the Societ à Italiana per la Menopausa (SIM) and the Società Italiana della Terza Età (SIGiTE).
Joint recommendations for the diagnosis and treatment of vulvo-vaginal atrophy in women in the peri- and post-menopausal phases from the Società Italiana per la Menopausa (SIM) and the Società Italiana della Terza Età (SIGiTE). Minerva Ginecol. 2019 Oct;71(5):345-352 Authors: Cagnacci A, Gallo M, Gambacciani M, Lello S, Società Italiana della Menopausa (SIM) and the Società Italiana di Ginecologia della Terza Età (SIGiTE) Abstract Herein, joint recommendations for diagnosis and treatment of vulvo-vaginal atrophy (VVA) in women in the peri- and post-menopausal p...
Source: Minerva Ginecologica - November 10, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

A randomized single-blind placebo-controlled study of a Visnadine Emulgel formulation on healthy postmenopausal women.
CONCLUSIONS: The topical use of Visnadine on female external genitalia may increase regional vascularization affecting turgidity and sensorial threshold of the area of application. PMID: 31698889 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 10, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

TNF- α effect on human delivery onset by CB1/TRPV1 crosstalk: new insights into endocannabinoid molecular signaling in preterm vs. term labor. Analysis of the EC/EV pathway and predictive biomarkers for early diagnosis of preterm delivery.
We examined the expression of genes encoding for the components of EC/EV system (CB1, CB2, TRPV1, MAGL, FAAH, DAGL, NAPE-PLD) and for inflammatory cytokines (IL-6, TNF-α) with qRT-PCR techniques, in human placental samples from preterm delivery (at 30 and at 34 weeks) compared to term delivery (40 weeks, control group). RESULTS: We found a marked increase of CB1, anandamide, and inflammatory cytokines, mainly TNF-α, together with TRPV1 down-regulation in term delivery group, compared to preterm groups (P
Source: Minerva Ginecologica - November 10, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Optimizing high risk HPV-based primary screening for cervical cancer in low- and middle-income countries: opportunities and challenges.
Authors: Pimple SA, Mishra GA Abstract Disparities in the incidence and mortality due to cervical cancer between developed and developing countries continue to persist due to suboptimal health care systems in low- to middle-income countries (LMICs) that are unable to implement organized programs for screening which lack the technical, infrastructure and financial resources for adequate coverage and access to quality assured cervical cancer screening services that further reduce their effectiveness. The challenges in introducing quality cytology screening in LMICs led to the evaluation of alternative screening appro...
Source: Minerva Ginecologica - November 10, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Contraception with the new intrauterine systems: a winning choice if shared!
Authors: di Spiezio Sardo A, Mastantuoni E, De Angelis MC, Zizolfi B Abstract Today the rate of unexpected pregnancy is still unacceptably high; long-acting reversible contraceptives, (LARC) seem to be an effective and modern solution. Intrauterine contraception (IUC) is the main exponent of the LARC and it is living a new exponential spread in the last years. Today IUC is the most widely used reversible contraceptive method and it is recommended by the major scientific gynecological societies. This review of the literature aims to retrace the history of intrauterine contraception and to focus attention on intraute...
Source: Minerva Ginecologica - November 10, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

The modified Ten-Group Robson Classification: a single center's way to improve cesarean section rate.
Authors: Mohd Faizal A, Sharifah Raihan SK, Yulianty A, Mahdy Zaleha A Abstract PMID: 31698893 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 10, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Which factors make the difference in the progression of cervical dilation in vaginal birth after cesarean section?
Authors: Consonni S, Incerti M, Bernasconi DP, Vergani P, Pintucci A, Ornaghi S, Fumagalli S, Locatelli A Abstract PMID: 31560181 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

An open trial of a visnadine emulgel topical application in post-menopausal superficial dyspareunia: daily vs. on-demand use.
Authors: Caputo A, Sparavigna A, Natoli A, Mandelli C Abstract PMID: 31560182 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - September 30, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pregnancy and feto-neonatal outcome in primary lymphedema affected woman.
Authors: Cavaliere AF, Perossini S, La Milia MC, Michelini S, Lanzone A, Inchingolo R, Scambia G Abstract PMID: 31287250 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 10, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

A preliminary magnetic resonance spectroscopy study of postmenopausal hormone effects on the brain.
Authors: Gianetto-Berruti A, Schranz AL, Bartha R, Feyles V Abstract PMID: 31287251 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - July 10, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Postpartum hemorrhage: not only hypertensive disorders in oocyte donation pregnancies.
Authors: Serena C, Comito C, Simeone S, Capannini E, Tosi N, Ottanelli S, Rambaldi MP, Coccia ME, Mecacci F, Petraglia F Abstract BACKGROUND: The aim of the study is to compare the obstetric outcome between single pregnancies obtained by medically-assisted procreation using oocyte donors (MAP-E) versus homologous gametes (MAP-O) and single spontaneous conception pregnancies (SC). METHODS: This is a retrospective case-control study on pregnancy outcome of consecutive singleton live birth pregnancies from MAP-E between January 2011 and August 2017 referred to Careggi University Hospital, Florence. The control gro...
Source: Minerva Ginecologica - July 6, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Circulating visfatin levels in the second and third trimester of pregnancies with gestational diabetes: a systematic review.
CONCLUSIONS: No significant difference in circulating visfatin levels in GDM during the second trimester of pregnancy (WMD -0.30 ng/mL, 95% CI: -2.06, 1.45, SE=0.895, P=0.733) was detected. Meta-analysis of the studies in the third trimester revealed a significant negative effect, that was however driven by only one study. This finding limits the meaningful interpretation of the pooled analysis. Significant heterogeneity was identified between studies, and meta-regression analysis showed that homeostatic model assessment for insulin resistance contributes significantly to heterogeneity. In conclusion, our findings suggest ...
Source: Minerva Ginecologica - July 6, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Postoperative infections in women undergoing hysterectomy for benign indications: a cohort study.
Authors: Carrubba AR, Whitmore GT, Radhakrishnan SJ, Sheeder J, Muffly TM Abstract BACKGROUND: There is limited data on the incidence of postoperative infections following hysterectomy by route of surgery. We hypothesize that vaginal hysterectomy has lower rates of postoperative infection than laparoscopic and abdominal hysterectomies. METHODS: A retrospective cohort study and independent hand review of charts of participants undergoing hysterectomy at five hospitals from September 2011 through May 2015 was performed. Cases were identified using International Classification of Diseases, Ninth Revision, Clinical...
Source: Minerva Ginecologica - May 31, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Combined systemic (fluconazole) and topical (metronidazole + clotrimazole) therapy for a new approach to the treatment and prophylaxis of recurrent candidiasis.
Authors: Genovese C, Cianci A, Corsello S, Ettore G, Mattana P, Tempera G Abstract Recurrent Vulvovaginal Candidiasis (RVVC) is an important pathological and infectious condition that can greatly impact a woman's health and quality of life. Clinical and epidemiological studies show that different types of therapies are able to eliminate the signs and symptoms of mycotic vaginitis in the acute phase, but so far none of these has proved able to significantly reduce the risk of long-term recurrence. In this review, based on the available literature and original data from a preliminary in vitro microbiological study on...
Source: Minerva Ginecologica - May 21, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Fertility preservation in breast cancer patients.
Authors: Rodgers RJ Abstract Breast cancer is the most commonly diagnosed cancer in women. As long-term survival rates have improved, there has been a concurrent increase in quality of life considerations, of which fertility preservation is of utmost importance. A number of fertility preservation options are available to women diagnosed with breast cancer, including administration of a GnRH agonist during chemotherapy in an attempt to minimize ovarian damage, oocyte or embryo cryopreservation prior to the administration of chemotherapy, in vitro maturation of oocytes or ovarian tissue cryopreservation. The safety o...
Source: Minerva Ginecologica - May 17, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Criteria, phenotypes and prevalence of polycystic ovary syndrome.
Authors: Belenkaia LV, Lazareva LM, Walker W, Lizneva DV, Suturina LV Abstract Polycystic ovarian syndrome (PCOS) is known as one of the most frequent endocrine diseases in women worldwide. However, this term does not completely capture the diversity of clinical signs associated with this syndrome e.g., menstrual irregularity and clinical features of androgen excess, which are though commonplace in women with PCOS, they are not included under the definition of PCOS, limited to polycystic ovarian morphology (PCOM). Utilizing the most globally accepted criterion used today in the diagnosis of PCOS, the authors of thi...
Source: Minerva Ginecologica - May 17, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pertussis vaccination in pregnancy: how many pediatric hospitalizations could be prevented?
Authors: Mesini A, Moscatelli A, Castagnola E Abstract Pertussis is a severe disease in children, especially in neonates and it is preventable by vaccination during pregnancy. After the observation of a 2-month-old toddler who needed extracorporeal membrane oxygenation for severe RSV plus Bordetella pertussis infection, we performed a review of all cases of pertussis admitted at the Istituto Giannina Gaslini, Genoa, Italy, from 2012 to 2018. We retrieved 72 cases of admission for pertussis, 46% aging less than 3 months, 42% with at least one comorbidity. Two patients needed ICU admission. Pertussis vaccination duri...
Source: Minerva Ginecologica - May 17, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Fertility preservation in female cancer patients-state of the art.
Authors: Findeklee S, Radosa JC, Takacs ZF, Hamza A, Sima RM, Solomayer EF, Sklavounos P Abstract Protecting fertility in the presence of cancer has become highly significant, as the desire to give birth to a child is increasingly postponed to later in life, and long-term survival with cancer has increased. A variety of fertility-preserving methods have been developed. To find them we did a literature search in Medline with the term "female fertility preservation in cancer" in December 2017. 2381 different publications were found. After screening the abstracts 78 publications in English, French or German ...
Source: Minerva Ginecologica - April 19, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Application of failure mode and effect analysis (FMEA) in total laparoscopic hysterectomy (TLH) in benign conditions.
CONCLUSIONS: It is our opinion that the systematic implementation of the FMEA model can reduce the risk of human error during laparoscopic surgery, improving patient safety. PMID: 30938115 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - April 4, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Knowledge, attitudes, beliefs and practices of obstetrics-gynecologists on seasonal influenza and pertussis immunizations in pregnant women: preliminary results from North-Western Italy.
CONCLUSIONS: Sampled OBGYN were largely favorable towards vaccination of pregnant women. As knowledge of official recommendations was identified as a main predictor of appropriate behavior at least for Tdap practice, future educational interventions could eventually improve immunization rates. PMID: 30938116 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - April 4, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Double stimulation in the same ovarian cycle (DuoStim) is an intriguing strategy to improve oocyte yield and the number of competent embryos in a short timeframe.
Authors: Vaiarelli A, Cimadomo D, Argento C, Ubaldi N, Trabucco E, Drakopoulos P, Venturella R, Conforti A, Alviggi C, Rienzi L, Ubaldi FM Abstract Proper ovarian stimulation regimens are crucial for any patient undergoing IVF. However, maximizing the oocyte yield in advanced maternal age patients with poor or suboptimal response is still a challenge. In fact, no standard treatment has been outlined yet to manage these women. Across the last years, an improved efficiency of the IVF units via blastocyst culture, vitrification and reliable embryo selection approaches paved the way to the investigation of novel unconv...
Source: Minerva Ginecologica - March 10, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Global strategies for cervical cancer prevention and screening.
Authors: Pimple S, Mishra G Abstract Cervical cancer is highly preventable and can be easily treated if detected at early stages. However there is disproportionate high burden of cervical cancer incidence and mortality in low-middle income (LMIC) country settings that lack organised screening and prevention programs. Robust evidence for prevention and screening of cervical cancer is currently available. However there are barriers for country specific adoption and implementation. These pose unique challenges such as organising prevention and screening services delivery through the current health infrastructure, acce...
Source: Minerva Ginecologica - February 28, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

New diagnostic tools and therapeutic approaches in gynecology: considerations for innovative strategies.
Authors: Di Donato V, Benedetti Panici P Abstract PMID: 30781937 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - February 22, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Three-dimensional printing models on reproductive surgery and human reproduction: systematic review and critical applications.
CONCLUSIONS: 3D models for human reproduction are feasible. They might improve assisted reproductive techniques, help in pre-surgical planning for reproductive surgeries, and provide accurate measures of ovarian reserve. Besides, we see future applications in endometrioma research and in the fabrication of devices, such as embryo transfer catheter and a 3D printed embryo. PMID: 30756546 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - February 15, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Human endogenous retroviruses HERV-H, HERV-W and HERV-K in preeclampsia.
Authors: Bergallo M, Tovo PA, Bertino E, Daprà V, Pirra A, Montanari P, Galliano I, Calvi C Abstract PMID: 30756547 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - February 15, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Combination of weekly topotecan and gemcitabine as a salvage treatment in patients with recurrent ovarian cancer: a phase I study.
CONCLUSIONS: The weekly administration of gemcitabine/topotecan regimen in patients with pretreated metastatic ovarian cancer is an active chemotherapy combination, even in heavily pretreated patients, with a manageable toxicity profile which merits further investigation. PMID: 30727721 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - February 9, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Anti-M üllerian hormone (AMH) regulates stemness-promoting factors in fresh and previously vitrified-warmed ovarian cortex.
Anti-Müllerian hormone (AMH) regulates stemness-promoting factors in fresh and previously vitrified-warmed ovarian cortex. Minerva Ginecol. 2019 Feb 06;: Authors: Detti L, Fletcher NM, Uhlmann RA, Peregrin-Alvarez I, Roman RA, Saed GM Abstract PMID: 30727722 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - February 9, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pelvic organ prolapse and voiding function before and after surgery.
Authors: Palmieri S, Manodoro S, Cola A, Spelzini F, Milani R, Frigerio M Abstract PMID: 30727723 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - February 9, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Understanding sexual pain in endometriosis.
Authors: Aerts L, Grangier L, Dallenbach P, Wenger JM, Streuli I, Bianchi-Demicheli F, Pluchino N Abstract Sexual dysfunctions, particularly sexual pain, are common in adult women of all ages. In patients with endometriosis, a chronic gynaecological pain condition affecting women of reproductive age, sexual pain is the third most common symptom. Multiple biological factors are involved in endometriosis-related sexual pain including tissue damage, inflammation, hormonal changes, alterations within the peripheral and central nervous system and pelvic floor muscle dysfunctions. Conceptual models of sexual pain espouse...
Source: Minerva Ginecologica - February 9, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Role of a natural integrator based on lipoic acid, palmitoiletanolamide and myrrh in the treatment of chronic pelvic pain and endometriosis.
Authors: De Leo V, Cagnacci A, Cappelli V, Biasioli A, Leonardi D, Seracchioli R Abstract Dysmenorrhea and chronic pelvic pain occur in a significantly higher percentage in women with endometriosis; this benign condition has an incidence ranging from 5 to 10% in the general population, while 35% to 50% of infertile women are affected. Treatment of the symptoms demands integrated approaches with the use of anti-inflammatory substances or drugs and lifestyle changes, including attention to diet. The use of traditional anti-inflammatory drugs over the long term is not very successful because of the fear of side effect...
Source: Minerva Ginecologica - February 1, 2019 Category: OBGYN Tags: Minerva Ginecol Source Type: research

New evidences and clarifications by world leaders in maternal fetal medicine.
Authors: Sisti G Abstract PMID: 30547497 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - December 14, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Histological evaluation of the prevalence of adenomyosis, myomas and of their concomitance.
The objective of this study is to evaluate the prevalence of adenomyosis, leiomyomas and of their concomitance in women who underwent hysterectomy. METHODS: An observational study carried out on a cohort of 347 women who underwent hysterectomy from a sample of 2383 patients who had gynecological surgery for benign disease in a single University Hospital between 2013 and 2016. An histological evaluation of all surgical specimens was carried out for the presence of adenomyosis and leiomyomas. Prevalence of adenomyosis alone, of leiomyomas alone or of their concomitance was evaluated. RESULTS: In 140 women, indication...
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Knowledge and attitudes of midwives regarding reprotoxic agents during pregnancy: snapshot of the Marseille area, southern France.
Authors: Sunyach C, Didierjean H, Bretelle F, Perrin J, Courbiere B Abstract PMID: 30486634 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Updates on the management of placenta accreta spectrum.
Authors: Di Mascio D, Calì G, D'antonio F Abstract Placenta accreta spectrum (PAS) disorders is a multifactorial process that encompasses a heterogeneous group of conditions characterized by an abnormal invasion of trophoblastic tissue through the myometrium and uterine serosa. PAS is associated with a high burden of adverse maternal outcomes including severe life-threatening hemorrhage, need for blood transfusion, damage to adjacent organs, and death. Prenatal screening of PAS is mandatory so that women may be counselled about the severity of this condition to plan management with a multidisciplinary team a...
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Cumulative live birth rates in IVF.
CONCLUSIONS: Cumulative LBR are a more suitable are more comprehensive when reporting success in an IVF program. Cumulative LBR increase with the number of oocytes retrieved, suggesting that ovarian stimulation may have a minimal or no detrimental effect on oocyte/embryo quality. PMID: 30486636 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Fetoscopic spina bifida repair.
CONCLUSIONS: Continued refinement of a minimally invasive strategy for prenatal treatment of spina bifida is necessary to maximize benefits to the child and further minimize maternal risks and preterm birth. PMID: 30486637 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Uterine transposition technique: update and review.
Authors: Ribeiro R, Baiocchi G, Tsunoda AT, Linhares JC, Pareja R Abstract To review and discuss the uterine transposition technique for preserving fertility in patients who require pelvic radiotherapy. Uterine transposition was developed from adapting well-established surgical techniques with the goal of keeping the uterus and adnexa outside the radiotherapy field in order to preserve their function. The uterine transposition technique is presented step by step, with discussion of the literature that served as the basis for the technique's development. Its most recent modifications, resulting from the authors' exp...
Source: Minerva Ginecologica - November 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Evaluation of safety and skin tolerability of organic cotton pads in case of irritative vulvitis.
CONCLUSIONS: Results demonstrated that organic cotton pads, in each part, are safe and do not impair any physiological activities of the tissue substrates. PMID: 30465412 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 23, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Is fertility sparing surgery a treatment option for young patients with yolk sac tumor?
We present a narrative review of the multispecialty fertility sparing surgical and medical approach of women with YST. PMID: 30465413 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 23, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pearls in clinical obstetrics: challenges in anticoagulation in pregnancy.
Authors: Della Torre M, Digiovanni LM, Sutherland MB Abstract Women are at increased risk for VTE during both pregnancy and in the post-partum period. We have conducted a comprehensive literature review of the use of anticoagulation in pregnancy for pregnant women at increased risk for venous thromboembolism (VTE). Multiple factors, including physiologic and pharmacokinetic changes make the treatment and prevention of VTE complicated in pregnancy. Adequate treatment and prevention of VTE in pregnancy is critically important, yet good quality medical studies continue to be lacking. There is a growing amount of data ...
Source: Minerva Ginecologica - October 27, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Update in non invasive prenatal testing.
Authors: D'ambrosio V, Squarcella A, Vena F, Di Mascio D, Corno S, Pajno C, Piccioni MG, Brunelli R, Pizzuti A, Benedetti Panici P, Giancotti A Abstract Non-invasive prenatal test (NIPT) has revolutionized the approach to prenatal diagnosis and, to date, it is the most superior screening method for the common autosomal aneuploidies, mostly trisomy 21. This screening has having a significant population-wide impact on the uptake of conventional screening and diagnostic testing. In recent years, emerging genomic technologies, largely based around next generation sequencing, have expanded the analyses to the sub- chrom...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Effects of adenomyosis on obstetric outcomes: a literature review.
CONCLUSIONS: The potential consequences of adenomyosis during pregnancy are difficult to evaluate because, now, there are few data available concerning adenomyosis and major obstetrical complications and because the study populations of those studies were small. Our results suggest that women with adenomyosis have needed of a prenatal management in a tertiary center. PMID: 30318871 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Management of endometriosis from diagnosis to treatment. Roadmap for the future.
Authors: Muzii L, Di Tucci C, Di Feliciantonio M, Galati G, Marchetti C, Perniola G, Pecorini F, Benedetti Panici P Abstract Endometriosis, in spite of decades of research on the topic, remains a mysterious and elusive disease. Both in the fields of diagnosis and treatment, many issues remain unresolved, and the scientific community strives in trying to find universal criteria for diagnosis, and algorithms of treatment that may be universally applied. Recently, there has been a shift away from the view of the need of invasive diagnosis and therapy with the universal use of laparoscopy. Today the diagnosis of endome...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Epigenetics and the vaginal microbiome: influence of the microbiota on the histone deacetylase level in vaginal epithelial cells from pregnant women.
Authors: Witkin SS, Nasioudis D, Leizer J, Minis E, Boester A, Forney LJ Abstract Histone deacetylase (HDAC) influences the acetylation status of histones at gene promotor loci, providing an epigenetic mechanism that regulates gene expression. We determined if variations in the composition of the vaginal microbiome in pregnant women were associated with alterations in the level of HDAC1 in vaginal epithelial cells and whether this influenced the concentration of compounds present in vaginal fluid. Vaginal epithelial cells were obtained from 150 women in their first trimester of pregnancy, lysed and assayed for HDAC...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Managing fetal growth restriction: surveillance tests and their interpretation.
Authors: Seravalli V, Di Tommaso M, Petraglia F Abstract The main challenges in pregnancies affected by fetal growth restriction consist in identifying signs of disease progression and determining the appropriate timing of delivery. The risk of continuing the pregnancy must be balanced with the risk of prematurity, which depends on gestational age. To allow appropriate monitoring of the growth-restricted fetus, several surveillance tests are available. These include ultrasound Doppler velocimetry of feto-placental vessels, cardiotocography, and amniotic fluid evaluation. It is well known that the combination of tes...
Source: Minerva Ginecologica - October 17, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research