Age-adjusted treatment of cervical intraepithelial 1 lesions by superficial or regular loop excision of transformation zone.
Authors: Siegler E, Fuchs L, Lavie O, Saked-Misan P, Machulki L, Segev Y Abstract BACKGROUND: The loop electrosurgical excision procedure (LEEP) is one of the treatments for cervical intraepithelial neoplasia 1 (CIN1). One of the risks of LEEP is preterm birth. We evaluated final pathological diagnoses following LEEP as treatment for CIN1 lesions, for procedures in which cone height was determined by patients' age. METHODS: A retrospective study of 329 women diagnosed with CIN1 on a cervical biopsy and treated by LEEP. In patients under age 35 years, a thin LEEP COIN was performed, and in women over 35 years, a...
Source: Minerva Ginecologica - June 1, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Managing fertile women under lithium treatment: the challenge of a Teratology Information Service.
CONCLUSIONS: Lithium treatment in fertile women is a very delicate topic, where risks and benefits of discontinuing therapy when women plan to become pregnant should be accurately evaluated. Thorough peri-conceptional counselling is crucial for the outcome of pregnancy and for maternal health status during preconception, gestation and breastfeeding. PMID: 29845825 [PubMed - in process] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - June 1, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Successful pregnancy in a woman previously suffering from β-thalassaemia following transplantation of ovarian tissue cryopreserved before puberty.
Successful pregnancy in a woman previously suffering from β-thalassaemia following transplantation of ovarian tissue cryopreserved before puberty. Minerva Ginecol. 2018 Apr 24;: Authors: Matthews SJ, Picton HM, Ernst E, Andersen CY Abstract Ovarian tissue removed from a nine year old girl suffering from thalassemia was kept deep- frozen for 14 years before being transplanted back to the now adult woman. Subsequently, she conceived following IVF treatment and delivered a healthy baby where the oocyte derived from the transplanted tissue. This is the first woman worldwide to have a baby where the ov...
Source: Minerva Ginecologica - April 27, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Challenges of fertility preservation in leukemia patients.
Authors: Shapira M, Raanani H, Derech Chaim S, Meirow D Abstract An ongoing increase in survival rates among young leukemia patients is accompanied by a growing attention to possible long-term complications such as chemotherapy induced ovarian insufficiency and infertility. Therefore, an important element of the management of these patients is fertility preservation, which is challenged by considerations specific for leukemia. Such considerations include prepuberty, poor medical condition on presentation and the need for urgent chemotherapy, all of which may preclude the use of conventional assisted reproductive te...
Source: Minerva Ginecologica - April 27, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Fertility preservation in women, focusing on cancer, benign diseases and social reasons.
Authors: Donnez J PMID: 29696943 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - April 27, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Techniques for ovarian tissue transplantation and results.
Authors: Donnez J, Manavella DD, Dolmans MM Abstract Fertility preservation has emerged as a field of growing interest thanks to increasingly effective cancer treatments in women. For young women with good prospects of surviving cancer, fertility preservation counseling before gonadotoxic treatment is imperative to offer them a potential chance of future childbearing. Ovarian tissue cryopreservation and transplantation rises as a strategy for fertility preservation, especially for prepubertal girls, adolescents and women in whom cancer treatment cannot be delayed. Numerous surgical techniques have been reported and...
Source: Minerva Ginecologica - April 15, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Fertility preservation in women with ovarian endometriosis.
Authors: Donnez J, García-Solares J, Dolmans MM Abstract Endometriosis is a frequently encountered benign gynecological disease that may be responsible for infertility. Treatment of endometriosis-associated infertility has been investigated using both medical and surgical therapeutic modalities. Therapy has essentially three main objectives: (i) to preserve and improve fertility, (ii) to reduce pain, and (iii) to delay recurrence. The aim of this paper is to focus on fertility preservation in women with severe endometriosis. In ovarian endometriosis-associated infertility, a medico-surgical approach remains ...
Source: Minerva Ginecologica - April 15, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pregnancy complications in infertile patients with polycystic ovary syndrome: updated evidences.
Authors: Palomba S, Falbo A, Daolio J, Battaglia FA, LA Sala GB Abstract Polycystic ovary syndrome (PCOS) is a common female disorder with a pathogenesis still today not completely known. To the present, PCOS is considered more than just a reproductive disorder since several metabolic consequences that could affect women's health during different stages of reproductive and post-reproductive life were reported. The aim of the current review was to evaluate present evidence-based data regarding the pregnancy complications in infertile patients with PCOS. An extensive literature search until February 2018 was performe...
Source: Minerva Ginecologica - April 15, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

From isolation of human ovarian follicles to the artificial ovary: tips and tricks.
This article discusses some essential points for the creation of a TAO and reviews the latest progress made. PMID: 29644331 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - April 15, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Indications for fertility preservation in women from malignant diseases to benign conditions to age-related fertility decline.
Authors: Dolmans MM, Donnez J Abstract Oocyte vitrification and ovarian tissue cryopreservation are 2 common fertility preservation options. Oocyte vitrification provides the highest yield for women with benign diseases or those seeking fertility preservation for age-related fertility decline. This technique is also indicated for cancer women if cancer treatment can be post-poned. Ovarian tissue cryopreservation has some specific indications. There is indeed no other alternative for fertility preservation in prepubertal girls, adolescents and cancer women in whom cancer treatment cannot be postponed. This review fo...
Source: Minerva Ginecologica - April 15, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Risk of transplanting malignant cells in cryopreserved ovarian tissue.
Authors: Dolmans MM, Masciangelo R Abstract Improvements in cancer treatments have increased the chances of survival of young cancer patients, but have given rise to other issues, like premature ovarian insufficiency and infertility. Preservation and subsequent restoration of ovarian function in these patients is now possible thanks to ovarian tissue cryopreservation and transplantation. However, safety concerns about the possible presence of cancerous cells in the tissue to be cryopreserved must be addressed. Indeed, reimplantation of malignant cell-contaminated ovarian tissue could potentially lead to recurrence ...
Source: Minerva Ginecologica - April 15, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Ovarian preservation in locally advanced cervical cancer undergoing neoadjuvant chemotherapy and radical surgery: our experience and analysis of the literature.
CONCLUSIONS: Our data suggest that ovarian preservation at the time of surgery is a safe option among women with LACC after NACT with no detrimental impact on oncologic outcome. Further prospective studies are warranted. PMID: 29600835 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - March 31, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Giant endometrial polyps: does size matter?
Authors: van Staalduinen B, Stahler A, Abied C, Shats R, Lakhi NA PMID: 29553218 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - March 23, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Cryobiology of ovarian tissues: known knowns and known unknowns.
Authors: Devireddy RV Abstract To model the cryobiological responses of cells and tissues, the cellular membrane permeability characteristics are often measured at suprazero temperatures as well as at subzero temperatures with and without the presence of extra-cellular ice. These measured membrane permeability characteristics are then used to predict the responses of cells and tissues for a given thermal insult with the ultimate aim of mitigating the damage caused during the freeze-thaw process. This brief review articles summarizes efforts from my research group over the past 15 years as related to cryobiology of ...
Source: Minerva Ginecologica - March 14, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Vitrification of human oocytes.
We present the general experience of our group and others in FP for both oncological and non oncological reasons. PMID: 29527869 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - March 14, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Laparoscopic versus abdominal myomectomy: trend and pattern of practice among reproductive age population in Hospital Sultan Abdul Halim Sungai Petani, Kedah Malaysia.
Authors: Ahmad MF, Sheng KL, Kathirgamanathan S, Kannaiah K PMID: 29464941 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - February 25, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

[Hydrating cleansing: efficacy and tolerability of new formulations with hyaluronic acid 0.2% for intimate hygiene in the woman in fertile age and menopause].
Authors: Albani F, Bonfigli A, Consolaro F, Rigano L, Campisi M Abstract Dehydration of genital areas, known as vaginal dryness, frequently affects woman's life, from fertile to postmenopausal period, and must be treated with specific products, including proper intimate cleansing. Based on that, two new cleanser formulations, characterized by Hyaluronic Acid 0.2% as main ingredient, have been developed (Hyalo Gyn® Intimo Active and Hyalo Gyn® Intimo Advance), with the aim to provide an effective hydration of the vaginal, vulvar, perianal and anal areas beyond guaranteeing daily intimate hygiene. The two int...
Source: Minerva Ginecologica - February 15, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Quality of life in women with advanced pelvic organ prolapse treated with Gellhorn pessary.
Authors: Palmieri S, Cola A, Milani R, Manodoro S, Frigerio M PMID: 29442481 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - February 15, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Validation of diagnostic methods for peritoneal carcinomatosis secondary to ovarian cancer. CT-scan, PET-CT or laparoscopy, what is the best?
Authors: Manzanedo I, Losada B, Martínez-Torres B, Pereira F, Serrano Á, Juez I, Pérez-Viejo E, Gutiérrez D, Peiró V, Aulló C PMID: 29431339 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - February 14, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Diagnostic accuracy of endocervicoscopy as preoperative tool to improve the excisional treatment of cervical pre-neoplastic lesions.
Authors: DE Franciscis P, LA Manna V, Schiattarella A, Ambrosio D, Labriola D, Procaccianti R, Ammaturo FP, Morlando M, Torella M Abstract AIM: To evaluate the diagnostic accuracy of endocervicoscopy as a pre-operative examination to improve the outcome of the excisional treatment (LEEP) of high-grade cervical preneoplastic lesions. METHODS: Patients with histologic diagnosis of CIN II-CIN III undergoing LEEP divided in two groups: in Group A (85 women) a preoperative endocervicoscopy was performed, in Group B (85 women) no additional examination was performed before LEEP. The size of the surgical specimen (H, ...
Source: Minerva Ginecologica - February 2, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Oral misoprostol versus intravaginal dinoprostone for labor induction: a comparison study.
CONCLUSIONS: Misoprostol shows a higher VD rate with fewer patients needing a second type of induction and a shorter time to the onset of active labor and to VD. PMID: 29376620 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - January 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Transvaginal native-tissue repair of vaginal vault prolapse.
CONCLUSIONS: Transvaginal repair with native-tissue procedures is safe and effective in correcting post-hysterectomy vaginal vault prolapse and represents a valid alternative to prosthetic procedures for vaginal vault prolapse treatment. PMID: 29376621 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - January 30, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

[Customization of hormonal contraception].
Authors: DE Leo V, Cianci A, DI Carlo C, Cappelli V, Fruzzetti F Abstract In the last few years new oral contraceptives have been marketed showing a better safety profile for women. They are the result of important changes made to the old compounds. As far as the estrogenic component, with the aim of decreasing side effects, the dose of ethinyl estradiol has been reduced and synthetic estrogens have been replaced by natural estradiol, further improving the safety profile. Also the progestin component in the last years has been changed in terms of dose, endocrine and metabolic characteristics. Levonorgestrel is an a...
Source: Minerva Ginecologica - January 20, 2018 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Current management of ovarian endometriomas.
Authors: Muzii L, DI Tucci C, DI Mascio D, DI Feliciantonio M, Capri O, Pietrangeli D, Rech F, Benedetti Panici P Abstract The choice of treatment in case of ovarian endometriomas is one of the most discussed topics in Reproductive Medicine. Management options include expectancy, medical treatment, surgery, in-vitro fertilization (IVF), or a combination of the above. The main presenting symptom, i.e. pain or infertility, usually guide the choice of treatment. Medical treatment is usually preferred as the first line option when pain is the associated symptom, whereas surgery or IVF are preferred in case of associate...
Source: Minerva Ginecologica - December 7, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Sentinel lymph node mapping in endometrial cancer: a systematic review and meta-analysis.
CONCLUSIONS: SLN mapping is a feasible and accurate alternative to stage patients with endometrial cancer. Utilizing indocyanine green results in the highest SLN detection rates. Future studies should prospectively examine the impact of SLN mapping on progression-free and overall survival. PMID: 29185673 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - December 1, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Electromechanical Morcellators' black-box warning: tribulations, expectations and solutions.
Authors: Sarkar P, Mikhail E, Hoyte L, Plosker S, Imudia A Abstract Laparoscopic minimally invasive gynecologic surgery (MIGS) for benign conditions results in decreased morbidity, and faster recovery, compared with laparotomy. Tissue fragmentation by electromechanical morcellation permits the removal of large specimens through small laparoscopic incisions. Since the US Food and Drug Administration (FDA) published its safety warning about the risk of power morcellators spreading cancer during fibroid surgery in 2014, power morcellation has become rare. MIGS for fibroids and other large tissue specimens has declined...
Source: Minerva Ginecologica - November 24, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Intrapartum care quality indicators: a literature review.
CONCLUSIONS: We identified 80 indicators that should be used to measure the quality of low risk intrapartum care. Although the majority of indicators we could monitor through hospital databases and the Italian Birth Register - CeDAP are outcome indicators, it is important to give attention also to process indicators that measure the activities performed and whether or not they are evidence-based. For a low risk population they could measure adherence with guidelines that promote and support the normality of the process. PMID: 29161798 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 24, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review of the literature.
CONCLUSIONS: The procedure-related risks of miscarriage following amniocentesis and CVS are lower than currently quoted to women. PMID: 29161799 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - November 24, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

[Role of vitamin D in female reproduction].
Authors: DE Leo V, Cappelli V, Morgante G, DI Sabatino A Abstract La vit. D, o calcitriolo, è stata identificata inizialmente nei primi anni '20 ed ha un ruolo chiave nella regolazione del metabolismo osseo, nell'omeostasi del calcio e del fosforo e nel promuovere la mineralizzazione ossea. Le azioni della vit. D sono mediante tramite un recettore nucleare (VDR), che è espresso in numerosi organi come l'intestino, l'osso e il rene, ma anche nelle gonadi, nel seno, nel pancreas, nel sistema cardiovascolare, nel cervello (microglia) e nelle cellule del sistema immunitario. In tutti questi tessuti bersag...
Source: Minerva Ginecologica - November 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Adenomyosis: fertility and obstetric outcome. A comprehensive literature review.
Authors: Buggio L, Monti E, Gattei U, Dridi D, Vercellini P Abstract Adenomyosis is a benign condition characterized by the presence of endometrial glands and stroma deep within the myometrium. In recent years, the potential negative impact of adenomyosis on in vitro fertilization clinical outcomes has gained momentum, as well as, the possible link of this condition with obstetrical complications. The aim of this narrative review is to elucidate the possible association between uterine adenomyosis, infertility, and poor obstetrical outcomes. Several theories have been proposed to clarify the potential harmful impac...
Source: Minerva Ginecologica - November 10, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Upcoming strategies in obstetrics: how the technology of clinical audit may reduce cesarean birth.
Authors: Paracchini S, Masturzo B, Tangolo D, Roletti E, Piazzese A, Attini R, Rolfo A, Todros T Abstract BACKGROUND: The rate of cesarean delivery is currently increasing all over Europe. In Italy it reaches 38% of all child births. Therefore, it is important to identify the clinical and organizational variables that determine the appropriateness of elective cesarean delivery. With this aim we chose the technology of clinical audit, a process that promotes improvement in clinical practice through systematic review of clinical care in relation with explicit standards derived from scientific literature. METHODS:...
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

[Differential diagnosis and management of abnormal uterine bleeding in adolescence].
Authors: Motta T, Laganà AS, Valenti G, LA Rosa VL, Noventa M, Vitagliano A, Chiofalo B, Rapisarda AM, Rossetti D, Vitale SG Abstract Abnormal uterine bleeding (AUB) is defined as any atypical genital bleeding originating from the uterine cavity, without the characteristics of normal menstrual period. AUB is an important symptom both for adolescents and their parents, and it usually leads to a state of anxiety. Although about 95% of AUB could be considered as a dysfunctional disorder, AUB requires well-defined diagnostic procedures in order to detect a physical cause, ruling out complex or systemic diseases,...
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Efficacy and acceptance of the sacral neuromodulation in the treatment of female lower urinary tract dysfunctions.
Authors: Adile B, Speciale P, Gugliotta G, Consiglio P, Manzone M, Adile G, Saitta S, Perino A, Calagna G PMID: 29083137 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

An early-customized low glycaemic-index diet prevents adverse pregnancy outcomes in overweight/obese women.
Authors: Petrella E, Tamborrino V, DI Cerbo L, Neri I, Facchinetti F Abstract OBJECTIVE: To determine whether the prescription and follow-up of a behavioral program (customized nutritional advices and a constant physical activity) influences the occurrence of unfavorable maternal/neonatal outcomes among overweight/obese women. METHODS: A case-control study (1:3) included single pregnant women with BMI≥25, enrolled at 1st trimester. Cases (95) were prescribed (by both the dietitian and gynecologist) a low-glycemic index diet with an average intake of 1700/1800 Kcal/day plus 30 minutes walking at least 3 times...
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Ultrasonography reappraisal of tubal patency in Assisted Reproduction Technology patients: comparison between 2D and 3D- sonohysterosalpingography. A pilot study.
Authors: Riganelli L, Casorelli A, Caccetta J, Merlino L, Mariani M, Savone D, Carrone A, Franceschetti S, Aragona C, Pietrangeli D, Aragona A, Capri O, Piccioni MG Abstract BACKGROUND: The aim of this study was to compare 2D and 3D-sonohysterosalpingography (2D - 3D- HyFoSy) with previous diagnostic laparoscopy in the diagnosis of tubal patency, and compare each procedure in terms of procedure's time, perceived pain and complication rate. METHODS: We prospectively recruited infertile women, previously submitted to laparoscopy and randomly allocated into 2D-HyFoSy (group I) and 3D-HyFoSy (group II). We analyzed...
Source: Minerva Ginecologica - October 31, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Pregnancy outcomes in women with endometriosis.
CONCLUSIONS: In our population, endometriosis was not found as a risk factor for obstetrical complications or adverse perinatal outcomes. Larger population based cohort studies are needed to clarify the relationship between endometriosis and adverse pregnancy outcomes. PMID: 29063747 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 25, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Increasing survival of metastatic breast cancer through locoregional surgery.
CONCLUSIONS: Our cohort supports that locoregional treatment in selected patients with de novo metastatic breast cancer significantly improved survival, so it might be considered in combination with systemic therapy. PMID: 28994557 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Flexible CO2 laser fiber: first look at the learning curve required in gynecological laparoscopy training.
Authors: Vanni VS, Ottolina J, Candotti G, Castellano LM, Tandoi I, DE Stefano F, Poppi G, Ferrari S, Candiani M Abstract BACKGROUND: The advent of flexible CO2 laser fiber to gynecology arena might represent a turning point in the use of laser energy on a large-scale basis in gynecological surgery. However, there might be some concerns regarding the degree of surgical skills required to use the flexible system. The purpose of our study is to evaluate whether flexible CO2 laser fiber is technically accessible. METHODS: Fourteen residents in Obstetrics and Gynecology without surgical experience attending laparos...
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Spontaneous rupture of bilateral pelvic vessels following vacuum assisted vaginal delivery.
Authors: Yandel A, Jiang X, Yochim MN, Schnatz PF PMID: 28994559 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Epidemiology and pathogenesis of fulminant viral hepatitis in pregnant women: a review.
Authors: Tosone G, Simeone D, Spera AM, Viceconte G, Bianco V, Orlando R Abstract The pregnancy-associated immunological and hormonal changes may alter the immune response to infectious agents, including hepatitis viruses. Therefore, this phenomenon may affect the clinical course and the outcome of acute viral hepatitis in pregnant women. For this reason, we have focused on epidemiological and pathogenetic aspects of the fulminant liver failure caused by acute viral hepatitis reviewing PubMED in April of 2017. Although all the viruses might cause a fulminant AVH in a pregnant woman, the large majority of fulminant ...
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Urine protein to creatinine ratio: a point of care for the diagnosis of preeclampsia.
CONCLUSIONS: 1)the UPCR test is highly correlated with 24h-UPET;2)we propose a novel and sensitive cut-off for the diagnosis of preeclampsia by UPCR test;and 3)the UPCR test can be used for the identification of hypertensive patients with preeclampsia and severe disease. PMID: 28994561 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Can unexplained infertility be evaluated by a new immunological four biomarkers panel? A pilot study.
CONCLUSIONS: Further validation studies are needed to prove that there is a correlation between unexplained infertility and immunological disorders screened by the IMMUNOX Panel, nevertheless our data shows that this diagnostic approach may be helpful to predict and to identify women at higher risk of IVF cycles failure. PMID: 28994562 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

An update on the genetics of pre-eclampsia.
Authors: Agius A, Sultana R, Camenzuli C, Calleja-Agius J, Balzan R Abstract Pre-eclampsia is a progressive multisystem disorder that is exclusive to human pregnancy and defined as new hypertension presenting after 20 weeks with significant proteinuria. It is a multifactorial condition with a strong genetic component and several genes have been linked with this disorder. The main players implicated in the pathogenesis of preeclampsia include immune maladaptation, haemodynamics, endothelial function, thrombophilic disorders, oxidative stress and lipid metabolism. All of these mechanisms encompass genetic factors tha...
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Targeted therapy for ovarian cancer: the rapidly evolving landscape of PARP inhibitor use.
CONCLUSIONS: The landscape of PARP inhibitor use for ovarian cancer is rapidly evolving and PARP inhibitors have become more available as a targeted therapy option for ovarian cancer treatment. PMID: 28994564 [PubMed - as supplied by publisher] (Source: Minerva Ginecologica)
Source: Minerva Ginecologica - October 11, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Morcellation of occulted sarcomas during laparoscopic myomectomy and hystrectomy for patients with large fibroid uterus.
Authors: Tinelli A, Farghaly SA Abstract In April 2014, the United States of America Food and Drug Administration (FDA) published a safety communication warning of the risk of an unsuspected uterine sarcoma being morcellated during a laparoscopic procedure, and advised against the use of power morcellation. In November of the same year, this agency stated: 1. Laparoscopic power morcellators are contraindicated for removal of uterine tissue containing suspected fibroids in patients who are peri- or post-menopausal, or are candidates for "en bloc" tissue removal. 2. Laparoscopic power morcellators are contr...
Source: Minerva Ginecologica - October 5, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Menopause and hormone replacement therapy. The 2017 recommendations of the Italian Menopause Society.
Authors: Gambacciani M, Biglia N, Cagnacci A, DI Carlo C, Caruso S, Cicinelli E, DE Leo V, Farris M, Gambera A, Guaschino S, Lanzone A, Paoletti AM, Russo N, Vicariotto F, Villa P, Volpe A Abstract In the last decade the risk benefits ratio of HRT has been reevaluated mainly in tens of cardiovascular risk. Present Consensus Statement is largely inspired by the Global Consensus on Menopausel Hormone Therapy in 2013 and 2016 by leading global menopause societies (The American Society for Reproductive Medicine, The Asia Pacific Menopause Federation, The Endocrine Society, The European Menopause and Andropause Society,...
Source: Minerva Ginecologica - October 5, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Prognosis and cost-effectiveness of IVF in poor responders according to the Bologna criteria.
Authors: Busnelli A, Somigliana E Abstract Poor ovarian response (POR) to controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) is one of the most challenging issue in the field of reproductive medicine. However, even if improving IVF outcome in poor responders (PORs) represents a main priority, the lack of a unique definition of POR has hampered research in this area. In order to overcome this impediment, an ESHRE Campus Workshop was organized in Bologna in 2010 and reached a consensus on the criteria for the diagnosis of POR ('Bologna criteria'). In this review we aimed to estimate the progno...
Source: Minerva Ginecologica - September 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

A modern approach to the management of patients candidate to assisted reproductive technologies.
Authors: Venturella R, Vaiarelli A, Lico D, Ubaldi FM, Zullo F, DI Carlo C Abstract The growing use of Assisted Reproductive Technologies (ART) and the incorrect information from mass media, determined in the public the wrong idea that the right moment of life for programming a pregnancy can be delayed well beyond the physiological fertile age. Spare and insufficient health authorities' interventions are driven to explain to the general population the reduction of the fertility potential of couples and particularly of women with advancing age. This situation, characterized by more and more women seeking for pregnan...
Source: Minerva Ginecologica - September 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Optimising preconception health in women of reproductive age.
Authors: Lang AY, Boyle JA, Fitzgerald G, Teede H, Mazza D, Moran LJ, Harrison C Abstract There is a growing realisation that efforts to optimise the health of women and reduce the risk of adverse maternal, perinatal and neonatal outcomes during pregnancy should commence in the preconception period. The preconception period (prior to or between pregnancies) provides an opportune time to address reproductive intentions and promote and support wellbeing and healthy behaviour change regardless of pregnancy intention. Research over the last 30 years has explored the influence of a range of preconception risk factors an...
Source: Minerva Ginecologica - September 14, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Gynecological and obstetrical management of rheumatic diseases in reproductive age.
Authors: Pepe F, Stracquadanio M, Privitera A, Ciotta L, DE Luca F Abstract The gynecologist's role in the management of rheumatic patients is complex: it includes the prevention of damage caused by drugs, the counseling about contraception to avoid pregnancy while taking teratogen drugs, the scheduling of pregnancy during the quiescent phase of the specific disease, the replacement of teratogen drugs and a competent management of the pregnancy. The task is carried out as part of a multidisciplinary team with particular attention on differential diagnosis between specific complications of pregnancy and the complica...
Source: Minerva Ginecologica - September 13, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research