Distribution and frequency of ace-1 and kdr mutations of Culex pipiens subgroup in the Republic of Korea
This study categorized Culex pipiens mosquitoes subgroup from 13 regions in the ROK into Culex pallens and Culex pipiens f. molestus, and target site genotypes for acetylcholinesterase-1 (ace-1) and voltage-gated sodium channel (vgsc) genes were identified for each taxon. Screening for ace-1 did not identify a resistant allele (G119S) in Cx. pipiens f. molestus, and heterozygous resistance (AGC/GGC) was identified in one Cx. pallens collected in Mokpo. In vgsc, knockdown resistance (kdr) mutations [TTT(L1014F) and TCA(L1014S)] were present in both taxa, with Cx. pipiens f. molestus having homozygous resistance (TTT/TTT): 4...
Source: Acta Tropica - November 1, 2023 Category: Infectious Diseases Authors: Jiseung Jeon Jihun Ryu Kwang Shik Choi Source Type: research
Viruses, Vol. 15, Pages 2200: Molecular and Cellular Mechanisms Underlying Neurologic Manifestations of Mosquito-Borne Flavivirus Infections
This article aims to highlight mechanisms of cellular damage that are common across several flavivirus members and mechanisms that are more unique to specific members. Our goal is to inspire further research to improve understanding of this area in the hope of identifying treatment options for flavivirus-associated neurologic changes. (Source: Viruses)
Source: Viruses - October 31, 2023 Category: Virology Authors: Britanie M. Blackhurst Kristen E. Funk Tags: Review Source Type: research
Mosquito-borne flaviviruses and type I interferon: catch me if you can!
Mosquito-borne flaviviruses include many viruses that are important human pathogens, including Yellow fever virus, Dengue virus, Zika virus and West Nile virus. While these viruses have long been confined to tropical regions, they now pose a global public health concern, as the geographical distribution of their mosquito vectors has dramatically expanded. The constant threat of flavivirus emergence and re-emergence underlines the need for a better understanding of the relationships between these viruses and their hosts. In particular, unraveling how these viruses manage to bypass antiviral immune mechanisms could enable th...
Source: Frontiers in Microbiology - October 30, 2023 Category: Microbiology Source Type: research
Viral Anterior Uveitis: A Practical and Comprehensive Review of Diagnosis and Treatment
This article provides an updated literature review of the epidemiology, clinical manifestations, diagnostic tools, and treatment options for viral anterior uveitis.PMID:37862684 | DOI:10.1080/09273948.2023.2271077 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 20, 2023 Category: Allergy & Immunology Authors: Yun Feng Ruby Garcia William Rojas-Carabali Carlos Cifuentes-Gonz ález Ikhwanuliman Putera Jingyi Li Rina La Distia Nora Padmamalini Mahendradas Vishali Gupta Alejandra de-la-Torre Rupesh Agrawal Source Type: research
Viral Anterior Uveitis: A Practical and Comprehensive Review of Diagnosis and Treatment
This article provides an updated literature review of the epidemiology, clinical manifestations, diagnostic tools, and treatment options for viral anterior uveitis.PMID:37862684 | DOI:10.1080/09273948.2023.2271077 (Source: Herpes)
Source: Herpes - October 20, 2023 Category: Infectious Diseases Authors: Yun Feng Ruby Garcia William Rojas-Carabali Carlos Cifuentes-Gonz ález Ikhwanuliman Putera Jingyi Li Rina La Distia Nora Padmamalini Mahendradas Vishali Gupta Alejandra de-la-Torre Rupesh Agrawal Source Type: research
Viral Anterior Uveitis: A Practical and Comprehensive Review of Diagnosis and Treatment
This article provides an updated literature review of the epidemiology, clinical manifestations, diagnostic tools, and treatment options for viral anterior uveitis.PMID:37862684 | DOI:10.1080/09273948.2023.2271077 (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 20, 2023 Category: Allergy & Immunology Authors: Yun Feng Ruby Garcia William Rojas-Carabali Carlos Cifuentes-Gonz ález Ikhwanuliman Putera Jingyi Li Rina La Distia Nora Padmamalini Mahendradas Vishali Gupta Alejandra de-la-Torre Rupesh Agrawal Source Type: research
Ubiquitin accumulation induced by the finger and palm sub-domains of NS5 modulates the replication of West Nile virus
In this study, the association between ubiquitin accumulation and WNV pathogenicity was investigated. Ubiquitin accumulation was detected in cells infected with NY99 strain belonging to lineage-1, but not FCG and Zmq16 strains belonging to lineage-2. Substitution of the Finger and Palm sub-domains of NS5 from lineage-1 to -2 decreased ubiquitin accumulation and viral replication. Furthermore, the survival rate was increased, and viral replication and ubiquitin accumulation in the brain were attenuated, in mice inoculated with the substituted WNV compared with lineage-1 WNV. Therefore, the intracellular ubiquitin accumulati...
Source: Virology - October 19, 2023 Category: Virology Authors: Shintaro Kobayashi Ryoko Kawakami Chisaki Takeda Keisuke Maezono Passawat Thammahakin Haruto Eguchi Bernard M Hang'ombe Yasuko Orba Hirofumi Sawa Kentaro Yoshii Hiroaki Kariwa Source Type: research
Ubiquitin accumulation induced by the finger and palm sub-domains of NS5 modulates the replication of West Nile virus
In this study, the association between ubiquitin accumulation and WNV pathogenicity was investigated. Ubiquitin accumulation was detected in cells infected with NY99 strain belonging to lineage-1, but not FCG and Zmq16 strains belonging to lineage-2. Substitution of the Finger and Palm sub-domains of NS5 from lineage-1 to -2 decreased ubiquitin accumulation and viral replication. Furthermore, the survival rate was increased, and viral replication and ubiquitin accumulation in the brain were attenuated, in mice inoculated with the substituted WNV compared with lineage-1 WNV. Therefore, the intracellular ubiquitin accumulati...
Source: Virology - October 19, 2023 Category: Virology Authors: Shintaro Kobayashi Ryoko Kawakami Chisaki Takeda Keisuke Maezono Passawat Thammahakin Haruto Eguchi Bernard M Hang'ombe Yasuko Orba Hirofumi Sawa Kentaro Yoshii Hiroaki Kariwa Source Type: research
Chemical Composition and Larvicidal Properties of Essential Oils from Wild and Cultivated < em > Artemisia campestris < /em > L., an Endemic Plant in Morocco
In this study, essential oils (EOs) extracted from the aerial parts of both wild and cultivated Artemisia campestris L. plants were tested for larvicidal activity against Culex pipiens (Diptera: Culicidae), a pest mosquito widely suspected to be the vector responsible for West Nile virus transmission. The research aims at comparing the chemical composition and insecticidal activity of cultivated and wild A. campestris EOs. The EOs were obtained by hydrodistillation from the plant's aerial parts and were analyzed using GC-MS. Furthermore, the larviciding experiment was carried out following the standard WHO protocol. The re...
Source: The Scientific World Journal - October 18, 2023 Category: Science Authors: Abdellatif Alami Abdelhakim El Ouali Lalami Saoussan Annemer Fouad El-Akhal Yassine Ez Zoubi Abdellah Farah Source Type: research
Infectious etiologies among post-donation deferrals in a military blood donation center
CONCLUSION: The rates of post-donation deferral for transfusion-transmissible infections were low in this military cohort. Our findings suggest that donor testing in deployed service members should focus on HBV, HCV, and T. pallidum and highlight the need for better diagnostics for HIV, Chagas, and HTLV-I/II.PMID:37850496 | DOI:10.1111/trf.17584 (Source: Transfusion)
Source: Transfusion - October 18, 2023 Category: Hematology Authors: Somin Kwon Brian G Casleton Glorimar Z Rivera Melita M Gella Erin L Winkler John W Kieffer Angela B Osuna Theresa M Casey Heather C Yun Joseph E Marcus Source Type: research
Chemical Composition and Larvicidal Properties of Essential Oils from Wild and Cultivated < em > Artemisia campestris < /em > L., an Endemic Plant in Morocco
In this study, essential oils (EOs) extracted from the aerial parts of both wild and cultivated Artemisia campestris L. plants were tested for larvicidal activity against Culex pipiens (Diptera: Culicidae), a pest mosquito widely suspected to be the vector responsible for West Nile virus transmission. The research aims at comparing the chemical composition and insecticidal activity of cultivated and wild A. campestris EOs. The EOs were obtained by hydrodistillation from the plant's aerial parts and were analyzed using GC-MS. Furthermore, the larviciding experiment was carried out following the standard WHO protocol. The re...
Source: The Scientific World Journal - October 18, 2023 Category: Science Authors: Abdellatif Alami Abdelhakim El Ouali Lalami Saoussan Annemer Fouad El-Akhal Yassine Ez Zoubi Abdellah Farah Source Type: research
