Severe Neuroinvasive West Nile Virus in Association With Anti-CD20 Monotherapy for Multiple Sclerosis
The objective of this study was to report on the development of neuroinvasive West Nile virus (WNV) infection in the context of anti-CD20 monotherapy for multiple sclerosis (MS).
Methods
This is a case series study.
Results
In 2021–2022, we observed 4 cases of neuroinvasive WNV infection in our patient population of 2009 patients with MS on ocrelizumab, compared with a total of 46 cases of neuroinvasive WNV infection reported in Pennsylvania and 40 in New Jersey. Odds were 258 times that of the general population (95% confidence interval 97–691), 2 p < 0.0001). All were women aged 41–61 years with va...
Source: Neurology Neuroimmunology and Neuroinflammation - August 10, 2023 Category: Neurology Authors: Thebault, S., Gandelman, S., Lane, C., Kim, E. J., Pileggi, C., Zuroff, L., Yamashita, L. D., Schindler, M. K., Chiu, C., Wilson, M. R., Berger, J. R., Markowitz, C., Bar-Or, A., Fuller, R., Brandstadter, R., Pruitt, A. A., Jacobs, D. A. Tags: Encephalitis, Viral infections, Multiple sclerosis Clinical/Scientific Note Source Type: research
Fast-response electrochemical biosensor based on a truncated aptamer and MXene heterolayer for West Nile virus detection in human serum
Bioelectrochemistry. 2023 Aug 4;154:108540. doi: 10.1016/j.bioelechem.2023.108540. Online ahead of print.ABSTRACTWest Nile virus (WNV) is a mosquito-borne flavivirus that can cause West Nile fever, meningitis, encephalitis, and polio. Early detection of WNV is important to prevent infection spread on the field. To commercialize the electrochemical biosensor for WNV, rapid target detection with the cheap manufacture cost is essential. Here, we developed a fast-response electrochemical biosensor consisting of a truncated WNV aptamer/MXene (Ti3C2Tx) bilayer on round-type micro gap. To reduce the target binding time, the appli...
Source: Bioelectrochemistry - August 9, 2023 Category: Biochemistry Authors: Hanbin Park Nayeon Kwon Goeun Park Moonbong Jang Yein Kwon Yejin Yoon Jeongyun An Junhong Min Taek Lee Source Type: research
Fast-response electrochemical biosensor based on a truncated aptamer and MXene heterolayer for West Nile virus detection in human serum
Bioelectrochemistry. 2023 Aug 4;154:108540. doi: 10.1016/j.bioelechem.2023.108540. Online ahead of print.ABSTRACTWest Nile virus (WNV) is a mosquito-borne flavivirus that can cause West Nile fever, meningitis, encephalitis, and polio. Early detection of WNV is important to prevent infection spread on the field. To commercialize the electrochemical biosensor for WNV, rapid target detection with the cheap manufacture cost is essential. Here, we developed a fast-response electrochemical biosensor consisting of a truncated WNV aptamer/MXene (Ti3C2Tx) bilayer on round-type micro gap. To reduce the target binding time, the appli...
Source: Bioelectrochemistry - August 9, 2023 Category: Biochemistry Authors: Hanbin Park Nayeon Kwon Goeun Park Moonbong Jang Yein Kwon Yejin Yoon Jeongyun An Junhong Min Taek Lee Source Type: research
Fast-response electrochemical biosensor based on a truncated aptamer and MXene heterolayer for West Nile virus detection in human serum
Bioelectrochemistry. 2023 Aug 4;154:108540. doi: 10.1016/j.bioelechem.2023.108540. Online ahead of print.ABSTRACTWest Nile virus (WNV) is a mosquito-borne flavivirus that can cause West Nile fever, meningitis, encephalitis, and polio. Early detection of WNV is important to prevent infection spread on the field. To commercialize the electrochemical biosensor for WNV, rapid target detection with the cheap manufacture cost is essential. Here, we developed a fast-response electrochemical biosensor consisting of a truncated WNV aptamer/MXene (Ti3C2Tx) bilayer on round-type micro gap. To reduce the target binding time, the appli...
Source: Bioelectrochemistry - August 9, 2023 Category: Biochemistry Authors: Hanbin Park Nayeon Kwon Goeun Park Moonbong Jang Yein Kwon Yejin Yoon Jeongyun An Junhong Min Taek Lee Source Type: research
Fast-response electrochemical biosensor based on a truncated aptamer and MXene heterolayer for West Nile virus detection in human serum
Bioelectrochemistry. 2023 Aug 4;154:108540. doi: 10.1016/j.bioelechem.2023.108540. Online ahead of print.ABSTRACTWest Nile virus (WNV) is a mosquito-borne flavivirus that can cause West Nile fever, meningitis, encephalitis, and polio. Early detection of WNV is important to prevent infection spread on the field. To commercialize the electrochemical biosensor for WNV, rapid target detection with the cheap manufacture cost is essential. Here, we developed a fast-response electrochemical biosensor consisting of a truncated WNV aptamer/MXene (Ti3C2Tx) bilayer on round-type micro gap. To reduce the target binding time, the appli...
Source: Bioelectrochemistry - August 9, 2023 Category: Biochemistry Authors: Hanbin Park Nayeon Kwon Goeun Park Moonbong Jang Yein Kwon Yejin Yoon Jeongyun An Junhong Min Taek Lee Source Type: research
Fast-response electrochemical biosensor based on a truncated aptamer and MXene heterolayer for West Nile virus detection in human serum
Bioelectrochemistry. 2023 Aug 4;154:108540. doi: 10.1016/j.bioelechem.2023.108540. Online ahead of print.ABSTRACTWest Nile virus (WNV) is a mosquito-borne flavivirus that can cause West Nile fever, meningitis, encephalitis, and polio. Early detection of WNV is important to prevent infection spread on the field. To commercialize the electrochemical biosensor for WNV, rapid target detection with the cheap manufacture cost is essential. Here, we developed a fast-response electrochemical biosensor consisting of a truncated WNV aptamer/MXene (Ti3C2Tx) bilayer on round-type micro gap. To reduce the target binding time, the appli...
Source: Bioelectrochemistry - August 9, 2023 Category: Biochemistry Authors: Hanbin Park Nayeon Kwon Goeun Park Moonbong Jang Yein Kwon Yejin Yoon Jeongyun An Junhong Min Taek Lee Source Type: research
Viruses, Vol. 15, Pages 1707: Seroprevalence of IgG Antibodies Directed against Dengue, Chikungunya and West Nile Viruses and Associated Risk Factors in Madagascar, 2011 to 2013
y Andriamandimby
Arboviruses have been shown to circulate in Madagascar, including West Nile, dengue, and chikungunya viruses, though the extent of their circulation remains poorly documented. We estimated the seroprevalence of these three arboviruses in Madagascar and determined risk factors associated with seropositivity. Serum samples obtained from 1680 individuals surrounding the Sentinel Health Centers network in all regions of the country were analyzed using ELISA and hemagglutination inhibition assays for dengue, chikungunya, and West Nile viruses IgG antibodies, and multivariate logistic regression models were ...
Source: Viruses - August 8, 2023 Category: Virology Authors: Ana ïs Broban Marie-Marie Olive Michael Luciano Tantely Anne-Claire Dorsemans Fanjasoa Rakotomanana Jean-Pierre Ravalohery Christophe Rogier Jean-Michel Heraud Soa Fy Andriamandimby Tags: Article Source Type: research
Detection of disease-associated microglia among various microglia phenotypes induced by West Nile virus infection in mice
In this study, we examined the diversity of microglia phenotypes caused by WNV infection by assessing various microglia markers and identified disease-associated microglia in WNV-infected mouse brain tissue. Cells positive for general microglia markers such as Iba1, P2RY12, or TMEM119 were detected in the control and WNV-infected brain tissue. The morphology of the positive cells in brain tissue infected by WNV was different from that of control brain tissue, indicating that WNV infection induced activation of microglia. The activated microglia were classified into various phenotypes by investigation of specific marker exp...
Source: Journal of NeuroVirology - August 8, 2023 Category: Neurology Source Type: research
House Sparrows Vary Seasonally in Their Ability to Transmit West Nile Virus
Physiological and Biochemical Zoology, Ahead of Print. (Source: Physiological and Biochemical Zoology)
Source: Physiological and Biochemical Zoology - August 1, 2023 Category: Zoology Authors: Kyle K. Koller Meredith E. Kernbach Darrys Reese Thomas R. Unnasch Lynn B. Martin Source Type: research
Ocular Findings Aid in Diagnosis of West Nile Virus
CONCLUSIONS: West Nile virus should be considered in patients with acute febrile or neurological illness during mosquito season.PMID:37494654 (Source: WMJ)
Source: WMJ - July 26, 2023 Category: General Medicine Authors: Brandon K Winward Justin L Gottlieb Jonathan S Chang Luke Bradbury Nenita Maganti Chintan Pathak Benjamin J Fowler Source Type: research
Ocular Findings Aid in Diagnosis of West Nile Virus
CONCLUSIONS: West Nile virus should be considered in patients with acute febrile or neurological illness during mosquito season.PMID:37494654 (Source: WMJ)
Source: WMJ - July 26, 2023 Category: General Medicine Authors: Brandon K Winward Justin L Gottlieb Jonathan S Chang Luke Bradbury Nenita Maganti Chintan Pathak Benjamin J Fowler Source Type: research
Ocular Findings Aid in Diagnosis of West Nile Virus
CONCLUSIONS: West Nile virus should be considered in patients with acute febrile or neurological illness during mosquito season.PMID:37494654 (Source: WMJ)
Source: WMJ - July 26, 2023 Category: General Medicine Authors: Brandon K Winward Justin L Gottlieb Jonathan S Chang Luke Bradbury Nenita Maganti Chintan Pathak Benjamin J Fowler Source Type: research
Ocular Findings Aid in Diagnosis of West Nile Virus
CONCLUSIONS: West Nile virus should be considered in patients with acute febrile or neurological illness during mosquito season.PMID:37494654 (Source: WMJ)
Source: WMJ - July 26, 2023 Category: General Medicine Authors: Brandon K Winward Justin L Gottlieb Jonathan S Chang Luke Bradbury Nenita Maganti Chintan Pathak Benjamin J Fowler Source Type: research
Ocular Findings Aid in Diagnosis of West Nile Virus
CONCLUSIONS: West Nile virus should be considered in patients with acute febrile or neurological illness during mosquito season.PMID:37494654 (Source: WMJ)
Source: WMJ - July 26, 2023 Category: General Medicine Authors: Brandon K Winward Justin L Gottlieb Jonathan S Chang Luke Bradbury Nenita Maganti Chintan Pathak Benjamin J Fowler Source Type: research
Ocular Findings Aid in Diagnosis of West Nile Virus
CONCLUSIONS: West Nile virus should be considered in patients with acute febrile or neurological illness during mosquito season.PMID:37494654 (Source: WMJ)
Source: WMJ - July 26, 2023 Category: General Medicine Authors: Brandon K Winward Justin L Gottlieb Jonathan S Chang Luke Bradbury Nenita Maganti Chintan Pathak Benjamin J Fowler Source Type: research
