Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
In this study, a functional NLRP3 inflammasome was reconstructed in human HEK293T cells and the effect of some nonstructural proteins of individual Flaviviridae viruses on it was studied. This model did not reveal any impact of nonstructural NS1 proteins of the West Nile virus, NS3 of hepatitis C virus, or NS5 of tick-borne encephalitis virus on the inflammasome components content. At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it...
Source: Molekuliarnaia Biologiia - September 27, 2023 Category: Molecular Biology Authors: A A Latanova K K Tuchinskaya E S Starodubova V L Karpov Source Type: research
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
In this study, a functional NLRP3 inflammasome was reconstructed in human HEK293T cells and the effect of some nonstructural proteins of individual Flaviviridae viruses on it was studied. This model did not reveal any impact of nonstructural NS1 proteins of the West Nile virus, NS3 of hepatitis C virus, or NS5 of tick-borne encephalitis virus on the inflammasome components content. At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it...
Source: Molekuliarnaia Biologiia - September 27, 2023 Category: Molecular Biology Authors: A A Latanova K K Tuchinskaya E S Starodubova V L Karpov Source Type: research
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
In this study, a functional NLRP3 inflammasome was reconstructed in human HEK293T cells and the effect of some nonstructural proteins of individual Flaviviridae viruses on it was studied. This model did not reveal any impact of nonstructural NS1 proteins of the West Nile virus, NS3 of hepatitis C virus, or NS5 of tick-borne encephalitis virus on the inflammasome components content. At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it...
Source: Molekuliarnaia Biologiia - September 27, 2023 Category: Molecular Biology Authors: A A Latanova K K Tuchinskaya E S Starodubova V L Karpov Source Type: research
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
In this study, a functional NLRP3 inflammasome was reconstructed in human HEK293T cells and the effect of some nonstructural proteins of individual Flaviviridae viruses on it was studied. This model did not reveal any impact of nonstructural NS1 proteins of the West Nile virus, NS3 of hepatitis C virus, or NS5 of tick-borne encephalitis virus on the inflammasome components content. At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it...
Source: Molekuliarnaia Biologiia - September 27, 2023 Category: Molecular Biology Authors: A A Latanova K K Tuchinskaya E S Starodubova V L Karpov Source Type: research
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
In this study, a functional NLRP3 inflammasome was reconstructed in human HEK293T cells and the effect of some nonstructural proteins of individual Flaviviridae viruses on it was studied. This model did not reveal any impact of nonstructural NS1 proteins of the West Nile virus, NS3 of hepatitis C virus, or NS5 of tick-borne encephalitis virus on the inflammasome components content. At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it...
Source: Molekuliarnaia Biologiia - September 27, 2023 Category: Molecular Biology Authors: A A Latanova K K Tuchinskaya E S Starodubova V L Karpov Source Type: research
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
In this study, a functional NLRP3 inflammasome was reconstructed in human HEK293T cells and the effect of some nonstructural proteins of individual Flaviviridae viruses on it was studied. This model did not reveal any impact of nonstructural NS1 proteins of the West Nile virus, NS3 of hepatitis C virus, or NS5 of tick-borne encephalitis virus on the inflammasome components content. At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it...
Source: Molekuliarnaia Biologiia - September 27, 2023 Category: Molecular Biology Authors: A A Latanova K K Tuchinskaya E S Starodubova V L Karpov Source Type: research
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
In this study, a functional NLRP3 inflammasome was reconstructed in human HEK293T cells and the effect of some nonstructural proteins of individual Flaviviridae viruses on it was studied. This model did not reveal any impact of nonstructural NS1 proteins of the West Nile virus, NS3 of hepatitis C virus, or NS5 of tick-borne encephalitis virus on the inflammasome components content. At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it...
Source: Molekuliarnaia Biologiia - September 27, 2023 Category: Molecular Biology Authors: A A Latanova K K Tuchinskaya E S Starodubova V L Karpov Source Type: research
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
In this study, a functional NLRP3 inflammasome was reconstructed in human HEK293T cells and the effect of some nonstructural proteins of individual Flaviviridae viruses on it was studied. This model did not reveal any impact of nonstructural NS1 proteins of the West Nile virus, NS3 of hepatitis C virus, or NS5 of tick-borne encephalitis virus on the inflammasome components content. At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it...
Source: Molekuliarnaia Biologiia - September 27, 2023 Category: Molecular Biology Authors: A A Latanova K K Tuchinskaya E S Starodubova V L Karpov Source Type: research
Hepatitis C Virus Nonstructural Protein 3 Increases Secretion of Interleukin-lbeta in HEK293T Cells with a Reconstructed NLRP3 Inflammasome
In this study, a functional NLRP3 inflammasome was reconstructed in human HEK293T cells and the effect of some nonstructural proteins of individual Flaviviridae viruses on it was studied. This model did not reveal any impact of nonstructural NS1 proteins of the West Nile virus, NS3 of hepatitis C virus, or NS5 of tick-borne encephalitis virus on the inflammasome components content. At the same time, in the presence of the NS1 of the West Nile virus and NS5 of the tick-borne encephalitis virus, the level of secretion of interleukin-1beta did not change, whereas in the presence of the NS3 protein of the hepatitis C virus, it...
Source: Molekuliarnaia Biologiia - September 27, 2023 Category: Molecular Biology Authors: A A Latanova K K Tuchinskaya E S Starodubova V L Karpov Source Type: research
Glycolytic shift during West Nile virus infection provides new therapeutic opportunities
Viral rewiring of host bioenergetics and immunometabolism may provide novel targets for therapeutic interventions against viral infections. Here, we have explored the effect on bioenergetics during the infecti... (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - September 27, 2023 Category: Neurology Authors: Patricia Mingo-Casas, Ana-Bel én Blázquez, Marta Gómez de Cedrón, Ana San-Félix, Susana Molina, Estela Escribano-Romero, Eva Calvo-Pinilla, Nereida Jiménez de Oya, Ana Ramírez de Molina, Juan-Carlos Saiz, María-Jesús Pérez-Pérez and Miguel A. M Tags: Research Source Type: research
Heat and disease will exact a heavy toll as climate warms
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Malaria cases could ebb in an even hotter world. But other diseases will get worse
BY Kai Kupferschmidt
This special issue of
Science
was supported by the Pulitzer Center and the Vapnek Family Foundation.
Earth scientists often call climate change a “great global experiment,” which humanity is heedlessly performing as we pump greenhouse gases into the atmosphere. The dire consequences are already becoming clear—not just for the workings of the planet, but for our ow...
Source: Science of Aging Knowledge Environment - September 26, 2023 Category: Geriatrics Source Type: research
Belgian < i > Culex pipiens pipiens < /i > are competent vectors for West Nile virus while < i > Culex modestus < /i > are competent vectors for Usutu virus
Conclusions/SignificanceThis is the first report that BelgianCulex mosquitoes can transmit both WNV and USUV, forewarning the risk of human transmission. More research is needed to understand the potential influence ofWolbachia on arbovirus transmission inCulex modestus mosquitoes. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - September 20, 2023 Category: Tropical Medicine Authors: Alina Soto Source Type: research
Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage
Virus Res. 2023 Sep 14:199222. doi: 10.1016/j.virusres.2023.199222. Online ahead of print.ABSTRACTFlaviviruses include medically important mosquito-borne pathogens, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), dengue virus (DENV) and West Nile virus (WNV), that cause hundreds of millions of infections each year. Currently, there are no approved effect therapies against mosquito-borne flaviviruses. The flaviviruses encoded nonstructural protein 1 (NS1) is a secreted glycoprotein widely involved in viral replication, immune evasion, and directly causing tissue-specific damage during flaviviruses infection. U...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Quan Zeng Jiaqi Liu Chenlin Hao Bo Zhang Honglei Zhang Source Type: research
Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage
Virus Res. 2023 Sep 14:199222. doi: 10.1016/j.virusres.2023.199222. Online ahead of print.ABSTRACTFlaviviruses include medically important mosquito-borne pathogens, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), dengue virus (DENV) and West Nile virus (WNV), that cause hundreds of millions of infections each year. Currently, there are no approved effect therapies against mosquito-borne flaviviruses. The flaviviruses encoded nonstructural protein 1 (NS1) is a secreted glycoprotein widely involved in viral replication, immune evasion, and directly causing tissue-specific damage during flaviviruses infection. U...
Source: Virus Research - September 16, 2023 Category: Virology Authors: Quan Zeng Jiaqi Liu Chenlin Hao Bo Zhang Honglei Zhang Source Type: research
Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage
Virus Res. 2023 Sep 14:199222. doi: 10.1016/j.virusres.2023.199222. Online ahead of print.ABSTRACTFlaviviruses include medically important mosquito-borne pathogens, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), dengue virus (DENV) and West Nile virus (WNV), that cause hundreds of millions of infections each year. Currently, there are no approved effect therapies against mosquito-borne flaviviruses. The flaviviruses encoded nonstructural protein 1 (NS1) is a secreted glycoprotein widely involved in viral replication, immune evasion, and directly causing tissue-specific damage during flaviviruses infection. U...
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Quan Zeng Jiaqi Liu Chenlin Hao Bo Zhang Honglei Zhang Source Type: research
