Viruses, Vol. 16, Pages 599: Circulation of West Nile Virus and Usutu Virus in Europe: Overview and Challenges
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West Nile Virus (WNV) and Usutu Virus (USUV) are both neurotropic mosquito-borne viruses belonging to the Flaviviridae family. These closely related viruses mainly follow an enzootic cycle involving mosquitoes as vectors and birds as amplifying hosts, but humans and other mammals can also be infected through mosquito bites. WNV was first identified in Uganda in 1937 and has since spread globally, notably in Europe, causing periodic outbreaks associated with severe cases of neuroinvasive diseases such as meningitis and encephalitis. USUV was initially isolated in 1959 in Swaziland and has also spread to Europe, primar...
Source: Viruses - April 12, 2024 Category: Virology Authors: Yannick Simonin Tags: Perspective Source Type: research
Bilateral multifocal chorioretinitis as the only presentation of acute West Nile virus infection: a case report
To describe a case of bilateral multifocal chorioretinitis as the only presentation of acute West Nile virus (WNV) infection in the absence of neurological involvement. (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - April 10, 2024 Category: Opthalmology Authors: Nicola Valsecchi, Chiara Veronese, Matilde Roda, Antonio Pasquale Ciardella and Luigi Fontana Tags: Case Report Source Type: research
West Nile Virus Emergence in Germany 2019: Looking for Hidden Human West Nile Virus Infections
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - April 3, 2024 Category: Infectious Diseases Authors: Raskit Lachmann Cristina Domingo Christina Frank Andreas Ochs Andreas Karl Pauly Marijke Weber-Schehl Michael Schmidt Torsten Tonn Thomas H. M üller Luisa Barzon Alessandro Sinigaglia Sarah Esquevin Karina Preu ßel Ruth Offergeld Source Type: research
A Specific Pattern of Routine Cerebrospinal Fluid Parameters Might Help to Identify Cases of West Nile Virus Neuroinvasive Disease
CONCLUSIONS: Cases with WNV ME showed a specific pattern of routine CSF parameters and demographic data that allowed for their identification with good accuracy. These findings might help to guide the diagnostic workup in cases with viral ME, in particular allowing the timely identification of cases with ME due to WNV.PMID:38543707 | PMC:PMC10974314 | DOI:10.3390/v16030341 (Source: Herpes)
Source: Herpes - March 28, 2024 Category: Infectious Diseases Authors: Johann Otto Pelz Christoph M ühlberg Isabel Friedrich Lorenz Weidhase Silke Zimmermann Melanie Maier Corinna Pietsch Source Type: research
Viruses, Vol. 16, Pages 527: Orthoflavivirus Lammi in Russia: Possible Transovarial Transmission and Trans-Stadial Survival in Aedes cinereus (Diptera, Culicidae)
lina G. Karganova
In the last few years, there has been a dramatic increase in the number of discovered viruses that are transmitted by arthropods. Some of them are pathogenic for humans and mammals, and the pathogenic potential of others is unknown. The genus Orthoflavivirus belongs to the family Flaviviridae and includes arboviruses that cause severe human diseases with damage to the central nervous system and hemorrhagic fevers, as well as viruses with unknown vectors and viruses specific only to insects. The latter group includes Lammi virus, first isolated from a mosquito pool in Finland. It is known that Lammi vi...
Source: Viruses - March 28, 2024 Category: Virology Authors: Ivan S. Kholodilov Sergey V. Aibulatov Alexei V. Khalin Alexandra E. Polienko Alexander S. Klimentov Oxana A. Belova Anastasiya A. Rogova Sergey G. Medvedev Galina G. Karganova Tags: Brief Report Source Type: research
WSV2023 - The second meeting of the world society for virology: One health - One world - One virology
Discussions further explored SARS-CoV-2 RNA replicons as vaccine candidates, SARS-CoV-2 in humans and animals, and the significance of plant viruses in the 'One Health' paradigm. The presence of the presidents from three virology societies, namely the American, Indian, and Korean Societies for Virology, highlighted the event's significance. Additionally, past president of the American Society for Virology (ASV), formally declared the partnership between ASV and WSV during the conference.PMID:38527382 | DOI:10.1016/j.virol.2024.110049 (Source: Virology)
Source: Virology - March 25, 2024 Category: Virology Authors: Ahmed S Abdel-Moneim Modra Murovska Maria S öderlund-Venermo Vikram N Vakharia William C Wilson Douglas P Gladue Matthew D Moore Covadonga Alonso Sayed F Abdelwahab Marietjie Venter Yashpal S Malik Shi Zhengli Shailendra K Saxena Anupam Varma Richard J K Source Type: research
WSV2023 - The second meeting of the world society for virology: One health - One world - One virology
Discussions further explored SARS-CoV-2 RNA replicons as vaccine candidates, SARS-CoV-2 in humans and animals, and the significance of plant viruses in the 'One Health' paradigm. The presence of the presidents from three virology societies, namely the American, Indian, and Korean Societies for Virology, highlighted the event's significance. Additionally, past president of the American Society for Virology (ASV), formally declared the partnership between ASV and WSV during the conference.PMID:38527382 | DOI:10.1016/j.virol.2024.110049 (Source: Virology)
Source: Virology - March 25, 2024 Category: Virology Authors: Ahmed S Abdel-Moneim Modra Murovska Maria S öderlund-Venermo Vikram N Vakharia William C Wilson Douglas P Gladue Matthew D Moore Covadonga Alonso Sayed F Abdelwahab Marietjie Venter Yashpal S Malik Shi Zhengli Shailendra K Saxena Anupam Varma Richard J K Source Type: research
Accelerating targeted mosquito control efforts through mobile West Nile virus detection
Different mosquito control strategies have been implemented to mitigate or prevent mosquito-related public health situations. Modern mosquito control largely relies on multiple approaches, including targeted, ... (Source: Parasites and Vectors)
Source: Parasites and Vectors - March 18, 2024 Category: Microbiology Authors: Zsaklin Varga, Rub én Bueno-Marí, José Risueño Iranzo, Kornélia Kurucz, Gábor Endre Tóth, Brigitta Zana, Safia Zeghbib, Tamás Görföl, Ferenc Jakab and Gábor Kemenesi Tags: Research Source Type: research
An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus
Vet Res. 2024 Mar 16;55(1):32. doi: 10.1186/s13567-024-01290-1.ABSTRACTOutbreaks of West Nile virus (WNV) occur periodically, affecting both human and equine populations. There are no vaccines for humans, and those commercialised for horses do not have sufficient coverage. Specific antiviral treatments do not exist. Many drug discovery studies have been conducted, but since rodent or primate cell lines are normally used, results cannot always be transposed to horses. There is thus a need to develop relevant equine cellular models. Here, we used induced pluripotent stem cells to develop a new in vitro model of WNV-infected ...
Source: Cell Research - March 17, 2024 Category: Cytology Authors: Marielle Cochet Fran çois Piumi Kamila Gorna No émie Berry Ga ëlle Gonzalez Anne Danckaert Nathalie Aulner Odile Blanchet St éphan Zientara Francesc Xavier Donadeu H élène Munier-Lehmann Jennifer Richardson Alexandra Benchoua Muriel Coulpier Source Type: research
Movement disorders associated with pediatric encephalitis
Handb Clin Neurol. 2024;200:229-238. doi: 10.1016/B978-0-12-823912-4.00018-9.ABSTRACTNew onset movement disorders are a common clinical problem in pediatric neurology and can be infectious, inflammatory, metabolic, or functional in origin. Encephalitis is one of the more important causes of new onset movement disorders, and movement disorders are a common feature (~25%) of all encephalitis. However, all encephalitides are not the same, and movement disorders are a key diagnostic feature that can help the clinician identify the etiology of the encephalitis, and therefore appropriate treatment is required. Movement disorders...
Source: Herpes - March 17, 2024 Category: Infectious Diseases Authors: Russell C Dale Shekeeb S Mohammad Source Type: research
Movement disorders associated with pediatric encephalitis
Handb Clin Neurol. 2024;200:229-238. doi: 10.1016/B978-0-12-823912-4.00018-9.ABSTRACTNew onset movement disorders are a common clinical problem in pediatric neurology and can be infectious, inflammatory, metabolic, or functional in origin. Encephalitis is one of the more important causes of new onset movement disorders, and movement disorders are a common feature (~25%) of all encephalitis. However, all encephalitides are not the same, and movement disorders are a key diagnostic feature that can help the clinician identify the etiology of the encephalitis, and therefore appropriate treatment is required. Movement disorders...
Source: Herpes - March 17, 2024 Category: Infectious Diseases Authors: Russell C Dale Shekeeb S Mohammad Source Type: research
An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus
AbstractOutbreaks of West Nile virus (WNV) occur periodically, affecting both human and equine populations. There are no vaccines for humans, and those commercialised for horses do not have sufficient coverage. Specific antiviral treatments do not exist. Many drug discovery studies have been conducted, but since rodent or primate cell lines are normally used, results cannot always be transposed to horses. There is thus a need to develop relevant equine cellular models. Here, we used induced pluripotent stem cells to develop a new in vitro model of WNV-infected equine brain cells suitable for microplate assay, and assessed ...
Source: Veterinary Research - March 16, 2024 Category: Veterinary Research Source Type: research
Viruses, Vol. 16, Pages 383: Inflammatory Response Associated with West Nile Neuroinvasive Disease: A Systematic Review
Conclusions: Further studies are needed to understand the pathogenesis of WNND and to investigate the extent and the way the host inflammatory response either helps in controlling the infection or in worsening the outcomes. This might prove useful both for the development of target therapies and for the development of molecular markers allowing early identification of patients displaying an inflammatory response that puts them at a higher risk of developing neuroinvasive disease and who might thus benefit from early antiviral therapies. (Source: Viruses)
Source: Viruses - February 29, 2024 Category: Virology Authors: Alessandro Pavesi Giorgio Tiecco Luca Rossi Anita Sforza Andrea Ciccarone Federico Compostella Sofia Lovatti Lina Rachele Tomasoni Francesco Castelli Eugenia Quiros-Roldan Tags: Systematic Review Source Type: research
Blood-feeding patterns of Culex pipiens biotype pipiens and pipiens/molestus hybrids in relation to avian community composition in urban habitats
Culex pipiens sensu stricto (s.s.) is considered the primary vector of Usutu virus and West Nile virus, and consists of two morphologically identical but behaviourally distinct biotypes (Cx. pipiens biotype pipie... (Source: Parasites and Vectors)
Source: Parasites and Vectors - February 29, 2024 Category: Microbiology Authors: Rody Blom, Louie Krol, Melissa Langezaal, Maarten Schrama, Krijn B. Trimbos, Daan Wassenaar and Constantianus J. M. Koenraadt Tags: Research Source Type: research
Low-temperature culture enhances production of flavivirus virus-like particles in mammalian cells
Appl Microbiol Biotechnol. 2024 Feb 28;108(1):242. doi: 10.1007/s00253-024-13064-y.ABSTRACTFlavivirus virus-like particles (VLPs) exhibit a striking structural resemblance to viral particles, making them highly adaptable for various applications, including vaccines and diagnostics. Consequently, increasing VLPs production is important and can be achieved by optimizing expression plasmids and cell culture conditions. While attempting to express genotype III (GIII) Japanese encephalitis virus (JEV) VLPs containing the G104H mutation in the envelope (E) protein, we failed to generate VLPs in COS-1 cells. However, VLPs product...
Source: Applied Microbiology and Biotechnology - February 28, 2024 Category: Microbiology Authors: Yi-Chin Fan Jo-Mei Chen Yi-Ying Chen Wei-Li Hsu Gwong-Jen Chang Shyan-Song Chiou Source Type: research
