Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage
Virus Res. 2023 Sep 16;336:199222. doi: 10.1016/j.virusres.2023.199222. Online ahead of print.ABSTRACTFlaviviruses include medically important mosquito-borne pathogens, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), dengue virus (DENV) and West Nile virus (WNV), that cause hundreds of millions of infections each year. Currently, there are no approved effect therapies against mosquito-borne flaviviruses. The flaviviruses encoded nonstructural protein 1 (NS1) is a secreted glycoprotein widely involved in viral replication, immune evasion, and directly causing tissue-specific damage during flaviviruses infectio...
Source: Virus Research - September 16, 2023 Category: Virology Authors: Quan Zeng Jiaqi Liu Chenlin Hao Bo Zhang Honglei Zhang Source Type: research
Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage
Virus Res. 2023 Sep 16;336:199222. doi: 10.1016/j.virusres.2023.199222. Online ahead of print.ABSTRACTFlaviviruses include medically important mosquito-borne pathogens, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), dengue virus (DENV) and West Nile virus (WNV), that cause hundreds of millions of infections each year. Currently, there are no approved effect therapies against mosquito-borne flaviviruses. The flaviviruses encoded nonstructural protein 1 (NS1) is a secreted glycoprotein widely involved in viral replication, immune evasion, and directly causing tissue-specific damage during flaviviruses infectio...
Source: Virus Research - September 16, 2023 Category: Virology Authors: Quan Zeng Jiaqi Liu Chenlin Hao Bo Zhang Honglei Zhang Source Type: research
Making sense of flavivirus non-strctural protein 1 in innate immune evasion and inducing tissue-specific damage
Virus Res. 2023 Sep 16;336:199222. doi: 10.1016/j.virusres.2023.199222. Online ahead of print.ABSTRACTFlaviviruses include medically important mosquito-borne pathogens, such as Zika virus (ZIKV), Japanese encephalitis virus (JEV), dengue virus (DENV) and West Nile virus (WNV), that cause hundreds of millions of infections each year. Currently, there are no approved effect therapies against mosquito-borne flaviviruses. The flaviviruses encoded nonstructural protein 1 (NS1) is a secreted glycoprotein widely involved in viral replication, immune evasion, and directly causing tissue-specific damage during flaviviruses infectio...
Source: Virus Research - September 16, 2023 Category: Virology Authors: Quan Zeng Jiaqi Liu Chenlin Hao Bo Zhang Honglei Zhang Source Type: research
The Latest on West Nile Virus in the US
This Medical News article discusses recent US data on West Nile virus disease. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 13, 2023 Category: General Medicine Source Type: research
Viruses, Vol. 15, Pages 1900: Ecological Niche Modeling of Aedes and Culex Mosquitoes: A Risk Map for Chikungunya and West Nile Viruses in Zambia
This study aimed to examine the contribution of climatic variables to the distribution of Culex and Aedes mosquito species, which are potential vectors of CHIKV, WNV, and other arboviruses of public-health concern. Mosquitoes collected from Lusaka as well as from the Central and Southern provinces of Zambia were sorted by species within the Culex and Aedes genera, both of which have the potential to transmit viruses. The MaxEnt software was utilized to predict areas at risk of WNV and CHIKV based on the occurrence data on mosquitoes and environmental covariates. The model predictions show three distinct spatial hotspots, r...
Source: Viruses - September 8, 2023 Category: Virology Authors: Rachel Milomba Velu Geoffrey Kwenda Samuel Bosomprah Moses Ngongo Chisola Michelo Simunyandi Caroline Cleopatra Chisenga Flavien Nsoni Bumbangi Nicholus Chintu Sande Limonty Simubali Monicah Mirai Mburu John Tembo Matthew Bates Martin Chitolongo Simuunza Tags: Article Source Type: research
Elucidating the role of dsRNA sensing and Toll6 in antiviral responses of Culex quinquefasciatus cells
The first step of any immune response is the recognition of foreign molecular structures inside the host organism. An important molecule that is generally foreign to eukaryotic cells is long double-stranded RNA (dsRNA), which can be generated during virus replication. The mechanisms of sensing viral dsRNA are well-studied in mammalian systems but are only poorly understood in insects, including disease vectors such as Culex quinquefasciatus mosquitoes. These mosquitoes are vectors for important arboviruses, such as West Nile virus, and Culex species mosquitoes are distributed across the globe in many temperate and tropical...
Source: Frontiers in cellular and infection microbiology - August 30, 2023 Category: Microbiology Source Type: research
West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2021
This report summarizes 2021 surveillance data reported to CDC by U.S. jurisdictions for nationally notifiable arboviruses; the report excludes chikungunya, dengue, yellow fever, and Zika virus disease cases, because these infections were acquired primarily through travel during 2021. Forty-nine states and the District of Columbia reported 3,035 cases of domestic arboviral disease, including those caused by West Nile (2,911), La Crosse (40), Jamestown Canyon (32), Powassan (24), St. Louis encephalitis (17), unspecified California serogroup (six), and eastern equine encephalitis (five) viruses. Among the WNV disease cases, 2...
Source: MMWR Morb Mortal Wkl... - August 24, 2023 Category: Epidemiology Authors: Anna C Fagre Shelby Lyons J Erin Staples Nicole Lindsey Source Type: research
West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2021
This report summarizes 2021 surveillance data reported to CDC by U.S. jurisdictions for nationally notifiable arboviruses; the report excludes chikungunya, dengue, yellow fever, and Zika virus disease cases, because these infections were acquired primarily through travel during 2021. Forty-nine states and the District of Columbia reported 3,035 cases of domestic arboviral disease, including those caused by West Nile (2,911), La Crosse (40), Jamestown Canyon (32), Powassan (24), St. Louis encephalitis (17), unspecified California serogroup (six), and eastern equine encephalitis (five) viruses. Among the WNV disease cases, 2...
Source: MMWR Morb Mortal Wkl... - August 24, 2023 Category: Epidemiology Authors: Anna C Fagre Shelby Lyons J Erin Staples Nicole Lindsey Source Type: research
West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2021
This report summarizes 2021 surveillance data reported to CDC by U.S. jurisdictions for nationally notifiable arboviruses; the report excludes chikungunya, dengue, yellow fever, and Zika virus disease cases, because these infections were acquired primarily through travel during 2021. Forty-nine states and the District of Columbia reported 3,035 cases of domestic arboviral disease, including those caused by West Nile (2,911), La Crosse (40), Jamestown Canyon (32), Powassan (24), St. Louis encephalitis (17), unspecified California serogroup (six), and eastern equine encephalitis (five) viruses. Among the WNV disease cases, 2...
Source: MMWR Morb Mortal Wkl... - August 24, 2023 Category: Epidemiology Authors: Anna C Fagre Shelby Lyons J Erin Staples Nicole Lindsey Source Type: research
West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2021
This report summarizes 2021 surveillance data reported to CDC by U.S. jurisdictions for nationally notifiable arboviruses; the report excludes chikungunya, dengue, yellow fever, and Zika virus disease cases, because these infections were acquired primarily through travel during 2021. Forty-nine states and the District of Columbia reported 3,035 cases of domestic arboviral disease, including those caused by West Nile (2,911), La Crosse (40), Jamestown Canyon (32), Powassan (24), St. Louis encephalitis (17), unspecified California serogroup (six), and eastern equine encephalitis (five) viruses. Among the WNV disease cases, 2...
Source: MMWR Morb Mortal Wkl... - August 24, 2023 Category: Epidemiology Authors: Anna C Fagre Shelby Lyons J Erin Staples Nicole Lindsey Source Type: research
West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2021
This report summarizes 2021 surveillance data reported to CDC by U.S. jurisdictions for nationally notifiable arboviruses; the report excludes chikungunya, dengue, yellow fever, and Zika virus disease cases, because these infections were acquired primarily through travel during 2021. Forty-nine states and the District of Columbia reported 3,035 cases of domestic arboviral disease, including those caused by West Nile (2,911), La Crosse (40), Jamestown Canyon (32), Powassan (24), St. Louis encephalitis (17), unspecified California serogroup (six), and eastern equine encephalitis (five) viruses. Among the WNV disease cases, 2...
Source: MMWR Morb Mortal Wkl... - August 24, 2023 Category: Epidemiology Authors: Anna C Fagre Shelby Lyons J Erin Staples Nicole Lindsey Source Type: research
Uncovering the neurological effects of West Nile virus during a record-breaking southern Spain outbreak in 2020 –2021
The 2020 –21 West Nile Virus (WNV) outbreak in Andalusia, Spain, was the largest reported in the country, with eight cases of West Nile Neuroinvasive Disease (WNND) diagnosed in a tertiary hospital. Diagnosis of WNND is based on detecting WNV RNA, viral isolation, or demonstrating a specific immune respons e against the virus, with additional tests used to support the diagnosis. Treatment remains supportive, with variable outcomes. The potential efficacy of plasma exchange (PLEX) in select cases raises the possibility of an autoimmune component secondary to infectious pathology of the central nervous system. (Source: Jou...
Source: Journal of Neuroimmunology - August 24, 2023 Category: Allergy & Immunology Authors: Juan Diego Guerra Hiraldo, Alejandro Fuerte-Hortig ón, Ana Domínguez-Mayoral, Sandra De la Rosa Riestra, Zaira R. Palacios-Baena, Félix Sánchez Fernández, Rocio López Ruiz, Diego Pascual-Vaca, Carmen Menéndez de León, Rafael Jiménez Hurtado, Sara Tags: Short Communication Source Type: research
Fundamental neurochemistry review: Glutamatergic dysfunction as a central mechanism underlying flavivirus ‐induced neurological damage
Physiological glutamatergic transmission and flavivirus-induced pathological alterations. On average, 400 million cases of infection by flaviviruses are reported every year. Several of these viruses may cause neurologic symptoms in a subset of patients. Here, we review studies that suggest that replication of neurotropic flavivirus causes massive release of pro-inflammatory mediators leading to increased release and compromised reuptake of glutamate, ultimately causing excitotoxicity, reactive oxygen species production, and cell death. We also discuss current data suggesting that pharmacological approaches that counteract ...
Source: Journal of Neurochemistry - August 22, 2023 Category: Neuroscience Authors: Clara O. Nogueira,
Tamires Rocha,
Daniel F. Messor,
Isis N. O. Souza,
Julia R. Clarke Tags: REVIEW Source Type: research
Viruses, Vol. 15, Pages 1783: Arboviral Risk Associated with Solid Organ and Hematopoietic Stem Cell Grafts: The Prophylactic Answers Proposed by the French High Council of Public Health in a National Context
r Nicolas de Lamballerie
Diseases caused by arboviruses are on the increase worldwide. In addition to arthropod bites, most arboviruses can be transmitted via accessory routes. Products of human origin (labile blood products, solid organs, hematopoietic stem cells, tissues) present a risk of contamination for the recipient if the donation is made when the donor is viremic. Mainland France and its overseas territories are exposed to a complex array of imported and endemic arboviruses, which differ according to their respective location. This narrative review describes the risks of acquiring certain arboviral diseases fr...
Source: Viruses - August 22, 2023 Category: Virology Authors: Bruno Pozzetto Gilda Grard Guillaume Durand Marie-Claire Paty Pierre Gallian Sophie Lucas-Samuel St éphanie Diéterlé Muriel Fromage Marc Durand Didier Lepelletier Christian Chidiac Bruno Hoen Xavier Nicolas de Lamballerie Tags: Review Source Type: research
Survival effects of antibiotic exposure during the larval and adult stages in the West Nile virus vector Culex pipiens
We analyzed adult survival effects of antibiotic exposure during mosquito development through a paired two-way factorial experimental design. Larval exposure to antibiotics significantly increased the survival rate of nontreated adult females. In addition, for both male and female mosquitoes, shorter larvalad libitum feeding periods rapidly reduced the survival rate of antibiotic-treated mosquitoes compared to those emerged later, while these differences disappeared in control adult mosquitoes. AbstractThe ability of mosquitoes to transmit a pathogen is affected, among other factors, by their survival rate, which is partly...
Source: Insect Science - August 10, 2023 Category: Biology Authors: Marta Garrig ós,
Mario Garrido,
Manuel Morales‐Yuste,
Josué Martínez‐de la Puente,
Jesús Veiga Tags: ORIGINAL ARTICLE Source Type: research
