Fatal acute undifferentiated febrile illness among clinically suspected leptospirosis cases in Colombia, 2016 –2019
Conclusions/SignificanceThis study underscores the importance of early and accurate recognition of leptospirosis to prevent mortalities. Moreover, it draws attention to the existence of other febrile syndromes in Colombia, including rickettsiosis and brucellosis, that currently lack sufficient human surveillance and regular reporting. Expanding laboratory surveillance to include viruses such as Hantavirus, Mayaro virus, Oropouche virus, and West Nile virus is crucial. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - October 16, 2023 Category: Tropical Medicine Authors: Eliana L. Parra Barrera Source Type: research
Development of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain
This study highlights the effectiveness of introducing mutations in the FL domain in MBFV SVPs with lineage I ISFV-derived amino acids to produce SVP antigens with low cross-reactivity and demonstrates an improvement in the accuracy of indirect ELISA-based serodiagnosis for MBFV infections. KEY POINTS: • The FL domain of Lineage I ISFV has a different antigenicity from that of MBFVs. • Mutated SVPs reduce the binding of cross-reactive antibodies in indirect ELISAs. • Inoculation of mutated SVPs induces antibodies with low cross-reactivity.PMID:37831184 | DOI:10.1007/s00253-023-12817-5 (Source: Applied Microbiology and Biotechnology)
Source: Applied Microbiology and Biotechnology - October 13, 2023 Category: Microbiology Authors: Koshiro Tabata Yukari Itakura Takuma Ariizumi Manabu Igarashi Hiroko Kobayashi Kittiya Intaruck Mai Kishimoto Shintaro Kobayashi William W Hall Michihito Sasaki Hirofumi Sawa Yasuko Orba Source Type: research
Development of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain
This study highlights the effectiveness of introducing mutations in the FL domain in MBFV SVPs with lineage I ISFV-derived amino acids to produce SVP antigens with low cross-reactivity and demonstrates an improvement in the accuracy of indirect ELISA-based serodiagnosis for MBFV infections. KEY POINTS: • The FL domain of Lineage I ISFV has a different antigenicity from that of MBFVs. • Mutated SVPs reduce the binding of cross-reactive antibodies in indirect ELISAs. • Inoculation of mutated SVPs induces antibodies with low cross-reactivity.PMID:37831184 | DOI:10.1007/s00253-023-12817-5 (Source: Applied Microbiology and Biotechnology)
Source: Applied Microbiology and Biotechnology - October 13, 2023 Category: Microbiology Authors: Koshiro Tabata Yukari Itakura Takuma Ariizumi Manabu Igarashi Hiroko Kobayashi Kittiya Intaruck Mai Kishimoto Shintaro Kobayashi William W Hall Michihito Sasaki Hirofumi Sawa Yasuko Orba Source Type: research
Development of flavivirus subviral particles with low cross-reactivity by mutations of a distinct antigenic domain
This study highlights the effectiveness of introducing mutations in the FL domain in MBFV SVPs with lineage I ISFV-derived amino acids to produce SVP antigens with low cross-reactivity and demonstrates an improvement in the accuracy of indirect ELISA-based serodiagnosis for MBFV infections. KEY POINTS: • The FL domain of Lineage I ISFV has a different antigenicity from that of MBFVs. • Mutated SVPs reduce the binding of cross-reactive antibodies in indirect ELISAs. • Inoculation of mutated SVPs induces antibodies with low cross-reactivity.PMID:37831184 | DOI:10.1007/s00253-023-12817-5 (Source: Applied Microbiology and Biotechnology)
Source: Applied Microbiology and Biotechnology - October 13, 2023 Category: Microbiology Authors: Koshiro Tabata Yukari Itakura Takuma Ariizumi Manabu Igarashi Hiroko Kobayashi Kittiya Intaruck Mai Kishimoto Shintaro Kobayashi William W Hall Michihito Sasaki Hirofumi Sawa Yasuko Orba Source Type: research
Symbiotic Wolbachia in mosquitoes and its role in reducing the transmission of mosquito-borne diseases: updates and prospects
Mosquito-borne diseases such as malaria, dengue fever, West Nile virus, chikungunya, Zika fever, and filariasis have the greatest health and economic impact. These mosquito-borne diseases are a major cause of morbidity and mortality in tropical and sub-tropical areas. Due to the lack of effective vector containment strategies, the prevalence and severity of these diseases are increasing in endemic regions. Nowadays, mosquito infection by the endosymbiotic Wolbachia represents a promising new bio-control strategy. Wild-infected mosquitoes had been developing cytoplasmic incompatibility (CI), phenotypic alterations, and nutr...
Source: Frontiers in Microbiology - October 13, 2023 Category: Microbiology Source Type: research
Proteome Analysis for Inflammation Related to Acute and Convalescent Infection
In conclusion, we demonstrated that irrespective of the pathogen type, there are common immunoregulatory and proinflammatory signals. (Source: Inflammation)
Source: Inflammation - October 13, 2023 Category: Allergy & Immunology Source Type: research
Cellular co-infections of West Nile virus and Usutu virus influence virus growth kinetics
The mosquito-borne flaviviruses West Nile virus (WNV) and Usutu virus (USUV) pose a significant threat to the health of humans and animals. Both viruses co-circulate in numerous European countries including Ge... (Source: Virology Journal)
Source: Virology Journal - October 13, 2023 Category: Virology Authors: Christin K örsten, Hannah Reemtsma, Ute Ziegler, Susanne Fischer, Birke A. Tews, Martin H. Groschup, Cornelia Silaghi, Ana Vasic and Cora M. Holicki Tags: Brief Report Source Type: research
New Prognostic Parameter of West Nile Virus: Platelet Distribution Width
Vector-Borne and Zoonotic Diseases, Ahead of Print. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - October 12, 2023 Category: Infectious Diseases Authors: Ahmed Cihad Genc O ğuz Karabay Ertu ğrul Güçlü Aylin Çalıca Utku Asl ı Vatan Nazan Tuna G ökçen Budak Adem Şimşek Cem Uzun Sevgi Alan H üseyin Doğuş Okan Fevziye Turkoglu Genc Aziz Öğütlü Source Type: research
West Nile virus in the Iberian Peninsula: using equine cases to identify high-risk areas for humans
ConclusionA risk map highlighting the risk areas for potential future cases could be cost-effective as a means of promoting preventive measures to decrease incidence of WNV infection in Europe, based on a One Health surveillance approach.PMID:37796440 | DOI:10.2807/1560-7917.ES.2023.28.40.2200844 (Source: Euro Surveill)
Source: Euro Surveill - October 5, 2023 Category: Infectious Diseases Authors: Jos é-María García-Carrasco Antonio-Rom án Muñoz Jes ús Olivero Marina Segura Ignacio Garc ía-Bocanegra Raimundo Real Source Type: research
West Nile virus in the Iberian Peninsula: using equine cases to identify high-risk areas for humans
ConclusionA risk map highlighting the risk areas for potential future cases could be cost-effective as a means of promoting preventive measures to decrease incidence of WNV infection in Europe, based on a One Health surveillance approach.PMID:37796440 | PMC:PMC10557382 | DOI:10.2807/1560-7917.ES.2023.28.40.2200844 (Source: Euro Surveill)
Source: Euro Surveill - October 5, 2023 Category: Infectious Diseases Authors: Jos é-María García-Carrasco Antonio-Rom án Muñoz Jes ús Olivero Marina Segura Ignacio Garc ía-Bocanegra Raimundo Real Source Type: research
West Nile virus in the Iberian Peninsula: using equine cases to identify high-risk areas for humans
ConclusionA risk map highlighting the risk areas for potential future cases could be cost-effective as a means of promoting preventive measures to decrease incidence of WNV infection in Europe, based on a One Health surveillance approach.PMID:37796440 | PMC:PMC10557382 | DOI:10.2807/1560-7917.ES.2023.28.40.2200844 (Source: Euro Surveill)
Source: Euro Surveill - October 5, 2023 Category: Infectious Diseases Authors: Jos é-María García-Carrasco Antonio-Rom án Muñoz Jes ús Olivero Marina Segura Ignacio Garc ía-Bocanegra Raimundo Real Source Type: research
West Nile virus in the Iberian Peninsula: using equine cases to identify high-risk areas for humans
ConclusionA risk map highlighting the risk areas for potential future cases could be cost-effective as a means of promoting preventive measures to decrease incidence of WNV infection in Europe, based on a One Health surveillance approach.PMID:37796440 | PMC:PMC10557382 | DOI:10.2807/1560-7917.ES.2023.28.40.2200844 (Source: Euro Surveill)
Source: Euro Surveill - October 5, 2023 Category: Infectious Diseases Authors: Jos é-María García-Carrasco Antonio-Rom án Muñoz Jes ús Olivero Marina Segura Ignacio Garc ía-Bocanegra Raimundo Real Source Type: research
West Nile virus in the Iberian Peninsula: using equine cases to identify high-risk areas for humans
ConclusionA risk map highlighting the risk areas for potential future cases could be cost-effective as a means of promoting preventive measures to decrease incidence of WNV infection in Europe, based on a One Health surveillance approach.PMID:37796440 | PMC:PMC10557382 | DOI:10.2807/1560-7917.ES.2023.28.40.2200844 (Source: Euro Surveill)
Source: Euro Surveill - October 5, 2023 Category: Infectious Diseases Authors: Jos é-María García-Carrasco Antonio-Rom án Muñoz Jes ús Olivero Marina Segura Ignacio Garc ía-Bocanegra Raimundo Real Source Type: research
