Case report: Synchronous tumors of the female reproductive tract in systemic lupus erythematosus: report of two cases and review of the literature
ConclusionThe presence of synchronous tumors of the reproductive tract in patients with SLE is uncommon and can be easily disregarded. It is crucial to highlight that SLE patients with multiple primary malignancies exhibit notable late-stage presentation at the time of diagnosis, inadequate disease-free survival, poor overall survival, rapid progression rates, and mortality. Consequently, greater awareness must be raised regarding synchronous reproductive tract tumors in patients with SLE. Regular comprehensive cancer screening and management should be implemented for individuals diagnosed with SLE. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 21, 2024 Category: Cancer & Oncology Source Type: research
Efficacy of pembrolizumab in advanced cancer of the vulva: a systematic review and single-arm meta-analysis
This study suggests that one-third of women with advanced or recurrent vulvar cancer may, without the influence of PD-L1 status, benefit from pembrolizumab treatment despite a decline in both PFS and OS at 12 months. These findings provide support for considering pembrolizumab in the treatment paradigm for this specific subset of cancer patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023391888 (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 19, 2024 Category: Cancer & Oncology Source Type: research
Vulvar cancer incidence and net survival in Sweden 1960 to 2019: A population ‐based national study
ConclusionsThe age-standardized incidence of vulvar cancer cases in Sweden was stable between 1960 and 2019. During the study period, an increase in adenocarcinoma and a decrease in malignant melanoma cases was found. Five-year net survival increased by 20 percent units during the study period. For squamous cell carcinoma, an increased age-specific 5-year net survival was observed for all age groups, apart for women aged ≥85. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - February 15, 2024 Category: OBGYN Authors: Louise Moberg,
Avalon Sundqvist,
Erik Holmberg,
Paul W. Dickman,
Christer Borgfeldt Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
“Evaluation of the impact of a protocol for immediate vulvar reconstruction after vulvectomy”
This study, five years after its introduction, assesses the impact of this intervention on the postoperative evolution of vulvectomy patients.In January 2017 we introduced a protocol for immediate vulvar reconstruction that considered four criteria of high risk for postoperative dehiscence. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - January 31, 2024 Category: Cosmetic Surgery Authors: Valentin Yuste, Ester Sanz, Isabel Negredo Source Type: research
Evaluation of the impact of a protocol for immediate vulvar reconstruction after vulvectomy
This study, five years after its introduction, assesses the impact of this intervention on the postoperative evolution of vulvectomy patients.In January 2017 we introduced a protocol for immediate vulvar reconstruction that considered four criteria of high risk for postoperative dehiscence. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - January 31, 2024 Category: Cosmetic Surgery Authors: Valentin Yuste, Ester Sanz, Isabel Negredo Tags: Correspondence and Communications Source Type: research
Effect of HPV Oncoprotein on Carbohydrate and Lipid Metabolism in Tumor Cells
This article aims to elucidate the role of Human Papillomavirus (HPV) in reshaping cellular metabolism and the application of metabolic changes in the research of related diseases. Targeting cancer metabolism may serve as an effective strategy to support traditional cancer treatments, as metabolic reprogramming is crucial for malignant transformation in cancer.PMID:38284713 | DOI:10.2174/0115680096266981231215111109 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - January 29, 2024 Category: Cancer & Oncology Authors: Biqing Chen Yichao Wang Yishi Wu Tianmin Xu Source Type: research
Use of Rectus Flaps in Reconstructive Surgery for Gynecologic Cancer
In conclusion, pelvic reconstruction with RAM/RAMP flaps, at the time of radical surgery for gynecologic cancer, is an uncommon procedure. In our case series, we had a significant complication rate with the most common being infection and necrosis. The development of a team approach, with input from services including Gynecologic Oncology and Plastic Surgery should be developed to decrease post-operative complications and improve patient outcomes.PMID:38248111 | PMC:PMC10814897 | DOI:10.3390/curroncol31010026 (Source: Current Oncology)
Source: Current Oncology - January 22, 2024 Category: Cancer & Oncology Authors: Oleksandra Dzyubak Lina Salman Allan Covens Source Type: research
Case report: A kidney metastasis from vulvar squamous cell carcinoma
ConclusionAlthough renal metastasis from vulvar SCC is rare, renal metastasis should be considered for the patient with a history of vulvar cancer, whenever a mass is identified in the kidney. Timely surgical removal of renal metastasis may prolong the survival time. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 16, 2024 Category: Cancer & Oncology Source Type: research
Surgery as primary treatment improved overall survival in vulvar squamous cancer: A single center study with 108 women
Vulvar cancer is a rare gynecological malignancy with high morbidity and mortality rates. The American incidence rate is 2.6 per 100,000 women/year, and the mortality rate is 0.5 per 100,000 women/year [1]. It is an elderly disease, although the incidence in younger groups is increasing, probably related to HPV infection [2]. The literature is scarce due to its rarity, a challenge for developing guidelines on management [3]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - January 13, 2024 Category: OBGYN Authors: Hisa Matsumoto Videira, Mariana Miguel Camargo, Julio Cesar Teixeira, Aline Evangelista Satiago, Larissa Bastos Eloy Costa, Diama Bhadra Vale Tags: Full length article Source Type: research
Cancers, Vol. 16, Pages 276: Pelvic Exenteration for Recurrent Vulvar Cancer: A Retrospective Study
Björn Lampe
Pelvic exenteration (PE) is one of the most radical surgical approaches. In earlier times, PE was associated with high morbidity and mortality. Nowadays, due to improved selection of suitable patients, perioperative settings, and postoperative care, patients’ outcomes have been optimized. To investigate patients’ outcomes and identify possible influencing clinical and histopathological factors, we analysed 17 patients with recurrent vulvar cancer who underwent PE in our department between 2007 and 2022. The median age was 64.9 years, with a difference of 40 years between the ...
Source: Cancers - January 8, 2024 Category: Cancer & Oncology Authors: Sabrina Classen-von Spee Saher Baransi Nando Fix Friederike Rawert Ver ónica Luengas-Würzinger Ruth Lippert Michelle Bonin-Hennig Peter Mallmann Bj örn Lampe Tags: Article Source Type: research
Accuracy of ICG compared with technetium-99 m for sentinel lymph node biopsy in vulvar cancer
CONCLUSION(S): ICG shows comparable performance parameters to the gold-standard of radioisotope localization.PMID:38183845 | DOI:10.1016/j.ejogrb.2023.12.037 (Source: Reproductive Biology)
Source: Reproductive Biology - January 6, 2024 Category: Reproduction Medicine Authors: Alberto Rafael Guijarro-Campillo Pablo Padilla-Iserte B árbara Couso Diego Erasun Jes ús Utrilla-Layna Octavio Arencibia Ana Boldo-Roda Juan Gilabert-Estell és Nadia Veiga V íctor Lago Jos é Miguel Cárdenas-Rebollo Santiago Domingo Source Type: research
Sentinel Lymph Node Evaluation in Early-Stage Vulvar Cancer
Opinion StatementSentinel lymph node mapping (SLNM) and dissection (SLND) should be used as an alternative to full inguinofemoral lymph node dissection (IFLND) in select patients with early-stage vulvar cancer. IFLND is associated with high postoperative complications such as wound breakdown, lymphedema, lymphocyst formation, and infection. SLND in select patients offers a safe, effective, and less morbid alternative. Candidates for SLND include patients with a unifocal vulvar tumor less than four centimeters, clinically negative lymph nodes, and no prior inguinofemoral surgeries. SLND should ideally be performed by a high...
Source: Current Treatment Options in Oncology - January 3, 2024 Category: Cancer & Oncology Source Type: research
Accuracy of ICG compared with technetium-99m for sentinel lymph node biopsy in vulvar cancer
Surgery is the primary treatment for early-stage vulvar cancer, including radical local excision with groin evaluation [1,2]. Vulvar cancer guidelines recommend inguinal sentinel lymph node biopsy (SLN) as a standard-of-care in patients with squamous unifocal tumors (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - January 2, 2024 Category: OBGYN Authors: Alberto Rafael Guijarro-Campillo, Pablo Padilla-Iserte, B árbara Couso, Diego Erasun, Jesús Utrilla-Layna, Octavio Arencibia, Ana Boldo-Roda, Juan Gilabert-Estellés, Nadia Veiga, Víctor Lago, José Miguel Cárdenas-Rebollo, Santiago Domingo Tags: Full length article Source Type: research
Accuracy of ICG compared with technetium-99 m for sentinel lymph node biopsy in vulvar cancer
Surgery is the primary treatment for early-stage vulvar cancer, including radical local excision with groin evaluation [1,2]. Vulvar cancer guidelines recommend inguinal sentinel lymph node biopsy (SLN) as a standard-of-care in patients with squamous unifocal tumors (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - January 2, 2024 Category: OBGYN Authors: Alberto Rafael Guijarro-Campillo, Pablo Padilla-Iserte, B árbara Couso, Diego Erasun, Jesús Utrilla-Layna, Octavio Arencibia, Ana Boldo-Roda, Juan Gilabert-Estellés, Nadia Veiga, Víctor Lago, José Miguel Cárdenas-Rebollo, Santiago Domingo Tags: Full length article Source Type: research
The expression of corticotropin-releasing hormone family peptides in premalignant and malignant vulvar lesions
ConclusionsStress response system and CRH family peptides seem to have a role in inflammation maintenance and progression of vulvar premalignant lesions to malignancy. It seems that stress peptides may locally modulate the stroma through Fas/FasL upregulation, possibly contributing to vulvar cancer development. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - January 1, 2024 Category: Cancer & Oncology Source Type: research
