Comorbidity in patients with Lichen sclerosus: a retrospective cohort study
This study confirmed the association between LS and vulvar cancer (OR = 17.4; 95% CI 12.1–25.3), penis cancer (OR = 9.1; 95% CI 4.3–18.9), prostate cancer (OR = 2.0; 95% CI 1.6–2.4) and breast cancer (OR = 1.6; 95% CI 1.4–1.8). LS was also associated with Crohn´s disease (OR = 2.0; 95% CI 1.6–2.6) and diabetes mellitus type 1 (OR = 1.9; 95% CI 1.6–2.1). The present study revealed novel important data regarding the association of LS with cancer and autoimmune diseases, emphasising the importance of sufficient t reatment and follow-up of patients with LS. However, future studies are neede...
Source: European Journal of Medical Research - September 11, 2023 Category: Research Source Type: research
Po46
For patients with inoperable locally advanced vulvar cancer (LAVC), concurrent chemoradiation is the standard of care. Given proximity to nearby critical structures, many patients with LAVC are unable to undergo surgical resection, increasing the risk of local failure in these patients. Dose-escalation of external beam radiotherapy (EBRT) has been studied as a significant means by which local control (LC) outcomes might be improved, however, sparing of critical organs at risk (OARs) remains a clinical challenge. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Hayden Anthony Ansinelli, Arjit Baghwala, Chengfeng (Brandon) Li, Ramiro Pino, E. Brian Butler, Bin S. Teh, Andrew M. Farach Source Type: research
Po31
Effective treatment for locally-advanced vulvar cancer remains a challenge and often requires multi-modality care. Unresectable disease may be managed with a combination of chemotherapy, external beam radiation (EBRT), and brachytherapy. Cesium-131 Low Dose Rate (LDR) interstitial brachytherapy is an effective modality to deliver high-quality localized radiation. This case report highlights the technique and efficacy of Cesium-131 LDR interstitial brachytherapy as a part of multimodal therapy in treating a medically inoperable patient with advanced age and multiple medical comorbidities. (Source: Brachytherapy)
Source: Brachytherapy - September 1, 2023 Category: Cancer & Oncology Authors: Jeremiah Johnson, Zeta Chow, Ali Soleimani-Meigooni, Denise Fabian Source Type: research
Temporal trends of failure-to-rescue following perioperative complications in vulvar cancer surgery in the United States
CONCLUSION: Vulvar cancer patients undergoing surgical treatment had increased comorbidity over time with an increase in high-risk complications. However, failure-to-rescue rate has decreased significantly.PMID:37597497 | DOI:10.1016/j.ygyno.2023.08.002 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 19, 2023 Category: Cancer & Oncology Authors: Matthew W Lee Andrew Vallejo Rachel S Mandelbaum Annie A Yessaian Huyen Q Pham Laila I Muderspach Lynda D Roman Maximilian Klar Jason D Wright Koji Matsuo Source Type: research
Temporal trends of failure-to-rescue following perioperative complications in vulvar cancer surgery in the United States
CONCLUSION: Vulvar cancer patients undergoing surgical treatment had increased comorbidity over time with an increase in high-risk complications. However, failure-to-rescue rate has decreased significantly.PMID:37597497 | DOI:10.1016/j.ygyno.2023.08.002 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 19, 2023 Category: Cancer & Oncology Authors: Matthew W Lee Andrew Vallejo Rachel S Mandelbaum Annie A Yessaian Huyen Q Pham Laila I Muderspach Lynda D Roman Maximilian Klar Jason D Wright Koji Matsuo Source Type: research
Vulvar cancer survival by primary treatment modality: A retrospective cohort study
CONCLUSIONS: Vulvar cancer survival was not statistically different among women treated with primary radiation compared to primary surgery when controlling for stage. Surgery followed by adjuvant radiation demonstrated elevated rates of lymphedema. Primary radiation therapy may be an acceptable alternative to primary surgery in women who are likely to need adjuvant therapy.PMID:37562168 | DOI:10.1016/j.ygyno.2023.07.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 10, 2023 Category: Cancer & Oncology Authors: Kelly H Bruce Amy Alabaster Arthur-Quan M Tran Source Type: research
Vulvar cancer survival by primary treatment modality: A retrospective cohort study
CONCLUSIONS: Vulvar cancer survival was not statistically different among women treated with primary radiation compared to primary surgery when controlling for stage. Surgery followed by adjuvant radiation demonstrated elevated rates of lymphedema. Primary radiation therapy may be an acceptable alternative to primary surgery in women who are likely to need adjuvant therapy.PMID:37562168 | DOI:10.1016/j.ygyno.2023.07.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 10, 2023 Category: Cancer & Oncology Authors: Kelly H Bruce Amy Alabaster Arthur-Quan M Tran Source Type: research
Vulvar cancer survival by primary treatment modality: A retrospective cohort study
CONCLUSIONS: Vulvar cancer survival was not statistically different among women treated with primary radiation compared to primary surgery when controlling for stage. Surgery followed by adjuvant radiation demonstrated elevated rates of lymphedema. Primary radiation therapy may be an acceptable alternative to primary surgery in women who are likely to need adjuvant therapy.PMID:37562168 | DOI:10.1016/j.ygyno.2023.07.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 10, 2023 Category: Cancer & Oncology Authors: Kelly H Bruce Amy Alabaster Arthur-Quan M Tran Source Type: research
Vulvar cancer survival by primary treatment modality: A retrospective cohort study
CONCLUSIONS: Vulvar cancer survival was not statistically different among women treated with primary radiation compared to primary surgery when controlling for stage. Surgery followed by adjuvant radiation demonstrated elevated rates of lymphedema. Primary radiation therapy may be an acceptable alternative to primary surgery in women who are likely to need adjuvant therapy.PMID:37562168 | DOI:10.1016/j.ygyno.2023.07.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 10, 2023 Category: Cancer & Oncology Authors: Kelly H Bruce Amy Alabaster Arthur-Quan M Tran Source Type: research
Vulvar cancer survival by primary treatment modality: A retrospective cohort study
CONCLUSIONS: Vulvar cancer survival was not statistically different among women treated with primary radiation compared to primary surgery when controlling for stage. Surgery followed by adjuvant radiation demonstrated elevated rates of lymphedema. Primary radiation therapy may be an acceptable alternative to primary surgery in women who are likely to need adjuvant therapy.PMID:37562168 | DOI:10.1016/j.ygyno.2023.07.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 10, 2023 Category: Cancer & Oncology Authors: Kelly H Bruce Amy Alabaster Arthur-Quan M Tran Source Type: research
Vulvar cancer survival by primary treatment modality: A retrospective cohort study
CONCLUSIONS: Vulvar cancer survival was not statistically different among women treated with primary radiation compared to primary surgery when controlling for stage. Surgery followed by adjuvant radiation demonstrated elevated rates of lymphedema. Primary radiation therapy may be an acceptable alternative to primary surgery in women who are likely to need adjuvant therapy.PMID:37562168 | DOI:10.1016/j.ygyno.2023.07.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 10, 2023 Category: Cancer & Oncology Authors: Kelly H Bruce Amy Alabaster Arthur-Quan M Tran Source Type: research
Vulvar cancer survival by primary treatment modality: A retrospective cohort study
CONCLUSIONS: Vulvar cancer survival was not statistically different among women treated with primary radiation compared to primary surgery when controlling for stage. Surgery followed by adjuvant radiation demonstrated elevated rates of lymphedema. Primary radiation therapy may be an acceptable alternative to primary surgery in women who are likely to need adjuvant therapy.PMID:37562168 | DOI:10.1016/j.ygyno.2023.07.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 10, 2023 Category: Cancer & Oncology Authors: Kelly H Bruce Amy Alabaster Arthur-Quan M Tran Source Type: research
Vulvar cancer survival by primary treatment modality: A retrospective cohort study
CONCLUSIONS: Vulvar cancer survival was not statistically different among women treated with primary radiation compared to primary surgery when controlling for stage. Surgery followed by adjuvant radiation demonstrated elevated rates of lymphedema. Primary radiation therapy may be an acceptable alternative to primary surgery in women who are likely to need adjuvant therapy.PMID:37562168 | DOI:10.1016/j.ygyno.2023.07.013 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - August 10, 2023 Category: Cancer & Oncology Authors: Kelly H Bruce Amy Alabaster Arthur-Quan M Tran Source Type: research
Incidence of inguinofemoral lymph node metastases at the first local recurrence of vulvar cancer: a Dutch nationwide study
British Journal of Cancer, Published online: 28 July 2023; doi:10.1038/s41416-023-02373-0Incidence of inguinofemoral lymph node metastases at the first local recurrence of vulvar cancer: a Dutch nationwide study (Source: British Journal of Cancer)
Source: British Journal of Cancer - July 28, 2023 Category: Cancer & Oncology Authors: Noortje Pleunis Anne-Floor W. Pouwer Maaike H. M. Oonk Helena C. van Doorn Ming Y. Tjiong Jacobus van der Velden Henry Zijlmans Mariette I. E. van Poelgeest Eleonora B. van Dorst Brigitte F. M. Slangen Lia C. G. Verhoef Johanna M. A. Pijnenborg Joanne A. Source Type: research
Cancers, Vol. 15, Pages 3844: Selective Removal of Only Clinically Suspicious Positive Lymph Nodes Instead of a Complete Inguino-Femoral Lymph Node Dissection in Squamous Cell Carcinoma of the Vulva
Conclusion. This retrospective study in a cohort of women with vulvar cancer corroborates previous smaller studies that have shown that the selective removal of suspicious inguinal nodes yields similar oncological outcomes compared with patients matched for important prognostic variables and treated with a complete IFL when both are followed by radiotherapy. (Source: Cancers)
Source: Cancers - July 28, 2023 Category: Cancer & Oncology Authors: Guus Fons Nikki B. Thuijs Ming Tjiong Lukas J. A. Stalpers Jacobus van der Velden Tags: Article Source Type: research
